Chapter 4. Mechanisms of allergen immunotherapy

Clinical and Experimental Allergy Reviews

Volumn 4, Issue SUPPL. 2, 2004, Pages 56-60

  Akdis, M ^a   Schmidt Weber, C ^a   Jutel, M ^a   Akdis, C A ^a   Blaser, Kurt ^a  

^a SWISS INSTITUTE OF ALLERGY AND ASTHMA RESEARCH SIAF   (Switzerland)

Author keywords

Allergen; IL 10; Immunotherapy; Normal immunity; T reg; TGF

Indexed keywords

ALLERGEN; BEE VENOM; CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G4; INSECT VENOM; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; INTERLEUKIN 5; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE A2; PROTEIN KINASE ZAP 70; PROTEIN P85; SMAD ANCHOR FOR RECEPTOR ACTIVATION; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSFORMING GROWTH FACTOR BETA;

ALLERGEN SPECIFIC IMMUNOTHERAPY; ALLERGIC DISEASE; ALLERGIC RHINITIS; ANTIBODY PRODUCTION; BIRCH; CONFERENCE PAPER; CYTOKINE RELEASE; DERMATOPHAGOIDES; HUMAN; IMMEDIATE TYPE HYPERSENSITIVITY; IMMUNOLOGICAL TOLERANCE; IMMUNOTHERAPY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; POLLEN; PRIORITY JOURNAL; SUPPRESSOR CELL; T LYMPHOCYTE SUBPOPULATION;

EID: 11844274659     PISSN: 14729725     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-9725.2004.00035.x     Document Type: Conference Paper

References (16)

1. 2. Int Arch Allergy Immunol 1998; 117:1-10.
2. 2-specific T cell clones from human allergic and non-allergic individuals: cytokine patterns change in response to the antigen concentration. Eur J Immunol 1992; 22:1357-63.
3. Akdis CA, Blaser K. IL-10 induced anergy in peripheral T cell and reactivation by microenvironmental cytokines: two key steps in specific immunotherapy. FASEB J 1999; 13:603-9.
4. Akdis CA, Blaser K. Mechanisms of interleukin-10 mediated immune suppression. Immunology 2001; 103:131-6.
5. Akdis CA, Blesken T, Akdis M, Wüthrich B, Blaser K. Role of IL-10 in specific immunotherapy. J Clin Invest 1998; 102:98-106.
6. 2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro. J Clin Invest 1996; 98:1676-83.
7. Akdis M, Taylor A, Verhagen J et al. Immune response in healthy and allergic individuals are characterized by a fine balance between allergen-specific T Regulatory 1 and T helper 2 cells. J Exp Med 2004; 199:1567-75.
8. REG cells and allergy: a question of balance and antigen-specificicity. Nat Rev Immunol [online] 2003: http://www.nature.com/nri/focus/rglymph [accessed on 20 September 2004].
9. Jutel M, Akdis M, Budak F et al. IL-10 and TGF-β cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 2003; 33:1205-14.
10. Durham SR, Till SJ. Immunologic changes associated with allergen immunotherapy. J Allergy Clin Immunol 1998; 102:157-64.
11. 2. J Immunol 1993; 150:3582-91.
12. 2 induces specific T cell anergy in bee sting allergic patients. J Allergy Clin Immunol 1998; 101:747-54.
13. Carbadillo JM, Carbadillo-Perrig N, Oberli-Schrammli A, Heusser CH, Blaser K. Regulation of IgE and IgG4 responses by allergen-specific T-cell clones to bee venom phospholipase A2 in vitro. J Allergy Clin Immunol 1994; 93:758-67.
14. Akdis CA, Joss A, Akdis M, Faith A, Blaser K. A molecular basis for T cell suppression by IL-10: CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding. FASEB J 2000; 14:1666-9.
15. Joss A, Akdis M, Faith A, Blaser K, Akdis CA. IL-10 directly acts on T cells by specifacally altering the CD28 co-stimulation pathway. Eur J Immunol 2000; 30:1683-90.
16. Kunzmann S, Wohlfahrt JG, Itoh S et al. SARA and Hgs attenuate susceptibility to TGF-β1-mediated T-cell suppression. FASEB J 2003; 17:194-202.