In vitro binding experiments with a valerian, hops and their fixed combination extract (Ze91019) to selected central nervous system receptors

Phytomedicine

Volumn 11, Issue 7-8, 2004, Pages 633-638

  Abourashed, E A ^a   Koetter, U ^b   Brattstrom A ^c  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b GLAXOSMITHKLINE   (United States)

^c Zeller Medical AG   (Switzerland)

Author keywords

CNS sedative activity; Humulus lupulus; Receptor binding; Valerian hops extract; Valeriana officinalis

Indexed keywords

ADENOSINE; BRAIN RECEPTOR; DOPAMINE RECEPTOR; MELATONIN; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; MELATONIN RECEPTOR; NEUROPEPTIDE Y RECEPTOR; PLANT EXTRACT; RECEPTOR SUBTYPE; SEROTONIN 4E RECEPTOR; SEROTONIN 6 RECEPTOR; SEROTONIN 7 RECEPTOR; UNCLASSIFIED DRUG; VALERIAN HOPS EXTRACT; ZE 91019;

ARTICLE; BINDING AFFINITY; CENTRAL NERVOUS SYSTEM; DRUG MECHANISM; DRUG RECEPTOR BINDING; GABAERGIC SYSTEM; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; TRADITIONAL MEDICINE;

HUMULUS LUPULUS; VALERIANA; VALERIANA OFFICINALIS;

EID: 10844275745     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2004.03.005     Document Type: Article

References (22)

1. Valerianae radix-Valerian Root. 1997. ESCOP Monographs, European Scientific Cooperative on Phytotherapy.
2. Humulus lupulus [Hops], 1998. PDR for Herbal Medicines. Medical Economics Company, Inc., Montvale, NJ, pp. 900-901.
3. 3H]GBR12935 binding in vitro to rat striatal membranes: labeling of dopamine uptake complex. J. Neurochem, 48, 1887-1896.
4. Bos, R., Woerdenbag, H.J., DeSmet, P.A.G.M., Scheffer, J.J.C., 1997. Valeriana species. In: De Smet, P.A.G.M., Keller, K., Hansel, R., Chandler, R.F. (Eds.), Adverse Effects of Herbal Drugs, vol. 3. Springer, Berlin, Heidelberg, pp. 165-180.
5. Bravo, L., Cabo, J., Fraile, A., Jimenez, J., Villar, A., 1974. Estudio Farmacodinamico del Lupulo (Humulus lupulus L.) Accion Tranquilizante [Study of the Pharmacodynamics of the Tranquilizing Effect of Hops (Humulus lupulus L.). Boll. Chim. Farm. 113, 310-315.
6. Chambers, J., Ames, R.S., Bergsma, D., Muir, A., Fitzgerald, L.R., Hervieu, G., Dytko, G.M., Foley, J.J., Martin, J., Liu, W., Park, J., Ellis, C., Ganguly, S., Konchar, S., Cluderay, J., Leslie, R., Wilson, S., Sarau, H.M., 1999. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature 400, 261-265.
7. Fauteck, J.D., Pietz, B., Winterhoff, H., Wittkowski, W., 1996. Interaction of Valeriana officinalis with melatonin receptors: a possible explanation of its biological action. Phytomedicine 3, 76.
8. 34]neuro-peptide Y: a specific receptor agonist. Proc. Natl. Acad. Sci. USA 87, 182-186.
9. Graff, A., Williamson, E., Upton, R., Bevill, A., Ertl, F., Reich, E., Martinez, M., Lange, M., Wang, W., 1999. Valerian Root: Valeriana officinalis: Analytical, Quality Control, and Therapeutic Monograph.
10. 2 dopamine receptor. Proc. Natl. Acad. Sci. USA 86, 9762-9766.
11. 3 receptor expressed in transfected cell lines. Eur. J. Pharmacol. 266, 79-85.
12. 4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines. Br. J. Pharmacol. 129, 771-781.
13. Monsma, F.J., Shen, Y., Ward, R.P., Hamblin, M.W., Sibley, D.R., 1993. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol. Pharmacol. 43, 320-327.
14. Munoz, M., Sautel, M., Martinez, R., Sheikh, S.P., Walker, P., 1995. Characterization of the human Y1 neuropeptide Y receptor expressed in insect cells. Mol. Cell Endocrinol. 107, 77-86.
15. Müller, C.E., Schumacher, B., Abourashed, E.A., Koetter, U., 2002. Interaction of valerian extracts and a fixed valerian-hop extract combination with adenosine receptors. Life Sci. 71, 1939-1949.
16. Pickering, D.S., Niles, L.P., 1990. Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus. Eur. J. Pharmacol. 175, 71-77.
17. Rivkees, S.A., Cassone, V.M., Weaver, D.R., Reppert, S.M., 1989. Melatonin receptors in chick brain: characterization and localization. Endocrinology 125, 363-368.
18. 7 serotonin receptor subtype. J. Biol. Chem. 268, 18200-18204.
19. 5 receptor with higher affinity for dopamine than D1. Nature 350, 614-619.
20. 4 receptor variants in the human population. Nature 358, 149-152.
21. Wohlfart, R., Hänsel, R., Schmidt, H., 1983, Nachweis sedativ-hypnotischer Wirkstoffe im Hopfen 4. Mitteilung: Die Pharmakologie des Hopfeninhaltsstoffes 2-Methyl-3-buten-2-ol [The Sedativ-hypnotic Principle of Hops 4. Communication: Pharmacology of 2-Methyl-3-buten-2-ol]. Planta Med. 48, 120-123.
22. 1 dopamine receptors. Nature 347, 76-80.