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Volumn 64, Issue 2, 2005, Pages 388-393

De novo synthesis of diacylglycerol in endothelium may mediate the association between PAI-1 and the insulin resistance syndrome

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL; GEMFIBROZIL; HEPARIN; INSULIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN KINASE C; TRANSCRIPTION FACTOR SP1; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

EID: 11144342329     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2004.03.038     Document Type: Article
Times cited : (5)

References (88)
  • 1
    • 0043124344 scopus 로고    scopus 로고
    • Does postprandial storage of triglycerides in endothelial cells contribute to the endothelial dysfunction associated with insulin resistance and fatty diets?
    • McCarty M.F. Does postprandial storage of triglycerides in endothelial cells contribute to the endothelial dysfunction associated with insulin resistance and fatty diets? Med. Hypotheses. 61:2003;167-172
    • (2003) Med. Hypotheses , vol.61 , pp. 167-172
    • McCarty, M.F.1
  • 2
    • 11144322982 scopus 로고    scopus 로고
    • AMPK activation as a strategy for reversing the endothelial lipotoxicity underlying the increased vascular risk associated with insulin resistance syndrome
    • in press
    • McCarty MF. AMPK activation as a strategy for reversing the endothelial lipotoxicity underlying the increased vascular risk associated with insulin resistance syndrome. Med Hypoth 2004; in press
    • (2004) Med Hypoth
    • McCarty, M.F.1
  • 3
    • 0034905890 scopus 로고    scopus 로고
    • Impaired non-esterified fatty acid suppression is associated with endothelial dysfunction in insulin resistant subjects
    • Balletshofer B.M., Rittig K., Volk A., Maerker E., Jacob S., Rett K., et al. Impaired non-esterified fatty acid suppression is associated with endothelial dysfunction in insulin resistant subjects. Horm. Metab. Res. 33:2001;428-431
    • (2001) Horm. Metab. Res. , vol.33 , pp. 428-431
    • Balletshofer, B.M.1    Rittig, K.2    Volk, A.3    Maerker, E.4    Jacob, S.5    Rett, K.6
  • 5
    • 0033765672 scopus 로고    scopus 로고
    • High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells
    • Inoguchi T., Li P., Umeda F., Yu H.Y., Kakimoto M., et al. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes. 49:2000;1939-1945
    • (2000) Diabetes , vol.49 , pp. 1939-1945
    • Inoguchi, T.1    Li, P.2    Umeda, F.3    Yu, H.Y.4    Kakimoto, M.5
  • 6
    • 0036176365 scopus 로고    scopus 로고
    • Insulin resistance and vascular function
    • Baron A.D. Insulin resistance and vascular function. J. Diabetes Complicat. 16:2002;92-102
    • (2002) J. Diabetes Complicat. , vol.16 , pp. 92-102
    • Baron, A.D.1
  • 7
    • 0037328928 scopus 로고    scopus 로고
    • Malonyl-CoA and AMP-activated protein kinase (AMPK): Possible links between insulin resistance in muscle and early endothelial cell damage in diabetes
    • Ruderman N.B., Cacicedo J.M., Itani S., Yagihashi N., Saha A.K., et al. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochem. Soc. Trans. 31:2003;202-206
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 202-206
    • Ruderman, N.B.1    Cacicedo, J.M.2    Itani, S.3    Yagihashi, N.4    Saha, A.K.5
  • 8
    • 0035947574 scopus 로고    scopus 로고
    • Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase
    • Michell B.J., Chen Z., Tiganis T., Stapleton D., Katsis F., Power D.A., et al. Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. J. Biol. Chem. 276:2001;17625-17628
    • (2001) J. Biol. Chem. , vol.276 , pp. 17625-17628
    • Michell, B.J.1    Chen, Z.2    Tiganis, T.3    Stapleton, D.4    Katsis, F.5    Power, D.A.6
  • 9
    • 0030667807 scopus 로고    scopus 로고
    • Activation of nuclear factor-κB in cultured endothelial cells by increased glucose concentration: Prevention by calphostin C
    • Pieper G.M., Riaz u.H. Activation of nuclear factor-κB in cultured endothelial cells by increased glucose concentration: prevention by calphostin C. J. Cardiovasc. Pharmacol. 30:1997;528-532
    • (1997) J. Cardiovasc. Pharmacol. , vol.30 , pp. 528-532
    • Pieper, G.M.1    Riaz, U.H.2
  • 10
    • 0031956685 scopus 로고    scopus 로고
    • Biphasic regulation of transcription factor nuclear factor-κB activity in human endothelial cells by lysophosphatidylcholine through protein kinase C-mediated pathway
    • Sugiyama S., Kugiyama K., Ogata N., Doi H., Ota Y., et al. Biphasic regulation of transcription factor nuclear factor-κB activity in human endothelial cells by lysophosphatidylcholine through protein kinase C-mediated pathway. Arterioscler. Thromb. Vasc. Biol. 18:1998;568-576
    • (1998) Arterioscler. Thromb. Vasc. Biol. , vol.18 , pp. 568-576
    • Sugiyama, S.1    Kugiyama, K.2    Ogata, N.3    Doi, H.4    Ota, Y.5
  • 11
    • 0037432593 scopus 로고    scopus 로고
    • Oleic acid induces endothelin-1 expression through activation of protein kinase C and NF-κ B
    • Park J.Y., Kim Y.M., Song H.S., Park K.Y., Kim Y.M., Kim M.S., et al. Oleic acid induces endothelin-1 expression through activation of protein kinase C and NF-κ B. Biochem. Biophys. Res. Commun. 303:2003;891-895
    • (2003) Biochem. Biophys. Res. Commun. , vol.303 , pp. 891-895
    • Park, J.Y.1    Kim, Y.M.2    Song, H.S.3    Park, K.Y.4    Kim, Y.M.5    Kim, M.S.6
  • 12
    • 0141832847 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk
    • Juhan-Vague I., Alessi M.C., Mavri A., Morange P.E. Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk. J. Thromb. Haemost. 1:2003;1575-1579
    • (2003) J. Thromb. Haemost. , vol.1 , pp. 1575-1579
    • Juhan-Vague, I.1    Alessi, M.C.2    Mavri, A.3    Morange, P.E.4
  • 13
    • 0141835015 scopus 로고    scopus 로고
    • Insulin resistance, inflammation, and the prediabetic state
    • Haffner S.M. Insulin resistance, inflammation, and the prediabetic state. Am. J. Cardiol. 92:2003;18J-26J
    • (2003) Am. J. Cardiol. , vol.92
    • Haffner, S.M.1
  • 14
    • 0035975586 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor type-1 in cardiovascular disease. Status report 2001
    • Huber K., Christ G., Wojta J., Gulba D. Plasminogen activator inhibitor type-1 in cardiovascular disease. Status report 2001. Thromb. Res. 103(Suppl 1):2001;S7-S19
    • (2001) Thromb. Res. , vol.103 , Issue.SUPPL. 1
    • Huber, K.1    Christ, G.2    Wojta, J.3    Gulba, D.4
  • 15
    • 0035169759 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor type-1 (part one): Basic mechanisms, regulation, and role for thromboembolic disease
    • Huber K. Plasminogen activator inhibitor type-1 (part one): basic mechanisms, regulation, and role for thromboembolic disease. J. Thromb. Thrombolys. 11:2001;183-193
    • (2001) J. Thromb. Thrombolys. , vol.11 , pp. 183-193
    • Huber, K.1
  • 16
    • 0036838748 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1: Physiologic role, regulation, and the influence of common pharmacologic agents
    • Tsikouris J.P., Suarez J.A., Meyerrose G.E. Plasminogen activator inhibitor-1: physiologic role, regulation, and the influence of common pharmacologic agents. J. Clin. Pharmacol. 42:2002;1187-1199
    • (2002) J. Clin. Pharmacol. , vol.42 , pp. 1187-1199
    • Tsikouris, J.P.1    Suarez, J.A.2    Meyerrose, G.E.3
  • 17
    • 0035082403 scopus 로고    scopus 로고
    • Fibrinolytic variables in patients with recurrent venous thrombosis: A prospective cohort study
    • Crowther M.A., Roberts J., Roberts R., Johnston M., Stevens P., Skingley P., et al. Fibrinolytic variables in patients with recurrent venous thrombosis: a prospective cohort study. Thromb. Haemost. 85:2001;390-394
    • (2001) Thromb. Haemost. , vol.85 , pp. 390-394
    • Crowther, M.A.1    Roberts, J.2    Roberts, R.3    Johnston, M.4    Stevens, P.5    Skingley, P.6
  • 19
    • 0036881059 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 levels and polymorphisms
    • Francis C.W. Plasminogen activator inhibitor-1 levels and polymorphisms. Arch. Pathol. Lab. Med. 126:2002;1401-1404
    • (2002) Arch. Pathol. Lab. Med. , vol.126 , pp. 1401-1404
    • Francis, C.W.1
  • 20
    • 0030764551 scopus 로고    scopus 로고
    • PAI-1, obesity, insulin resistance and risk of cardiovascular events
    • Juhan-Vague I., Alessi M.C. PAI-1, obesity, insulin resistance and risk of cardiovascular events. Thromb. Haemost. 78:1997;656-660
    • (1997) Thromb. Haemost. , vol.78 , pp. 656-660
    • Juhan-Vague, I.1    Alessi, M.C.2
  • 21
    • 0038518463 scopus 로고    scopus 로고
    • Promoter (4G/5G) plasminogen activator inhibitor-1 genotype and plasminogen activator inhibitor-1 levels in blacks, Hispanics, and non-Hispanic whites: The Insulin Resistance Atherosclerosis Study
    • Festa A., D'Agostino R. Jr., Rich S.S., Jenny N.S., Tracy R.P., Haffner S.M. Promoter (4G/5G) plasminogen activator inhibitor-1 genotype and plasminogen activator inhibitor-1 levels in blacks, Hispanics, and non-Hispanic whites: the Insulin Resistance Atherosclerosis Study. Circulation. 107:2003;2422-2427
    • (2003) Circulation , vol.107 , pp. 2422-2427
    • Festa, A.1    D'agostino Jr., R.2    Rich, S.S.3    Jenny, N.S.4    Tracy, R.P.5    Haffner, S.M.6
  • 22
    • 0024240538 scopus 로고
    • Insulin stimulates the synthesis of plasminogen activator inhibitor 1 by the human hepatocellular cell line Hep G2
    • Alessi M.C., Juhan-Vague I., Kooistra T., Declerck P.J., Collen D. Insulin stimulates the synthesis of plasminogen activator inhibitor 1 by the human hepatocellular cell line Hep G2. Thromb. Haemost. 60:1988;491-494
    • (1988) Thromb. Haemost. , vol.60 , pp. 491-494
    • Alessi, M.C.1    Juhan-Vague, I.2    Kooistra, T.3    Declerck, P.J.4    Collen, D.5
  • 23
    • 0032143386 scopus 로고    scopus 로고
    • Augmentation of arterial endothelial cell expression of the plasminogen activator inhibitor type-1 (PAI-1) gene by proinsulin and insulin in vivo
    • Nordt T.K., Sawa H., Fujii S., Bode C., Sobel B.E. Augmentation of arterial endothelial cell expression of the plasminogen activator inhibitor type-1 (PAI-1) gene by proinsulin and insulin in vivo. J. Mol. Cell Cardiol. 30:1998;1535-1543
    • (1998) J. Mol. Cell Cardiol. , vol.30 , pp. 1535-1543
    • Nordt, T.K.1    Sawa, H.2    Fujii, S.3    Bode, C.4    Sobel, B.E.5
  • 24
    • 0032745738 scopus 로고    scopus 로고
    • Expression of plasminogen activator inhibitor type I in genotyped human endothelial cell cultures: Genotype-specific regulation by insulin
    • Grenett H.E., Benza R.L., Li X.N., Aikens M.L., Grammer J.R., Brown S.L., et al. Expression of plasminogen activator inhibitor type I in genotyped human endothelial cell cultures: genotype-specific regulation by insulin. Thromb. Haemost. 82:1999;1504-1509
    • (1999) Thromb. Haemost. , vol.82 , pp. 1504-1509
    • Grenett, H.E.1    Benza, R.L.2    Li, X.N.3    Aikens, M.L.4    Grammer, J.R.5    Brown, S.L.6
  • 25
    • 0026078722 scopus 로고
    • The acute effect of insulin on tissue plasminogen activator and plasminogen activator inhibitor in man
    • Landin K., Tengborn L., Chmielewska J., Von Schenck H., Smith U. The acute effect of insulin on tissue plasminogen activator and plasminogen activator inhibitor in man. Thromb. Haemost. 65:1991;130-133
    • (1991) Thromb. Haemost. , vol.65 , pp. 130-133
    • Landin, K.1    Tengborn, L.2    Chmielewska, J.3    Von Schenck, H.4    Smith, U.5
  • 27
    • 0030874906 scopus 로고    scopus 로고
    • Hyperinsulinemia and hypofibrinolysis: Effects of short-term optimized glycemic control with continuous insulin infusion in type II diabetic patients
    • Lormeau B., Aurousseau M.H., Valensi P., Paries J., Attali J.R. Hyperinsulinemia and hypofibrinolysis: effects of short-term optimized glycemic control with continuous insulin infusion in type II diabetic patients. Metabolism. 46:1997;1074-1079
    • (1997) Metabolism , vol.46 , pp. 1074-1079
    • Lormeau, B.1    Aurousseau, M.H.2    Valensi, P.3    Paries, J.4    Attali, J.R.5
  • 28
    • 0027537594 scopus 로고
    • Insulin therapy in type 2 diabetic subjects suppresses plasminogen activator inhibitor (PAI-1) activity and proinsulin-like molecules independently of glycaemic control
    • Jain S.K., Nagi D.K., Slavin B.M., Lumb P.J., Yudkin J.S. Insulin therapy in type 2 diabetic subjects suppresses plasminogen activator inhibitor (PAI-1) activity and proinsulin-like molecules independently of glycaemic control. Diabet. Med. 10:1993;27-32
    • (1993) Diabet. Med. , vol.10 , pp. 27-32
    • Jain, S.K.1    Nagi, D.K.2    Slavin, B.M.3    Lumb, P.J.4    Yudkin, J.S.5
  • 29
    • 0031937736 scopus 로고    scopus 로고
    • Induction of hyperinsulinemia combined with hyperglycemia and hypertriglyceridemia increases plasminogen activator inhibitor 1 in blood in normal human subjects
    • Calles-Escandon J., Mirza S.A., Sobel B.E., Schneider D.J. Induction of hyperinsulinemia combined with hyperglycemia and hypertriglyceridemia increases plasminogen activator inhibitor 1 in blood in normal human subjects. Diabetes. 47:1998;290-293
    • (1998) Diabetes , vol.47 , pp. 290-293
    • Calles-Escandon, J.1    Mirza, S.A.2    Sobel, B.E.3    Schneider, D.J.4
  • 30
    • 0141429031 scopus 로고    scopus 로고
    • Increased plasma levels of plasminogen activator inhibitor-1 and soluble vascular cell adhesion molecule after triacylglycerol infusion in man
    • Krebs M., Geiger M., Polak K., Vales A., Schmetterer L., Wagner O.F., et al. Increased plasma levels of plasminogen activator inhibitor-1 and soluble vascular cell adhesion molecule after triacylglycerol infusion in man. Thromb. Haemost. 90:2003;422-428
    • (2003) Thromb. Haemost. , vol.90 , pp. 422-428
    • Krebs, M.1    Geiger, M.2    Polak, K.3    Vales, A.4    Schmetterer, L.5    Wagner, O.F.6
  • 31
    • 0030480352 scopus 로고    scopus 로고
    • Synergistic augmentation of expression of plasminogen activator inhibitor type-1 induced by insulin, very-low-density lipoproteins, and fatty acids
    • Schneider D.J., Sobel B.E. Synergistic augmentation of expression of plasminogen activator inhibitor type-1 induced by insulin, very-low-density lipoproteins, and fatty acids. Coron. Artery Dis. 7:1996;813-817
    • (1996) Coron. Artery Dis. , vol.7 , pp. 813-817
    • Schneider, D.J.1    Sobel, B.E.2
  • 32
    • 0033674377 scopus 로고    scopus 로고
    • Identification and localization of a fatty acid response region in the human plasminogen activator inhibitor-1 gene
    • Chen Y., Billadello J.J., Schneider D.J. Identification and localization of a fatty acid response region in the human plasminogen activator inhibitor-1 gene. Arterioscler. Thromb. Vasc. Biol. 20:2000;2696-2701
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 2696-2701
    • Chen, Y.1    Billadello, J.J.2    Schneider, D.J.3
  • 33
    • 0036248575 scopus 로고    scopus 로고
    • The independence of signaling pathways mediating increased expression of plasminogen activator inhibitor type 1 in HepG2 cells exposed to free fatty acids or triglycerides
    • Chen Y., Schneider D.J. The independence of signaling pathways mediating increased expression of plasminogen activator inhibitor type 1 in HepG2 cells exposed to free fatty acids or triglycerides. Int. J. Exp. Diabetes Res. 3:2002;109-118
    • (2002) Int. J. Exp. Diabetes Res. , vol.3 , pp. 109-118
    • Chen, Y.1    Schneider, D.J.2
  • 34
    • 0036986057 scopus 로고    scopus 로고
    • Effect of fatty acid chain length and thioesterification on the augmentation of expression of plasminogen activator inhibitor-1
    • Chen Y., Sobel B.E., Schneider D.J. Effect of fatty acid chain length and thioesterification on the augmentation of expression of plasminogen activator inhibitor-1. Nutr. Metab. Cardiovasc. Dis. 12:2002;325-330
    • (2002) Nutr. Metab. Cardiovasc. Dis. , vol.12 , pp. 325-330
    • Chen, Y.1    Sobel, B.E.2    Schneider, D.J.3
  • 35
    • 0035409351 scopus 로고    scopus 로고
    • Transcriptional regulation of plasminogen activator inhibitor type 1 gene by insulin: Insights into the signaling pathway
    • Banfi C., Eriksson P., Giandomenico G., Mussoni L., Sironi L., Hamsten A., et al. Transcriptional regulation of plasminogen activator inhibitor type 1 gene by insulin: insights into the signaling pathway. Diabetes. 50:2001;1522-1530
    • (2001) Diabetes , vol.50 , pp. 1522-1530
    • Banfi, C.1    Eriksson, P.2    Giandomenico, G.3    Mussoni, L.4    Sironi, L.5    Hamsten, A.6
  • 36
    • 0037036447 scopus 로고    scopus 로고
    • A Forkhead/winged helix-related transcription factor mediates insulin-increased plasminogen activator inhibitor-1 gene transcription
    • Vulin A.I., Stanley F.M. A Forkhead/winged helix-related transcription factor mediates insulin-increased plasminogen activator inhibitor-1 gene transcription. J. Biol. Chem. 277:2002;20169-20176
    • (2002) J. Biol. Chem. , vol.277 , pp. 20169-20176
    • Vulin, A.I.1    Stanley, F.M.2
  • 37
    • 0037307621 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 and hypoxia response elements mediate the induction of plasminogen activator inhibitor-1 gene expression by insulin in primary rat hepatocytes
    • Kietzmann T., Samoylenko A., Roth U., Jungermann K. Hypoxia-inducible factor-1 and hypoxia response elements mediate the induction of plasminogen activator inhibitor-1 gene expression by insulin in primary rat hepatocytes. Blood. 101:2003;907-914
    • (2003) Blood , vol.101 , pp. 907-914
    • Kietzmann, T.1    Samoylenko, A.2    Roth, U.3    Jungermann, K.4
  • 38
    • 0032954778 scopus 로고    scopus 로고
    • Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
    • Dresner A., Laurent D., Marcucci M., Griffin M.E., Dufour S., Cline G.W., et al. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J. Clin. Invest. 103:1999;253-259
    • (1999) J. Clin. Invest. , vol.103 , pp. 253-259
    • Dresner, A.1    Laurent, D.2    Marcucci, M.3    Griffin, M.E.4    Dufour, S.5    Cline, G.W.6
  • 39
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
    • Griffin M.E., Marcucci M.J., Cline G.W., Bell K., Barucci N., Lee D., et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes. 48:1999;1270-1274
    • (1999) Diabetes , vol.48 , pp. 1270-1274
    • Griffin, M.E.1    Marcucci, M.J.2    Cline, G.W.3    Bell, K.4    Barucci, N.5    Lee, D.6
  • 40
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
    • Yu C., Chen Y., Cline G.W., Zhang D., Zong H., Wang Y., et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J. Biol. Chem. 277:2002;50230-50236
    • (2002) J. Biol. Chem. , vol.277 , pp. 50230-50236
    • Yu, C.1    Chen, Y.2    Cline, G.W.3    Zhang, D.4    Zong, H.5    Wang, Y.6
  • 41
    • 0031860340 scopus 로고    scopus 로고
    • Protein kinase C activation and the development of diabetic complications
    • Koya D., King G.L. Protein kinase C activation and the development of diabetic complications. Diabetes. 47:1998;859-866
    • (1998) Diabetes , vol.47 , pp. 859-866
    • Koya, D.1    King, G.L.2
  • 42
    • 0025040551 scopus 로고
    • Regulation of endothelial tissue plasminogen activator and plasminogen activator inhibitor type 1 synthesis by diacylglycerol, phorbol ester, and thrombin
    • Grulich-Henn J., Muller-Berghaus G. Regulation of endothelial tissue plasminogen activator and plasminogen activator inhibitor type 1 synthesis by diacylglycerol, phorbol ester, and thrombin. Blut. 61:1990;38-44
    • (1990) Blut , vol.61 , pp. 38-44
    • Grulich-Henn, J.1    Muller-Berghaus, G.2
  • 43
    • 0025679001 scopus 로고
    • Heparin-binding growth factor-1 modulation of plasminogen activator inhibitor-1 expression. Interaction with cAMP and protein kinase C-mediated pathways
    • Konkle B.A., Kollros P.R., Kelly M.D. Heparin-binding growth factor-1 modulation of plasminogen activator inhibitor-1 expression. Interaction with cAMP and protein kinase C-mediated pathways. J. Biol. Chem. 265:1990;21867-21873
    • (1990) J. Biol. Chem. , vol.265 , pp. 21867-21873
    • Konkle, B.A.1    Kollros, P.R.2    Kelly, M.D.3
  • 44
    • 0025873774 scopus 로고
    • Role of protein kinase C and cyclic adenosine monophosphate in the regulation of tissue-type plasminogen activator, plasminogen activator inhibitor-1, and platelet-derived growth factor mRNA levels in human endothelial cells. Possible involvement of proto-oncogenes c-jun and c-fos
    • Kooistra T., Bosma P.J., Toet K., Cohen L.H., Griffioen M., et al. Role of protein kinase C and cyclic adenosine monophosphate in the regulation of tissue-type plasminogen activator, plasminogen activator inhibitor-1, and platelet-derived growth factor mRNA levels in human endothelial cells. Possible involvement of proto-oncogenes c-jun and c-fos. Arterioscler. Thromb. 11:1991;1042-1052
    • (1991) Arterioscler. Thromb. , vol.11 , pp. 1042-1052
    • Kooistra, T.1    Bosma, P.J.2    Toet, K.3    Cohen, L.H.4    Griffioen, M.5
  • 45
    • 0025861744 scopus 로고
    • Regulation of type I plasminogen activator inhibitor synthesis by protein kinase C and cAMP in bovine aortic endothelial cells
    • Slivka S.R., Loskutoff D.J. Regulation of type I plasminogen activator inhibitor synthesis by protein kinase C and cAMP in bovine aortic endothelial cells. Biochim. Biophys. Acta. 1094:1991;317-322
    • (1991) Biochim. Biophys. Acta , vol.1094 , pp. 317-322
    • Slivka, S.R.1    Loskutoff, D.J.2
  • 46
    • 0033002258 scopus 로고    scopus 로고
    • Endothelin-1 enhances plasminogen activator inhibitor-1 production by human brain endothelial cells via protein kinase C-dependent pathway
    • Zidovetzki R., Wang J.L., Kim J.A., Chen P., Fisher M., Hofman F.M. Endothelin-1 enhances plasminogen activator inhibitor-1 production by human brain endothelial cells via protein kinase C-dependent pathway. Arterioscler. Thromb. Vasc. Biol. 19:1999;1768-1775
    • (1999) Arterioscler. Thromb. Vasc. Biol. , vol.19 , pp. 1768-1775
    • Zidovetzki, R.1    Wang, J.L.2    Kim, J.A.3    Chen, P.4    Fisher, M.5    Hofman, F.M.6
  • 47
    • 0028966472 scopus 로고
    • Angiotensin II induces plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells
    • Feener E.P., Northrup J.M., Aiello L.P., King G.L. Angiotensin II induces plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells. J. Clin. Invest. 95:1995;1353-1362
    • (1995) J. Clin. Invest. , vol.95 , pp. 1353-1362
    • Feener, E.P.1    Northrup, J.M.2    Aiello, L.P.3    King, G.L.4
  • 48
    • 0030069660 scopus 로고    scopus 로고
    • Regulation of plasminogen activator inhibitor activity by plasmin in endothelial cells
    • Shi G.Y., Wang S.J., Chang B., Tasi C.F., Lin M.T., Chang W.C., et al. Regulation of plasminogen activator inhibitor activity by plasmin in endothelial cells. Thromb. Res. 81:1996;75-84
    • (1996) Thromb. Res. , vol.81 , pp. 75-84
    • Shi, G.Y.1    Wang, S.J.2    Chang, B.3    Tasi, C.F.4    Lin, M.T.5    Chang, W.C.6
  • 49
    • 0033597961 scopus 로고    scopus 로고
    • Very low density lipoprotein-mediated signal transduction and plasminogen activator inhibitor type 1 in cultured HepG2 cells
    • Banfi C., Mussoni L., Ris P., Cattaneo M.G., Vicentini L., Battaini F., et al. Very low density lipoprotein-mediated signal transduction and plasminogen activator inhibitor type 1 in cultured HepG2 cells. Circ. Res. 85:1999;208-217
    • (1999) Circ. Res. , vol.85 , pp. 208-217
    • Banfi, C.1    Mussoni, L.2    Ris, P.3    Cattaneo, M.G.4    Vicentini, L.5    Battaini, F.6
  • 50
    • 0034004141 scopus 로고    scopus 로고
    • Protein kinase C-beta mediates lipoprotein-induced generation of PAI-1 from vascular endothelial cells
    • Ren S., Shatadal S., Shen G.X. Protein kinase C-beta mediates lipoprotein-induced generation of PAI-1 from vascular endothelial cells. Am. J. Physiol. Endocrinol. Metab. 278:2000;E656-E662
    • (2000) Am. J. Physiol. Endocrinol. Metab. , vol.278
    • Ren, S.1    Shatadal, S.2    Shen, G.X.3
  • 51
    • 0037072740 scopus 로고    scopus 로고
    • The hexosamine pathway regulates the plasminogen activator inhibitor-1 gene promoter and Sp1 transcriptional activation through protein kinase C-beta I and -delta
    • Goldberg H.J., Whiteside C.I., Fantus I.G. The hexosamine pathway regulates the plasminogen activator inhibitor-1 gene promoter and Sp1 transcriptional activation through protein kinase C-beta I and -delta. J. Biol. Chem. 277:2002;33833-33841
    • (2002) J. Biol. Chem. , vol.277 , pp. 33833-33841
    • Goldberg, H.J.1    Whiteside, C.I.2    Fantus, I.G.3
  • 52
    • 0032967916 scopus 로고    scopus 로고
    • Nicotine increases plasminogen activator inhibitor-1 production by human brain endothelial cells via protein kinase C-associated pathway
    • Zidovetzki R., Chen P., Fisher M., Hofman F.M., Faraci F.M. Nicotine increases plasminogen activator inhibitor-1 production by human brain endothelial cells via protein kinase C-associated pathway. Stroke. 30:1999;651-655
    • (1999) Stroke , vol.30 , pp. 651-655
    • Zidovetzki, R.1    Chen, P.2    Fisher, M.3    Hofman, F.M.4    Faraci, F.M.5
  • 53
    • 0028127865 scopus 로고
    • A common response element mediates differential effects of phorbol esters and forskolin on type-1 plasminogen activator inhibitor gene expression in human breast carcinoma cells
    • Knudsen H., Olesen T., Riccio A., Ungaro P., Christensen L., Andreasen P.A. A common response element mediates differential effects of phorbol esters and forskolin on type-1 plasminogen activator inhibitor gene expression in human breast carcinoma cells. Eur. J. Biochem. 220:1994;63-74
    • (1994) Eur. J. Biochem. , vol.220 , pp. 63-74
    • Knudsen, H.1    Olesen, T.2    Riccio, A.3    Ungaro, P.4    Christensen, L.5    Andreasen, P.A.6
  • 56
    • 0031963391 scopus 로고    scopus 로고
    • Very-low-density lipoprotein response element in the promoter region of the human plasminogen activator inhibitor-1 gene implicated in the impaired fibrinolysis of hypertriglyceridemia
    • Eriksson P., Nilsson L., Karpe F., Hamsten A. Very-low-density lipoprotein response element in the promoter region of the human plasminogen activator inhibitor-1 gene implicated in the impaired fibrinolysis of hypertriglyceridemia. Arterioscler. Thromb. Vasc. Biol. 18:1998;20-26
    • (1998) Arterioscler. Thromb. Vasc. Biol. , vol.18 , pp. 20-26
    • Eriksson, P.1    Nilsson, L.2    Karpe, F.3    Hamsten, A.4
  • 57
    • 0031047343 scopus 로고    scopus 로고
    • Attenuation by gemfibrozil of expression of plasminogen activator inhibitor type 1 induced by insulin and its precursors
    • Nordt T.K., Kornas K., Peter K., Fujii S., Sobel B.E., Kubler W., et al. Attenuation by gemfibrozil of expression of plasminogen activator inhibitor type 1 induced by insulin and its precursors. Circulation. 95:1997;677-683
    • (1997) Circulation , vol.95 , pp. 677-683
    • Nordt, T.K.1    Kornas, K.2    Peter, K.3    Fujii, S.4    Sobel, B.E.5    Kubler, W.6
  • 58
    • 0032983734 scopus 로고    scopus 로고
    • Effects of fibrate compounds on expression of plasminogen activator inhibitor-1 by cultured endothelial cells
    • Nilsson L., Takemura T., Eriksson P., Hamsten A. Effects of fibrate compounds on expression of plasminogen activator inhibitor-1 by cultured endothelial cells. Arterioscler. Thromb. Vasc. Biol. 19:1999;1577-1581
    • (1999) Arterioscler. Thromb. Vasc. Biol. , vol.19 , pp. 1577-1581
    • Nilsson, L.1    Takemura, T.2    Eriksson, P.3    Hamsten, A.4
  • 59
    • 0035167845 scopus 로고    scopus 로고
    • Attenuation by fibrates of plasminogen activator inhibitor type-1 expression in human arterial smooth muscle cells
    • Nordt T.K., Lutzi S., Ruef J., Peter K., Klar E., Kubler W., et al. Attenuation by fibrates of plasminogen activator inhibitor type-1 expression in human arterial smooth muscle cells. Thromb. Haemost. 86:2001;1305-1313
    • (2001) Thromb. Haemost. , vol.86 , pp. 1305-1313
    • Nordt, T.K.1    Lutzi, S.2    Ruef, J.3    Peter, K.4    Klar, E.5    Kubler, W.6
  • 60
    • 0029871877 scopus 로고    scopus 로고
    • Gemfibrozil treatment of combined hyperlipoproteinemia. No improvement of fibrinolysis despite marked reduction of plasma triglyceride levels
    • Broijersen A., Eriksson M., Wiman B., Angelin B., Hjemdahl P. Gemfibrozil treatment of combined hyperlipoproteinemia. No improvement of fibrinolysis despite marked reduction of plasma triglyceride levels. Arterioscler. Thromb. Vasc. Biol. 16:1996;511-516
    • (1996) Arterioscler. Thromb. Vasc. Biol. , vol.16 , pp. 511-516
    • Broijersen, A.1    Eriksson, M.2    Wiman, B.3    Angelin, B.4    Hjemdahl, P.5
  • 61
    • 0029910102 scopus 로고    scopus 로고
    • Effects of gemfibrozil therapy on glucose tolerance, insulin sensitivity and plasma plasminogen activator inhibitor activity in hypertriglyceridaemia
    • Asplund-Carlson A. Effects of gemfibrozil therapy on glucose tolerance, insulin sensitivity and plasma plasminogen activator inhibitor activity in hypertriglyceridaemia. J. Cardiovasc. Risk. 3:1996;385-390
    • (1996) J. Cardiovasc. Risk , vol.3 , pp. 385-390
    • Asplund-Carlson, A.1
  • 62
    • 0030695967 scopus 로고    scopus 로고
    • Effects of gemfibrozil and ciprofibrate on plasma levels of tissue-type plasminogen activator, plasminogen activator inhibitor-1 and fibrinogen in hyperlipidaemic patients
    • Kockx M., de Maat M.P., Knipscheer H.C., Kastelein J.J., Kluft C., Princen H.M., et al. Effects of gemfibrozil and ciprofibrate on plasma levels of tissue-type plasminogen activator, plasminogen activator inhibitor-1 and fibrinogen in hyperlipidaemic patients. Thromb. Haemost. 78:1997;1167-1172
    • (1997) Thromb. Haemost. , vol.78 , pp. 1167-1172
    • Kockx, M.1    De Maat, M.P.2    Knipscheer, H.C.3    Kastelein, J.J.4    Kluft, C.5    Princen, H.M.6
  • 63
    • 0343049036 scopus 로고    scopus 로고
    • Fibrinolytic proteins and progression of coronary artery disease in relation to gemfibrozil therapy
    • Hamsten A., Syvanne M., Silveira A., Luong L.A., Nieminen M.S., Humphries S., et al. Fibrinolytic proteins and progression of coronary artery disease in relation to gemfibrozil therapy. Thromb. Haemost. 83:2000;397-403
    • (2000) Thromb. Haemost. , vol.83 , pp. 397-403
    • Hamsten, A.1    Syvanne, M.2    Silveira, A.3    Luong, L.A.4    Nieminen, M.S.5    Humphries, S.6
  • 64
    • 0030066399 scopus 로고    scopus 로고
    • Elaboration of type-1 plasminogen activator inhibitor from adipocytes. A potential pathogenetic link between obesity and cardiovascular disease
    • Lundgren C.H., Brown S.L., Nordt T.K., Sobel B.E., Fujii S. Elaboration of type-1 plasminogen activator inhibitor from adipocytes. A potential pathogenetic link between obesity and cardiovascular disease. Circulation. 93:1996;106-110
    • (1996) Circulation , vol.93 , pp. 106-110
    • Lundgren, C.H.1    Brown, S.L.2    Nordt, T.K.3    Sobel, B.E.4    Fujii, S.5
  • 65
    • 0030975615 scopus 로고    scopus 로고
    • Production of plasminogen activator inhibitor 1 by human adipose tissue: Possible link between visceral fat accumulation and vascular disease
    • Alessi M.C., Peiretti F., Morange P., Henry M., Nalbone G., Juhan-Vague I. Production of plasminogen activator inhibitor 1 by human adipose tissue: possible link between visceral fat accumulation and vascular disease. Diabetes. 46:1997;860-867
    • (1997) Diabetes , vol.46 , pp. 860-867
    • Alessi, M.C.1    Peiretti, F.2    Morange, P.3    Henry, M.4    Nalbone, G.5    Juhan-Vague, I.6
  • 66
    • 0031882421 scopus 로고    scopus 로고
    • Adipose tissue secretion of plasminogen activator inhibitor-1 in non-obese and obese individuals
    • Eriksson P., Reynisdottir S., Lonnqvist F., Stemme V., Hamsten A., Arner P. Adipose tissue secretion of plasminogen activator inhibitor-1 in non-obese and obese individuals. Diabetologia. 41:1998;65-71
    • (1998) Diabetologia , vol.41 , pp. 65-71
    • Eriksson, P.1    Reynisdottir, S.2    Lonnqvist, F.3    Stemme, V.4    Hamsten, A.5    Arner, P.6
  • 67
    • 0033028415 scopus 로고    scopus 로고
    • Expression of plasminogen activator inhibitor-1 in human adipose tissue: A role for TNF-alpha?
    • Cigolini M., Tonoli M., Borgato L., Frigotto L., Manzato F., Zeminian S., et al. Expression of plasminogen activator inhibitor-1 in human adipose tissue: a role for TNF-alpha? Atherosclerosis. 143:1999;81-90
    • (1999) Atherosclerosis , vol.143 , pp. 81-90
    • Cigolini, M.1    Tonoli, M.2    Borgato, L.3    Frigotto, L.4    Manzato, F.5    Zeminian, S.6
  • 69
    • 0033063052 scopus 로고    scopus 로고
    • TNF-alpha and insulin, alone and synergistically, induce plasminogen activator inhibitor-1 expression in adipocytes
    • Sakamoto T., Woodcock-Mitchell J., Marutsuka K., Mitchell J.J., Sobel B.E., Fujii S. TNF-alpha and insulin, alone and synergistically, induce plasminogen activator inhibitor-1 expression in adipocytes. Am. J. Physiol. 276:1999;C1391-C1397
    • (1999) Am. J. Physiol. , vol.276
    • Sakamoto, T.1    Woodcock-Mitchell, J.2    Marutsuka, K.3    Mitchell, J.J.4    Sobel, B.E.5    Fujii, S.6
  • 70
    • 0033000074 scopus 로고    scopus 로고
    • Glucocorticoids and insulin promote plasminogen activator inhibitor 1 production by human adipose tissue
    • Morange P.E., Aubert J., Peiretti F., Lijnen H.R., Vague P., Verdier M., et al. Glucocorticoids and insulin promote plasminogen activator inhibitor 1 production by human adipose tissue. Diabetes. 48:1999;890-895
    • (1999) Diabetes , vol.48 , pp. 890-895
    • Morange, P.E.1    Aubert, J.2    Peiretti, F.3    Lijnen, H.R.4    Vague, P.5    Verdier, M.6
  • 71
    • 0141540455 scopus 로고    scopus 로고
    • Rosiglitazone inhibits the insulin-mediated increase in PAI-1 secretion in human abdominal subcutaneous adipocytes
    • Harte A.L., McTernan P.G., McTernan C.L., Smith S.A., Barnett A.H., Kumar S. Rosiglitazone inhibits the insulin-mediated increase in PAI-1 secretion in human abdominal subcutaneous adipocytes. Diabetes Obes. Metab. 5:2003;302-310
    • (2003) Diabetes Obes. Metab. , vol.5 , pp. 302-310
    • Harte, A.L.1    McTernan, P.G.2    McTernan, C.L.3    Smith, S.A.4    Barnett, A.H.5    Kumar, S.6
  • 72
    • 0032730926 scopus 로고    scopus 로고
    • Lack of evidence for secretion of plasminogen activator inhibitor-1 by human subcutaneous adipose tissue in vivo
    • Yudkin J.S., Coppack S.W., Bulmer K., Rawesh A., Mohamed-Ali V. Lack of evidence for secretion of plasminogen activator inhibitor-1 by human subcutaneous adipose tissue in vivo. Thromb. Res. 96:1999;1-9
    • (1999) Thromb. Res. , vol.96 , pp. 1-9
    • Yudkin, J.S.1    Coppack, S.W.2    Bulmer, K.3    Rawesh, A.4    Mohamed-Ali, V.5
  • 73
    • 0033984744 scopus 로고    scopus 로고
    • Inflammation, obesity, stress and coronary heart disease: Is interleukin-6 the link?
    • Yudkin J.S., Kumari M., Humphries S.E., Mohamed-Ali V. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis. 148:2000;209-214
    • (2000) Atherosclerosis , vol.148 , pp. 209-214
    • Yudkin, J.S.1    Kumari, M.2    Humphries, S.E.3    Mohamed-Ali, V.4
  • 74
    • 0033037150 scopus 로고    scopus 로고
    • Interleukin-6 as a central mediator of cardiovascular risk associated with chronic inflammation, smoking, diabetes, and visceral obesity: Down-regulation with essential fatty acids, ethanol and pentoxifylline
    • McCarty M.F. Interleukin-6 as a central mediator of cardiovascular risk associated with chronic inflammation, smoking, diabetes, and visceral obesity: down-regulation with essential fatty acids, ethanol and pentoxifylline. Med. Hypotheses. 52:1999;465-477
    • (1999) Med. Hypotheses , vol.52 , pp. 465-477
    • McCarty, M.F.1
  • 76
    • 0026541127 scopus 로고
    • Human HuH-7 hepatoma cells express urokinase and plasminogen activator inhibitor-1: Identification, characterization and regulation by inflammatory mediators
    • Arndt A., Murphy P., Hart D.A. Human HuH-7 hepatoma cells express urokinase and plasminogen activator inhibitor-1: identification, characterization and regulation by inflammatory mediators. Biochim. Biophys. Acta. 1138:1992;149-156
    • (1992) Biochim. Biophys. Acta , vol.1138 , pp. 149-156
    • Arndt, A.1    Murphy, P.2    Hart, D.A.3
  • 77
    • 0028233247 scopus 로고
    • Induction of plasminogen activator inhibitor-1 in HepG2 human hepatoma cells by mediators of the acute phase response
    • Healy A.M., Gelehrter T.D. Induction of plasminogen activator inhibitor-1 in HepG2 human hepatoma cells by mediators of the acute phase response. J. Biol. Chem. 269:1994;19095-19100
    • (1994) J. Biol. Chem. , vol.269 , pp. 19095-19100
    • Healy, A.M.1    Gelehrter, T.D.2
  • 78
    • 0029878086 scopus 로고    scopus 로고
    • The production of heparin cofactor II is not regulated by inflammatory cytokines in human hepatoma cells: Comparison with plasminogen activator inhibitor type-1
    • Koike C., Hayakawa Y., Niiya K., Sakuragawa N., Sasaki H. The production of heparin cofactor II is not regulated by inflammatory cytokines in human hepatoma cells: comparison with plasminogen activator inhibitor type-1. Thromb. Haemost. 75:1996;298-302
    • (1996) Thromb. Haemost. , vol.75 , pp. 298-302
    • Koike, C.1    Hayakawa, Y.2    Niiya, K.3    Sakuragawa, N.4    Sasaki, H.5
  • 79
    • 12444315125 scopus 로고    scopus 로고
    • Increased expression of plasminogen activator inhibitor-1 by mediators of the acute phase response: A potential progenitor of vasculopathy in hypertensives
    • Dong J., Fujii S., Goto D., Furumoto T., Kaneko T., Zaman T.A., et al. Increased expression of plasminogen activator inhibitor-1 by mediators of the acute phase response: a potential progenitor of vasculopathy in hypertensives. Hypertens. Res. 26:2003;723-729
    • (2003) Hypertens. Res. , vol.26 , pp. 723-729
    • Dong, J.1    Fujii, S.2    Goto, D.3    Furumoto, T.4    Kaneko, T.5    Zaman, T.A.6
  • 81
    • 0032745726 scopus 로고    scopus 로고
    • Relationship between visceral fat and PAI-1 in overweight men and women before and after weight loss
    • Kockx M., Leenen R., Seidell J., Princen H.M., Kooistra T. Relationship between visceral fat and PAI-1 in overweight men and women before and after weight loss. Thromb. Haemost. 82:1999;1490-1496
    • (1999) Thromb. Haemost. , vol.82 , pp. 1490-1496
    • Kockx, M.1    Leenen, R.2    Seidell, J.3    Princen, H.M.4    Kooistra, T.5
  • 82
    • 3543065104 scopus 로고    scopus 로고
    • Effect of weight change and metformin on fibrinolysis and the von Willebrand factor in obese nondiabetic subjects: The BIGPRO1 Study. Biguanides and the Prevention of the Risk of Obesity
    • Charles M.A., Morange P., Eschwege E., Andre P., Vague P., Juhan-Vague I. Effect of weight change and metformin on fibrinolysis and the von Willebrand factor in obese nondiabetic subjects: the BIGPRO1 Study. Biguanides and the Prevention of the Risk of Obesity. Diabetes Care. 21:1998;1967-1972
    • (1998) Diabetes Care , vol.21 , pp. 1967-1972
    • Charles, M.A.1    Morange, P.2    Eschwege, E.3    Andre, P.4    Vague, P.5    Juhan-Vague, I.6
  • 83
    • 0034071999 scopus 로고    scopus 로고
    • Improvement by the insulin-sensitizing agent, troglitazone, of abnormal fibrinolysis in type 2 diabetes mellitus
    • Kato K., Yamada D., Midorikawa S., Sato W., Watanabe T. Improvement by the insulin-sensitizing agent, troglitazone, of abnormal fibrinolysis in type 2 diabetes mellitus. Metabolism. 49:2000;662-665
    • (2000) Metabolism , vol.49 , pp. 662-665
    • Kato, K.1    Yamada, D.2    Midorikawa, S.3    Sato, W.4    Watanabe, T.5
  • 84
    • 0034126428 scopus 로고    scopus 로고
    • Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects
    • Kruszynska Y.T., Yu J.G., Olefsky J.M., Sobel B.E. Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects. Diabetes. 49:2000;633-639
    • (2000) Diabetes , vol.49 , pp. 633-639
    • Kruszynska, Y.T.1    Yu, J.G.2    Olefsky, J.M.3    Sobel, B.E.4
  • 85
    • 0030893613 scopus 로고    scopus 로고
    • Metformin therapy is associated with a decrease in plasma plasminogen activator inhibitor-1, lipoprotein(a), and immunoreactive insulin levels in patients with the polycystic ovary syndrome
    • Velazquez E.M., Mendoza S.G., Wang P., Glueck C.J. Metformin therapy is associated with a decrease in plasma plasminogen activator inhibitor-1, lipoprotein(a), and immunoreactive insulin levels in patients with the polycystic ovary syndrome. Metabolism. 46:1997;454-457
    • (1997) Metabolism , vol.46 , pp. 454-457
    • Velazquez, E.M.1    Mendoza, S.G.2    Wang, P.3    Glueck, C.J.4
  • 86
    • 0036714281 scopus 로고    scopus 로고
    • Should patients with polycystic ovarian syndrome be treated with metformin?
    • Seli E., Duleba A.J. Should patients with polycystic ovarian syndrome be treated with metformin? Hum. Reprod. 17:2002;2230-2236
    • (2002) Hum. Reprod. , vol.17 , pp. 2230-2236
    • Seli, E.1    Duleba, A.J.2
  • 87
    • 18144451494 scopus 로고    scopus 로고
    • Beneficial effects of metformin on haemostasis and vascular function in man
    • Grant P.J. Beneficial effects of metformin on haemostasis and vascular function in man. Diabetes Metab. 29:2003;6S44-6S52
    • (2003) Diabetes Metab. , vol.29
    • Grant, P.J.1


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