Transgenic rabbits expressing human apolipoprotein(a) develop more extensive atherosclerotic lesions in response to a cholesterol-rich diet

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 21, Issue 1, 2001, Pages 88-94

  Fan, Jianglin ^a   Shimoyamada, Hiroaki ^a   Sun, Huijun ^a   Marcovina, Santica ^b   Honda, Kazuo ^c   Watanabe, Teruo ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b UNIVERSITY OF WASHINGTON   (United States)

^c ASTELLAS PHARMA INC   (Japan)

Author keywords

Apolipoproteins; Atherosclerosis; Lipoproteins; Transgenic rabbits

Indexed keywords

APOLIPOPROTEIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RESPONSE; CAROTID ARTERY; CHOLESTEROL DIET; CONTROLLED STUDY; DIETARY INTAKE; ILIAC ARTERY; IMMUNOHISTOCHEMISTRY; LIPID COMPOSITION; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; NONHUMAN; PRIORITY JOURNAL; RABBIT; RESTENOSIS; RISK FACTOR; TRANSGENIC ANIMAL;

EID: 0035162581     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.21.1.88     Document Type: Article

References (29)

1. The mysteries of lipoprotein(a)
2. Lipoprotein(a) and atherosclerosis
3. Lipoprotein (a), and coronary heart disease
4. A prospective study of lipoprotein(a) and the risk of myocardial infarction
5. Lipoprotein(a) in coronary heart disease: Is it a risk factor after all?
6. Detection and quantification of lipoprotein(a) in the arterial wall of 107 coronary bypass patients
7. Immunostaining of human autopsy aortas with antibodies to modified apolipoprotein B and apoprotein(a)
8. Lipoprotein[a] is the major apoB-containing lipoprotein in the plasma of a hibernator, the hedgehog (Erinaceus europaeus)
9. Atherogenesis in transgenic mice expressing human apolipoprotein(a)
10. The apolipoprotein(a) gene is regulated by sex hormones and acute-phase inducers in YAC transgenic mice
11. Reconstitution of lipoprotein(a) by infusion of human low density lipoprotein into transgenic mice expressing human apolipoprotein(a)
12. Human apolipoprotein A-I prevents atherosclerosis associated with apolipoprotein[a] in transgenic mice
13. Modification of apolipoprotein(a) lysine binding site reduces atherosclerosis in transgenic mice
14. Relative contributions of apolipoprotein (a) and apolipoprotein-B to the development of fatty lesions in the proximal aorta of mice
15. Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: No accentuation by apolipoprotein (a)
16. Assembly of lipoprotem (a) in transgenic rabbits expressing human apolipoprotein (a)
17. Apolipoprotein(a) yeast artificial chromosome transgenic rabbits: Lipoprotein(a) assembly with human and rabbit apolipoprotein B
18. Transgenic rabbit models for biomedical research: Current status, basic methods and future perspectives
19. Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma
20. Defects of the LDL receptor in WHHL transgenic rabbits lead to a marked accumulation of plasma lipoprotein (a)
21. Regression of atherosclerosis in normotensive and hypertensive rabbits: A quantitative analysis of cholesterol-induced aortic and coronary lesions with an image-processing system
22. Preferential influx and decreased fractional loss of lipoprotein(a) in atherosclerotic compared with nonlesioned rabbit aorta
23. Polymorphic forms of Lp(a) with different structural and functional properties: Cold-induced self-association and binding to fibrin and lysine-Sepharose
24. Interaction of lipoprotein Lp(a) and low density lipoprotein with glycosaminoglycans from human aorta
25. The Watanabe heritable hyperlipidemic rabbit is a suitable experimental model to study differences in tissue response between intimal and medical injury after balloon angioplasty
26. Activation of transforming growth factor-beta is inhibited in transgenic apolipoprotein(a) mice
27. Saturation and suppression of hepatic lipoprotein receptors: A mechanism for the hypercholesterolemia of cholesterol-fed rabbits
28. The low density lipoprotein receptor is not required for normal catabolism of Lp(a) in humans
29. Relation of serum lipoprotein(a) concentration and apolipoprotein(a) phenotype to coronary heart disease in patients with familial hypercholesterolemia