Expression of cyclin-dependent kinases inhibitors p21(WAF1) and p27(KIP1) in Benign, premalignant and malignant laryngeal lesions. Correlation with cell cycle regulatory proteins

In Vivo

Volumn 18, Issue 6, 2004, Pages 719-724

  Peschos, D ^a   Tsanou, E ^a   Stefanou, D ^a   Damala, C ^a   Vougiouklakis, T ^a   Mitselou, A ^a   Agnantis, N J ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

Author keywords

Cell cycle regulatory proteins; Laryngeal cancer; p21; p27; Proliferation markers

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN D; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E; CYCLINE; KI 67 ANTIGEN; PROTEIN P53; REGULATOR PROTEIN;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CARCINOMA IN SITU; CONTROLLED STUDY; CORRELATION ANALYSIS; DYSPLASIA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; INVASIVE CARCINOMA; KERATOSIS; LARYNX CARCINOMA; MAJOR CLINICAL STUDY; PAPILLOMA; PRECANCER; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA;

EID: 11844279741     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Barnes DM: Cell cycle. J Clin Pathol (Mol Pathol) 51: 310-316, 1998.
2. Sherr CJ: Mammalian G1 cyclins. Cell 73: 1059-1065, 1993.
3. Kato J: Induction of S phase by G1 regulatory factors. Front Biosci 4: 787-792, 1999.
4. Sherr C J: D-type cyclins. Trends Biochem. Sci 20: 187-190, 1995.
5. Lloyd R V, Erickson L A and Jin L: P27 kip1: A multifunctional cyclin-dependent-kinase inhibitor with prognostic significance in human cancers. Am J Pathol 154: 313-323, 1999.
6. Scambia G, Catozzi L, Benedetti-Panici P et al: Expression of ras oncogene p21 protein in normal and neoplastic laryngeal tissues: correlation with histopathological features and epidermal growth factor receptors. Br J Cancer 69: 995-999, 1994.
7. Patel V, Jakus J, Harris CM, Ensley JF, Robbins KC and Yeudall WA: Altered expression and activity of G1/S cyclins and cyclin-dependent kinases characterize squamous cell carcinomas of the head and neck. Int J Cancer 73: 551-555, 1997.
8. Erber R, Klein W, Andl T, Enders C et al: Aberrant p21. (CIP1/WAF1) protein accumulation in head-and-neck cancer. Int J Cancer 74: 383-389, 1997.
9. Jeannon JP, Soames J, Lunec J, Awwad S, Ashton V and Wilson JA: Expression of cyclin-dependent kinase inhibitor p21(WAF1) and p53 tumour suppressor gene in laryngeal cancer. Clin Otolaryngol 25: 23-27, 2000.
10. Hirvikoski P, Kellokoski JK, Kumpulainen EJ, Virtaniemi JA, Johansson RT and Kosma VM: Down-regulation of p21/WAF1 is related to advanced and dedifferentiated laryngeal squamous cell carcinoma. J Clin Pathol 52: 440-444, 1999.
11. Hirai T, Hayashi K, Takumida M, Ueda T, Hirakawa K and Yajin K: Reduced expression of p27 is correlated with progression in precancerous lesions of the larynx. Auris Nasus Larynx 30: 163-168, 2003.
12. Fan GK, Fujieda S, Sunaga H, Tsuzuki H, Ito N and Saito H: Expression of protein p27 is associated with progression and prognosis in laryngeal cancer. Laryngoscope 109: 815-820, 1999.
13. Schipper JH, Frixen UH, Behrens J, Unger A, Jahnke K and Birchmeier W: E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res 51: 6328-6337, 1991.
14. Tamura N, Dong Y, Sui L, Tai Y et al: Cyclin-dependent kinase inhibitor p27 is related to cell proliferation and prognosis in laryngeal squamous cell carcinomas. J Laryngol Otol 115: 400-406, 2001.
15. Pruneri G, Pignataro L, Carboni N, Buffa R et al: Clinical relevance of expression of the CIP/KIP cell-cycle inhibitors p21 and p27 in laryngeal cancer. J Clin Oncol 17: 3150-3159, 1999.
16. Ioachim E, Peschos D, Goussia A and Mittari E: Expression patterns of cyclins D1, E in laryngeal epithelial lesions: correlation with other cell cycle regulators and clinicopathological features. Exp Clin Cancer Res 23: 277-283, 2004.
17. Goussia A, Ioachim E and Peschos D: Immunohistochemical expression of cathepsin D in laryngeal epithelial lesions: correlation with CD44 expression, p53 and Rb status and proliferation associated indices. Anticancer Res 19: 3055-3060, 1999.
18. Filipits M, Puhalla H and Wrba F: Low p27Kip1 expression is an independent prognostic factor in gallbladder carcinoma Anticancer Res 23: 675-679, 2003.
19. Tsihlias J, Kapusta LR, DeBoer G and Morava-Protzner I: Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma. Cancer Res 58: 542-548, 1998
20. Ioachim E, Assimakopoulos D, Agnantis NJ, Peschos D, Zissi A and Skevas A: Altered patterns of retinoblastoma gene product expression in benign, premalignant and malignant epithelium of the larynx: an immunohistochemical study including correlation with p53, bcl-2 and proliferating indices. Anticancer Res 19: 541-545, 1999.
21. Yuen PW, Lam KY, Choy JT, Ho WK and Wei WI: Clinicopathological significance of p53 and p21 expression in the surgical treatment of laryngeal carcinoma. Anticancer Res 20: 4863-4866, 2000.
22. Coqueret O: New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment? Trends Cell Biol 13: 65-70, 2003.
23. Ibrahim SO, Lillehaug JR and Vasstrand EN: Mutations of the cell cycle regulatory genes p161NK4A and p21WAF1 and the metastasis-inducing gene S100A4 are infrequent and unrelated to p53 tumour suppressor gene status and data on survival in oropharyngeal squamous cell carcinomas. Anticancer Res 23: 4593-4600, 2003.
24. Sheaff RJ, Groudine M, Gordon M, Roberts JM and Clurman BE: Cyclin E-CDK2 is a regulator of p27Kip1. Genes Dev 11: 1464-1478, 1997.
25. Kawamata N, Morosetti R, Miller CW and Park D: Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies. Cancer Res 55: 2266-2269, 1995.
26. Liu M, Lawson G, Delos M, Jamart J et al: Prognostic value of cell proliferation markers, tumour suppressor proteins and cell adhesion molecules in primary squamous cell carcinoma of the larynx and hypopharynx. Eur Arch Otorhinolaryngol 260: 28-34, 2003.
27. El-Deiry WS, Tokino T, Velculescu VE, Levy DB et al: WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825, 1993.
28. Dong Y, Sui L, Tai Y, Sugimoto K and Tokuda M: The overexpression of cyclin-dependent kinase (CDK) 2 in laryngeal squamous cell carcinomas. Anticancer Res 21: 103-108, 2001.
29. Dong Y, Sui L, Watanabe Y, Sugimoto K and Tokuda M: Aberrant expression of cyclin A in laryngeal squamous cell carcinoma. Anticancer Res 22: 83-9, 2002
30. Jacks T and Weinberg RA: The expanding role of cell cycle regulators. Science 280: 1035-1036, 1998.