The disruption of JEN1 from Candida albicans impairs the transport of lactate

Molecular Membrane Biology

Volumn 21, Issue 6, 2004, Pages 403-411

  Soares Silva, Isabel ^a   Paiva, Sandra ^a   Kötter, Peter ^b   Entian, Karl Dieter ^b   Casal, Margarida ^a  

^a UNIVERSITY OF MINHO   (Portugal)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Candida albicans; JEN1; Lactate; Monocarboxylate transport; Yeast

Indexed keywords

ACETIC ACID; GLUCOSE; LACTIC ACID; LEUCINE; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER; PERMEASE; PROPIONIC ACID; PYRUVIC ACID; SERINE;

ALLELE; ARTICLE; CANDIDA ALBICANS; CODON; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; FUNGAL GENE; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION; JEN1 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PH; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BIOLOGICAL TRANSPORT; CANDIDA ALBICANS; CELL MEMBRANE; FUNGAL PROTEINS; GENE EXPRESSION; LACTIC ACID; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT;

CANDIDA; CANDIDA ALBICANS; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 11144341410     PISSN: 09687688     EISSN: None     Source Type: Journal    
DOI: 10.1080/09687860400011373     Document Type: Article

References (33)

1. Andrade, R. P. and Casal, M., 2001, Expression of the lactate permease gene JEN1 from the yeast Saccharomyces cerevisiae. Fungal Genet. Biol., 32, 105-111.
2. Ansaldi, M., Lepelletier, M. and Mejean, V., 1996, Site-specific mutagenesis by using an accurate recombinant polymerase chain reaction method. Anal. Biochem., 234, 110-111.
3. Boeke, J. D., LaCroute, F. and Fink, G. R., 1984, A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol. Gen. Genet., 197, 345-346.
4. Bojunga, N. and Entian, K. D., 1999, Cat8p, the activator of gluconeogenic genes in Saccharomyces cerevisiae, regulates carbon source-dependent expression of NADP-dependent cytosolic isocitrate dehydrogenase (Idp2p) and lactate permease (Jen1p). Mol. Gen. Genet., 262, 869-875.
5. Casal, M. and Leão, C., 1995, Utilization of short-chain monocarboxylic acids by the yeast Torulaspora delbrueckii: specificity of the transport systems and their regulation. Biochim. Biophys. Acta, 1267, 122-130.
6. Casal, M., Cardoso, H. and Leão, C., 1996, Mechanisms regulating the transport of acetic acid in Saccharomyces cerevisiae. Microbiology, 142, 1385-1390.
7. Casal, M., Paiva, S., Andrade, R. P., Gancedo, C. and Leão, C., 1999, The lactate-proton symport of Saccharomyces cerevisiae is encoded by JEN1. J. Bacteriol., 181, 2620-2623.
8. Cássio, F., Leão, C. and van Uden, N., 1987, Transport of lactate and other short-chain monocarboxylates in the yeast Saccharomyces cerevisiae. Appl. Environ. Microbiol., 53, 509-513.
9. Cássio, F., Côrte-Real, M. and Leão, C., 1993, Quantitative analysis of proton movements associated with the uptake of weak carboxylic acids. The yeast Candida utilis as a model. Biochim. Biophys. Acta, 1153, 59-66.
10. De Backer, M. D., Magee, P. T. and Pla, J., 2000, Recent developments in molecular genetics of Candida albicans. Annu. Rev. Microbiol., 54, 463-498.
11. Fonzi, W. A. and Irwin, M. Y., 1993, Isogenic strain construction and gene mapping in Candida albicans. Genetics, 134, 717-728.
12. Gancedo, J. M., 1998, Yeast carbon catabolite repression. Microbiol. Mol. Biol. Rev., 62, 334-361.
13. Gerami-Nejad, M., Berman, J. and Gale, C. A., 2001, Cassettes for PCR-mediated construction of green, yellow, and cyan fluorescent protein fusions in Candida albicans. Yeast, 18, 859-864.
14. Hedges, D., Proft, M. and Entian, K. D., 1995, CAT8, a new zinc cluster-encoding gene necessary for derepression of gluconeogenic enzymes in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol., 15, 1915-1922.
15. Hoffman, C. S. and Winston, F., 1987, A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. Gene, 57, 267-272.
16. Kaur, S. and Mishra, P., 1994, Differential increase in cytoplasmic pH at bud and germ tube formation in Candida albicans: studies of a nongerminative variant. Can. J. Microbiol., 40, 720-723.
17. Lorenz, M. C. and Fink, G. R., 2001, The glyoxylate cycle is required for fungal virulence. Nature, 412, 83-86.
18. Lorenz, M. C. and Fink, G. R., 2002, Life and death in a macrophage: role of the glyoxylate cycle in virulence. Eukaryot. Cell., 1, 657-662.
19. Makuc, J., Paiva, S., Schauen, M., Kramer, R., Andre, B., Casal, M., Leão, C. and Boles, E., 2001, The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane. Yeast, 18, 1131-1143.
20. Moosa, M. W., Sobel, J. D., Elhalis, H., Du, W. and Akins, R. A., 2004, Fungicidal activity of fluconazole against Candida albicans in a synthetic vagina-simulative medium. Antimicrob Agents Chemother., 48, 161-167.
21. Mumberg, D., Müller, R. and Funk, M., 1995, Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene, 156, 119-122.
22. Negredo, A., Monteoliva, L., Gil, C., Pla, J. and Nombela, C., 1997, Cloning, analysis and one-step disruption of the ARG5, 6 gene of Candida albicans. Microbiology, 143, 297-302.
23. Newman, A., 1994, Analysis of pre-mRNA splicing in yeast. In S. J. Higgins and B. D. Hames, eds RNA Processing, A Practical Approach (IRL Press, Oxford), pp. 182-183.
24. Odds, F. C., 1985, Morphogenesis in Candida albicans. Crit. Rev. Microbiol., 12, 45-93.
25. Odds, F. C., 1988, Candida and Candidosis. (Balliére Tindall, London).
26. Paiva, S., Devaux, F., Barbosa, S., Jacq, C. and Casal, M., 2004, Ady2p is essential for the acetate permease activity in the yeast Saccharomyces cerevisiae. Yeast, 2, 201-210.
27. Proft, M., Kötter, P., Hedges, D., Bojunga, N. and Entian, K. D., 1995, CAT5, a new gene necessary for derepression of gluconeogenic enzymes in Saccharomyces cerevisiae. Embo J., 14, 6116-6126.
28. Sambrook, J., Fritsch, E. F. and Maniatis, T., 1989, Molecular Cloning: A Laboratory Manual, 2nd edn (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY).
29. Santos, M. A., Keith, G. and Tuite, M. F., 1993, Non-standard translational events in Candida albicans mediated by an unusual seryl-tRNA with a 5′-CAG-3′ (leucine) anticodon. Embo J., 12, 607-616.
30. Soares-Silva, I., Schuller, D., Andrade, R. P., Baltazar, F., Cássio, F. and Casal, M., 2003, Functional expression of the lactate permease Jen1p of Saccharomyces cerevisiae in Pichia pastoris. Biochem. J., 376, 781-787.
31. Stewart, E., Gow, N. A. and Bowen, D. V., 1988, Cytoplasmic alkalinization during germ tube formation in Candida albicans. J. Gen. Microbiol., 134, 1079-1087.
32. Stewart, E., Hawser, S. and Gow, N. A., 1989, Changes in internal and external pH accompanying growth of Candida albicans: studies of non-dimorphic variants. Arch. Microbiol., 151, 149-153.
33. Wach, A., Brachat, A., Pohlmann, R. and Philippsen, P., 1994, New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast, 10, 1793-1808.