Porphyrin distortion during affinity maturation of a ferrochelatase antibody, monitored by resonance Raman spectroscopy

Journal of the American Chemical Society

Volumn 126, Issue 50, 2004, Pages 16361-16367

  Venkateshrao, Swarnalatha ^a   Yin, Jun ^b,c,d   Jarzȩcki, Andrzej A ^a,e   Schultz, Peter G ^c   Spiro, Thomas G ^a  

^a PRINCETON UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CATALYSIS; RAMAN SCATTERING; RAMAN SPECTROSCOPY;

GERMLINE RESIDUES; PORPHYRIN VIBRATION; SUBSTRATE STRAIN MECHANISM;

PORPHYRINS;

ANTIBODY; FERROCHATALASE ANTIBODY; FERROCHELATASE; HAPTEN ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; MESOPORPHYRIN; METAL ION; NITROGEN; PYRROLE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; DENSITY FUNCTIONAL THEORY; EXPERIMENTAL MODEL; GEOMETRY; PREDICTION; PROTEIN BINDING; RAMAN SPECTROMETRY; SPECTROSCOPY; SPECTRUM; VIBRATION;

COMPUTER SIMULATION; FERROCHELATASE; IMMUNOGLOBULIN FRAGMENTS; MESOPORPHYRINS; MODELS, CHEMICAL; MODELS, MOLECULAR; PYRROLES; SPECTRUM ANALYSIS, RAMAN;

EID: 11444266840     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0465395     Document Type: Article

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