Control of particle size by coagulation of novel condensation aerosols in reservoir chambers

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 15, Issue 4, 2002, Pages 359-368

  Hong, John N ^a   Hindle, Michael ^a   Byron, Peter R ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Aerosol; Condensation aerosol generator; Particle size

Indexed keywords

BENZIL; BENZILIC ACID DERIVATIVE; PROPYLENE GLYCOL; UNCLASSIFIED DRUG;

AEROSOL; AIR; ARTICLE; CAPILLARY AEROSOL GENERATOR; DEVICE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG TARGETING; MEDIAN AERODYNAMIC DIAMETER; MOUDI CASCADE IMPACTOR; PARTICLE SIZE; RESPIRATORY SYSTEM;

AEROSOLS; ANALYSIS OF VARIANCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EQUIPMENT DESIGN; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; PHENYLGLYOXAL; PROPYLENE GLYCOL; VEHICLES;

EID: 0036959322     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/08942680260473434     Document Type: Article

References (16)

1. Hindle, M., P.R. Byron, R.N. Jashnani, et al. 1998. High efficiency fine particle generation using novel condensation technology. Respir. Drug Delivery VI:97-102.
2. Howell, T., and W. Sweeney. 1998. Aerosol and a method and apparatus for generating an aerosol. United States Patent 5,743,251, Philip Morris Inc., New York.
3. Gupta, R., M. Hindle, and P.R. Byron. 2001. Solute and concentration effects in a novel pharmaceutical condensation aerosol generator. AAPS PharmSci 3:3148(suppl).
4. Gupta, R., M. Hindle, P.R. Byron, et al. 2001. Vehicle effects on the performance of a novel pharmaceutical condensation aerosol generator. AAPS PharmSci 3:3150(suppl).
5. Whytlaw-Gray, R. 1935. The process of coagulation in smokes. J. Chem. Soc. 1:268-280.
6. Gillespie T., and G.O. Langsstroth. 1950. The effect of relative humidity on coagulation and surface losses of ammonium chloride smoke. Can. J. Chem. 29:133-139.
7. Hinds, W.C. 1999. Aerosol Technology: Properties, Behavior, and Measurement of Airborne Particles. Wiley, New York.
8. Lesniewski, T.K., and W. Koch. 1998. Production of rounded Ti- and Al-hydroxide particles in a turbulent jet by coagulation-controlled growth followed by rapid coalescence. J. Aerosol Sci. 29:81-98.
9. Maetzing, H., W. Baumann, and H.R. Paur. 1996. Bimodal aerosol coagulation with simultaneous condensation/evaporation. J. Aerosol. Sci. 27:S363-S364.
10. Smoluchowski, M. 1917. Versuch einer mathematischen theorie der koagulationskinetik kolloider losungen. Z. Physik. Chem. 92:129-168.
11. The United States Pharmacopeia (vol. 24) and National Formulary (vol. 19). 2000. United States Pharmacopeial Convention, Inc., Rockville, MD, pp. 1901-1908.
12. Newman, S.P., and M.T. Newhouse. 1996. Effect of add-on devices for aerosol drug delivery: deposition studies and clinical aspects. J. Aerosol Med. 9:55-68.
13. Barry, P.W., and C. O'Callaghan. 1995. The effect of delay, multiple actuations and spacer static charge on the in vitro delivery of Budesonide from the Nebuhaler. Br. J. Clin. Pharmacol. 40:76-78.
14. Marple, V.A., K.L. Rubow, and S.M. Behm. 1991. A Microorifice Uniform Deposit Impactor (MOUDI): description, calibration, and use. Aerosol Sci. Tech. 14:434-446.
15. Lee, K.W., and H. Chen. 1984. Coagulation rate of polydispersed particles. Aerosol Sci. Tech. 3:327-334.
16. Byron, P.R., S.S. Davis, M.D. Bubb, et al. 1977. Pharmaceutical implications of particle growth at high relative humidities. Pestic. Sci. 8:521-526.