Transmission risk of hepatitis C virus via semen during assisted reproduction: How real is it?

Human Reproduction

Volumn 19, Issue 12, 2004, Pages 2711-2717

  Abou Setta, Ahmed M ^a  

^a EGYPTIAN IVF ET CENTER   (Egypt)

Author keywords

Hepatitis C virus; ICSI; IVF; Sperm; Viral transmission

Indexed keywords

ARTICLE; BODY FLUID; CLINICAL PROTOCOL; DANGEROUS GOODS; DISEASE ASSOCIATION; HEALTH CARE POLICY; HEALTH CENTER; HEALTH PROGRAM; HEPATITIS C VIRUS; HOSPITAL INFECTION; HUMAN; INFECTION PREVENTION; INFECTION RISK; INFERTILITY; MALE; MEDICAL SPECIALIST; NONHUMAN; PATIENT SELECTION; REPRODUCTION; SAFETY; SCREENING TEST; SEXUAL TRANSMISSION; SPERM; SPERM DONOR; VIRUS DETECTION; VIRUS HEPATITIS; VIRUS TRANSMISSION;

HEPATITIS C VIRUS;

EID: 11144317318     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/deh509     Document Type: Article

References (80)

1. Abusheikha N, Akagbosu F, Marcus S, Lass A, Cousins C and Brinsden P (1999) Viral screening and assisted conception treatment - the Bourn Hall experience. J Assist Reprod Genet 16,337-339.
2. Akahane Y, Kojima M, Sugai Y, Sakamoto M, Miyazaki Y, Tanaka T, Tsuda F, Mishiro S, Okamoto H, Miyakawa Y et al. (1994) Hepatitis C virus infection in spouses of patients with type C chronic liver disease. Ann Intern Med 120,748-752.
3. Alter HJ (1990) Clinical, virological and epidemiological basis for the treatment of chronic non-A, non-B hepatitis. J Hepatol 11 (Suppl 1),S19-S25.
4. Alter HJ (1993) The detection, transmission, and outcome of hepatitis C virus infection. Infect Agents Dis 2,155-166.
5. Alter HJ (1995) To C or not to C: these are the questions. Blood 85, 1681-1695.
6. Bahadur G and Tedder RS (1997a) Safety during sperm banking. Hum Reprod 12,198.
7. Bahadur G and Tedder RS (1997b) Quarantine and cryopreservation. Hum Reprod 12,2579-2580.
8. Beld M, Sentjens R, Rebers S, Weel J, Wertheim-van Dillen P, Sol C and Boom R (2000) Detection and quantitation of hepatitis C virus RNA in feces of chronically infected individuals. J Clin Microbiol 38,3442-3444.
9. Belec L, Legoff J, Si-Mohamed A, Bloch F, Matta M, Mbopi-Keou FX and Payan C (2003) Cell-associated, non-replicating strand(+) hepatitis C virus-RNA shedding in cervicovaginal secretions from chronically HCV-infected women. J Clin Virol 27,247-251.
10. Benifla JL, Sifer C, Bringuier AF, Blanc-Layrac G, Camus E, Madelenat P and Feldmann G (2002) Induced apoptosis and expression of related proteins in granulosa cells from women undergoing IVF: a preliminary study. Hum Reprod 17,916-920.
11. Bourlet T, Levy R, Maertens A, Tardy JC, Grattard F, Cordonier H, Laurent JL, Guerin JF and Pozzetto B (2002) Detection and characterization of hepatitis C virus RNA in seminal plasma and spermatozoon fractions of semen from patients attempting medically assisted conception. J Clin Microbiol 40,3252-3255.
12. Bourlet T, Levy R, Laporte S, Blachier S, Bocket L, Cassuto G, Chollet L, Leruez-Ville M, Maertens A, Mousnier F et al. (2003) Multicenter quality control for the detection of hepatitis C virus RNA in seminal plasma specimens. J Clin Microbiol 41,789-793.
13. Bresters D, Mauser-Bunschoten EP, Reesink HW, Roosendaal G, van der Poel CL, Chamuleau RA, Jansen PL, Weegink CJ, Cuypers HT, Lelie PN et al. (1993) Sexual transmission of hepatitis C virus. Lancet 342(8865),210-211.
14. Caldwell SH, Sue M, Bowden JH, Dickson RC, Driscoll CJ, Yeaton P, Stevenson WC, Ishitani MB, McCullough CS, Pruett TL et al. (1996) Hepatitis C virus in body fluids after liver transplantation. Liver Transpl Surg 2,124-129.
15. Caporaso N, Ascione A and Stroffolini T (1998) Spread of hepatitis C virus infection within families. Investigators of an Italian Multicenter Group. J Viral Hepat 5,67-72.
16. Cassuto NG, Sifer C, Feldmann G, Bouret D, Moret F, Benifla JL, Porcher R, Naouri M, Neuraz A, Alvarez S et al. (2002) A modified RT-PCR technique to screen for viral RNA in the semen of hepatitis C virus-positive men. Hum Reprod 17,3153-3156.
17. Centers for Disease Control and Prevention (1997) Transmission of hepatitis C virus infection associated with home infusion therapy for hemophilia. J Am Med Assoc 278,1057-1058.
18. Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW and Houghton M (1989) Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244,359-362.
19. Clarke GN (1999) Sperm cryopreservation: is there a significant risk of cross-contamination? Hum Reprod 14,2941-2943.
20. Cohen MS, Hoffman IF, Royce RA, Kazembe P, Dyer JR, Daly CC, Zimba D, Vernazza PL, Maida M, Fiscus SA et al. (1997) Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1. AIDSCAP Malawi Research Group. Lancet 349(9069),1868-1873.
21. Cooreman MP and Schoondermark-Van de Ven EM (1996) Hepatitis C virus: biological and clinical consequences of genetic heterogeneity. Scand J Gastroenterol Suppl 218,106-115.
22. Debono E, Halton P, Bourliere M, Gerolami-Santandrea V, Gastaldi M, Castellani P, Cartouzou G, Botta-Fridlund D, Cau P and Gauthier A (2000) Absence of hepatitis C genome in semen of infected men by polymerase chain reaction, branched DNA and in situ hybridization. Liver 20, 257-261.
23. Devaux A, Soula V, Sifer C, Branger M, Naouri M, Porcher R, Poncelet C, Neuraz A, Alvarez S, Benifla JL et al. (2003) Hepatitis C virus detection in follicular fluid and culture media from HCV+ women, and viral risk during IVF procedures. Hum Reprod 18,2342-2349.
24. Dienstag JL (1997) Sexual and perinatal transmission of hepatitis C. Hepatology 26 (3 Suppl 1),66S-70S.
25. Donnelly ET, Steele EK, McClure N and Lewis SE (2001) Assessment of DNA integrity and morphology of ejaculated spermatozoa from fertile and infertile men before and after cryopreservation. Hum Reprod 16, 1191-1199.
26. Dore GJ and Kaldor JM (2000) Detection of HCV RNA in semen. Lancet 356(9240),1520.
27. Everhart JE, Di Bisceglie AM, Murray LM, Alter HJ, Melpolder JJ, Kuo G and Hoofnagle JH (1990) Risk for non-A, non-B (type C) hepatitis through sexual or household contact with chronic carriers. Ann Intern Med 112, 544-545.
28. Fiore RJ, Potenza D, Monno L, Appice A, DiStefano M, Giannelli A, LaGrasta L, Romanelli C, DiBari C and Pastore G (1995) Detection of HCV RNA in serum and seminal fluid from HIV-1 co-infected intravenous drug addicts. J Med Virol Aug 46,364-367.
29. Fried MW, Shindo M, Fong TL, Fox PC, Hoofnagle JH and Di Bisceglie AM (1992) Absence of hepatitis C viral RNA from saliva and semen of patients with chronic hepatitis C. Gastroenterology 102(2 Pt 1), 1306-1308.
30. Halfon P, Riflet H, Renou C, Quentin Y and Cacoub P (2001) Molecular evidence of male-to-female sexual transmission of hepatitis C virus after vaginal and anal intercourse. J Clin Microbiol 39,1204-1206.
31. Hanabusa H, Kuji N, Kato S, Tagami H, Kaneko S, Tanaka H and Yoshimura Y (2000) An evaluation of semen processing methods for eliminating HIV-1. AIDS 14,1611-1616.
32. Hsu HH, Wright TL, Luba D, Martin M, Feinstone SM, Garcia G and Greenberg HB (1991) Failure to detect hepatitis C virus genome in human secretions with the polymerase chain reaction. Hepatology 14,763-767.
33. Janssens PM (1997) Safety during sperm banking. Hum Reprod 12,2579.
34. Kao JH, Chen PJ, Yang PM, Lai MY, Sheu JC, Wang TH and Chen DS (1992) Intrafamilial transmission of hepatitis C virus: the important role of infections between spouses. J Infect Dis 166,900-903.
35. Kao JH, Hwang YT, Chen PJ, Yang PM, Lai MY, Wang TH and Chen DS (1996) Transmission of hepatitis C virus between spouses: the important role of exposure duration. Am J Gastroenterol 91,2087-2090.
36. Karmochkine M, Carrat F, Valleron AJ and Raguin G (1998) Transmission modes of hepatitis C virus. Presse Med 27,871-876.
37. Keck C, Gerber-Schafer C, Clad A, Wilhelm C and Breckwoldt M (1998) Seminal tract infections: impact on male fertility and treatment options. Hum Reprod Update 4,891-903.
38. Kotwal GJ (1993) Routine laboratory diagnosis of hepatitis C virus infection. J Hepatol 17 (Suppl 3),S83-S89.
39. Kotwal GJ, Baroudy BM, Kuramoto IK, McDonald FF, Schiff GM, Holland PV and Zeldis JB (1992) Detection of acute hepatitis C virus infection by ELISA using a synthetic peptide comprising a structural epitope. Proc Natl Acad Sci USA 89,4486-4489.
40. Kumar RM (1998) Interspousal and intrafamilial transmission of hepatitis C virus: a myth or a concern? Obstet Gynecol 91,426-431.
41. Kumar RM and Shahul S (1998) Role of breast-feeding in transmission of hepatitis C virus to infants of HCV-infected mothers. J Hepatol 29, 191-197.
42. Leruez-Ville M, Kunstmann JM, De Almeida M, Rouzioux C and Chaix ML (2000) Detection of hepatitis C virus in the semen of infected men. Lancet 356(9223),42-43.
43. Letur-Könirsch H, Collin G, Sifer C, Devaux A, Kuttenn F, Madelenat P, Brun-Vezinet F, Feldmann G and Benifla JL (2003) Safety of cryopreservation straws for human gametes or embryos: a study with human immunodeficiency virus-1 under cryopreservation conditions. Hum Reprod 18, 140-144.
44. Levy R, Najioullah F, Keppi B, Thouvenot D, Bosshard S, Lornage J, Lina B, Guerin JF and Aymard M (1997) Detection of cytomegalovirus in semen from a population of men seeking infertility evaluation. Fertil Steril 68,820-825.
45. Levy R, Layani-Milon MP, Giscard D'Estaing S, Najioullah F, Lornage J, Aymard M and Lina B (1999) Screening for Chlamydia trachomatis and Ureaplasma urealyticum infection in semen from asymptomatic male partners of infertile couples prior to in vitro fertilization. Int J Androl 22, 113-118.
46. Levy R, Tardy JC, Bourlet T, Cordonier H, Mion F, Lornage J and Guerin JF (2000) Transmission risk of hepatitis C virus in assisted reproductive techniques. Hum Reprod 15,810-816.
47. Levy R, Bourlet T, Maertens A, Salle B, Lornage J, Laurent JL, Pozzetto B and Guerin JF (2002) Pregnancy after safe IVF with hepatitis C virus RNA-positive sperm. Hum Reprod 17,2650-2653.
48. Lion TC, Chang TT, Young KC, Lin XZ, Lin CY and Wu HL (1992) Detection of HCV RNA in saliva, urine, seminal fluid, and ascites. J Med Virol 37,197-202.
49. Lissen E, Alter HJ, Abad MA, Torres Y, Perez-Romero M, Leal M, Pineda JA, Torronteras R and Sanchez-Quijano A (1993) Hepatitis C virus infection among sexually promiscuous groups and the heterosexual partners of hepatitis C virus infected index cases. Eur J Clin Microbiol Infect Dis 12,827-831.
50. Liu FH, Tian GS and Fu XX (1994) Detection of plus and minus strand hepatitis C virus RNA in peripheral blood mononuclear cells and spermatid. Zhonghua Yi Xue Za Zhi 74(325),284-286.
51. Manno M, Marchesan E, Crovatto M, Martelli P, Tomei F and Adamo V (2003) Preliminary evidence on the safety of ICSI with testicular spermatozoa in HCV-infected male: a case report. Hum Reprod 18,1666-1668.
52. Mansour RT, Fahmy IM, Taha AK, Tawab NA, Serour GI and Aboulghar MA (2003) Intracytoplasmic spermatid injection can result in the delivery of normal offspring. J Androl 24,757-764.
53. Marina S, Marina F, Alcolea R, Exposito R, Huguet J, Nadal J and Verges A (1998) Human immunodeficiency virus type 1-serodiscordant couples can bear healthy children after undergoing intrauterine insemination. Fertil Steril 70,35-39.
54. Mayer KH and Anderson DJ (1995) Heterosexual HIV transmission. Infect Agents Dis 4,273-284.
55. McKee TA, Avery S, Majid A and Brinsden PR (1996) Risks for transmission of hepatitis C virus during artificial insemination. Fertil Steril 66, 161-163.
56. Meseguer M, Garrido N, Gimeno C, Remohi J, Simon C and Pellicer A (2002) Comparison of polymerase chain reaction-dependent methods for determining the presence of human immunodeficiency virus and hepatitis C virus in washed sperm. Fertil Steril 78,1199-1202.
57. Mesquita PE, Granato CF and Castelo A (1997) Risk factors associated with hepatitis C virus (HCV) infection among prostitutes and their clients in the city of Santos, Sao Paulo State, Brazil. J Med Virol 51,338-343.
58. Moyer LA, Mast EE and Alter MJ (1999) Hepatitis C: Part II. Prevention counseling and medical evaluation. Am Fam Physician 59(357),349-354.
59. Numata N, Ohori H, Hayakawa Y, Saitoh Y, Tsunoda A and Kanno A (1993) Demonstration of hepatitis C virus genome in saliva and urine of patients with type C hepatitis: usefulness of the single round polymerase chain reaction method for detection of the HCV genome. J Med Virol 41,120-128.
60. Nyamathi A, Robbins WA, Fahey JL, Wiley D, Pekler VA, Longshore D, Robins TA, Singh J and Saab S (2002) Presence and predictors of hepatitis C virus RNA in the semen of homeless men. Biol Res Nurs 4,22-30.
61. Osella AR, Massa MA, Joekes S, Blanch N, Yacci MR, Centonze S and Sileoni S (1998) Hepatitis B and C virus sexual transmission among homosexual men. Am J Gastroenterol 93,49-52.
62. Pasquier C, Daudin M, Righi L, Berges L, Thauvin L, Berrebi A, Massip P, Puel J, Bujan L and Izopet J (2000) Sperm washing and virus nucleic acid detection to reduce HIV and hepatitis C virus transmission in serodiscordant couples wishing to have children. AIDS 14,2093-2099.
63. Pasquier C, Bujan L, Daudin M, Righi L, Berges L, Thauvin L, Berrebi A, Massip P, Puel J and Izopet J (2003) Intermittent detection of hepatitis C virus (HCV) in semen from men with human immunodeficiency virus type 1 (HIV-1) and HCV. J Med Virol 69,344-349.
64. Pekler VA, Robbins WA, Nyamathi A, Yashina TL, Leak B and Robins TA (2003) Use of versant TMA and bDNA 3.0 assays to detect and quantify hepatitis C virus in semen. J Clin Lab Anal 17,264-270.
65. Russel PH, Lyaruu VH, Millar JD, Curry MR and Watson PF (1997) The potential transmission of infectious agents by semen packaging during storage for artificial insemination. Anim Reprod Sci 47,337-342.
66. Scotto G, Savastano AM, Fazio V, Conte PE, Ferrara S, Mangano A and Tantimonaco G (1996) Sexual transmission of hepatitis C virus infection. Eur J Epidemiol 12,241-244.
67. Semprini AE, Persico T, Thiers V, Oneta M, Tuveri R, Serafini P, Boschini A, Giuntelli S, Pardi G and Brechot C (1998) Absence of hepatitis C virus and detection of hepatitis G virus/GB virus C RNA sequences in the semen of infected men. J Infect Dis 177,848-854.
68. Semprini AE, Vucetich A and Persico T (2001) Hepatitis C detection. Lancet 357(9255),557.
69. Sifer C, Benifla JL, Branger M, Devaux A, Brun-Vezinet F, Madelenat P and Feldmann G (2002) Effects of hepatitis C virus on the apoptosis percentage of granulosa cells in vivo in women undergoing IVF: preliminary results. Hum Reprod 17,1773-1776.
70. Steyaert SR, Leroux-Roels GG and Dhont M (2000) Infections in IVF: review and guidelines. Hum Reprod Update 6,432-441.
71. Tachet A, Dulioust E, Salmon D, De Almeida M, Rivalland S, Finkielsztejn L, Heard I, Jouannet P, Sicard D and Rouzioux C (1999) Detection and quantification of HIV-1 in semen: identification of a subpopulation of men at high potential risk of viral sexual transmission. AIDS 13, 823-831.
72. Tang Z, Yang D, Hao L, Tang Z, Huang Y and Wang S (1996) Detection and significance of HCV RNA in saliva, seminal fluid and vaginal discharge in patients with hepatitis C. J Tongji Med Univ 16(24),11-13.
73. Tedder RS, Zuckerman MA, Goldstone AH, Hawkins AE, Fielding A, Briggs EM, Irwin D, Blair S, Gorman AM, Patterson KG et al. (1995) Hepatitis B transmission from contaminated cryopreservation tank. Lancet 346(8968),137-140.
74. Terada S, Kawanishi K and Katayama K (1992) Minimal hepatitis C infectivity in semen. Ann Intern Med 117,171-172.
75. Thomas DL, Zenilman JM, Alter HJ, Shih JW, Galai N, Carella AV and Quinn TC (1995) Sexual transmission of hepatitis C virus among patients attending sexually transmitted diseases clinics in Baltimore - an analysis of 309 sex partnerships. J Infect Dis 171,768-775.
76. Wyld R, Robertson JR, Brettle RP, Mellor J, Prescott L and Simmonds P (1997) Absence of hepatitis C virus transmission but frequent transmission of HIV-1 from sexual contact with doubly-infected individuals. J Infect 35,163-166.
77. Young KC, Chang TT, Liou TC and Wu HL (1993) Detection of hepatitis C virus RNA in peripheral blood mononuclear cells and in saliva. J Med Virol 41,55-60.
78. Zein NN (2000) Clinical significance of hepatitis C virus genotypes. Clin Microbiol Rev 13,223-235.
79. Zein NN and Persing DH (1996) Hepatitis C genotypes: current trends and future implications. Mayo Clin Proc 71,458-462.
80. Zhao XP, Yang DL, Tang ZY, Huang YC, Hao LJ, Cheng L and Zhou W (1995) Infectivity and risk factors of hepatitis C virus transmission through sexual contact. J Tongji Med Univ 15,147-150.