IGF-I stimulates proliferation of spontaneously immortalized human keratinocytes (HACAT) by autocrine/paracrine mechanisms

Journal of Endocrinological Investigation

Volumn 27, Issue 2, 2004, Pages 142-149

  Pozzi, G ^a   Guidi, M ^b   Laudicina, F ^b   Marazzi, M ^c   Falcone, L ^c   Betti, R ^b   Crosti, C ^b   Muller E E ^b   DiMattia, G E ^d   Locatelli, V ^e   Torsello, Antonio ^e  

^a LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c OSPEDALE NIGUARDA CA GRANDA   (Italy)

^d UNIVERSITY OF WESTERN ONTARIO   (Canada)

^e UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Autocrine paracrine interactions; EGF; HaCat; IGF I; Keratinocytes

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; MONOCLONAL ANTIBODY; SOMATOMEDIN B; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ARTICLE; AUTOCRINE EFFECT; CELL DIVISION; CELL GROWTH; CELL IMMORTALIZATION; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; KERATINOCYTE; NORTHERN BLOTTING; PARACRINE SIGNALING; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SYNTHESIS; SKIN DISEASE;

EID: 11144355808     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03346259     Document Type: Article

References (41)

1. Sporn MB, Roberts AB. Autocrine growth factors and cancer. Nature 1985, 313: 745-7.
2. Pollak MN, Schally AV. Mechanisms of antineoplastic action of somatostatin analogs. Proc Soc Exp Biol Med 1998, 217: 143-52.
3. Di Giovanni J, Bol DK, Wilker E, et al. Constitutive expression of insulin-like growth factor-1 in epidermal basal cells of transgenic mice leads to spontaneous tumor promotion. Cancer Res 2000, 15: 1561-70.
4. Wang XJ, Greenhalgh DA, Roop DR. Transgenic coexpression of v-Ha-ras and transforming growth factor alpha increases epidermal hyperproliferation and tumorigenesis and predisposes to malignant conversion via endogenous c-Ha-ras activation. Mol Carcinog 2000, 27: 200-9.
5. Gold LI, Jussila T, Fusenig NE, Stenback F. TGF-β isoforms are differentially expressed in increasing malignant grades of HaCaT keratinocytes, suggesting separate roles in skin carcinogenesis. J Pathol 2000, 190: 579-88.
6. Giles CG, Marks R, Foley P. The incidence of non-melanocytic skin cancer in Australia. Br Med J 1988, 296: 13-7.
7. Maciag T, Nemore RE, Weistain R, Glochrest BA. An endocrine approach to the control of epidermal growth: serum free cultivation of human keratinocytes. Science 1981, 211: 1452-4.
8. Tsao MC, Walthall BJ, Ham RG. Clonal growth of normal human keratinocytes in a defined medium. J Cell Physiol 1982, 110: 219-29.
9. Boyce ST, Ham RG. Calcium-regulated differentation of normal human epidermal keratinocytes in chemically defined clonal culture and serum free-culture. J Invest Dermatol 1983, 81: 33S-40S.
10. Wille JJ, Pittelkow MR, Shipley GD, Scott RE. Integrated control of growth and differentation of normal human prokeratinocytes cultured in serum-free medium: clonal analyses, growth kinetics and cell cycle studies. Cell Physiol 1984, 121: 31-44.
11. Girolomoni G, Phillips JT, Bergstresser PR. Prolactin stimulates proliferation of cultured human keratinocytes. J Invest Dermatol 1993, 101: 275-9.
12. Shipley GD, Keeble WW, Hendrickson JE, Coffey RJ, Pittelkow MRJ. Growth of normal human keratinocytes and fibroblasts in serum-free medium is stimulated by acidic and basic fibroblast growth factor. J Cell Physiol 1989, 138: 511-8.
13. Aaronsons SA, Rubin JS, Finch PW, et al. Growth factor-regulated pathways in epithelial cell proliferation. Am Rev Respir Dis 1990, 142(Suppl): S7-S1O.
14. Ferrara N, Schweigerer L, Neufeld G, Mitchell R, Gospodarowicz D. Pituitary follicular cells produce basic fibroblast growth factor. Proc Natl Acad Sci USA 1987, 84: 5773-7.
15. Haselbacher G, Schwab MB, Pasi A, Humbel E. Insulin-like growth factor II (IGF II) in human brain: regional distribution of IGF II and higher molecular mass forms. Proc Natl Acad Sci USA 1985, 82: 2153-7.
16. Van Wik JJ. Biological actions and physiological control mechanisms. In: Li CH ed. Hormonal Proteins and Peptides. Vol XXII. New York: Academic Press. 1985, 82-125.
17. Daughaday WH, Rotwein P. Insulin-like growth factors I and II. Peptide, messenger ribonucleic aid and gene structures, serum and tissue concentrations. Endocrine Rev 1989, 10: 68-91.
18. Barreca A, De Luca M, Del Monte P, et al. In vitro paracrine regulation of human keratinocyte growth by fibroblast derived insulin-like growth factors. J Cell Physiol 1992, 151: 262-8.
19. Tavakkol A, Elder JT, Griffiths CEM, et al. Expression of growth hormone receptor, insulin-like growth factor I (IGF-I) and IGF-I receptor mRNA and proteins in human skin. J Invest Dermatol 1992: 99: 343-9.
20. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 1988, 106: 761-71.
21. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Met 1983, 65: 55-63.
22. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid quanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987, 162: 156-9.
23. Torsello A, Vrontakis ME, Schroedter IC, Vuille JC, Ikejiani C, Friesen, HG. Steroid and tissue specific modulation of galanin gene expression in the male rat reproductive system. Endocrinology 1992, 130: 3301-6.
24. Gilchrest BA, Karassik RL, Wilkins LM, Vrabel MA, Macaig T. Autocrine and paracrine stimulation of cells derived from human skin. J Cell Physiol 1983, 117: 235-40.
25. Shipley GD, Pittelkow MR. Control of growth and differentiation in vitro of human keratinocytes cultured in serum-free medium. Arch Dermatol 1987, 123: 1541a-4a.
26. Minuto F, Barreca A, Del Monte P, Giordano G. Paracrine actions of IGF binding proteins. Acta Endocrinol (Copenh) 1991, 124: 63-9.
27. Eming SA, Snow RG, Yarmush ML, Morgan JR. Targeted expression of insulin-like growth factor to human keratinocytes: modification of the autocrine control of keratinocyte proliferation. J Invest Dermatol 1996, 107: 113-20.
28. Marinaro JA, Hendrich EC, Leeding KS, Bach LA. HaCaT human keratinocytes express IGF-II, IGFBP-6, and an acid-activated protease with activity against IGFBP-6. Am J Physiol 1999, 276: E536-42.
29. Neely EK, Morhenn VB, Hintz RL, Wilson DM, Rosenfeld RG. Insulin-like growth factors are mitogenic for human keratinocytes and a squamous cell carcinoma. J Invest Dermatol 1991, 96: 104-10.
30. El-Badry OM, Romanus JA, Helman LJ, Cooper MJ, Rechler MM, Israel MA. Autonomous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor II. J Clin Invest 1989, 84: 829-39.
31. Steller MA, Delgado CH, Bartels CJ, Woodworth CD, Zou Z. Overexpression of the insulin-like growth factor-1 receptor and autocrine stimulation in human cervical cancer cells. Cancer Res 1996, 56: 1761-5.
32. Macauly VM. Insulin-like growth factor and cancer. Brit J Cancer 1992, 65: 311-20.
33. Kornfeld S. Structure and function of mannose 6-phosphate/insulin-like growth factor II receptors. Ann Rev Biochem 1992, 61: 307-30.
34. Baserga R, Porcu P, Rubini M, Sell C. Cell cycle control by the IGF-I receptor and its ligands. Adv Exp Med Biol 1993, 343: 105-12.
35. McCubrey JA, Steelman LS, Mayo MW, Algate PA, Dellow RA, Kaleko M. Growth-promoting effects of insulin-like growth factor-1 (IGF-I) on hematopoietic cells: overexpression of introduced IGF-I receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism. Blood 1991, 78: 921-9.
36. Frasca F, Pandini G, Scalia P, et al. Insulin receptor isoform A, a newly recognized high affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol 1999, 19: 3278-88.
37. Vella V, Pandini G, Sciacca L, et al. A Novel autocrine loop involving IGF-II and the insulin receptor isoform-A stimulates growth of thyroid cancer. J Clin Endocrinol Met 2002, 87: 245-54.
38. Sciacca L, Mineo R, Pandini G, Murabito A, Vigneri R, Belfiore A. In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A. Oncogene 2002, 21: 8240-50.
39. Zendegui JG, Inman WH, Carpenter G. Modulation of the mitogenic response of an epidermal growth factor-dependent keratinocyte line by dexamethasone, insulin, and transforming growth factor-beta. J Cell Physiol 1988, 136: 257-65.
40. Daub H, Wallasch C, Lankenau A., Herrlich A, Ullrich A. Signal characteristics of G protein-transactivated EGF receptor. EMBO Journal 1997, 16: 7032-44.
41. Stoll SW, Benedict M, Mitra R, Hiniker A, Elder JT, Nunez G. EGF receptor signaling inhibits keratinocyte apoptosis: evidence for mediation by BcI-XL. Oncogene 1998, 16:1493-9.