Large cutaneous rabbit papillomas that persist during cyclosporin A treatment can regress spontaneously after cessation of immunosuppression

Journal of General Virology

Volumn 86, Issue 1, 2005, Pages 55-63

  H , Jiafen ^a,b   Peng, Xuwen ^b   Cladel, Nancy M ^a,b   Pickel, Martin D ^a,b   Christensen, Neil D ^a,b  

^a PENN STATE CANCER INSTITUTE   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ASPARTIC ACID; CYCLOSPORIN A; GLUTAMINE; GLYCINE; PROLINE; PROTEIN E6; SERINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGENICITY; ARTICLE; BODY WEIGHT DISORDER; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DISEASE COURSE; DRUG WITHDRAWAL; GENE CONSTRUCT; GENE MUTATION; HOST RESISTANCE; IMMUNE DEFICIENCY; IMMUNITY; IMMUNOSUPPRESSIVE TREATMENT; INBRED STRAIN; NONHUMAN; ONCOVIRINAE; OUTBRED STRAIN; PRIORITY JOURNAL; RABBIT; SKIN PAPILLOMA; TIME; TUMOR GROWTH; TUMOR REGRESSION; TUMOR VOLUME; VIRUS STRAIN;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, INBRED STRAINS; ANIMALS, OUTBRED STRAINS; BODY WEIGHT; CD4-CD8 RATIO; COTTONTAIL RABBIT PAPILLOMAVIRUS; CYCLOSPORINE; DISEASE MODELS, ANIMAL; IMMUNOCOMPROMISED HOST; IMMUNOSUPPRESSIVE AGENTS; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASM REGRESSION, SPONTANEOUS; ONCOGENE PROTEINS, VIRAL; PAPILLOMA; PLASMIDS; RABBITS; SKIN NEOPLASMS; TIME FACTORS;

COTTONTAIL RABBIT PAPILLOMAVIRUS; ORYCTOLAGUS CUNICULUS;

EID: 11444265792     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.80448-0     Document Type: Article

References (24)

1. Ali, A. T. M. M., Morley, J. & Rumjanek, V. M. (1982). Cyclosporin-A inhibits accumulation of lymphocytes within lymph nodes. Immunology 47, 345-349.
2. Andrus, L. & Lafferty, K. J. (1981). Inhibition of T-cell activity by cyclosporin A. Scand J Immunol 15, 449-458.
3. Bavinck, J. N., Gissman, L., Claas, F. H. & 7 other authors (1993). Relation between skin cancer, humoral responses to human papillomaviruses, and HLA class II molecules in renal transplant recipients. J Immunol 151, 1579-1586.
4. Brandsma, J. L. (1994). Animal models of human-papillomavirus-associated oncogenesis. Intervirology 37 189-200.
5. Breitburd, F., Ramoz, N., Salmon, J. & Orth, G. (1996). HLA control in the progression of human papillomavirus infections. Semin Cancer Biol 7, 359-371.
6. Christensen, N. D., Han, R. & Kreider, J. W. (1999). Cottontail rabbit papillomavirus. In Persistent Viral Infections, pp. 485-502. Edited by R. Ahmed & I. S. Y. Chen. Chichester, UK: Wiley.
7. Davidson, E. J., Davidson, J. A., Sterling, J. C., Baldwin, P. J. W., Kitchener, H. C. & Stern, P. L. (2003). Association between human leukocyte antigen polymorphism and human papillomavirus 16-positive vulval intraepithelial neoplasia in British women. Cancer Res 63, 400-403.
8. Dupont, E., Huygen, K., Schandene, L., Vandercruys, M., Palfliet, K. & Wybran, J. (1985). Influence of in vivo immunosuppressive drugs on production of lymphokines. Transplantation 39, 143-147.
9. Euvrard, S., Kanitakis, J. & Claudy, A. (2003). Skin cancers after organ transplantation. N Engl J Med 348, 1681-1691.
10. Furumoto, H. & Irahara, M. (2002). Human papilloma virus (HPV) and cervical cancer. J Med Invest 49, 124-133.
11. Han, R., Breitburd, F., Marche, P. N. & Orth, G. (1992) Linkage of regression and malignant conversion of rabbit viral papillomas to MHC class II genes. Nature 356, 66-68.
12. Han, R., Cladel, N. M., Reed, C. A., Peng, X. & Christensen, N. D. (1999). Protection of rabbits from viral challenge by gene gun-based intracutaneous vaccination with a combination of cottontail rabbit papillomavirus E1, E2, E6, and E7 genes. J Virol 73, 7039-7043.
13. Hu, J., Cladel, N. M., Pickel, M. D. & Christensen, N. D. (2002a). Amino acid residues in the carboxy-terminal region of cottontail rabbit papillomavirus E6 influence spontaneous regression of cutaneous papillomas. J Virol 76, 11801-11808.
14. Hu, J., Han, R., Cladel, N. M., Pickel, M. D. & Christensen, N. D. (2002b). Intracutaneous DNA vaccination with the E8 gene of cottontail rabbit papillomavirus induces protective immunity against virus challenge in rabbits. J Virol 76, 6453-6459.
15. Jenkins, M. K., Schwartz, R. H. & Pardoll, D. M. (1988) Effects of cyclosporine A on T cell development and clonal deletion. Science 241, 1655-1658.
16. Orth, G., Favre, M., Breitburd, F., Croissant, O., Jablonska, S., Obalek, S., Jarzabek-Chorzelska, M. & Rzesa, G. (1980 . Epidermodysplasia verruciformis: a model for the role of papillomaviruses in human cancer. In Viruses in Naturally Occurring Cancers, vol. 7, pp. 259-282. Edited by M. Essex, G. Todaro & H. zur Hausen. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
17. Salmon, J., Ramoz, N., Cassonnet, P., Orth, G. & Breitburd, F. (1997). A cottontail rabbit papillomavirus strain (CRPVb) with strikingly divergent E6 and E7 oncoproteins: an insight in the evolution of papillomaviruses. Virology 235, 228-234.
18. Salmon, J., Nonnenmacher, M., Cazé, S., Flamant, P., Croissant, O., Orth, G. & Breitburd, F. (2000). Variation in the nucleotide sequence of cottontail rabbit papillomavirus a and b subtypes affects wart regression and malignant transformation and level of viral replication in domestic rabbits. J Virol 74, 10766-10777.
19. Shah, A. K., Brundage, R. C., Gratwohl, A. & Sawchuk, R. J. (1992). Pharmacokinetic model for subcutaneous absorption of cyclosporine in the rabbit during chronic treatment. J Pharm Sci 81, 491-495.
20. Sundaram, P., Tigelaar, R. E., Xiao, W. & Brandsma, J. L. (1998). Intracutaneous vaccination of rabbits with the E6 gene of cottontail rabbit papillomavirus provides partial protection against virus challenge. Vaccine 16, 613-623.
21. Tieben, L. M., Berkhout, R. J. M., Smits, H. L., Bouwes Bavinck J. N., Vermeer, B. J., Bruijn, J. A., Van der Woude, F. J. & ter Schegget, J. (1994). Detection of epidermodysplasia verruciformis-like human papillomavirus types in malignant and premalignant skin lesions of renal transplant recipients. Br J Dermatol 131, 226-230.
22. Turazza, E., Lapena, A., Sprovieri, O., Torres, C. P., Gurucharri, C., Maciel, A., Lema, B., Grinstein, S. & Kahn, T. (1997 . Low-risk human papillomavirus types 6 and 11 associated with carcinomas of the genital and upper aero-digestive tract. Acta Obstet Gynecol Scand 76, 271-276.
23. Walboomers, J. M. M., Jacobs, M. V., Manos, M. M. & 7 other authors (1999). Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 189, 12-19.
24. Won, Y.-H., Sauder, D. N. & McKenzie, R. C. (1994). Cyclosporin A inhibits keratinocyte cytokine gene expression. Br J Dermatol 130, 312-319.