Antiapoptotic effect both in vivo and in vitro of A20 when transfected into rat hippocampal neurons

Acta Pharmacologica Sinica

Volumn 26, Issue 1, 2005, Pages 33-38

  Miao, Hong Sheng ^a,b   Yu, Lu Yang ^c   Hui, Guo Zhen ^a   Guo, Li He ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^c NONE

Author keywords

A20 protein; Apoptosis; Middle cerebral artery infarction; Primary hippocampal neurons; Tumor necrosis factor

Indexed keywords

PROTEIN A20; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CELL SURVIVAL; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; EMBRYO; GENE OVEREXPRESSION; GENE TRANSFER; GENETIC TRANSFECTION; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL; NONHUMAN; PROTEIN EXPRESSION; RAT;

ANIMALS; APOPTOSIS; CELLS, CULTURED; GENE EXPRESSION; HIPPOCAMPUS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEURONS; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 11844252041     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2005.00002.x     Document Type: Article

References (18)

1. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995, 267: 1456-62.
2. Opipari AW Jr, Hu HM, Yabkowitz R, Dixit VM. The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. J Biol Chem 1992; 267: 12424-7.
3. Yu LY, Lin B, Zhang ZL, Guo LH. Direct transfer of A20 gene into pancreas protected mice from streptozotocin-induced diabetes. Acta Pharmacol Sin 2004; 25: 721-6.
4. Song HY, Rothe M, Goeddel DV. The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. Proc Natl Acad Sci USA 1996; 93: 6721-5.
5. Ferran C, Stroka DM, Badrichani AZ, Cooper JT. A20 inhibits NF-kappaB activation in endothelial cells without sensitizing to tumor necrosis factor-mediated apoptosis. Blood 1998; 91: 2249-58.
6. Beyaert R, Heyninck K, Van Huffel S. A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis. Biochem Pharmacol 2000; 60: 1143-51.
7. Costantini LC, Bakowska JC, Breakefield XO, Isacson O. Gene therapy in the CNS. Gene Therapy 2000; 7: 93-109.
8. West MJ, Slomianka L, Gundersen HJ. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 1991; 231: 482-97.
9. Stephenson D, Yin T, Smalstig EB, Hsu MA, Clemens J. Transcription factor nuclear factor-kappa B is activated in neurons after focal cerebral ischemia. J Cereb Blood Flow Metab 2000; 20: 592-603.
10. Markgraf CG, Green EJ, Hurwitz BE, Morikawa E, Schneiderman N, et al. Sensorimotor and cognitive consequences of middle cerebral artery occlusion in rats. Brain Res 1992; 575: 238-46.
11. Yao H, Takasawa R, Fukuda K, Shiokawa D, Sadanaga-Akiyoshi F, Ibayashi S, et al. DNA fragmentation in ischemic core and penumbra in focal cerebral ischemia in rats. Brain Res Mol Brain Res 2001; 91: 112-8.
12. Dixit VM, Green S, Sarma V, Holzman LB, Wolf FW, O'Rourke K, et al. Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin. J Biol Chem 1990; 265: 2973-8.
13. Grossmann M, Nakamura Y, Grumont R, Gerondakis S. New insights into the roles of ReL/NF-κB transcription factors in immune function, hemopoiesis and human disease. Int J Biochem Cell Biol 1999; 31: 1209-19.
14. Nussbaum RL, Ellis CE. Alzheimer's disease and Parkinson's disease. N Engl J Med 2003; 348: 1356-64.
15. Neumann E, Schaefer-Ridder M, Wang Y, Hofschneider PH. Gene transfer into mouse lyoma cells by electroporation in high electric fields. The EMBO J 1982; 1: 841-5.
16. Snider BJ, Gottron FJ, Choi DW. Apoptosis and necrosis in cerebrovascular disease. Ann N Y Acad Sci 1999; 893: 243-53.
17. Martin-Villalba A, Herr I, Jeremias I, Hahne M, Debatin KM, et al. CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons. J Neurosci 1999; 19: 3809-17.
18. Schneider A, Martin-Villalba A, Weih F, Vogel J, Wirth T, Schwaninger M. NF-kappaB is activated and promotes cell death in focal cerebral ischemia. Nat Med 1999; 5: 554-9.