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Volumn 174, Issue 1, 2005, Pages 557-563

Human autoantibodies modulate the T cell epitope repertoire but fail to unmask a pathogenic cryptic epitope

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; EPITOPE; THYROID PEROXIDASE;

EID: 10844266513     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.1.557     Document Type: Article
Times cited : (22)

References (50)
  • 1
    • 23444461024 scopus 로고
    • How B and T cells talk to each other
    • Clark, E. A., and J. A. Ledbetter. 1994. How B and T cells talk to each other. Nature 367:425.
    • (1994) Nature , vol.367 , pp. 425
    • Clark, E.A.1    Ledbetter, J.A.2
  • 3
    • 0021209335 scopus 로고
    • Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors
    • Rock, K. L., B. Benacerraf, and A. K. Abbas. 1984. Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. J. Exp. Med. 160:1102.
    • (1984) J. Exp. Med. , vol.160 , pp. 1102
    • Rock, K.L.1    Benacerraf, B.2    Abbas, A.K.3
  • 4
    • 0021956416 scopus 로고
    • Antigen-specific interaction between T and B cells
    • Lanzavecchia, A. 1985. Antigen-specific interaction between T and B cells. Nature 314:537.
    • (1985) Nature , vol.314 , pp. 537
    • Lanzavecchia, A.1
  • 6
    • 0029129468 scopus 로고
    • Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: Evidence that the protective mechanism depends on changes in the cytokine response and migratory properties of the autoantigen-specific T cells
    • Saoudi, A., S. Simmonds, I. Huitinga, and D. Mason. 1995. Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: evidence that the protective mechanism depends on changes in the cytokine response and migratory properties of the autoantigen-specific T cells. J. Exp. Med. 182:335.
    • (1995) J. Exp. Med. , vol.182 , pp. 335
    • Saoudi, A.1    Simmonds, S.2    Huitinga, I.3    Mason, D.4
  • 7
    • 0024320379 scopus 로고
    • Epitope-directed processing of specific antigen by B lymphocytes
    • Davidson, H. W., and C. Watts. 1989. Epitope-directed processing of specific antigen by B lymphocytes. J. Cell Biol. 109:85.
    • (1989) J. Cell Biol. , vol.109 , pp. 85
    • Davidson, H.W.1    Watts, C.2
  • 8
    • 0029035307 scopus 로고
    • Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants
    • Simitsek, P. D., D. G. Campbell, A. Lanzavecchia, N. Fairweather, and C. Watts. 1995. Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants. J. Exp. Med. 181:1957.
    • (1995) J. Exp. Med. , vol.181 , pp. 1957
    • Simitsek, P.D.1    Campbell, D.G.2    Lanzavecchia, A.3    Fairweather, N.4    Watts, C.5
  • 9
    • 0036183220 scopus 로고    scopus 로고
    • Antibody modulation of antigen presentation: Positive and negative effects on presentation of the tetanus toxin antigen via the murine B cell isoform of FcγRII
    • Antoniou, A. N., and C. Watts. 2002. Antibody modulation of antigen presentation: positive and negative effects on presentation of the tetanus toxin antigen via the murine B cell isoform of FcγRII. Eur. J. Immunol. 32:530.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 530
    • Antoniou, A.N.1    Watts, C.2
  • 10
    • 0026509260 scopus 로고
    • Capacity of antigen uptake by B cells, fibroblasts or macrophages determines efficiency of presentation of a soluble self antigen (C5) to T lymphocytes
    • Stockinger, B. 1992. Capacity of antigen uptake by B cells, fibroblasts or macrophages determines efficiency of presentation of a soluble self antigen (C5) to T lymphocytes. Eur. J. Immunol. 22:1271.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 1271
    • Stockinger, B.1
  • 11
    • 0031003445 scopus 로고    scopus 로고
    • Fcγ receptor II dependency of enhanced presentation of major histocompatibility complex class II peptides by a B cell lymphoma
    • Berg, M., R. Uellner, and J. Langhorne. 1997. Fcγ receptor II dependency of enhanced presentation of major histocompatibility complex class II peptides by a B cell lymphoma. Eur. J. Immunol. 27:1022.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 1022
    • Berg, M.1    Uellner, R.2    Langhorne, J.3
  • 12
    • 0035555276 scopus 로고    scopus 로고
    • Determinants of autoimmune thyroid disease
    • Weetman, A. P. 2001. Determinants of autoimmune thyroid disease. Nat. Immunol. 2:769.
    • (2001) Nat. Immunol. , vol.2 , pp. 769
    • Weetman, A.P.1
  • 14
    • 0032145276 scopus 로고    scopus 로고
    • B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65 antigen in nonobese diabetic mice
    • Falcone, M., J. Lee, G. Patstone, B. Yeung, and N. Sarvetnick. 1998. B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65 antigen in nonobese diabetic mice. J. Immunol. 161:1163.
    • (1998) J. Immunol. , vol.161 , pp. 1163
    • Falcone, M.1    Lee, J.2    Patstone, G.3    Yeung, B.4    Sarvetnick, N.5
  • 15
    • 0033564684 scopus 로고    scopus 로고
    • Enhancing or suppressive effects of antibodies on processing of a pathogenic T eel epitope in thyroglobulin
    • Dai, Y., K. A. Carayanniotis, P. Eliades, P. Lymberi, P. Shepherd, Y. Kong, and G. Carayanniotis. 1999. Enhancing or suppressive effects of antibodies on processing of a pathogenic T eel] epitope in thyroglobulin. J. Immunol. 162:6987.
    • (1999) J. Immunol. , vol.162 , pp. 6987
    • Dai, Y.1    Carayanniotis, K.A.2    Eliades, P.3    Lymberi, P.4    Shepherd, P.5    Kong, Y.6    Carayanniotis, G.7
  • 16
    • 0033815194 scopus 로고    scopus 로고
    • GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65
    • Reijonen, H., T. L. Daniels, A. Lernmark, and G. T. Nepom. 2000. GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65. Diabetes 49:1621.
    • (2000) Diabetes , vol.49 , pp. 1621
    • Reijonen, H.1    Daniels, T.L.2    Lernmark, A.3    Nepom, G.T.4
  • 18
    • 0026733466 scopus 로고
    • Recognition by recombinant autoimmune thyroid disease-derived Fab fragments of a dominant conformational epitope on human thyroid peroxidase
    • Portolano, S., G. D. Chazenbalk, P. Seto, J. S. Hutchison, B. Rapoport, and S. M. McLachlan. 1992. Recognition by recombinant autoimmune thyroid disease-derived Fab fragments of a dominant conformational epitope on human thyroid peroxidase. J. Clin. Invest. 90:720.
    • (1992) J. Clin. Invest. , vol.90 , pp. 720
    • Portolano, S.1    Chazenbalk, G.D.2    Seto, P.3    Hutchison, J.S.4    Rapoport, B.5    McLachlan, S.M.6
  • 19
    • 0030576932 scopus 로고    scopus 로고
    • Autoantibody-mediated capture and presentation of autoantigen to T cells via the Fee receptor by a recombinant human autoantibody Fab converted to IgE
    • Guo, J., S. Quaratino, J. C. Jaume, G. Costante, M. Londei, S. M. McLachlan, and B. Rapoport. 1996. Autoantibody-mediated capture and presentation of autoantigen to T cells via the Fee receptor by a recombinant human autoantibody Fab converted to IgE. J. Immunol. Methods 195:81.
    • (1996) J. Immunol. Methods , vol.195 , pp. 81
    • Guo, J.1    Quaratino, S.2    Jaume, J.C.3    Costante, G.4    Londei, M.5    McLachlan, S.M.6    Rapoport, B.7
  • 21
    • 0030046168 scopus 로고    scopus 로고
    • Human self-reactive T cell clones expressing identical T cell receptor β chains differ in their ability to recognize a cryptic self-epitope
    • Quaratino, S., M. Feldmann, C. M. Dayan, O. Acuto, and M. Londei. 1996. Human self-reactive T cell clones expressing identical T cell receptor β chains differ in their ability to recognize a cryptic self-epitope. J. Exp. Med. 183:349.
    • (1996) J. Exp. Med. , vol.183 , pp. 349
    • Quaratino, S.1    Feldmann, M.2    Dayan, C.M.3    Acuto, O.4    Londei, M.5
  • 23
    • 0019401030 scopus 로고
    • Presence of the organ-specific "microsomal" autoantigen on the surface of human thyroid cells in culture: Its involvement in complement-mediated cytotoxicity
    • Khoury, E. L., L. Hammond, G. F. Bottazzo, and D. Doniach. 1981. Presence of the organ-specific "microsomal" autoantigen on the surface of human thyroid cells in culture: its involvement in complement-mediated cytotoxicity. Clin. Exp. Immunol. 45:316.
    • (1981) Clin. Exp. Immunol. , vol.45 , pp. 316
    • Khoury, E.L.1    Hammond, L.2    Bottazzo, G.F.3    Doniach, D.4
  • 24
    • 0034718505 scopus 로고    scopus 로고
    • Fully competent dendritic cells as inducers of T cell anergy in autoimmunity
    • Quaratino, S., L. P. Duddy, and M. Londei. 2000. Fully competent dendritic cells as inducers of T cell anergy in autoimmunity. Proc. Natl. Acad. Sci. USA 97:10911.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10911
    • Quaratino, S.1    Duddy, L.P.2    Londei, M.3
  • 25
    • 0024430122 scopus 로고
    • Relationship between immunological structure and biochemical properties of human thyroid peroxidase
    • Ruf, J., M. E. Toubert, B. Czarnocka, J. M. Durand-Gorde, M. Ferrand, and P. Carayon. 1989. Relationship between immunological structure and biochemical properties of human thyroid peroxidase. Endocrinology 125:1211.
    • (1989) Endocrinology , vol.125 , pp. 1211
    • Ruf, J.1    Toubert, M.E.2    Czarnocka, B.3    Durand-Gorde, J.M.4    Ferrand, M.5    Carayon, P.6
  • 26
    • 0028355129 scopus 로고
    • Recombinant thyroid peroxidase autoantibodies can be used for epitopic "fingerprinting" of thyroid peroxidase autoantibodies in the sera of individual patients
    • Nishikawa, T., G. Costante, M. F. Prummel, S. M. McLachlan, and B. Rapoport. 1994. Recombinant thyroid peroxidase autoantibodies can be used for epitopic "fingerprinting" of thyroid peroxidase autoantibodies in the sera of individual patients. J. Clin. Endocrinol. Metab. 78:944.
    • (1994) J. Clin. Endocrinol. Metab. , vol.78 , pp. 944
    • Nishikawa, T.1    Costante, G.2    Prummel, M.F.3    McLachlan, S.M.4    Rapoport, B.5
  • 27
    • 0028289244 scopus 로고
    • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α
    • Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Meet. 179:1109.
    • (1994) J. Exp. Meet. , vol.179 , pp. 1109
    • Sallusto, F.1    Lanzavecchia, A.2
  • 28
    • 0036164581 scopus 로고    scopus 로고
    • MMP and TIMP expression define the migratory characteristics of human monocyte-derived dendritic cells
    • Osman, M., M. Tortorella, M. Londei, and S. Quaratino. 2002. MMP and TIMP expression define the migratory characteristics of human monocyte-derived dendritic cells. Immunology 105:73.
    • (2002) Immunology , vol.105 , pp. 73
    • Osman, M.1    Tortorella, M.2    Londei, M.3    Quaratino, S.4
  • 29
    • 0028240762 scopus 로고
    • Transfection of thyroid autoantigens into EBV-transformed B cell lines: Recognition by Graves' disease thyroid T cells
    • Mullins, R. J., Y. Chernajovsky, C. Dayan, M. Londei, and M. Feldmann. 1994. Transfection of thyroid autoantigens into EBV-transformed B cell lines: recognition by Graves' disease thyroid T cells. J. Immunol. 152:5572.
    • (1994) J. Immunol. , vol.152 , pp. 5572
    • Mullins, R.J.1    Chernajovsky, Y.2    Dayan, C.3    Londei, M.4    Feldmann, M.5
  • 30
    • 0033394322 scopus 로고    scopus 로고
    • Fc receptors for IgG and antigen presentation on MHC class I and class II molecules
    • Amigorena, S., and C. Bonnerot. 1999. Fc receptors for IgG and antigen presentation on MHC class I and class II molecules. Semin. Immunol. 11:385.
    • (1999) Semin. Immunol. , vol.11 , pp. 385
    • Amigorena, S.1    Bonnerot, C.2
  • 31
    • 0035113959 scopus 로고    scopus 로고
    • Characteristics of inflammatory cells in spontaneous autoimmune thyroiditis of NOD.H-2h4 mice
    • Yu, S., B. Medling, H. Yagita, and H. Braley-Mullen. 2001. Characteristics of inflammatory cells in spontaneous autoimmune thyroiditis of NOD.H-2h4 mice. J. Autoimmun. 16:37.
    • (2001) J. Autoimmun. , vol.16 , pp. 37
    • Yu, S.1    Medling, B.2    Yagita, H.3    Braley-Mullen, H.4
  • 32
    • 0021859635 scopus 로고
    • Constraints in T-B cooperation related to epitope topology on E. coli β-galactosidase. I. The fine specificity of T cells dictates the fine specificity of antibodies directed to conformation-dependent determinants
    • Manca, F., A. Kunkl, D. Fenoglio, A. Fowler, E. Sercarz, and F. Celada. 1985. Constraints in T-B cooperation related to epitope topology on E. coli β-galactosidase. I. The fine specificity of T cells dictates the fine specificity of antibodies directed to conformation-dependent determinants. Eur. J. Immunol. 15:345.
    • (1985) Eur. J. Immunol. , vol.15 , pp. 345
    • Manca, F.1    Kunkl, A.2    Fenoglio, D.3    Fowler, A.4    Sercarz, E.5    Celada, F.6
  • 33
    • 0023214476 scopus 로고
    • Antibody conjugates mimic specific B cell presentation of antigen: Relationship between T and B cell specificity
    • Ozaki, S., and J. A. Berzofsky. 1987. Antibody conjugates mimic specific B cell presentation of antigen: relationship between T and B cell specificity. J. Immunol. 138:4133.
    • (1987) J. Immunol. , vol.138 , pp. 4133
    • Ozaki, S.1    Berzofsky, J.A.2
  • 34
    • 0023841756 scopus 로고
    • Preferential pairing of T-B specificities in the same antigen: The concept of directional help
    • Celada, F., and E. E. Sercarz. 1988. Preferential pairing of T-B specificities in the same antigen: the concept of directional help. Vaccine 6:94.
    • (1988) Vaccine , vol.6 , pp. 94
    • Celada, F.1    Sercarz, E.E.2
  • 35
    • 0029862687 scopus 로고    scopus 로고
    • B cells solicit their own help from T cells
    • Stockinger, B., T. Zal, A. Zal, and D. Gray. 1996. B cells solicit their own help from T cells. J. Exp. Med. 183:891.
    • (1996) J. Exp. Med. , vol.183 , pp. 891
    • Stockinger, B.1    Zal, T.2    Zal, A.3    Gray, D.4
  • 38
    • 0037450740 scopus 로고    scopus 로고
    • Prevention of arthritis by interleukin 10-producing B cells
    • Mauri, C., D. Gray, N. Mushtaq, and M. Londei. 2003. Prevention of arthritis by interleukin 10-producing B cells. J. Exp. Med. 197:489.
    • (2003) J. Exp. Med. , vol.197 , pp. 489
    • Mauri, C.1    Gray, D.2    Mushtaq, N.3    Londei, M.4
  • 39
    • 0035838981 scopus 로고    scopus 로고
    • Regulation of T cell immunity by dendritic cells
    • Lanzavecchia, A., and F. Sallusto. 2001. Regulation of T cell immunity by dendritic cells. Cell 106:263.
    • (2001) Cell , vol.106 , pp. 263
    • Lanzavecchia, A.1    Sallusto, F.2
  • 40
    • 0027267589 scopus 로고
    • Suppressive effect of antibody on processing of T cell epitopes
    • Watts, C., and A. Lanzavecchia. 1993. Suppressive effect of antibody on processing of T cell epitopes. J. Exp. Med. 178:1459.
    • (1993) J. Exp. Med. , vol.178 , pp. 1459
    • Watts, C.1    Lanzavecchia, A.2
  • 41
    • 0029006389 scopus 로고
    • How can cryptic epitopes trigger autoimmunity?
    • Lanzavecchia, A. 1995. How can cryptic epitopes trigger autoimmunity? J. Exp. Med. 181:1945.
    • (1995) J. Exp. Med. , vol.181 , pp. 1945
    • Lanzavecchia, A.1
  • 43
    • 0028818193 scopus 로고
    • Similar antigenic surfaces, rather than sequence homology, dictate T-cell epitope molecular mimicry
    • Quaratino, S., C. J. Thorpe, P. J. Travers, and M. Londei. 1995. Similar antigenic surfaces, rather than sequence homology, dictate T-cell epitope molecular mimicry. Proc. Natl. Acad. Sci. USA 92:10398.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 10398
    • Quaratino, S.1    Thorpe, C.J.2    Travers, P.J.3    Londei, M.4
  • 44
    • 0021269685 scopus 로고
    • Human T lymphocyte activation by monoclonal antibodies; OKT3, but not UCHT1, triggers mitogenesis via an interieukin 2-dependeni mechanism
    • Van Wauwe, J. P., J. G. Goossens, and P. C. Beverley. 1984. Human T lymphocyte activation by monoclonal antibodies; OKT3, but not UCHT1, triggers mitogenesis via an interieukin 2-dependeni mechanism. J. Immunol. 133:129.
    • (1984) J. Immunol. , vol.133 , pp. 129
    • Van Wauwe, J.P.1    Goossens, J.G.2    Beverley, P.C.3
  • 47
    • 0242579484 scopus 로고    scopus 로고
    • A novel polymorphism in the Fcγ receptor IIB (CD32B) transmembrane region alters receptor signaling
    • Li, X., J. Wu, R. H. Carter, J. C. Edberg, K. Su, G. S. Cooper, and R. P. Kimberly. 2003. A novel polymorphism in the Fcγ receptor IIB (CD32B) transmembrane region alters receptor signaling. Arthritis Rheum. 48:3242.
    • (2003) Arthritis Rheum. , vol.48 , pp. 3242
    • Li, X.1    Wu, J.2    Carter, R.H.3    Edberg, J.C.4    Su, K.5    Cooper, G.S.6    Kimberly, R.P.7
  • 49
    • 0021716298 scopus 로고
    • Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells
    • Londei, M., J. R. Lamb, G. F. Bottazzo, and M. Feldmann. 1984. Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells. Nature 312:639.
    • (1984) Nature , vol.312 , pp. 639
    • Londei, M.1    Lamb, J.R.2    Bottazzo, G.F.3    Feldmann, M.4
  • 50
    • 0021916755 scopus 로고
    • Human T-cell clones from autoimmune thyroid glands: Specific recognition of autologous thyroid cells
    • Londei, M., G. F. Bottazzo, and M. Feldmann. 1985. Human T-cell clones from autoimmune thyroid glands: specific recognition of autologous thyroid cells. Science 228:85.
    • (1985) Science , vol.228 , pp. 85
    • Londei, M.1    Bottazzo, G.F.2    Feldmann, M.3


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