Short term in vivo biocompatibility testing of biodegradable poly(D,L-lactide) - Growth factor coating for orthopaedic implants

Biomaterials

Volumn 26, Issue 18, 2005, Pages 4035-4040

  Wildemann, Britt ^a   Sander, Andre ^a   Schwabe, Philipp ^a   Lucke, Martin ^a   Stöckle, Ulrich ^a   Raschke, Michael ^b   Haas, Norbert P ^a   Schmidmaier, Gerhard ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Drug delivery system; ED1; Growth factors; Immunohistochemistry; Macrophages; Monocytes; Polylactide

Indexed keywords

BIOACTIVE COATINGS; MONOCYTES; ORTHOPEDIC SURGERY;

BIOCOMPATIBILITY; BIODEGRADATION; CELLS; COATINGS; DRUG PRODUCTS; FRACTURE; GROWTH KINETICS; IMMUNOLOGY; ORTHOPEDICS; POLYMERS; SURGERY;

IMPLANTS (SURGICAL);

DRUG CARRIER; POLYGLACTIN; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCOMPATIBILITY; BONE MARROW; CALLUS; CELL DENSITY; CONTROLLED STUDY; FEMALE; IMPLANT; MACROPHAGE; MATERIAL COATING; MONOCYTE; NONHUMAN; OSTEOCLAST; PRIORITY JOURNAL; RAT; SWINE; TIBIA FRACTURE;

ABSORBABLE IMPLANTS; ANIMALS; COATED MATERIALS, BIOCOMPATIBLE; DRUG IMPLANTS; FEMALE; FRACTURE HEALING; INSULIN-LIKE GROWTH FACTOR I; MATERIALS TESTING; POLYESTERS; RATS; RATS, SPRAGUE-DAWLEY; SWINE; TIBIAL FRACTURES; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TREATMENT OUTCOME;

SUIDAE;

EID: 11144284065     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2004.10.004     Document Type: Article

References (29)

1. G. Schmidmaier, B. Wildemann, A. Stemberger, N.P. Haas, and M. Raschke Biodegradable poly(D,L-lactide) coating of implants for continuous release of growth factors J Biomed Mater Res Appl Biomat 58 4 2001 449 455
2. R.B. Greenwald, K. Yang, H. Zhao, C.D. Conover, S. Lee, and D. Filpula Controlled release of proteins from their poly(ethylene glycol) conjugates drug delivery systems employing 1,6-elimination Bioconjug Chem 14 2 2003 395 403
3. R.K. Kulkarni, E.G. Moore, A.F. Hegyeli, and F. Leonard Biodegradable poly(lactic acid) polymers J Biomed Mater Res 5 1971 169 181
4. G. Schmidmaier, B. Wildemann, H. Bail, M. Lucke, T. Fuchs, A. Stemberger, A. Flyvbjerg, N.P. Haas, and M. Raschke Local application of growth factors (insulin-like growth factor-1 and transforming growth factor-β1) from a biodegradable poly(D,L-lactide) coating of osteosynthetic implants accelerates fracture healing in rats Bone 28 4 2001 341 350
5. G. Schmidmaier, B. Wildemann, F. Cromme, F. Kandziora, N.P. Haas, and M. Raschke BMP-2 coating of titanium implants increases biomechanical strength and accelerates bone remodeling in fracture treatment Bone 6 2002 618 622
6. M. Raschke, B. Wildemann, P. Inden, H. Bail, A. Flyvbjerg, J. Hoffmann, N.P. Haas, and G. Schmidmaier Insulin-like growth factor-1 and transforming growth factor-beta1 accelerates osteotomy healing using polylactide-coated implants as a delivery system a biomechanical and histological study in minipigs Bone 30 1 2002 144 151
7. F. Kandziora, G. Schmidmaier, G. Schollmeier, H. Bail, R. Pflugmacher, T. Gorke, M. Wagner, M. Raschke, T. Mittlmeier, and N.P. Haas IGF-I and TGF-beta1 application by a poly (D,L-lactide)-coated cage promotes intervertebral bone matrix formation in the sheep cervical spine Spine 27 16 2002 1710 1723
8. N. Ashammakhi, R. Suuronen, J. Tiainen, P. Tormala, and T. Waris Spotlight on naturally absorbable osteofixation devices J Craniofac Surg 14 2 2003 247 259
9. A. Lendlein Polymere als implantatwerkstoffe Chemie in unserer Zeit 33 5 1999 279 295
10. O. Bostman, E. Hirvensalo, J. Makinen, and P. Rokkanen Foreign-body reactions to fracture fixation implants of biodegradable synthetic polymers J Bone Joint Surg Br 72 4 1990 592 596
11. O.M. Bostman Osteolytic changes accompanying degradation of absorbable fracture fixation implants J Bone Joint Surg Br 73 4 1991 679 682
12. A. Weiler, H. Helling, U. Kirch, T. Zirbes, and K. Rehm Foreign-body reaction and the course of osteolysis after polyglycolide implants for fracture fixation - Experimental study in sheep J Bone Joint Surg 78B 1996 369 376
13. O.M. Bostman Intense granulomatous inflammatory lesions associated with absorbable internal fixation devices made of polyglycolide in ankle fractures Clin Orthop 278 1992 193 199
14. J.A. Tamada, and R. Langer Erosion kinetics of hydrolytically degradable polymers Proc Natl Acad Sci USA 90 1993 552 556
15. S. Gogolewski Bioresorbable polymers in trauma and bone surgery Injury 31 Suppl 4 2000 28 32
16. G. Schmidmaier, B. Wildemann, M. Lübberstedt, N.P. Haas, and M. Raschke IGF-I and TGF-beta 1 incorporated in a poly(D,L-lactide) implant coating stimulates osteoblast differentiation and collagen-1 production but reduces osteoblast proliferation in cell culture J Biomed Mater Res Appl Biomat 65b 2003 157 162
17. A.B. Mathur, T.O. Collier, W.J. Kao, M. Wiggins, M.A. Schubert, A. Hiltner, and J.M. Anderson In vivo biocompatibility and biostability of modified polyurethanes J Biomed Mater Res 36 2 1997 246 257
18. E.M. Greenfield, Y. Bi, A.A. Ragab, V.M. Goldberg, and R.R. Van De Motter The role of osteoclast differentiation in aseptic loosening J Orthop Res 20 1 2002 1 8
19. G. Schmidmaier, B. Wildemann, B. Melis, G. Krummrey, A. Einhorn, N. Haas, and M. Raschke Development and characterization of a standard closed tibial fracture model in the rat Eur J Trauma 30 2004 35 42
20. B. Wildemann, G. Schmidmaier, S. Ordel, R. Stange, N.P. Haas, and M. Raschke Cell proliferation and differentiation during fracture healing are influenced by locally applied IGF-I and TGF-1 comparison of two proliferation markers, PCNA and BrdU J Biomed Mater Res 65B 1 2003 150 156
21. B. Wildemann, G. Schmidmaier, N. Brenner, M. Huning, R. Stange, N.P. Haas, and M. Raschke Quantification, localization, and expression of IGF-I and TGF-beta1 during growth factor-stimulated fracture healing Calcif Tissue Int 74 2004 388 397
22. I. Sinisaari, H. Patiala, O. Bostman, E.A. Makela, E. Hirvensalo, E.K. Partio, P. Tormala, and P. Rokkanen Metallic or absorbable implants for ankle fractures a comparative study of infections in 3,111 cases Acta Orthop Scand 67 1 1996 16 18
23. B. Wildemann, P. Bamdad, C. Holmer, N.P. Haas, M. Raschke, and G. Schmidmaier Local delivery of growth factors from coated titanium plates increases osteotomy healing in rats Bone 34 5 2004 862 868
24. M. Lucke, G. Schmidmaier, S. Sadoni, B. Wildemann, R. Schiller, N. Haas, and M. Raschke Gentamicin coating of metallic implants reduces implant related osteomyelitis in rats Bone 32 5 2003 521 531
25. G. Schmidmaier, B. Wildemann, D. Ostapowicz, F. Kandziora, R. Stange, N.P. Haas, and M. Raschke Long-term effects of local growth factor (IGF-I and TGF-[beta]1) treatment on fracture healing A safety study for using growth factors J Orthop Res 22 3 2004 514 519
26. O. Bostman, and H. Pihlajamaki Clinical biocompatibility of biodegradable orthopaedic implants for internal fixation a review Biomaterials 21 24 2000 2615 2621
27. O.M. Bostman, and H.K. Pihlajamaki Adverse tissue reactions to bioabsorbable fixation devices Clin Orthop 371 2000 216 227
28. J. Viljanen, H. Pihlajamaki, A. Majola, P. Tormala, and P. Rokkanen Absorbable polylactide pins versus metallic Kirschner wires in the fixation of cancellous bone osteotomies in rats Ann Chir Gynaecol 86 1 1997 66 73
29. A. Prokop, A. Jubel, H.J. Helling, T. Eibach, C. Peters, S.E. Baldus, and K.E. Rehm Soft tissue reactions of different biodegradable polylactide implants Biomaterials 25 2 2004 259 267