Increased glomerular capillary pressure and size mediate glomerulosclerosis in SHR juxtamedullary cortex

American Journal of Physiology - Renal Physiology

Volumn 274, Issue 2 43-2, 1998, Pages

  Iversen, Bjarne M ^a,c   Amann, Kerstin ^b   Kvam, Fred I ^a   Wang, Xuemei ^a   Ofstad, Jarle ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

Hypertension; Laser Doppler flowmetry; Renal blood flow autoregulation; Sclerosis; Spontaneously hypertensive rat

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOREGULATION; CAPILLARY FLOW; CAPILLARY PRESSURE; CONTROLLED STUDY; FEMALE; GLOMERULOSCLEROSIS; GLOMERULUS CAPILLARY; HYPERTENSION; JUXTAGLOMERULAR APPARATUS; KIDNEY BLOOD FLOW; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CAPILLARY; GLOMERULUS; GLOMERULUS FILTRATION RATE; HOMEOSTASIS; LASER DOPPLER FLOWMETRY; PATHOLOGY; PATHOPHYSIOLOGY; SCLEROSIS; SPONTANEOUSLY HYPERTENSIVE RAT; VASCULARIZATION; WISTAR KYOTO RAT;

ANIMALS; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CAPILLARIES; GLOMERULAR FILTRATION RATE; HOMEOSTASIS; HYPERTENSION; KIDNEY GLOMERULUS; LASER-DOPPLER FLOWMETRY; MALE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SCLEROSIS;

EID: 0031990999     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.1998.274.2.f365     Document Type: Article

References (30)

1. Anderson, S., H. G. Rennke, and R. Zatz. Glomerular adaptation with normal aging and with long-term converting enzyme inhibition in rats. Am. J. Physiol. 267 (Renal Fluid Electrolyte Physiol. 36): F35-F43, 1994.
2. Arendshorst, W. J., and W. H. Beierwaltes. Renal and nephron hemodynamics in spontaneously hypertensive rats. Am. J. Physiol. 236 (Renal Fluid Electrolyte Physiol. 5): F246-F251, 1979.
3. Aukland, K., K. Heyeraas Tønder, and G. Naess. Capillary pressure in deep and superficial glomeruli of the rat kidney. Acta Physiol. Scand. 101: 418-427, 1977.
4. Azar, S., M. A. Johnsen, J. Scheinman, L. Bruno, and L. Tobian. Regulation of glomerular capillary pressure and filtration rate in young Kyoto hypertensive rats. Clin. Sci. (Colch.) 56: 203-209, 1979.
5. Bank, N., L. Alterman, and H. S. Aynedjian. Selective deep nephron hyperfiltration in uninephrectomized spontaneously hypertensive rats. Kidney Int. 24: 185-191, 1983.
6. Bidani, A., M. M. Schwartz, and E. J. Lewis. Renal autoregulation and vulnerability to hypertensive injury in remnant kidney. Am. J. Physiol. 252 (Renal Fluid Electrolyte Physiol. 21): F1003-F1010, 1987.
7. Bidani, A. K., K. A. Griffin, M. Picken, and D. M. Lansky. Continuous telemetric blood pressure monitoring and glomerular injury in the remnant kidney model. Am. J. Physiol. 265 (Renal Fluid Electrolyte Physiol. 34): F391-F398, 1993.
8. Daniels, F. H., W. J. Arendshorst, and R. G. Roberds. Tubuloglomerular feedback and autoregulation in spontaneously hypertensive rats. Am. J. Physiol. 258 (Renal Fluid Electrolyte Physiol. 27): F1479-F1489, 1990.
9. Fogo, A., Y. Yoshida, A. D. Click, T. Homma, and I. Ichikawa. Serial micropuncture analysis of glomerular function in two rat models of glomerular sclerosis. J. Clin. Invest. 82: 322-330, 1988.
10. Fujihara, C. K., D. M. Z. P. Limongi, H. C. F. de Oliveira, and R. Zatz. Absence of focal glomerulosclerosis in aging analbuminemic rats. Am. J. Physiol. 262 (Regulatory Integrative Comp. Physiol. 31): R947-R954, 1992.
11. Gøranson, A., N. M. Sjøquist, and H. R. Ulfendahl. Superficial and juxtamedullary nephron function during converting enzyme inhibition. Am. J. Physiol. 251 (Renal Fluid Electrolyte Physiol. 20): F25-F33, 1986.
12. Grond, J., J. Y. B. Buerskers, M. S. Schilitjuis, J. J. Weening, and J. D. Elema. Analysis of renal structural and functional features in two rat strains with a different susceptibility to glomerular sclerosis. Lab. Invest. 54: 77-83, 1986.
13. Heyeraas, K. J., and K. Aukland. Interlobular arterial resistance: influence of renal arterial pressure and angiotensin II. Kidney Int. 31: 1291-1298, 1987.
14. Intaglietta, M., R. F. Pawula, and W. R. Tompkins. Pressure measurements in the mammalian microvasculature. Microvasc. Res. 2: 212-220, 1970.
15. Iversen, B. M., F. I. Kvam, K. Matre, L. Mørkrid, G. Horvei, W. Bagchus, J. Grond, and J. Ofstad. Effect of mesangiolysis on autoregulation of renal blood flow and glomerular filtration rate in rats. Am. J. Physiol. 262 (Renal Fluid Electrolyte Physiol. 31): F361-F366, 1992.
16. Iversen, B. M., and J. Ofstad. Autoregulation of renal blood flow in chronic glomerulonephritic rats. Am. J. Physiol. 254 (Renal Fluid Electrolyte Physiol. 23): F284-F290, 1988.
17. Iversen, B. M., I. Sekse, and J. Ofstad. Resetting of renal blood flow autoregulation in spontaneously hypertensive rats. Am. J. Physiol. 252 (Renal Fluid Electrolyte Physiol. 21): F480-F480, 1987.
18. Mattson, D. L., S. Lu, R. J. Roman, and A. W. Cowley. Relationship between renal perfusion pressure and blood flow in different regions of the kidney. Am. J. Physiol. 264 (Regulatory Integrative Comp. Physiol. 33): R578-R583, 1993.
19. Navar, L. G. Renal autoregulation: perspectives from whole kidney and single nephron studies. Am. J. Physiol. 234 (Renal Fluid Electrolyte Physiol. 3): F357-F370, 1978.
20. Ofstad, J., G. Horvei, F. I. Kvam, L. Mørkrid, I. Sekse, E. Svarstad, and B. M. Iversen. Glomerular hemodynamics in progressive renal disease. Kidney Int. 41: S8-S14, 1992.
21. Olson, J. M., S. K. Wilson, and R. H. Heptinstall. Relation of glomerular injury to preglomerular resistance in experimental hypertension. Kidney Int. 29: 849-857, 1987.
22. Raij, L., S. Azar, and W. Keane. Mesangial immune injury, hypertension and progressive glomerular damage in Dahl rats. Kidney Int. 26: 137-143, 1984.
23. Simons, J. L., A. P. Provoost, S. Anderson, J. L. Troy, H. G. Rennke, D. J. Sandstrom, and B. M. Brenner. Pathogenesis of glomerular injury in the fawn-hooded rat: early glomerular capillary hypertension predicts glomerulosclerosis. J. Am. Soc. Nephrol. 3: 1775-1782, 1993.
24. Tenstad, O., H. E. Williamsom, G. Clausen, A. Øien, and K. Aukland. Glomerular filtration and tubular reabsorption of the basic polypeptide aprotinin. Acta Physiol. Scand. 152: 33-50, 1994.
25. Tøder Heyeraas, K., and K. Aukland. Glomerular capillary pressure in the rat. Validation of pressure measurements through corticotomy in the rat. Acta Physiol. Scand. 106: 93-95, 1979.
26. Wang, X., K. Aukland, J. Ofstad, and B. M. Iversen. Autoregulation of zonal glomerular filtration rate and renal blood flow in spontaneously hypertensive rats. Am. J. Physiol. 269 (Renal Fluid Electrolyte Physiol. 38): F515-F521, 1995.
27. Weibel, E. R. Stereological techniques for electron microscopic morphometry. In: Principles of Techniques of Electron Microscopy, edited by M. A. Hayat., New York: Van Nostrand-Reinhold, 1973, vol. 3, p. 237-296.
28. Wiederhjelm, C. A., J. W. Woodbury, S. Kirk, and R. F. Rushmer. Pulsatile pressures in the microcirculation of frog's mesentery. Am. J. Physiol. 207: 173-176, 1964.
29. Yoshida, Y., A. Fogo, and I. Ichikawa. Glomerular hypertrophy has a greater impact on glomerular sclerosis than adaptive hyperfunction in remnant kidney (Abstract). Kidney Int. 33: 327, 1988.
30. Yoshida, Y., A. Fogo, and I. Ichikawa. Glomerular hemodynamic changes vs. hypertrophy in experimental sclerosis. Kidney Int. 35: 654-660, 1989.