Diphenidol has no actual broad antiemetic activity in dogs and ferrets

Journal of Pharmacological Sciences

Volumn 96, Issue 3, 2004, Pages 301-306

  Nakayama, Hiroe ^a   Yamakuni, Hisashi ^a   Nakayama, Aya ^a   Maeda, Yasue ^a   Imazumi, Katsunori ^a   Matsuo, Masahiko ^a   Mutoh, Seitaro ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Apomorphine; Cisplatin; Copper sulfate; Loperamide; Pica

Indexed keywords

3 (2 METHOXY 5 TRIFLUOROMETHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; APOMORPHINE; CISPLATIN; COPPER SULFATE; DIFENIDOL; LOPERAMIDE; NEUROKININ 1 RECEPTOR ANTAGONIST;

ANIMAL EXPERIMENT; ANTIEMETIC ACTIVITY; ARTICLE; CHO CELL; CONTROLLED STUDY; DOG; DRUG RECEPTOR BINDING; FEMALE; FERRET; MALE; NONHUMAN; PICA; STATISTICAL ANALYSIS; VOMITING;

EID: 10944270384     PISSN: 13478613     EISSN: None     Source Type: Journal    
DOI: 10.1254/jphs.FPJ04035X     Document Type: Article

References (22)

1. Matsuki N, Ueno S, Kaji T, Ishihara A, Wang CH, Saito H. Emesis induced by cancer chemotherapeutic agents in the Suncus murinus: a new experimental model. Jpn J Pharmacol. 1988;48:303-306.
2. Andrews PLR, Okada F, Woods AJ, Hagiwara H, Kakaimoto S, Toyoda M, et al. The emetic and anti-emetic effects of the capsaicin analogue resiniferatoxin in Suncus murinus, the house musk shrew. Br J Pharmacol. 2000;130:1247-1254.
3. Mitchell D, Well C, Hoch N, Lind K, Woods SC, Mitchell LK. Poison induced pica in rats. Physiol Behav. 1976;17:691-697.
4. Takeda N, Hasegawa S, Morita M, Matsunaga T. Pica in rats is analogus to emesis: An animal model in emesis research. Pharmacol Biochem Behav. 1993;45:817-821.
5. Fox RA. Current status: animal models of nausea. In: Bianchi AL, Grelot L, Miller AD, King GL, editors. Mechanisms and control of emesis. Paris: John Libbey Eurotext; 1992. p. 341-350.
6. Grant VL. Do conditioned taste aversions result from activation of emetic mechanisms? Psycopharmacology (Berl). 1987;93: 405-415.
7. Leonard CA, Fujita T, Tedeschi DH, Zirkle CL, Fellows EJ. Observations on the pharmacology of diphenidol, a potent antiemetic. J Pharmacol Exp Ther. 1966;154:339-345.
8. Takeda N, Hasegawa S, Morita M, Horii A, Uno A, Yamatodani A, et al. Neuropharmacological mechanisms of emesis. 1. Effects of antiemetic drugs on motion- and apomorphine-induced pica in rats. Methods Find Exp Clin Pharmacol. 1995;17:589-596.
9. Takeda N, Hasegawa S, Morita M, Horii A, Uno A, Yamatodani A, et al. Neuropharmacological mechanisms of emesis. II. Effects of antiemetic drugs on cisplatin-induced pica in rats. Methods Find Exp Clin Pharmacol. 1995;17:647-652.
10. Gardner CJ, Twissell DJ, Dale TJ, Gale JD, Jordan CC, Kilpatrick GJ, et al. The broad-spectrum anti-emetic activity of the novel non-peptide tachykinin NK1 receptor antagonist GR203040. Br J Pharmacol. 1995;116:3158-3163.
11. Watson JW, Gonsalves SF, Fossa AA, McLean S, Seeger T, Obach S, et al. The anti-emetic effects of CP-99,994 in the ferret and the dog: role of the NK1 receptor. Br J Pharmacol. 1995;115:84-94.
12. Tattersall FD, Rycroft W, Francis B, Pearce D, Merchant K, MacLeod AM, et al. Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. Neuropharmacology. 1996;35:1121-1129.
13. Gonsalves S, Waton J, Ashton C. Broad spectrum antiemetic effects of CP-122,721, a tachykinin NK1 receptor antagonist, in ferrets. Eur J Pharmacol. 1996;305:181-185.
14. Yamakuni H, Sawai H, Maeda Y, Imazumi K, Sakuma H, Matsuo M, et al. Probable involvement of the 5-hydroxytryptamine4 receptor in methotrexate- induced delayed emesis in dogs. J Pharmacol Exp Ther. 2000;292:1002-1007.
15. Yamakuni H, Sawai-Nakayama H, Imazumi K, Maeda Y, Matsuo M, Manda T, et al. Resiniferatoxin antagonizes cisplatin-induced emesis in dogs and ferrets. Eur J Pharmacol. 2002; 442:273-278.
16. Fukuda H, Nakamura E, Koga T, Furukawa N, Shiroshita Y. The site of the anti-emetic action of tachykinin NK1 receptor antagonists may exist in the medullary area adjacent to the semicompact part of the nucleus ambiguous. Brain Res. 1999;818:439-449.
17. Kilpatrick GJ, Bunce KT, Tyers MB. 5-HT3 receptors. Med Res Rev. 1990;10:441-475.
18. Rudd JA, Yamamoto K, Yamatodani A, Takeda N. Differential action of ondansetron and dexamethasone to modify cisplatin-induced acute and delayed kaolin consumption ("pica") in rats. Eur J Pharmacol. 2002;454:47-52.
19. Andrews PLR, Rapeport WG, Sanger SJ. Neuropharmacology of emesis induced by anti-cancer therapy. Trends Pharmacol Sci. 1988;9:334-341.
20. Fukui H, Yamamoto M, Sasaki S, Sato S. Involvement of 5-HT3 receptors and vagal afferents in copper sulfate- and cisplatin-induced emesis in monkeys. Eur J Pharmacol. 1993;249:13-18.
21. Fukui H, Yamamoto M, Sato S. Vagal afferent fibers and peripheral 5-HT3 receptors mediate cisplatin-induced emesis in dogs. Jpn J Pharmacol. 1992;59:221-226.
22. Buhandari P, Bingham S, Andrews PLR. The neuropharmacology of loperamide-induced emesis in the ferret: the role of the area postrema, vagus, opiate and 5-HT3 receptors. Neuropharmacology. 1992;31:735-742.