JTE-522, a selective cyclooxygenase-2 inhibitor, inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular adenocarcinomas of colon in rats

International Journal of Cancer

Volumn 113, Issue 3, 2005, Pages 354-358

  Wei, Min ^a   Morimura, Keiichirou ^a   Wanibuchi, Hideki ^a   Shen, Jun ^a   Salim, Elsayed I ^a   Moku, Masaharu ^a   Hakoi, Katsuo ^a   Fukushima, Shoji ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Chemoprevention; Colon carcinogenesis; JTE 522; Selective cyclooxynenase 2 inhibitor; Tubular adenocarcinoma

Indexed keywords

TILMACOXIB;

ADENOMATOUS POLYP; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; COLON CARCINOGENESIS; COLON CARCINOMA; CONTROLLED STUDY; DNA MICROARRAY; DRUG EFFECT; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; TUMOR CLASSIFICATION;

1,2-DIMETHYLHYDRAZINE; ADENOCARCINOMA; ADENOMA; ANIMALS; BENZENESULFONATES; CARCINOGENS; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DISEASE PROGRESSION; GENE EXPRESSION PROFILING; ISOENZYMES; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXAZOLES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, INBRED F344; TUMOR MARKERS, BIOLOGICAL;

EID: 11144307284     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.20583     Document Type: Article

References (25)

1. Greenlee RT, Murray T, Bolden S, Wingo PA. Cancer statistics, 2000. CA Cancer J Clin 2000;50:7-33.
2. Janne PA, Mayer RJ. Chemoprevention of colorectal cancer. N Engl J Med 2000;342:1960-8.
3. Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci USA 1993;90:11693-7.
4. Needleman P, Isakson PC. The discovery and function of COX-2. J Rheumatol 1997;24(Suppl 49):6-8.
5. Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, DuBois RN. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 1994;107:1183-8.
6. Kutchera W, Jones DA, Matsunami N, Groden J, McIntyre TM, Zimmerman GA, White RL, Prescott SM. Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect. Proc Natl Acad Sci USA 1996;93:4816-20.
7. DuBois RN, Radhika A, Reddy BS, Entingh AJ. Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors. Gastroenterology 1996;110:1259-62.
8. Kawamori T, Rao CV, Seibert K, Reddy BS. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis. Cancer Res 1998;58:409-12.
9. Reddy BS, Hirose Y, Lubet R, Steele V, Kelloff G, Paulson S, Seibert K, Rao CV. Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis. Cancer Res 2000;60:293-7.
10. Rao CV, Indranie C, Simi B, Manning PT, Connor JR, Reddy BS. Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor. Cancer Res 2002;62:165-70.
11. Silverstein FE, Faich G, Goldstein JL, Simon LS, Pincus T, Whelton A, Makuch R, Eisen G, Agrawal NM, Stenson WF, Burr AM, Zhao WW, et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study, a randomized controlled trial. JAMA 2000;284:1247-55.
12. Steinbach G, Lynch PM, Phillips RK, Wallace MH, Hawk E, Gordon GB, Wakabayashi N, Saunders B, Shen Y, Fujimura T, Su LK, Levin B. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med 2000;342:1946-52.
13. Matsushita M, Masaki M, Yagi Y, Tanaka T, Wakitani K. Pharmacological profile of JTE-522, a novel prostaglandin H synthase-2 inhibitor, in rats. Inflamm Res 1997;46:461-6.
14. Sasai H, Masaki M, Wakitani K. Suppression of polypogenesis in a new mouse strain with a truncated Ape (Delta474) by a novel COX-2 inhibitor, JTE-522. Carcinogenesis 2000;21:95-8.
15. Sunayama K, Konno H, Nakamura T, Kashiwabara H, Shoji T, Tsuneyoshi T, Nakamura S. The role of cyclooxygenase-2 (COX-2) in two different morphological stages of intestinal polyps in APC (Del-ta474) knockout mice. Carcinogenesis 2002;23:1351-9.
16. Tomozawa S, Nagawa H, Tsuno N, Hatano K, Osada T, Kitayama J, Sunami E, Nita ME, Ishihara S, Yano H, Tsuruo T, Shibata Y, et al. Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522. Br J Cancer 1999;81:1274-9.
17. Nagatsuka I, Yamada N, Shimizu S, Ohira M, Nishino H, Seki S, Hirakawa K. Inhibitory effect of a selective cyclooxygenase-2 inhibitor on liver metastasis of colon cancer. Int J Cancer 2002;100:515-9.
18. Bird RP. Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 1995;93:55-71.
19. Takayama T, Katsuki S, Takahashi Y, Ohi M, Nojiri S, Sakamaki S, Kato J, Kogawa K, Miyake H, Niitsu Y. Aberrant crypt foci of the colon as precursors of adenoma and cancer. N Engl J Med 1998;339:1277-84.
20. Wei M, Morimura K, Wanibuchi H, Shen J, Doi K, Mitsuhashi M, Moku M, Salim EI, Fukushima S. Chemopreventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on 1, 2-dimethylhydrazine-induced rat colon Carcinogenesis. Cancer Lett 2003;202:11-6.
21. Sunter JP, Appleton DR, Wright NA, Watson AJ. Pathological features of the colonie tumours induced in rats by the administration of 1,2-dimethylhydrazine. Virch Arch B Cell Pathol 1978;29:211-23.
22. Sunter JP, Hull DL, Appleton DR, Watson AJ. Cell proliferation of colonie neoplasms in dimethylhydrazine-treated rats. Br J Cancer 1980;42:95-102.
23. Wei M, Wanibuchi H, Morimura K, Iwai S, Yoshida K, Endo G, Nakae D, Fukushima S. Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. Carcinogenesis 2002;23:1387-97.
24. Reddy BS, Maruyama H, Kelloff G. Dose-related inhibition of colon carcinogenesis by dietary piroxicam, a nonsteroidal antiinflammatory drug, during different stages of rat colon tumor development. Cancer Res 1987;47:5340-6.
25. Park HS, Goodlad RA, Wright NA. The incidence of aberrant crypt foci and colonie carcinoma in dimethylhydrazine-treated rats varies in a site-specific manner and depends on tumor histology. Cancer Res 1997;57:4507-10.