Expression patterns of cyclins D1, E in laryngeal epithelial lesions: Correlation with other cell cycle regulators (p53, pRb, Ki-67 and PCNA) and clinicopathological features

Journal of Experimental and Clinical Cancer Research

Volumn 23, Issue 2, 2004, Pages 277-283

  Ioachim, Elli ^a   Peschos, D ^a   Goussia, A ^a   Mittari, E ^a   Charalabopoulos, K ^a   Michael, M ^a   Salmas, M ^b   Vougiouklakis, Th ^a   Assimakopoulos, D ^a   Agnantis, N J ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

Cyclin D1; Cyclin E; Laryngeal lesions; P53; PRb; Proliferative activity

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN D1; CYCLIN E; CYCLINE; KI 67 ANTIGEN; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ADULT; AGED; ARTICLE; CANCER RECURRENCE; CANCER RISK; CANCER SURVIVAL; CARCINOMA IN SITU; CELL PROLIFERATION; DYSPLASIA; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INVASIVE CARCINOMA; KERATOSIS; LARYNX CANCER; LARYNX MUCOSA; LARYNX PAPILLOMATOSIS; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA IN SITU; CARCINOMA, SQUAMOUS CELL; CELL CYCLE; COHORT STUDIES; CYCLIN D1; CYCLIN E; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; KERATOSIS; KI-67 ANTIGEN; LARYNGEAL NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; NEOPLASMS, GLANDULAR AND EPITHELIAL; PAPILLOMA; PROLIFERATING CELL NUCLEAR ANTIGEN; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 3242717798     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Sherr C.J.: D-type cyclins. Trends Biochem. Sci. 20: 187-190, 1995.
2. Sheyn I., Noffsinger A.E. and Heffelfinger S.: Amplification and expression of the cyclin D1 gene in anal and esophageal carcinomas. Human Pathol. 28: 270-279, 1997.
3. Muller D., Millon R., Lidereau R. et al.: Frequent amplification of 11q13DNA markers is associated with lymph node involvement in human head and neck squamous cell carcinoma. Oral. Oncol. Eur. J. Cancer 30: 113-120, 1994.
4. Parise O., Janot F., Guerry R. et al.: Chromosome 11q13 gene amplifications in head and neck squamous cell carcinomas: relation with lymph node invasion. Int. J. Oncol. 5: 309-313, 1994.
5. Izzo J., Papadimitrakopoulou V., Lee J.S. et al.: Role of cyclin D1 (CCND1) in the multistep tumorigenesis process of head and neck squamous cell carcinomas (HNSCC). Proc. Am. Assoc. Cancer Res. 37: 539 (A3687), 1996.
6. Xu L., Davidson B.J., Murty V.V. et al.: TP53 gene mutations and CCND1 gene amplification in head and neck squamous cell carcinoma cell lines. Int. J. Cancer 59: 383-387, 1994.
7. Jares P., Fernandez PL., Campo E. et al: PRAD-1/Cyclin D1 Gene apmlification correlates with messenger RNA overexpression and tumor progression in human laryngeal carcinomas. Cancer Res. 54: 4813-4817, 1994.
8. Whisler L., Wood N., Caldarelli D. et al.: Regulators of proliferation and apoptosis in carcinoma of the larynx. Laryngoscope 108: 630-638, 1998.
9. Pignataro L., Capaccio P., Pruneri G. et al.: The predictive value of p53, MDM-2, cyclin D1 and Ki-67 in the progression from low-grade dysplasia towards carcinoma of the larynx. J. Laryngol. Otol. 112: 455-459, 1998.
10. Pignataro L., Pruneri G., Carboni N. et al.: Clinical relevance of cyclin D1 protein overexpression in laryngeal squamous cell carcinoma. J. Clin. Oncol. 16: 3069-3077, 1998.
11. Yoo S.S., Carter D., Turner B.C. et al.: Prognostic significance of cyclin D1 protein levels in early-stage larynx cancer treated with primary radiation. Int. J. Cancer 20: 22-28, 2000.
12. Uhlman D.L., Adams G., Knapp D., Aeppli D.M., Niehans G.: Immunohistochemical staining for markers of future neoplastic progression in the larynx. Cancer Res 56: 2199-205, 1996.
13. Vielba R., Bilbao J., Ispizua A.: p53 and cyclin D1 as prognostic factors in squamous cell carcinoma of the larynx. Laryngoscope 113: 167-172, 2003.
14. Cordon-Cardo C.: Mutation of cell cycle regulators, Biological and clinical amplications for human neoplasia. Am. J. Pathol. 147: 545-560, 1995.
15. Bito T., Ueda M., Ito A., Ichihashi M.: Less expression of cyclin E in cutaneous squamous cell carcinomas than in benign and premalignant keratinocytic lesions. J. Cutan. Pathol. 24: 305-308, 1997.
16. Matsumoto M., Furihata N., Ishikawa T., Ohtsuki Y. and Ogoshi S.: Comparison of deregulated expression of cyclin D1 and cyclin E with that of cyclin-dependent kinase (CDK4) and CDK2 in human oesophageal squamous cell carcinoma. Br. J. Cancer 80: 256-261, 1999.
17. Sarbia M., Bektas N., Muller W., Heep H., Borchard F. and Gabbert H.: Expression of cyclin E in dysplasia, carcinoma, and nonmalignant lesions of Barrett esophagus. Cancer 86: 2597-2601, 1999.
18. Ferlito A. and Friedmann I.: Squamous cell carcinoma. In: Neoplasms of the Larynx. 1st ed. Ferlito A. (ed). Churchill Livingstone. Edindurgh. 1993, pp. 113-133.
19. Michalides R., van Veelen N., Hart A., Loftus B., Wientjens E., and Balm A.: Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck. Cancer Res. 55: 975-978, 1995.
20. Wong R.J., Keel S.B., Glynn R.J., Varvares M.A.: Histological pattern of mandibular invasion by oral squamous cell carcinoma. Laryngoscope 110: 65-72, 2000.
21. Narayana A., Vaughan A.T., Guthuria S., Walter S.A., Reddy S.P.: Is p53 an independent prognostic factor in patients with laryngeal carcinoma? Cancer 82: 286-291, 1998.
22. Nakashima T., Wang X.F., Masuda M., Inokuchi A., Komiyama S.: Overexpression of p53 nuclear protein in premalignant and malignant laryngeal lesions. Eur. Arch. Otorhinolaryngol. 256: 56-59, 1999.
23. Takes R., Baantenburg de Jong B., Schuuring E., Hermans J., Vis A., Litvinov S., Krieken H.: Markers for assessment of nodal metastasis in laryngeal caercinoma. Arch. Otolaryngol. Head Neck Surg. 123: 412-419, 1997.
24. Ioachim E., Assimakopoulos D., Agnantis N.J., Peschos D., Zissi A. and Skevas A.: Altered patterns of retinoblastoma gene product expression in benign, premalignant, and malignant epithelium of the larynx: An immunohistochemical study including correlation with p53, bcl-2 and proliferating indices. Anticancer Res. 19: 541-546, 1999.
25. Lai R., Medeiros L.S., Wilson C.S. et al.: Expression of the cell-cycle-related protein E2F-1, p53, mdm-2, p21waf-1, and Ki-67 in multiple myeloma: correlation with cyclin-D1 immunoreactivity. Mod. Pathol. 11: 642-647, 1998.
26. Nakahara A., Shintani S., Mihara M., Kiyota A., Ueyama Y., Matsumura T.: Alterations of Rb, p16INK4A and cyclin D1 in the tumorigenesis of oral squamous cell carcinomas. Cancer Letters 160: 3-8, 2000.