Development of integrated microfluidic system for genetic analysis

Journal of Microlithography, Microfabrication and Microsystems

Volumn 2, Issue 4, 2003, Pages 340-355

  Hui Liu, Robin ^a   Grodzinsk, Piotr ^b  

^a ARIZONA STATE UNIVERSITY   (United States)

^b MOTOROLA INC   (United States)

Author keywords

Biochips; DNA analysis; Micro valves; Microfluidics; Micromixers; Plastic fabrication

Indexed keywords

EID: 11144319979     PISSN: 15371646     EISSN: None     Source Type: Journal    
DOI: 10.1117/1.1610483     Document Type: Article

References (52)

1. R.G. Crystal, "Transfer of genes to humans: early lessons and obstacles to success," Science 270, 404-410 (1995).
2. D.E.J. Bassett, M.B. Eisen, and M.S. Boguski, "Gene expression informatics It's all in your mine," Nat. Genet. 21(1 Sup.), 51-55 (1999).
3. D.J. Graves, "Powerful tools for genetic analysis come of age," Tibiech 17, 127-133 (1999).
4. D. Baltimore, "Our genome unveiled," Nature (London) 409, 814-816 (2001).
5. A.T. Woolley and R.A. Mathies, "Ultra-high-speed DNA sequencing using capillary eleetrophoresis chips," Anal. Chem. 67, 3676-3680 (1995).
6. P.O. Brown and D. Botstein, "Exploring the new world of the genome with DNA microarrays," Nat. Genet. 21(1 Sup.), 33-37 (1999).
7. H. Koster, K. Tang, D.-J. Fu, A. Braun, D. Boom, C.L. Smith, R.J. Cotter, and C.R. Cantor, "A strategy for rapid and efficient DNA sequencing by mass spectrometry," Nat. Biotechnol. 14, 1123-1128 (1996).
8. P. Mitchell, "Microfluidics Downsizing large-scale biology," Nat. Biotechnol. 19(8), 717-721 (2001).
9. S.C. Terry, J.H. Jerman, and J.B. Angell, "A gas chromatographic air analyzer fabricated on a silicon wafer," IEEE Trails. Electron Devices ED-26(12), 1880-1979 (1979).
10. E. Bassous, H.H. Taud, and L. Kuhn, "InkJet printing nozzle arrays etched in silicon," Appl. Phys. Lett. 31, 135-7 (1986).
11. P. Gravesen, J. Branebjerg, and O.S. Jensen, "Microfluidics -A review," J. Micromeclt. Microeng. 3, 168-182 (1993).
12. K. Petersen, "Biomedical applications of MEMS," Tech. Digest of IEEE Electron Devices Meeting, San Jose, CA, pp. 239-242 (1996).
13. N.P. Chereminisof, Fluid Flow, Ann Arbor Science (Butterworlh Group), Ann Arbor, MI (1981).
14. D.J. Harrison, A. Manz, Z. Fan, H. Ludi, and H.M. Widmer, "Capillary eleetrophoresis and sample injection systems integrated on a planar glass chip," Anal. Chem. 64, 1926-1932 (1992).
15. A.G. Hadd, D.E. Raymond, J.W. Halliwell, S.C. Jacobson, and J.M. Ramsey, "Microchip device for performing enzyme assays," Anal. Chem. 69, 3407-3412 (1997).
16. S.C. Jacobson and J.M. Ramsey, "Integrated microdevice for DNA restriction fragment analysis," Anal. Chem. 68(5), 720-723 (1996).
17. I. Kheterpal and R.A. Mathies, "Capillary array eleetrophoresis DNA sequencing," Anal. Chem. 71(1), 31A-37A (1999).
18. L.C. Waters, S.C. Jacobson, N. Kroutchinina, J. Khandurina, R.S. Foote, and J.M. Ramsey, "Microchip device for cell lysis, multiplex PCR amplification and electrophoretic sizing," Anal. Chem. 70, 158-162 (1998).
19. M.A. Nonhrup, B. Benett, D. Hadley, P. Landre, S. Lehew, J. Richards, and P. Stratton, "A miniature analytical instrument for nucleic acids based on micromachined silicon reaction chambers," Anal. Chem. 70, 918-922 (1998).
20. M. Kopp, A.D. Mello, and A. Manz, "Chemical amplification: Continuous-flow PCR on a chip," Science 280, 1046-1048 (1998).
21. T. Woolley, D. Hadley, P. Landre, A.J. deMello, R.A. Mathies, and M.A. Northrup, "Functional integration of PCR amplification and capillary eleetrophoresis in a microfabricated DNA analysis device," Anal. Chem. 68, 4081-4086 (1996).
22. C.H. Mastrangelo, M.A. Bums, and D.T. Burke, "Integrated micro-fabricated devices for genetic assays," in Proc. Microprocessor and Nanolechnology Conference, Yokohama, Japan, pp. 58-59 (1999).
23. O. Larsson, O. Ohman, A. Billman, L. Lundbladh, C. Lindell, and G. Palmskog, "Silicon based replication technology of 3D microstruc-tures by conventional CD-injection molding techniques," Tech. Digest of Transducers '97, Chicago, IL, pp. 1415-1418 (1997).
24. H. Becker, W. Dietz, and P. Dannberg, "Microfluidic manifolds by polymer hot embossing for micro total analysis system applications," in Micro Total Analysis Systems '98, D.J. Harrison and A. van den Berg, Eds., pp. 253-256, Kluwer Academic Publishers, The Netherlands (1998).
25. H. Yu, P. Sethu, T. Chan, N. Kroutchinina, J. Blackwell, C. Mastrangelo, and P. Grodzinski, "A miniaturized and integrated plastic thermal chemical reactor for genetic analysis," in Micro Total Analysis Systems '00, A. van den Berg, Ed., pp. 545-548, Kluwer Academic Publishers, The Netherlands (2000).
26. R.M. McCormick, R.J. Nelson, M.G. Alonso-Amigo, D.J. Benvegnu, and H.H. Hooper, "MicroChannel electrophoretic separations of DNA in injection-molded plastic substrates," Anal. Chem. 29, 2626-2630 (1997).
27. M. Zhao, A. J. Ricco, U. Nguyen, R. Crooks, and Q. Zhu, "Functional and efficient electrode-integrated microfluidic plastic devices," in Micro Total Analysis Systems '01, J.M. Ramsey, A. van den Berg, Eds., pp. 193-194, Kluwer Academic Publishers, The Netherlands (2001).
28. J. Brody and P. Yager, "Low Reynolds number micro-fluidic devices," Tech. Digest of IEEE Solid Stale Sensor and Actuator Workshop, Hilton Head, S.C., pp. 105-108 (1996).
29. H.T. Evensen, D.R. Meldrum, and D.L. Cunningham, "Automated fluid mixing in glass capillaries," Rev. Sci. Iustrum. 69, 519-526 (1998).
30. J. Evans, D. Liepmann, and A. Pisano, "Planar Laminar Mixer," in Proc. MEMS '97, Nayoga. Japan, pp. 96-101, IEEE (1997).
31. R.M. Moroney, R.M. White, and R.T. Howe, "Ultrasonically induced microtransport," in Proc. MEMS '95, The Netherlands, pp. 277-282 (1995).
32. J. Branebjerg, P. Gravesen, J.P. Krog, and C.R. Nielsen, "Fast mixing by lamination," in Proc. MEMS '96, San Diego, CA, pp. 441-446 (1996).
33. H. Mesinger, T. Richter, V. Hessel, J. Dopper, and W. Ehrfeld, "Mi-croreactor with integrated static mixer and analysis system," in Micro Total Analysis Systems '94. A. van den Berg, Ed., Kluwer Academic Publishers, The Netherlands, pp. 237-243 (1994).
34. R. Miyake, T.S.J. Lammerink, M. Elwenspoek, and J.H.J. Fluitman, "Micro mixer with fast diffusion," in Proc. MEMS '93, Ft. Lauder-dale, FL, pp. 248-253 (1993).
35. D. Leckband and G. Hammes, "Interactions between nucleotide binding sites on chloroplast coupling factor one during ATP hydrolysis," Biochem. J. 26, 2306-2312 (1997).
36. R.H. Liu, M. Ward, J. Bonanno, D. Ganser, M. Athavale, R. Adrian, D.J. Beebe, and P. Grodzinski, "Plastic in-line chaotic micromixer for biological applications," in Micro Total Analysis Systems '01, J.M. Ramsey, A. van den Berg, Eds., Kluwer Academic Publishers, The Netherlands, pp. 163-164 (2001).
37. H. Aref, "Stirring by chaotic advection," J. Fluid Mech. 145, 1-21 (1984).
38. W. Arter, "Ergodic stream-lines in steady convection," Phys. Lett. 97A, 171-174 (1983).
39. D.R. Sawyers, M. Sen, and H.C. Chang, "Effect of chaotic interfacial stretching on biomolecular chemical reaction in helical-coil reactors," Chem. Eng. J. 64, 129-139 (1996).
40. S.W. Jones, O.M. Thomas, and H. Aref, "Chaotic advection by laminar flow in a twisted pipe," J. Fluid Mech. 209, 335-357 (1989).
41. R.H. Liu, M. Stremler, K.V. Sharp, M.G. Olsen, J.G. Santiago, R.J. Adrian, H. Aref, and D.J. Beebe, "A passive micromixer: 3-D C-shape serpentine microchannel," J. Microelectromecli. Syst. 9(2), 190-197 (2000).
42. S.A. Elder, "Cavitation microstreaming," J. Acoust. Soc. Am. 31, 54-62 (1959).
43. R.H. Liu, R. Lenigk, and P. Grodzinski, "Acoustic micromixer for enhancement of DNA biochip systems," J. Microlilhogr., Microfabr., Microsyst. 2(3), 178-184 (2003).
44. G.T.A. Kovacs, Micromachined Transducers Sourcebook, WCB McGraw-Hill, Boston (1998).
45. W.S.N. Trimmer, "Microrobots and micromechanical systems," Sens. Actuators 19, 267-287 (1988).
46. M. Madou, Fundamentals of Microfabrication, CRC Press, Boca Raton, FL (1997).
47. K. Wilson and J.M. Walker, Principles and Techniques of Practical Biochemistry, 4th ed., Cambridge University Press, United Kingdom (1997).
48. D.J. Harrison, K. Fluri, K. Seiler, Z. Fan, C.S. Effenhauser, and A. Manz, "Micromachining a miniaturized capillary electrophoresis-based chemical analysis system on a chip," Science 261, 895-897 (1993).
49. R. M. Umek, S.W. Lin, J. Vielmetter, R.H. Terbrueggen, B. Irvine, C.J. Yu, J.F. Kayyem, H. Yowanto, G.F. Blackburn, D.H. Farkas, and Y.P. Chen, "Electronic detection of nucleic acids -A versatile platform for molecular diagnostics," J. Mol. Diagn. 3(2), 74-84 (2001).
50. J.C. Fettinger, "Stacked modules for micro flow systems in chemical analysis: Concept and studies using an enlarged model," Sens. Actuators A 17, 19-25 (1993).
51. M. Shikida, "Valve and semiconductor fabricating equipment using the same," U.S. Patent No. 5,284,179.
52. K. Stoll, "Electrofluidic circuit board assembly with fluid duets and electrical connections," U.S. Patent No. 4,549,248.