Stress proteins and regulation of microglial amyloid-β phagocytosis

Folia Pharmacologica Japonica

Volumn 124, Issue 6, 2004, Pages 407-413

  Kitamura, Yoshihisa ^a   Takata, Kazuyuki ^a   Taniguchi, Takashi ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Actin reorganization; Alzheimer's disease; Microglia; Neuroprotection; Phagocytosis

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 90; RAC1 PROTEIN;

ALZHEIMER DISEASE; CYTOSKELETON; ENDOPLASMIC RETICULUM; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; OLIGOMERIZATION; PATHOGENESIS; PHAGOCYTOSIS; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN FOLDING; REVIEW;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ENDOPLASMIC RETICULUM; HEAT-SHOCK PROTEINS; MICROGLIA; PHAGOCYTOSIS; RATS;

EID: 10944245470     PISSN: 00155691     EISSN: None     Source Type: Journal    
DOI: 10.1254/fpj.124.407     Document Type: Review

References (27)

1. Mori K. Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell. 2000;101:451-454.
2. Hardy J, Selkoe DJ. The amyloid hypothesis of alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002;297:353-356.
3. Kettenmann H, Ransom BR, editors. Neuroglia. New York and Oxford: Oxford University Press; 1995.
4. Dickson DW, Lee SC, Mattiace LA, Yen SH, Brosnan C. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia. 1993;7:75-83.
5. McGeer PL, McGeer EG. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Brain Res Rev. 1995 Sep;21 (2):195-218.
6. Kitamura Y, Nomura Y. Stress proteins and glial functions: possible therapeutic targets for neurodegenerative disorders. Pharmacol Ther. 2003;97:35-53.
7. Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, et al. Correlative memory deficits, A β elevation, and amyloid plaques in transgenic mice. Science. 1996;274:99-102.
8. Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-tur J, et al. Increased amyloid-β 42 (43) in brains of mice expressing mutant presenilin 1. Nature. 1996;383:710-713.
9. Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med. 1998;4:97-100.
10. Kakimura J, Kitamura Y, Takata K, Umeki M, Suzuki S, Shibagaki K, et al. Microglial activation and β-amyloid clearance induced by exogenous heat-shock proteins. FASEB J. (February 25, 2002) 10.1096/fj.01-0530fje; Summary. FASEB J. 2002;16:601-603.
11. Takata K, Kitamura Y, Tsuchiya D, Kawasaki T, Taniguchi T, Shimohama S. Heat shock protein-90-induced microglial clearance of exogenous amyloid-β1-42 in rat hippocampus in vivo. Neurosci Lett. 2003;344:87-90.
12. Kitamura Y, Shibagaki K, Takata K, Tsuchiya D, Taniguchi T, Gebicke-Haerter PJ, et al. Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-β (1-42) in rat microglia. J Pharmacol Sci. 2003;92;115-123.
13. Hall A. G proteins and small GTPases: distant relatives keep in touch. Science. 1998;280:2074-2075.
14. Miki H, Sasaki T, Takai Y, Takenawa T. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. Nature. 1998;391:93-96.
15. Miki H, Yamaguchi H, Suetsugu S, Takenawa T. IRSp 53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Nature. 2000; 408:732-735.
16. Takenawa T, Miki H. WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement. J Cell Sci. 2001;114:1801-1809.
17. Fukuoka M, Suetsugu S, Miki H, Fukami K, Endo T, Takenawa T. A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp 2/3 complex activation independent of Cdc42. J Cell Biol. 2001;152:471-482.
18. Maeda Y, Matsumoto M, Hori O, Kuwabara K, Ogawa S, Yan SD, et al. Hypoxia/reoxygenation-mediated induction of astrocyte interleukin 6: a paracrine mechanism potentially enhancing neuron survival. J Exp Med. 1994;180:2297-2308.
19. 2+ accumulation. Proc Natl Acad Sci USA. 1995;92:9328-9332.
20. Bruce AJ, Boling W, Kindy MS, Peschon J, Kraemer PJ, Carpenter MK, et al. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med. 1996;2:788-794.
21. Tamatani M, Che YH, Matsuzaki H, Ogawa S, Okado H, Miyake S, et al. Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NF-κB activation in primary hippocampal neurons. J Biol Chem. 1999;274:8531-8538.
22. Bustin M, Lehn DA, Landsman D. Structural features of the HMG chromosomal proteins and their genes. Biochim Biophys Acta. 1990;1049:231-243.
23. Parkkinen J, Raulo E, Merenmies J, Nolo R, Kajander EO, Baumann M, et al. Amphoterin, the 30-kDa protein in a family of HMGl-type polypeptides. J Biol Chem. 1993;268:19726-19736.
24. Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science. 1999;285:248-251.
25. Hori O, Brett J, Slattery T, Cao R, Zhang J, Chen JX, et al. The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. J Biol Chem. 1995;270:25752-25761.
26. Takata K, Kitamura Y, Kakimura J, Shibagaki K, Tsuchiya D, Taniguchi T, et al. Role of high mobility group protein-1 (HMG1) in amyloid-β homeostasis. Biochem Biophy Res Commun. 2003;301:699-703.
27. Kitamura Y, Takata K, Inden M, Tsuchiya D, Yanagisawa D, Nakata J, et al. Intracerebroventicular injection of microglia protects against focal brain ischemia. J Pharmacol Sci. 2004;94:203-206.