Nucleosomes indicate the in vitro radiosensitivity of irradiated bronchoepithelial and lung cancer cells

Tumor Biology

Volumn 25, Issue 5-6, 2004, Pages 321-326

  Holdenrieder, Stefan ^a   Stief, Jutta ^b   Bergner, Albrecht ^b   Gamarra, Fernando ^b   Mitlewski, Anke ^a   Nagel, Dorothea ^a   Huber, Rudolph M ^b   Stieber, Petra ^a,c  

^a Institute of Clinical Chemistry   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Apoptosis; Cancer; Cell cultures; Cell death; Irradiation; Lung; Nucleosomes; Radiosensitivity

Indexed keywords

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL COUNT; CELL TYPE; CONTROLLED STUDY; CULTURE MEDIUM; EPITHELIUM CELL; HUMAN; HUMAN CELL; IRRADIATION; LUNG CANCER; NUCLEOSOME; PRIORITY JOURNAL; RADIATION DOSE; RADIOSENSITIVITY; RANK SUM TEST; STATISTICAL SIGNIFICANCE; TIME;

EID: 11444264038     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1159/000081401     Document Type: Article

References (20)

1. Hendry JH, West CM: Apoptosis and mitotic cell death: Their relative contributions to normal-tissue and tumour radiation response. Int J Radiat Biol 1997;71:709-719.
2. Mirkovic N, Meyn RE, Hunter NR, Milas L: Radiation-induced apoptosis in a murine lymphoma in vivo. Radiother Oncol 1994;33:11-16.
3. Mirzaie-Joniani H, Eriksson D, Sheikholvaezin A, Johansson A, Löfroth PO, Johansson L, Stigbrand T: Apoptosis induced by low-dose and low-dose-rate radiation. Cancer 2002;94:1210-1214.
4. Leist M, Nicotera P: The shape of cell death. Biochem Biophys Res Commun 1997;236:1-9.
5. Szumiel I: Monitoring and signaling of radiation-induced damage in mammalian cells. Radiat Res 1998;150:92-101.
6. Albrechtsen N, Dornreiter I, Grosse F, Kim E, Wiesmüller L, Deppert W: Maintenance of genomic integrity by p53: Complementary roles for activated and non-activated p53. Oncogene 1999;18:7706-7717.
7. Sionov RV, Haupt Y: The cellular response to p53:The decision between life and death. Oncogene 1999;18:6145-6157.
8. Hengartner MO: The biochemistry of apoptosis. Nature 2000;407:770-776.
9. Kornberg R, Lorch Y: Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell 1999;98:285-294.
10. Luger K, Mäder AW, Richmond RK, Sargent DF, Richmond TJ: Crystal structure of the nucleosome core particle at 2.8. A resolution. Nature 1997;389:251-260.
11. Kerr JF, Winterford CM, Harmon BV: Apoptosis. Its significance in cancer and cancer therapy. Cancer 1994;73:2013-2026.
12. Wyllie AH, Arends MJ, Morris RG, Walker SW, Evan G: The apoptosis endonuclease and its regulation. Semin Immunol 1992;4:389-397.
13. Holdenrieder S, Stieber P, Bodenmüller H, Busch M, Fertig G, Fürst H, Schalhorn A, Schmeller N, Untch M, Seidel D: Nucleosomes in serum of patients with benign and malignant diseases. Int J Cancer 2001;95:114-120.
14. Bepler G, Koehler A, Kiefer P, Havemann K, Beisenherz K, Jaques G, Gropp C, Haeder M: Characterization of the state of differentiation of six newly established human non-small-cell lung cancer cell lines. Differentiation 1988;37:158-171.
15. Holdenrieder S, Stieber P, Bodenmüller H, Fertig G, Fürst H, Schmeller N, Untch M, Seidel D: Nucleosomes in serum as a marker for cell death. Clin Chem Lab Med 2001;39:596-605.
16. Kuroi K, Tanaka C, Toi M: Plasma nucleosome levels in node-negative breast cancer patients. Breast Cancer 1999;6:361-364.
17. Schär P: Spontaneous, DNA damage, genome instability, and cancer - When DNA replication escapes control. Cell 2001;104:329-332.
18. Hendry JH: Genomic instability: Potential contributions to tumour and normal tissue response, and second tumours, after radiotherapy. Radiother Oncol 2001;59:117-126.
19. Al-Batran SE, Astner ST, Supthut M, Gamarra F, Brueckner K, Welsch U, Knuechel R, Huber RM: Three-dimensional in vitro cocultivation of lung carcinoma cells with human bronchial organ culture as a model for bronchial carcinoma. Am J Respir Cell Mol Biol 1999;21:200-208.
20. Bergner A, Stief J, Holdenrieder S, Stieber P, Haimerl W, Passlick B, Waldschmidt A, Kummermehr J, Gamarra F, Huber RM: Effects of single-dose irradiation on bronchial epithelium: A comparison of BEAS 2B cell monolayers, human organ cultures and Goettinger minipigs. Radiat Res 2003;160:647-654.