Panic induction with cholecystokinin-tetrapeptide (CCK-4) increases plasma concentrations of the neuroactive steroid 3α, 5α tetrahydrodeoxycorticosterone (3α, 5α-THDOC) in healthy volunteers

Neuropsychopharmacology

Volumn 30, Issue 1, 2005, Pages 192-195

  Eser, Daniela ^a   Di Michele, Flavia ^b   Zwanzger, Peter ^a   Pasini, Augusto ^b   Baghai, Thomas C ^a   Schüle, Cornelius ^a   Rupprecht, Rainer ^a   Romeo, Elena ^b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Anxiety; CCK 4; Neuroactive steroids; Neurosteroids; Panic

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3ALPHA,5ALPHA TETRAHYDRODEOXYCORTICOSTERONE; 4 AMINOBUTYRIC ACID A RECEPTOR; CORTICOSTERONE DERIVATIVE; CORTICOTROPIN; HYDROCORTISONE; LACTATE SODIUM; NEUROSTEROID; TETRAGASTRIN; UNCLASSIFIED DRUG;

ACUTE PANIC INVENTORY; ADULT; ALLOSTERISM; ANXIETY; ARTICLE; CONTROLLED STUDY; FEMALE; GAS CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; MASS SPECTROMETRY; NORMAL HUMAN; PANIC; PRIORITY JOURNAL; RATING SCALE; STEROID BLOOD LEVEL; STRESS; TRANQUILIZING ACTIVITY;

ADRENOCORTICOTROPIC HORMONE; ADULT; DESOXYCORTICOSTERONE; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYDROCORTISONE; MALE; PANIC; PSYCHIATRIC STATUS RATING SCALES; STEROIDS; TETRAGASTRIN;

EID: 11144284080     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300572     Document Type: Article

References (21)

1. Barbaccia ML, Roscetti G, Bolacchi F, Concas A, Mostallino MC, Purdy RH et al (1996). Stress-induced increase in brain neuroactive steroids: antagonism by abecarnil. Pharmacol Biochem Behav 54: 205-210.
2. Brambilla F, Biggio G, Pisu MG, Bellodi L, Perna G, Bogdanovich-Djukic V et al (2003). Neurosteroid secretion in panic disorder. Psychiatry Res 118: 107-116.
3. Crawley JN, Glowa JR, Majewska MD, Paul SM (1986). Anxiolytic activity of an endogenous adrenal steroid. Brain Res 398: 382-385.
4. Dillon DJ, Gorman JM, Liebowitz MR, Fyer AJ, Klein DF (1987). Measurement of lactate-induced panic and anxiety. Psychiatry Res 20: 97-105.
5. Kellner M, Herzog L, Yassouridis A, Holsboer F, Wiedemann K (1995). Possible role of atrial natriuretic hormone in pituitary-adrenocortical unresponsiveness in lactate-induced panic. Am J Psychiatry 152: 1365-1367.
6. Kellner M, Yassouridis A, Jahn H, Wiedemann K (1997). Influence of clonidine on psychopathological, endocrine and respiratory effects of cholecystokinin tetrapeptide in patients with panic disorder. Psychopharmacology 133: 55-61.
7. Koszycki D, Zacharko RM, Le Melledo JM, Bradwejn J (1998). Behavioral, cardiovascular, and neuroendocrine profiles following CCK-4 challenge in healthy volunteers: a comparison of panickers and nonpanickers. Depress Anxiety 8: 1-7.
8. A receptor function. Trends Pharmacol Sci 16: 295-303.
9. Patchev VK, Montkowski A, Rouskova D, Koranyi L, Holsboer F, Almeida OF (1997). Neonatal treatment of rats with the neuroactive steroid tetrahydrodeoxycorticosterone (THDOC) abolishes the behavioral and neuroendocrine consequences of adverse early life events. J Clin Invest 99: 962-966.
10. Patchev VK, Shoaib M, Holsboer F, Almeida OF (1994). The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus. Neuroscience 62: 265-271.
11. Paul SM, Purdy RH (1992). Neuroactive steroids. FASEB J 6: 2311-2322.
12. Purdy RH, Morrow AL, Moore Jr PH, Paul SM (1991). Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain. Proc Natl Acad Sci USA 88: 4553-4557.
13. Reddy DS (2003). Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions? Trends Pharmacol Sci 24: 103-106.
14. Reddy DS, Rogawski MA (2002). Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility. J Neurosci 22: 3795-3805.
15. Rupprecht R (2003). Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties. Psychoneuroendocrinology 28: 139-168.
16. Rupprecht R, Holsboer F (1999). Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trends Neurosci 22: 410-416.
17. Strohle A, Pasini A, Romeo E, Hermann B, Spalletta G, di Michele F et al (2000). Fluoxetine decreases concentrations of 3 alpha, 5 alpha- tetrahydrodeoxycorticosterone (THDOC) in major depression. J Psychiatr Res 34: 183-186.
18. Strohle A, Romeo E, di Michele F, Pasini A, Hermann B, Gajewsky G et al (2003). Induced panic attacks shift gamma-aminobutyric acid type A receptor modulatory neuroactive steroid composition in patients with panic disorder: preliminary results. Arch Gen Psychiatry 60: 161-168.
19. Strohle A, Romeo E, di Michele F, Pasini A, Yassouridis A, Holsboer F et al (2002). GABA(A) receptor-modulating neuroactive steroid composition in patients with panic disorder before and during paroxetine treatment. Am J Psychiatry 159: 145-147.
20. Zwanzger P, Eser D, Aicher S, Schule C, Baghai TC, Padberg F et al (2003). Effects of alprazolam on cholecystokinin-tetrapeptide-induced panic and hypothalamic-pituitary-adrenal-axis activity: a placebo-controlled study. Neuropsychopharmacology 28: 979-984.
21. Zwanzger P, Eser D, Padberg F, Baghai TC, Schule C, Rupprecht R et al (2004). Neuroactive steroids are not affected by panic induction with 50 μg cholecystokinin-tetrapeptide (CCK-4) in healthy volunteers. J Psychiatric Res 38: 215-217.