Effect of dopexamine on hepatic metabolic activity in patients with septic shock

Shock

Volumn 15, Issue 6, 2001, Pages 427-431

  Kiefer, Peter ^a   Tugtekin, Ilyas ^a   Wiedeck, Heide ^a   Vogt, Josef ^a   Wachter, Uli ^a   Bracht, Hendrik ^a   Geldner, Götz ^a   Georgieff, Michael ^a   Radermacher, Peter ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Catecholamines; Endogenous glucose production; Hepato splanchnic metabolic rate

Indexed keywords

ALANINE; DOPAMINE; DOPEXAMINE; DRUG DERIVATIVE; GLUCOSE; GLUTAMIC ACID; KETONE BODY; LACTIC ACID DERIVATIVE; NORADRENALIN; OXYGEN; PYRUVIC ACID DERIVATIVE; VASODILATOR AGENT;

ADULT; AGED; ARTICLE; BLOOD; BLOOD FLOW; BLOOD PRESSURE; CLINICAL TRIAL; DRUG EFFECT; FEMALE; HEMODYNAMICS; HUMAN; LIVER; MALE; METABOLISM; MIDDLE AGED; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PHYSIOLOGY; SEPTIC SHOCK; SPLANCHNIC BLOOD FLOW; VASCULARIZATION;

ADULT; AGED; ALANINE; BLOOD PRESSURE; DOPAMINE; FEMALE; GLUCOSE; GLUTAMIC ACID; HEMODYNAMIC PROCESSES; HUMANS; KETONE BODIES; LACTATES; LIVER; MALE; MIDDLE AGED; NOREPINEPHRINE; OXYGEN; OXYGEN CONSUMPTION; PYRUVATES; REGIONAL BLOOD FLOW; SHOCK, SEPTIC; SPLANCHNIC CIRCULATION; VASODILATOR AGENTS;

EID: 0035374941     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-200115060-00003     Document Type: Article

References (31)

1. Dahn MS, Mitchell RA, Lange MP, Smith S, Jacobs LA: Hepatic metabolic response to injury and sepsis. Surgery 117:520-530, 1995.
2. Fong Y, Matthews DE, He W, Marano MA, Moldawer LL, Lowry SF: Whole body and splanchnic leucine, phenylalanine, and glucose kinetics during endotoxemia in humans. Am J Physiol 266:R419-R425, 1994.
3. Dahn MS, Lange P, Lobdell K, Hans B, Jacobs LA, Mitchell RA: Splanchnic and total body oxygen consumption differences in septic and injured patients. Surgery 101:69-80, 1987.
4. Dahn MS, Lange P, Wilson RF, Jacobs LA, Mitchell RA: Hepatic blood flow and splanchnic oxygen consumption measurements in clinical sepsis. Surgery 107:295-301, 1990.
5. Wilmore DW, Goodwin CW, Aulick LH, Powanda MC, Mason MD, Pruitt BA: Effect of injury and infection on visceral metabolism and circulation. Ann Surg 192:491-500, 1980.
6. Maynard ND, Bihari DJ, Dalton RN, Smithies MN, Mason RC: Increasing splanchnic blood flow in the critically ill. Chest 108:1648-1654, 1995.
7. Beam AG, Billing B, Sherlock S: The effect of adrenaline and norepinephrine on hepatic blood flow and splanchnic carbohydratemetabolism in man. J Physiol 115:430-441, 1951.
8. Meier-Hellmann A, Specht M, Hannemann L, Hassel H, Bredle DL, Reinhart K: Spalnchnic blood flow is greater in septic shock treated with norepinephrine than in severe sepsis. Intensive Care Med 22:1354-1359, 1996.
9. Reinelt H, Radermacher P, Kiefer P, Fischer G, Wachter U, Vogt J, Georgieff M: Impact of exogenous β-adrenoreceptor stimulation on hepato splanchnic oxygen kinetics and metabolic activity in septic shock. Crit Care Med 27:325-331, 1999.
10. Geisser W, Träger K, Hahn A, Georgieff M, Ensinger H: Metabolic and calorigenic effects of dopexamine in healthy volunteers. Crit Care Med 25:1332-1337, 1997.
11. Dawson JR, Thompson DS, Signy M, Juul SM, Turnbull P, Jenkins BS, Webb-Peploe MM: Acute hemodynamic and metabolic effects of dopexamine, a new dopaminergic receptor agonist, in patients with chronic heart failure. Br Heart J 54:313-320, 1985.
12. Hotchkiss RS, Karl IE: Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. JAMA 267:1503-1510, 1992.
13. Kiefer P, Tugtekin Y, Wiedeck H, Bracht H, Geldner G, Georgieff M, Radermacher P: Effect of a dopexamine-induced increase in cardiac index on splanchnic hemodynamics in septic shock. Am J Respir Crit Care Med 161:775-779, 2000.
14. Takala J, Keinänen O, Väisänen P: Measurement of gas exchange in intensive care: laboratory and clinical validation of new device. Crit Care Med 17:1041-1047, 1989.
15. Uusaro A, Ruokonen E, Takala J: Estimation of splanchnic blood flow by the Fick-principle in man and problems in the use of indocyanine green. Cardiovasc Res 30:106-112, 1995.
16. Leevy CM, Mendehall CL, Lesko W: Estimation of hepatic bloodflow with indocyanine green. J Clin Invest 41:1169-1179, 1962.
17. Wolfe RR: Isotopic measurement of glucose and lactate kinetics. Ann Med 22:163-170, 1990.
18. Ensinger H, Rantala A, Vogt J, Georgieff M, Takala J: Effect of dobutamine on splanchnic carbohydrate metabolism and amino acid and lactate balance after cardiac surgery. Anesthesiology 91:1587-1595, 1999.
19. Steele R: The influence of glucose loading and of injected insulin on hepatic glucose output. Ann NY Acad Sci 82:420-430, 1959.
20. Livesey G, Wilson PD, Dainty JR, Brown JC, Faulks RM, Roe MA, Newman TA, Eagles J, Mellon FA, Greenwood RH: Simultaneous time-varying systemic appearance of oral and hepatic glucose in addults monitored with stable isotopes. Am J Physiol 275:E717-E728, 1998.
21. Czok R, Lamprecht W: Pyruvat, Phosphoenolpyruvat und D-Glycerat-2-phosphat. In Bergmeyer HU, (ed): Methoden der Enzymatischen Analyse Band II. Weinheim: Verlag Chemie; 1970, pp 1407-1411.
22. Hohorst HJ. L-(+)-Lactat. In Bergmeyer HU (ed): Methoden der Enzymatischen Analyse Band II. Weinheim: Verlag Chemie; 1970, pp 1425-1429.
23. Mellanby J, Williamson DH: Acetoacetat. In Bergmeyer HU (ed): Methoden der Enzymatischen Analyse Band II. Weinheim: Verlag Chemie; 1970, pp 1776-1779.
24. Williamson DH, Mellanby J: D3-Hydroxybutyrat. In Bergmeyer HU (ed): Methoden der Enzymatischen Analyse Band II. Weinheim: Verlag Chemie; 1970, pp 1772-1775.
25. Ruokonen E, Takala J, Kari A, Saxén H, Mertsola J, Hansen EJ: Regional blood flow and oxygen transport in septic shock. Crit Care Med 21:1296-1303, 1993.
26. Reinelt H, Radermacher P, Fischer G, Geisser W, Wachter U, Wiedeck H, Georgieff M, Vogt J: Effects of a dobutamine-induced increase in splanchnic blood flow on hepatic metabolic activity in patients with septic shock. Anesthesiology 86:818-824, 1997.
27. 2 dependency exist in critically ill septic patients? Am J Respir Crit Care Med 157:1219-1225, 1998.
28. Uusaro A, Hartikainen, Parviainen M, Takala J: Metabolic stress modifies the thermogenic effect of dobutamine in man. Crit Care Med 23:674-680, 1995.
29. Steffes CP, Dahn MS, Lange MP: Oxygen transport-dependent splanchnic metabolism in the sepsis syndrome. Arch Surg 129:46-52, 1994.
30. MacGregor DA, Prielipp RC, Butterworth JF, James RL, Royster RL: Relative efficacy and potency of β-adrenoceptor agonists for generating c-AMP in human lymphocytes. Chest 109:194-200, 1996.
31. Bergeron R, Kjaer M, Simonsen L, Bülow J, Galbo H: Glucose production during exercise in humans: a-hv balance and isotopic-tracer measurements compared. J Appl Physiol 87:111-115, 1999.