Cyclooxygenase-2 overexpression is related to polypoid growth and K-ras gene mutation in T1 colorectal carcinomas

Diseases of the Colon and Rectum

Volumn 47, Issue 11, 2004, Pages 1915-1921

  Okawa, Takuya ^a   Yoshinaga, Keigo ^b   Uetake, Hiroyuki ^a   Sato, Takanobu ^a   Higuchi, Tetsuro ^a   Nemoto, Tetsuo ^a   Sugihara, Kenichi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b Department of Surgery   (Japan)

Author keywords

Colorectal cancer; Cyclooxygenase 2 overexpression; K ras mutation; Morphology; Nonpolypoid growth carcinoma; Polypoid growth carcinoma

Indexed keywords

CYCLOOXYGENASE 2;

ARTICLE; COLORECTAL CARCINOMA; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ONCOGENE K RAS; POLYMERASE CHAIN REACTION; POLYP; PROTEIN EXPRESSION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TUMOR GROWTH;

ADENOMA; ADENOMATOUS POLYPS; ADULT; AGED; AGED, 80 AND OVER; CHI-SQUARE DISTRIBUTION; CODON; COLORECTAL NEOPLASMS; CYCLOOXYGENASE 2; FEMALE; GENES, RAS; HUMANS; IMMUNOENZYME TECHNIQUES; ISOENZYMES; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; STATISTICS, NONPARAMETRIC;

EID: 11244303733     PISSN: 00123706     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10350-004-0684-y     Document Type: Article

References (48)

1. Giovannucci E, Egan KM, Hunter DJ, et al. Aspirin and the risk of colorectal cancer in women. N Engl J Med 1995;333:609-14.
2. Thun MJ, Namboodiri MM, Heath CW. Aspirin use and reduced risk of fatal colon cancer. N Engl J Med 1991; 325:1593-6.
3. Giardiello FM. NSAID-induced polyp regression in familial adenomatous polyposis patients. Gastroenterol Clin North Am 1996;25:349-61.
4. Steinbach G, Lynch PM, Phillips RK, et al. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med 2000;342:1946-52.
5. Smith WL, Garavito RM, DeWitt DL. Prostaglandin endoperoxide H synthases (cyclooxygenase)-1 and -2. J Biol Chem 1996;271:33157-60.
6. Williams CS, DuBois RN. Prostaglandin endoperoxide synthase: why two isoforms? Am J Physiol 1996;270: 393-400.
7. DuBois RN, Awad J, Morrow J, Roberts LJ, Bishop PR. Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-β1 and phorbol ester. J Clin Invest 1994;93:493-8.
8. Hao X, Bishop AE, Wallace M, et al. Early expression of cyclooxygenase-2 during sporadic colorectal carcinogenesis. J Pathol 1999;187:295-301.
9. Chen WS, Wei SJ, Liu JM, Hsiao M, Lin JK, Yang WK. Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac. Int J Cancer 2001;91:894-9.
10. Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, Dubois RN. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 1994;107: 1183-8.
11. Maekawa M, Sugano K, Sano H, et al. Increased expression of cyclooxygenase-2 to -1 in human colorectal cancers and adenomas, but not in hyperplastic polyps. Jpn J Clin Oncol 1998;28:421-6.
12. Chapple KS, Cartwright EJ, Hawcroft G, et al. Localization of cyclooxygenase-2 in human sporadic colorectal adenomas. Am J Pathol 2000;156:545-53.
13. Hasegawa K, Ichikawa W, Fujita T, et al. Expression of cyclooxygenase-2 (COX-2) mRNA in human colorectal adenomas. Eur J Cancer 2001;37:1469-74.
14. Sato T, Yoshinaga K, Okabe S, et al. Cyclooxygenase-2 expression in colorectal adenomas. Dis Colon Rectum 2003;46:786-92.
15. Jackman RJ, Mayo CW. The adenoma-carcinoma sequence in cancer of the colon. Surg Gynecol Obstet 1951;93:327-30.
16. Muto T, Bussey HJ, Morson BC. The evolution of cancer of the colon and rectum. Cancer 1975;36:2251-70.
17. Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal tumor development. N Engl J Med 1988;319:525-32.
18. Muto T, Kamiya J, Sawada T, et al. Small "flat adenoma" of the large bowel with special reference to its clinicopathologic features. Dis Colon Rectum 1985;28:847-51.
19. Kuramoto S, Ihara O, Sakai S, Shimazu R, Kaminishi M, Oohara T. Depressed adenoma in the large intestine: endoscopic features. Dis Colon Rectum 1990;33:108-12.
20. Adachi M, Muto T, Okinaga K, Morioka Y. Clinicopathologic features of the flat adenoma. Dis Colon Rectum 1991;34:981-6.
21. Wolber RA, Owe DA. Flat adenomas of the colon. Hum Pathol 1991;22:70-4.
22. Jaramillo E, Watanabe M, Slezak P, Rubio C. Flat neoplastic lesions of the colon and rectum detected by high-resolution video endoscopy and chromoscopy. Gastrointest Endosc 1995;42:114-22.
23. Rubio CA, Kumagai J, Kanamori T, Yanagisawa A, Nakamura K, Kato Y. Flat adenomas and flat adenocarcinomas of the colorectal mucosa in Japanese and Swedish patients. Dis Colon Rectum 1995;38:1075-9.
24. Cairns A, Quirke P. Flat adenomas. Br J Surg 1999;86: 1489-90.
25. Hart AR, Kudo S, Mackay EH, Mayberry JF, Atkin WS. Flat adenomas exist in asymptomatic people: important implications for colorectal cancer screening programmes. Gut 1998;43:229-31.
26. Saitoh Y, Waxman I, West AB, et al. Prevalence and distinctive biologic features of flat colorectal adenomas in a North American population. Gastroenterology 2001;120:1657-65.
27. Spratt JS, Ackerman LV, Louis S. Small primary adenocarcinomas of the colon and rectum. JAMA 1962;179: 337-46.
28. Crawford BE, Stromeyer FW. Small nonpolypoid carcinomas of the large intestine. Cancer 1983;51:1760-3.
29. Watanabe T, Sawada T, Kubota Y, et al. Malignant potential in flat elevations. Dis Colon Rectum 1993;36:548-53.
30. Shimoda T, Ikegami M, Fujisaki J, Matsui T, Aizawa S, Ishikawa E. Early colorectal carcinoma with special reference to its development de novo. Cancer 1989;64: 1138-46.
31. Kaneko K, Fujii T, Kato S, et al. Growth patterns and genetic changes of colorectal carcinoma. Jpn J Clin Oncol 1998;28:196-201.
32. Hasegawa H, Ueda M, Watanabe M, Teramoto T, Mukai M, Kitajima M. K-ras gene mutations in early colorectal cancer: flat elevated vs. polypoid-forming cancer. Oncogene 1995;10:1413-6.
33. Ohshima S, Shimizu Y, Takahara M. Detection of c-kiras gene mutation in paraffin sections of adenocarcinoma and atypical broncioloalveolar cell hyperplasia of human lung. Virchows Arch 1994;424:129-34.
34. Matsubayashi H, Watanabe H, Nishikura K, Ajioka Y, Kijima H, Saito T. Determination of pancreatic ductal carcinoma histogenesis by Analysis of mucous quality and K-ras mutation. Cancer 1998;82:651-60.
35. Ohno R, Yoshinaga K, Fujita T, et al. Depth of invasion parallels increased cyclooxygenase-2 levels in patients with gastric carcinoma. Cancer 2001;91:1876-81.
36. Uefuji K, Ichikura T, Mochizuki H, Shinomiya N. Expression of cyclooxygenase-2 protein in gastric adenocarcinoma. J Surg Oncol 1998;69:168-72.
37. Joo YE, Oh WT, Rew JS, Park CS, Choi SK, Kim SJ. Cyclooxygenase-2 expression is associated with well-differentiated and intestinal-type pathways in gastric carcinogenesis. Digestion 2002;66:222-9.
38. Ratnasinghe D, Tangrea J, Roth MJ, et al. Expression of cyclooxygenase-2 in Human squamous cell carcinoma of the esophagus; an immunohistochemical survey. Anticancer Res 1999;19:171-4.
39. Kuramoto S, Oohara T. Flat early cancers of the large intestine. Cancer 1989;64:905-55.
40. Herrera L, Hanna S, Castillo N, Petrelli NJ. Primary de novo adenocarcinoma of the colon measuring 8 mm in diameter with lymph node metastases. Dis Colon Rectum 1991;34:275-9.
41. Ikegami M. A pathological study on colorectal cancer from de novo carcinoma to advanced carcinoma. Acta Pathol Jpn 1987;37:21-37.
42. Matsui T, Yao T, Iwashita A. Natural history of early colorectal cancer. World J Surg 2000;24:1022-8.
43. Kobayashi M, Watanabe H, Ajioka Y, Honma T, Asakura H. Effect of K-ras mutation on Morphogenesis of colorectal adenomas and early cancers. Hum Pathol 1996;27:1042-9.
44. Rak J, Mitsuhashi Y, Bayko L, et al. Mutant ras oncogenes upregulate vegf/vpf expression -implications for induction and inhibition of the tumor angiogenesis. Cancer Res 1995;55:4575-80.
45. Ward RL, Todd AV, Santiago F, O'Connor T, Hawkins NJ. Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis. Cancer 1997;79:1106-13.
46. Watanabe T, Muto T. Colorectal carcinogenesis based on molecular biology of early colorectal cancer, with special reference to nonpolypoid (superficial) lesions. World J Surg 2000;24:1091-7.
47. Yamagata S, Muto T, Uchida Y, et al. Polypoid growth and K-ras codon 12 mutation in colorectal cancer. Cancer 1995;75:953-7.
48. Fujita M, Fukui H, Kusaka T, et al. Relationship between cyclooxygenase-2 expression and K-ras gene mutation in colorectal adenomas. J Gastroenterol Hepatol 2000; 15:1277-81.