Enhanced Mucosal Delivery of Antigen with Cell Wall Mutants of Lactic Acid Bacteria

Infection and Immunity

Volumn 72, Issue 5, 2004, Pages 2731-2737

  Grangette, Corinne ^a   Müller Alouf, Heide ^a   Hols, Pascal ^b   Goudercourt, Denise ^a   Delcour, Jean ^b   Turneer, Mireille ^c   Mercenier, Annick ^a,d  

^a INSTITUT PASTEUR DE LILLE   (France)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c PASTEUR INSTITUTE OF BRUSSELS   (Belgium)

^d NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE RACEMASE; ANTIGEN; IMMUNOGLOBULIN A; TETANUS TOXIN; TETANUS TOXIN SUBUNIT C; UNCLASSIFIED DRUG; VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; BACTERIAL CELL WALL; BACTERIAL STRAIN; BACTERIAL TRANSLOCATION; BACTERIUM CARRIER; CONTROLLED STUDY; FEMALE; GASTROINTESTINAL TRACT; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNITY; IMMUNIZATION; IMMUNOGENICITY; LACTIC ACID BACTERIUM; LACTOBACILLUS DELBRUECKII; LACTOBACILLUS PLANTARUM; MOUSE; MUCOSAL IMMUNITY; MUTANT; NONHUMAN; PRIORITY JOURNAL; STOMACH; VAGINA; WILD TYPE;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS; CELL WALL; FEMALE; GASTRIC MUCOSA; IMMUNITY, MUCOSAL; IMMUNIZATION; LACTOBACILLUS; LACTOCOCCUS LACTIS; MICE; MICE, INBRED C57BL; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; RECOMBINATION, GENETIC; TETANUS TOXIN;

EID: 11144358022     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.5.2731-2737.2004     Document Type: Article

References (31)

1. Chatfield, S. N., I. G. Charles, A. J. Makoff, M. D. Oxer, G. Dougan, D. Pickard, D. Slater, and N. F. Fairweather. 1992. Use of the nirB promoter to direct the stable expression of heterologous antigens in Salmonella oral vaccine strains: development of a single-dose oral telanus toxin vaccine. Bio/Technology 10:888-892.
2. + T lymphocytes. J. Immunol. 163:3029-3036.
3. de Ruyter, P. G., O. P. Kuipers, and W. M. de Vos. 1996. Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin. Appl. Environ. Microbiol. 62:3662-3667.
4. Drouault, S., G. Corthier, S. D. Ehrlich, and P. Renault. 1999. Survival, physiology, and lysis of Lactococcus lactis in the digestive tract. Appl. Environ. Microbiol. 65:4881-4886.
5. Dunstan, S. J., C. P. Simmons, and R. A. Strugnell. 1998. Comparison of the abilities of different attenuated Salmonella typhimurium strains to elicit humoral immune responses against a heterologous antigen. Behring Inst. Min. 98:732-740.
6. Gasson, M. J. 1983. Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast inducing curing. J. Bacteriol. 154:1-9.
7. Grangette, C., H. Muller-Alouf, M. Geoffroy, D. Goudercourt, M. Turneer, and A. Mercenier. 2002. Protection against tetanus toxin after intragastric administration of two recombinant lactic acid bacteria: impact of strain viability and in vivo persistence. Vaccine 20:3304-3309.
8. Grangette, C., H. Müller-Alouf, D. Goudercourt, M.-C. Geoffroy, M. Turneer, and A. Mercenier. 2001. Mucosal immune responses and protection against tetanus toxin after intranasal immunization with recombinant Lactobacillus plantarum. Infect. Immun. 69:1547-1553.
9. Heaton, M. P., R. B. Johnston, and T. L. Thompson. 1988. Controlled lysis of bacterial cells utilizing mutants with defective synthesis of D-alanine. Can. J. Microbiol. 34:256-261.
10. Hols, P., C. Defrenne, T. Ferain, S. Derzelle, B. Delplace, and J. Delcour. 1997. The alanine racemase gene is essential for growth of Lactobacillus plantarum. J. Bacteriol. 179:3804-3807.
11. Hols, P., M. Kleerebezem, A. N. Schanck, T. Ferain, J. Hugenholz, J. Delcour, and W. M. de Vos. 1999. Conversion of Lactococcus lactis from homolactic to homoalanine fermentation through metabolic engineering. Nat. Biotechnol. 17:588-592.
12. Hols, P., P. Slos, P. Dutot, J. Reymund, P. Chabot, B. Delplace, J. Delcour, and A. Mercenier. 1997. Efficient secretion of the model antigen M6-gp41E in Lactobacillus plantarum NCIMB 8826. Microbiology 143:2733-2741.
13. Jacobs, W. R., S. B. Snapper, L. Lugosi, and B. R. Bloom. 1990. Development of BCG as recombinant vaccine delivery vehicle. Curr. Top. Microbiol. Immunol. 155:153-160.
14. Klijn, N., A. H. Weerkamp, and W. M. de Vos. 1995. Genetic marking of Lactococcus lactis shows its survival in the human gastrointestinal tract. Appl. Environ. Microbiol. 61:2771-2774.
15. Kremer, L., L. Dupré, G. Riveau, A. Capron, and C. Locht. 1998. Systemic and mucosal immune responses after intranasal administration of recombinant Mycobacterium bovis Bacillus Calmette-Guérin expressing gluthathione S-transferase from Schistosoma haematobium. Infect. Immun. 66:5669-5676.
16. McComb, J. A. 1964. The prophylactic dose of homologous tetanus antitoxin. N. Engl. J. Med. 270:175-178.
17. Medaglini, D., A. Ciabattini, M. R. Spinosa, T. Maggi, H. Marcotte, M. R. Oggioni, and G. Pozzi. 2001. Immunization with recombinant. Streptococcus gordonii expressing tetanus toxin fragment C confers protection from lethal challenge in mice. Vaccine 19:1931-1939.
18. Medaglini, D., C. M. Rush, P. Sestini, and G. Pozzi. 1997. Commensal bacteria as vectors for mucosal vaccines against sexually transmitted diseases: vaginal colonization with recombinant streptococci induces local and systemic antibodies in mice. Vaccine 15:1330-1337.
19. Mielcarek, N., J. Cornette, A. M. Schacht, R. J. Pierce, C. Locht, A. Capron, and G. Riveau. 1997. Intranasal priming with recombinant Bordetella pertussis for the induction of a systemic immune response against a heterologous antigen. Infect. Immun. 65:544-550.
20. Neutra, M. R., E. Pringault, and J. P. Kraehenbuhl. 1996. Antigen sampling across epithelial barriers and induction of mucosal immune responses. Annu. Rev. Immunol. 14:275-300.
21. Norton, P. M., J. M. Wells, H. W. G. Brown, A. M. Macpherson, and R. W. F. Le Page. 1997. Protection against tetanus toxin in mice nasally immunized with recombinant Lactococcus lactis expressing tetanus toxin fragment C. Vaccine 15:616-619.
22. Ntamere, A. S., D. J. Taron, and F. C. Neuhaus. 1987. Assembly of D-alanyllipoteichoic acid in Lactobacillus casei: mutants deficient in the D-alanyl ester content of this amphiphile. J. Bacteriol. 169:1702-1711.
23. a. Palumbo, E., C. Favier, M. Deghorain, P. S. Cocconcelli, C. Grangette, A. Mercenier, E. Vaughan, and P. Hols. 2004. Knockout of the alanine race-mase gene in Lactobacillus plantarum results in septation defects and cell wall perforation. FEMS Microbiol. Lett. 233:131-138.
24. Parr, M. B., and E. L. Parr. 1990. Antigen recognition in the female reproductive tract. 1. Uptake of intraluminal protein tracers in the mouse vagina. J. Reprod. Immunol. 17:101-114.
25. Pavan, S., P. Hols, J. Delcour, M. C. Geoffroy, C. Grangette, M. Kleerebezem, and A. Mercenier. 2000. Adaptation of the nisin-controlled expression system in Lactobacillus plantarum: a tool to study in vivo biological effects. Appl. Environ. Microbiol. 66:4427-4432.
26. Reveneau N., M.-C. Geoffroy, C. Locht, P. Chagnaud, and A. Mercenier. 2001. Comparison of the immune responses induced by local immunizations with recombinant Lactobacillus plantarum producing tetanus toxin fragment C in different cellular locations. Vaccine 20:1769-3777.
27. Robinson, K., L. M. Chamberlain, K. M. Schofield, J. M. Wells, and R. W. F. Le Page. 1997. Oral vaccination of mice against tetanus with recombinant Lactococcus lactis. Nat. Biotechnol. 15:653-657.
28. Ryan, E. T., J. R. Butterton, R. Neal Smith, P. A. Carroll, T. I. Crean, and S. B. Calderwood. 1997. Protective immunity against Clostridium difficile toxin a induced by oral immunization with a live, attenuated Vibrio cholerae rector strain. Infect. Immun. 65:2941-2949.
29. Shaw, D. M., B. Gaerthé, R. J. Leer, J. G. M. M. Van Der Stap, C. Smittenaar, M.-J. Heijne den Bak-Glashouwer, J. E. R. Thole, F. J. Tielen, P. H. Poowels, and C. E. G. Havenith. 2000. Engineering the microflora to vaccinate the mucosa: serum immunoglobulin G responses and activated draining cervical lymph nodes following mucosal application of tetanus toxin fragment C-expressing lactobacilli. Immunology 100:510-518.
30. Thapar, M. A., E. L. Parr, and M. B. Parr. 1990. The effect of adjuvants on antibody titers in mouse vaginal fluid after intravaginal immunization. J. Reprod. Immunol. 17:207-216.
31. Vesa, T., P. Pochart, and P. Marteau. 2000. Pharmacokinetics of Lactobacillus plantarum NCIMB 8826, Lactobacillus fermentum KLD, and Lactococcus lactis MG 1363 in the human gastrointestinal tract, Aliment. Pharmacol. Ther. 14:823-828.