Evidence for the involvement of GABAA receptor blockade in convulsions induced by cephalosporins

Neuropharmacology

Volumn 45, Issue 3, 2003, Pages 304-314

  Sugimoto, Masahiro ^a   Uchida, Ichiro ^a   Mashimo, Takashi ^a   Yamazaki, Shunji ^b   Hatano, Kazuo ^b   Ikeda, Fumiaki ^b   Mochizuki, Yoshitaka ^b   Terai, Takao ^b   Matsuoka, Nobuya ^b  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

Cephalosporin; Convulsions; GABA; NMDA; Receptors

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; CEFAZOLIN; CEFEPIME; CEFOSELIS; CEFOTIAM; CEFOZOPRAN; CEFPIROME; CEFTAZIDIME; CEPHALOSPORIN DERIVATIVE; DIZOCILPINE; MUSCIMOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECOMBINANT RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; BRAIN SYNAPTOSOME; CONTROLLED STUDY; CONVULSION; CORRELATION ANALYSIS; CORRELATION COEFFICIENT; DRUG INHIBITION; DRUG POTENCY; DRUG RECEPTOR BINDING; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS;

EID: 0038642670     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(03)00188-6     Document Type: Article

References (48)

1. - conductance by different mechanisms. Experimentia. 41:1985;70-71.
2. A receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital. Nature. 366:1993;565-569.
3. Barker J.L., McBurney R.N., Mathers D.A. Convulsant-induced depression of amino acid responses in cultured mouse spinal neurons studied under voltage clamp. British Journal of Pharmacology. 80:1983;619-629.
4. Basile A.S., Huang J.M., Xie C., Webster D., Berlin C., Skolnick P. N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss. Nature Medicine. 2:1996;1338-1343.
5. Bormann J., Clapham D.E. γ-Aminobutyric acid receptor channels in adrenal chromaffin cells: a patch-clamp study. Proceedings of the National Academy of Sciences of the United States of America. 82:1985;2168-2172.
6. Dalby N.O., Thomsen C. Modulation of seizure activity in mice by metabotropic glutamate receptor ligands. Journal of Pharmacology and Experimental Therapeutics. 276:1996;516-522.
7. Day I.P., Goudie J., Nishiki K., Williams P.D. Correlation between in vitro and in vivo models of proconvulsive activity with the carbapenem antibiotics, biapenem, imipenem/cilastatin and meropenem. Toxicology Letters. 76:1995;239-243.
8. De Sarro G., Ammendola D., Nava F., De Sarro A. Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice. Brain Research. 671:1995a;131-140.
9. De Sarro A., Ammendola D., Zappala M., Grasso S., De Sarro G.B. Relationship between structure and convulsant properties of some β-lactam antibiotics following intracerebroventricular microinjection in rats. Antimicrobial Agents and Chemotherapy. 39:1995b;232-237.
10. Fariello R.G., McArhtur R.A., Bonsignori A., Cervini M.A., Maj R., Marrari P., Pevarello P., Wolf H.H., Woodhead J.W., White H.S., Varasi M., Salvati P., Post C. Preclinical evaluation of PNU-151774E as a novel anticonvulsant. Journal of Pharmacology and Experimental Therapeutics. 285:1998;397-403.
11. A response inhibition by β-lactam antibiotics in the pyramidal neurones of the rat cerebral cortex. British Journal of Pharmacology. 116:1995;3014-3020.
12. Gartside I.B. The actions of diazepam and phenytoin on a low dose penicillin epileptiform focus in the anesthetised rat. British Journal of Pharmacology. 62:1978;289-292.
13. Haley T.J., McCormick W.G. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. British Journal of Pharmacology. 12:1957;12-15.
14. Hantson P., Leonard F., Maloteaux J.M., Mahieu P. How epileptogenic are the recent antibiotics? Acta Clinica Belgica. 54:1999;80-87.
15. Hirano M., Masuyoshi S., Kondo S., Asai Y., Oki T. Distribution, metabolism and excretion of cefepime in rats. Chemotherapy (Tokyo). 39:(S-2):1991;97-103.
16. Hori S., Kurioka S., Matsuda M., Shimada J. Inhibitory effect of cephalosporins on γ-aminobutyric acid receptor binding in rat synaptic membranes. Antimicrobial Agents and Chemotherapy. 27:1985;650-651.
17. Hwa G.G.C., Avoli M. NMDA receptor antagonists CPP and MK-801 partially suppress the epileptiform discharges induced by the convulsant drug bicuculline in the rat neocortex. Neuroscience Letters. 98:1989;189-193.
18. Johnson H.C., Walker A.E. Intraventricular penicillin; a note of warning. Journal of American Medical Association. 127:1945;217-219.
19. Jones R.S.G. Epileptiform events induced by GABA-antagonists in entorhinal cortical cells in vitro are partly mediated by N-methyl-D-aspartate receptors. Brain Research. 457:1988;113-121.
20. Kamei C., Kitazumi K., Tsujimoto S., Yoshida T., Tasaka K. Comparative study of certain antibiotics on epileptogenic property, including (1Rpi, 5S, 6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[(R)-1- hydroxyethyl]-1-methyl-carbapenem-3-carboxylate (LJC10627), a carbapenem antibiotic with broad antimicrobial spectrum. Journal of Pharmacobiodynamics. 14:1991;509-517.
21. Kita Y., Kimura Y., Yamazaki T., Imada A. Cefozopran, a new cephem antibiotics: pharmacokinetics in experimental animals. Chemotherapy (Tokyo). 41:(S-4):1993;121-130.
22. 2+ and spermine on the NMDA receptors of rat hippocampal CA1 pyramidal neurons. The Journal of Physiology (London). 512:1998;29-46.
23. Masuko T., Kuno T., Kashiwagi K., Kusama T., Williams K., Igarashi K. Stimulatory and inhibitory properties of aminoglycoside antibiotics at N-methyl-D-aspartate receptors. Journal of Pharmacology and Experimental Therapeutics. 290:1999;1026-1033.
24. Mine Y., Watanabe Y., Sakamoto H., Hatano K., Kuno K., Higashi Y., Kamimura T., Matsumoto Y., Tawara S., Matsumoto F., Kuwahara S. In vitro antibacterial activity of FK037, a novel pareteral broad-spectrum cephalosporin. The Journal of Antibiotics. 46:1993a;71-87.
25. Mine Y., Watanabe Y., Sakamoto H., Hatano K., Wakai Y., Kamimura T., Tawara S., Matsumoto S., Matsumoto F., Kuwahara S. In vivo antibacterial activity of FK037, a novel parenteral broad-spectrum cephalosporin. The Journal of Antibiotics. 46:1993b;88-98.
26. Moore T.D., Bechtel T.P., Ayers L.W. Effect of multidose therapy on cerebrospinal fluid penetration of cefazolin. American Journal of Hospital Pharmacy. 38:1981;1496-1499.
27. Mori H., Mishina M. Structure and function of the NMDA receptor channel. Neuropharmacology. 34:1995;1219-1237.
28. Petri W.A. Jr. Antimicrobial agents: penicillins, cephalosporins, and other β-lactam. Hardman J.G., Limbird L.E., Gilman A.G. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 10th ed. 2001;1189-1218 McGraw-Hill, New York.
29. Pullan L.M., Stumpo R.J., Powel R.J., Paschetto K.A., Britt M. Neomycin is an agonist at a polyamine site on the N-methyl-D-aspartate receptor. Journal of Neurochemistry. 59:1992;2087-2093.
30. Sakamoto H., Hatano K., Higashi Y., Mine Y., Nakamoto S., Tawara S., Kamimura T., Matsumoto F., Kuwahara S. Animal pharmacokinetics of FK037, a novel parenteral broad-spectrum cephalosporin. The Journal of Antibiotics. 46:1993;120-130.
31. Schliamser S.E., Cars O., Norrby S.R. Neurotoxicity of β-lactam antibiotics: predisposing factors and pathogenesis. The Journal of Antimicrobial Chemotherapy. 27:1991;405-425.
32. Segal J.A., Skolnick P. Polyamine-like actions of aminoglycosides and aminoglycoside derivatives at NMDA receptors. European Journal of Pharmacology. 347:1998;311-317.
33. Segal J.A., Harris B.D., Kustova Y., Basile A., Skolnick P. Aminoglycoside neurotoxicity involves NMDA receptor activation. Brain Research. 815:1999;270-277.
34. Shimada J., Hori S., Kanemitsu K., Shoji Y., Nakashio S., Yanagawa A. A comparative study on the convulsant activity of carbapenems and beta lactams. Drugs under Experimental and Clinical Research. 18:1992;377-381.
35. Sieghart W. Structure and pharmacology of γ-aminobutyric acid A receptor subtypes. Pharmacological Reviews. 47:1995;181-234.
36. +-induced excitation and on penicillin-induced seizures. Neurological Research. 7:1985;202-206.
37. Study R.E., Barker J.L. Diazepam and (-)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of γ-aminobutyric acid responses in cultured central neurons. Proceedings of the National Academy of Sciences of the United States of America. 78:1981;7180-7184.
38. Sugimoto M., Uchida I., Mashimo M., Matsuoka N., Okada S., Yamazaki S., Hatano K., Ikeda F. The role of GABA-A receptors in the antibiotic-induced convulsion. Society of Neuroscience Abstract. 26:2000;631. (Abstract).
39. Sugimoto T., Sugimoto M., Uchida I., Mashimo T. Inhibitory effect of theophylline on recombinant γ-aminobutyric acidA receptor. Neuroreport. 12:2001;489-493.
40. A receptors. British Journal of Pharmacology. 135:2002;427-432.
41. Tsuchiya K., Kita Y., Yamazaki I., Kondo M., Noji Y., Fugono T. Absorption, distribution and excretion of cefmenoxime (SCE-1365), a novel broad-spectrum cephalosporin, in mice, rats, rabbits and dogs. Chemotherapy (Tokyo). 27:(S-3):1979;121-132.
42. A receptors dependent upon subunit composition. Neuron. 4:1990;919-928.
43. Walker A.E., Johnson H.C. Convulsive factor in commercial penicillin. Archives of Surgery. 50:1945;69-73.
44. Wallace K.L. Antibiotic-induced convulsions. Critical Care Clinics. 13:1997;741-762.
45. A receptor subtypes. International Review of Neurobiology. 38:1995;95-138.
46. Williams P.D., Bennett D.B., Comereski C.R. Animal model for evaluating the convulsive liability of β-lactam antibiotics. Antimicrobial Agents and Chemotherapy. 32:1988;758-760.
47. Yamazaki S., Mochizuki Y., Terai T., Sugimoto M., Uchida I., Matsuoka N., Mutoh S. Intracerebroventricular injection of the antibiotic cefoselis produces convulsion in mice via inhibition of GABA receptors. Pharmacology Biochemistry Behavior. 74:2002;53-59.
48. Yu Q.H., Kitazumi K., Kamei C., Tasaka K. Epileptogenic activity induced by intravenous injection of certain cephalosporins in rats. Journal of Pharmcobiodynamics. 7:1984;586-592.