Cefoselis, a β-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release

Journal of Neural Transmission

Volumn 111, Issue 12, 2004, Pages 1523-1535

  Ohtaki, K ^a   Matsubara, K ^a   Fujimaru, S ^a   Shimizu, K ^a   Awaya, T ^a   Suno, M ^a   Chiba, K ^a   Hayase, N ^a   Shiono, H ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

aminobutyric acid; Blood brain barrier; Cefazolin; Cefoselis; Excitatory amino acid; Glutamate; Microdialysis; Renal failure

Indexed keywords

4 AMINOBUTYRIC ACID; BETA LACTAM ANTIBIOTIC; CEFAZOLIN; CEFOSELIS; GLUTAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG PENETRATION; EPILEPSY; HIPPOCAMPUS; KIDNEY FAILURE; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; BLOOD-BRAIN BARRIER; BRAIN; CEFAZOLIN; CEFTIZOXIME; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; KIDNEY FAILURE; MALE; MICRODIALYSIS; RATS; RATS, WISTAR; SEIZURES;

EID: 11244324911     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00702-004-0177-0     Document Type: Article

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