HSP70 and GRP78 induced by endothelin-1 pretreatment enhance tolerance to hypoxia in cultured neonatal rat cardiomyocytes

Journal of Cardiovascular Pharmacology

Volumn 44, Issue SUPPL. 1, 2004, Pages

  Pan, Yan Xia ^a,b   Lin, Li ^a   Ren, An Jing ^a   Pan, Xiu Jie ^a   Chen, Hong ^a,d   Tang, Chao Shu ^c   Yuan, Wen Jun ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

^c PEKING UNIVERSITY   (China)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Cardiomyocyte; Endothelin 1 (ET 1); GRP78; HSP70; Hypoxia

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; ENDOTHELIN 1; GLUCOSE; GLUCOSE RELATED PROTEIN 78; HEAT SHOCK PROTEIN; LACTATE DEHYDROGENASE; MALONALDEHYDE; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; CELL CULTURE; CELL DAMAGE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; HEART MUSCLE CELL; HYPOXIA; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; STATISTICAL SIGNIFICANCE; TIME SERIES ANALYSIS; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; ENDOTHELIN-1; HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; L-LACTATE DEHYDROGENASE; MALONDIALDEHYDE; MOLECULAR CHAPERONES; MYOCYTES, CARDIAC; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHOROTHIOATE OLIGONUCLEOTIDES; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; UP-REGULATION;

EID: 11144302691     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fjc.0000166234.11336.a9     Document Type: Conference Paper

References (18)

1. Latchman DS. Heat shock proteins and cardiac protection. Cardiovasc Res. 2001;51:637-646.
2. Brar BK, Stephanou A, Wagstaff MJD, et al. Heat shock proteins delivered with a virus vector can protect cardiac cells against apoptosis as well as against thermal or hypoxic stress. J Mol Cell Cardiol. 1999;31:135-156.
3. Zhou JJ, Pei JM, Wang GY, et al. Inducible HSP70 mediates delayed cardioprotection via U-50488H pretreatment in rat ventricular myocytes. Am J Physiol. 2001;281:H40-H47.
4. Yu ZF, Luo H, Fu WM, et al. The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis:suppression of oxidative stress and stabilization of calcium homeostasis. Exp Neurol. 1999;155:302-314.
5. Miyake H, Hara I, Arakawa S, et al. Stress protein GRP78 prevents apoptosis induced by calcium inophore, ionomycin, but not by glycosylation inhibitor, tunimycin, in human prostate cancer cells. J Cell Biochem. 2000;77:396-408.
6. Hori O, Matsumoto M, Kuwabara K, et al. Exposure of astrocytes to hypoxia/reoxygenation enhances expression of glucose-regulated protein 78 facilitating astrocyte release of the neuroprotective cytokine interleukin 6. J Neurochem. 1996;66:973-979.
7. Aoki M, Tamatan M, Taniguchi M, et al. Hypothermie treatment restores glucose regulated protein 78 (GRP78) expression in ischemic brain. Brain Res Mol Brain Res. 2001;95:117-128.
8. Tonnessen T, Giaid A, Saleh D, et al. Increased in vivo expression and production of endothelin-1 by porcine cardiomyocytes subjected to ischemia. Circ Res. 1995;76:767-772.
9. Hide EJ, Piper J, Thiemermann C. Endothelin-1-induced reduction of myocardial infarction size by activation of ATP-sensitive potassium channels 1 a rabbit model of myocardial ischaemia and reperfusion. Br J Pharmacol. 1995;116:2597-2602.
10. Bugge E, Ytrehus K. Endothelin-1 can reduce infarct size through protein kinase C and KATP channels in the isolated rat heart. Cardiovasc Res. 1996;32:920-929.
11. Simpson P, Savion S. Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Circ Res. 1982;50:101-116.
12. Satoh T, Furuta K, Tomokiyo K, et al. Facilitatory roles of novel compounds designed from cyclopentenone prostaglandins on neurite outgrowth-promoting activities of nerve growth factor. J Neurochem. 2000;75:1092-1102.
13. Nakano A, Cohen MV, Downey JM. Ischemic preconditioning: from basic mechanisms to clinical applications. Pharmacol Ther. 2000;86:263-275.
14. Mark CH, Groot De MC, Illing B, et al. Endothelin-Iincreases susceptibility of isolated rat heart to ischemia/reperfusion injury by reducing coronary flow. J Mol Cell Cardiol. 1998;30:2657-2668.
15. Fink AL. Chaperone-mediated protein folding. Physiol Rev. 1999;79:425-449.
16. Koong AC, Chen EY, Lee AS, et al. Increased cytotoxicity of chronic hypoxia cells by molecular inhibition of GRP78 induction. Int J Radiat Oncol Biol Phys. 1994;28:661-666.
17. He H, McColl K, Distelhorst CW. Involvement of c-Fos in signaling grp78 induction following ER calcium release. Oncogene. 2000;19:5936-5943.
18. Pan YX, Lin L, Yuan WJ, et al. Preventive effect of endothelin-1 pretreatment on hypoxia-induced injury in cultured neonatal rat cardiomyocytes. Acta Physiol Sin. 2003;55:171-176.