hCDC4 and genetic instability in cancer

Cell Cycle

Volumn 3, Issue 6, 2004, Pages 691-692

  Rajagopalan, Harith ^a   Lengauer, Christoph ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Aneuploidy; Cancer; Genetic instability; Somatic mutation

Indexed keywords

CYCLIN E; TRASTUZUMAB;

ANEUPLOIDY; ANTINEOPLASTIC ACTIVITY; CANCER CELL; CARCINOGENESIS; CELL DIVISION; CHROMOSOMAL INSTABILITY; CHROMOSOME 19Q; COLORECTAL CANCER; DRUG MECHANISM; DRUG TARGETING; GENE; GENE AMPLIFICATION; GENE INACTIVATION; GENE MUTATION; GENETIC STABILITY; GENOME; HCDC4 GENE; HEREDITY; HUMAN; REVIEW;

EID: 10944249940     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.3.6.925     Document Type: Review

References (12)

1. Rajagopalan H, Jallepalli PV, Rago C, Velculescu VE, Kinzler KW, Vogelstein B, et al. Inactivation of hCDC4 can cause chromosomal instability. Nature 2004; 428:77-81.
2. Cahill DP, Lengauer C, Yu J, Riggins GJ, Willson JK, Markowitz SD, et al. Mutations of mitotic checkpoint genes in human cancers. Nature 1998; 392:300-3.
3. Venkitaraman AR. Chromosomal instability and cancer predisposition: insights from studies on the breast cancer susceptibility gene, BRCA2. Cold Spring Harb Symp Quant Biol 2000; 65:567-72.
4. Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, et al. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 2001; 294:173-7.
5. Strohmaier H, Spruck CH, Kaiser P, Won KA, Sangfelt O, Reed SI. Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 2001;413:316-22.
6. Spruck CH, Won KA, Reed Sl. Deregulated cyclin E induces chromosome instability. Nature 1999:401:297-300.
7. Nowak MA, Komarova NL, Sengupta A, Jallepalli PV, Shih IM, Vogelstein B, et al. The role of chromosomal instability in tumor initiation. Proc Natl Acad Sci USA 2002; 99:16226-31.
8. Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C. The significance of unstable chromosomes in colorectal cancer. Nat Rev Cancer 2003; 3:695-701.
9. Shih IM, Zhou W, Goodman SN, Lengauer C, Kinzler KW, Vogelstein B. Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis. Cancer Res 2001; 61:818-22.
10. Donnellan R, Chetty R. Cyclin E in human cancers. FASEB J 1999; 13:773-80.
11. Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nat Med 1997; 3:222-5.
12. Geng Y, Yu Q, Sicinska E, Das M, Schneider JE, Bhattacharya S, et al. Cyclin E ablation in the mouse. Cell 2003; 114:431-43.