메뉴 건너뛰기




Volumn 195, Issue 1-2, 1996, Pages 81-92

Autoantibody-mediated capture and presentation of autoantigen to T cells via the Fcε receptor by a recombinant human autoantibody Fab converted to IgE

Author keywords

Autoantigen capture; Autoantigen presentation; CD23; Fab, human; Fc receptor; IgE; T cell; Thyroid peroxidase; Thyroid peroxidase autoantibody

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; CD23 ANTIGEN; FC RECEPTOR; IMMUNOGLOBULIN E; THYROID PEROXIDASE;

EID: 0030576932     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-1759(96)00091-9     Document Type: Article
Times cited : (33)

References (45)
  • 2
    • 0027232106 scopus 로고
    • Recombinant human antibodies: Linkage of an Fab fragment from a combinatorial library to an Fc fragment for expression in mammalian cell culture
    • Bender, E., Woof, J.M., Atkin, J.D., Barker, M.D., Bebbington, C.R. and Burton, D.R. (1993) Recombinant human antibodies: linkage of an Fab fragment from a combinatorial library to an Fc fragment for expression in mammalian cell culture. Hum. Antibod. Hybridomas 4, 74.
    • (1993) Hum. Antibod. Hybridomas , vol.4 , pp. 74
    • Bender, E.1    Woof, J.M.2    Atkin, J.D.3    Barker, M.D.4    Bebbington, C.R.5    Burton, D.R.6
  • 3
    • 0027142433 scopus 로고
    • The immunodominant region on human thyroid peroxidase recognized by autoantibodies does not contain the monoclonal antibody 47/c21 linear epitope
    • Chazenbalk, G.D., Costante, G., Portolano, S., McLachlan, S.M. and Rapoport, B. (1993a) The immunodominant region on human thyroid peroxidase recognized by autoantibodies does not contain the monoclonal antibody 47/c21 linear epitope. J. Clin. Endocrinol. Metab. 77, 1715.
    • (1993) J. Clin. Endocrinol. Metab. , vol.77 , pp. 1715
    • Chazenbalk, G.D.1    Costante, G.2    Portolano, S.3    McLachlan, S.M.4    Rapoport, B.5
  • 4
    • 0027169311 scopus 로고
    • Human organ-specific autoimmune disease: Molecular cloning and expression of an autoantibody gene repertoire for a major autoantigen reveals an antigenic dominant region and restricted immunoglobulin gene usage in the target organ
    • Chazenbalk, G.D., Portolano, S., Russo, D., Hutchison, J.S., Rapoport, B. and McLachlan, S.M. (1993b) Human organ-specific autoimmune disease: molecular cloning and expression of an autoantibody gene repertoire for a major autoantigen reveals an antigenic dominant region and restricted immunoglobulin gene usage in the target organ. J. Clin. Invest. 92, 62.
    • (1993) J. Clin. Invest. , vol.92 , pp. 62
    • Chazenbalk, G.D.1    Portolano, S.2    Russo, D.3    Hutchison, J.S.4    Rapoport, B.5    McLachlan, S.M.6
  • 5
    • 0026654187 scopus 로고
    • Novel vectors for the expression of antibody molecules using variable regions generated by polymerase chain reaction
    • Coloma, M.J., Hastings, A., Wims, L.A. and Morrison, S.L. (1992) Novel vectors for the expression of antibody molecules using variable regions generated by polymerase chain reaction. J. Immunol. Methods 152, 89.
    • (1992) J. Immunol. Methods , vol.152 , pp. 89
    • Coloma, M.J.1    Hastings, A.2    Wims, L.A.3    Morrison, S.L.4
  • 7
    • 0024320379 scopus 로고
    • Epitope-directed processing of specific antigen by B lymphocytes
    • Davidson, H.W. and Watts, C. (1989) Epitope-directed processing of specific antigen by B lymphocytes. J. Cell Biol. 109, 85.
    • (1989) J. Cell Biol. , vol.109 , pp. 85
    • Davidson, H.W.1    Watts, C.2
  • 9
    • 0025175282 scopus 로고
    • Generation of a biologically-active, secreted form of human thyroid peroxidase by site-directed mutagenesis
    • Foti, D., Kaufman, K.D., Chazenbalk, G. and Rapoport, B. (1990) Generation of a biologically-active, secreted form of human thyroid peroxidase by site-directed mutagenesis. Mol. Endocrinol. 4, 786.
    • (1990) Mol. Endocrinol. , vol.4 , pp. 786
    • Foti, D.1    Kaufman, K.D.2    Chazenbalk, G.3    Rapoport, B.4
  • 10
    • 0023741027 scopus 로고
    • Epitopes on human acetylcholine receptor defined by monoclonal antibodies and myasthenia gravis sera
    • Heidenreich, F., Vincent, a., Roberts, A. and Newsom-Davis, J. (1988) Epitopes on human acetylcholine receptor defined by monoclonal antibodies and myasthenia gravis sera. Autoimmunity 1, 285.
    • (1988) Autoimmunity , vol.1 , pp. 285
    • Heidenreich, F.1    Vincent, A.2    Roberts, A.3    Newsom-Davis, J.4
  • 11
    • 0027196997 scopus 로고
    • Studies on antigen binding by intact and hinge-deleted chimeric antibodies
    • Horgan, C., Brown, K. and Pincus, S.H. (1993) Studies on antigen binding by intact and hinge-deleted chimeric antibodies. J. Immunol. 150, 5400.
    • (1993) J. Immunol. , vol.150 , pp. 5400
    • Horgan, C.1    Brown, K.2    Pincus, S.H.3
  • 12
    • 0028904259 scopus 로고
    • Thyroid peroxidase autoantibody fingerprints in hypothyroid and euthyroid individuals. I. Cross-sectional study in elderly women
    • Jaume, J.C., Costante, G., Nishikawa, T., Phillips, D.I.W., Rapoport, B. and McLachlan, S.M. (1995a) Thyroid peroxidase autoantibody fingerprints in hypothyroid and euthyroid individuals. I. Cross-sectional study in elderly women. J. Clin. Endocrinol. Metab. 80, 994.
    • (1995) J. Clin. Endocrinol. Metab. , vol.80 , pp. 994
    • Jaume, J.C.1    Costante, G.2    Nishikawa, T.3    Phillips, D.I.W.4    Rapoport, B.5    McLachlan, S.M.6
  • 15
    • 0025754265 scopus 로고
    • Overexpression of an immunologically-intact, secreted form of human thyroid peroxidase in eukaryotic cells
    • Kaufman, K.D., Foti, D., Seto, P. and Rapoport, B. (1991) Overexpression of an immunologically-intact, secreted form of human thyroid peroxidase in eukaryotic cells. Mol. Cell. Endocrinol. 78, 107.
    • (1991) Mol. Cell. Endocrinol. , vol.78 , pp. 107
    • Kaufman, K.D.1    Foti, D.2    Seto, P.3    Rapoport, B.4
  • 16
    • 0026697394 scopus 로고
    • Proliferative responses of peripheral blood mononuclear cells from patients with autoimmune thyroid disease to synthetic peptide epitopes of human thyroid peroxidase
    • Kawakami, Y., Fisfalen, M.-E. and DeGroot, L.J. (1992) Proliferative responses of peripheral blood mononuclear cells from patients with autoimmune thyroid disease to synthetic peptide epitopes of human thyroid peroxidase. Autoimmunity 13, 17.
    • (1992) Autoimmunity , vol.13 , pp. 17
    • Kawakami, Y.1    Fisfalen, M.-E.2    DeGroot, L.J.3
  • 17
    • 0004445079 scopus 로고
    • Low-affinity IgE receptor (CD23) function on mouse B cells: Role in IgE-dependent antigen focusing
    • Kehry, M.R. and Yamashita, L.C. (1989) Low-affinity IgE receptor (CD23) function on mouse B cells: Role in IgE-dependent antigen focusing. Proc. Natl. Acad. Sci. USA 86, 7556.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 7556
    • Kehry, M.R.1    Yamashita, L.C.2
  • 18
    • 0021956416 scopus 로고
    • Antigen-specific interaction between T and B cells
    • Lanzavecchia, A. (1985) Antigen-specific interaction between T and B cells. Nature 314, 537.
    • (1985) Nature , vol.314 , pp. 537
    • Lanzavecchia, A.1
  • 19
    • 0025240576 scopus 로고
    • Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes
    • Lanzavecchia, A. (1990) Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes. Ann. Rev. Immunol. 8, 773.
    • (1990) Ann. Rev. Immunol. , vol.8 , pp. 773
    • Lanzavecchia, A.1
  • 20
    • 0029006389 scopus 로고
    • How can cryptic epitopes trigger autoimmunity?
    • Lanzavecchia, A. (1995) How can cryptic epitopes trigger autoimmunity? J. Exp. Med. 181, 1945.
    • (1995) J. Exp. Med. , vol.181 , pp. 1945
    • Lanzavecchia, A.1
  • 21
    • 0021916755 scopus 로고
    • Human T cell clones from autoimmune thyroid glands: Specific recognition of autologous thyroid cells
    • Londei, M., Bottazzo, G.F. and Feldmann, M. (1985) Human T cell clones from autoimmune thyroid glands: Specific recognition of autologous thyroid cells. Science 228, 85.
    • (1985) Science , vol.228 , pp. 85
    • Londei, M.1    Bottazzo, G.F.2    Feldmann, M.3
  • 22
    • 0023936046 scopus 로고
    • Differential activation of T cell clones stimulated by macrophages exposed to antigen complexed with monoclonal antibodies. A possible influence of paratope specificity on the mode of antigen processing
    • Manca, F., Fenoglio, D., Kunkl, A., Cambiaggi, C., Sasso, M. and Celada, F. (1988) Differential activation of T cell clones stimulated by macrophages exposed to antigen complexed with monoclonal antibodies. A possible influence of paratope specificity on the mode of antigen processing. J. Immunol. 140, 2893.
    • (1988) J. Immunol. , vol.140 , pp. 2893
    • Manca, F.1    Fenoglio, D.2    Kunkl, A.3    Cambiaggi, C.4    Sasso, M.5    Celada, F.6
  • 23
    • 0027263260 scopus 로고
    • Endogenous antigen presentation by autoantigen-transfected Epstein-Barr virus-lymphoblastoid cells. 1. Generation of human thyroid peroxidase-reactive T cells and their T cell receptor repertoire
    • Martin, A., Magnusson, R.P., Kendler, D.L., Concepcion, E., Ben-Nun, A. and Davies, T.F. (1993) Endogenous antigen presentation by autoantigen-transfected Epstein-Barr virus-lymphoblastoid cells. 1. Generation of human thyroid peroxidase-reactive T cells and their T cell receptor repertoire. J. Clin. Invest. 91, 1567.
    • (1993) J. Clin. Invest. , vol.91 , pp. 1567
    • Martin, A.1    Magnusson, R.P.2    Kendler, D.L.3    Concepcion, E.4    Ben-Nun, A.5    Davies, T.F.6
  • 24
    • 0018188126 scopus 로고
    • IgE and IgE autoantibodies in patients with autoimmune thyroid disorders and their relatives
    • Matsui, Y., Heiner, D.C. and Beall, G.N. (1978) IgE and IgE autoantibodies in patients with autoimmune thyroid disorders and their relatives. Proc. Soc. Exp, Biol. Med. 158, 73.
    • (1978) Proc. Soc. Exp, Biol. Med. , vol.158 , pp. 73
    • Matsui, Y.1    Heiner, D.C.2    Beall, G.N.3
  • 25
    • 0029143341 scopus 로고
    • Peptide-selected T cell lines from myasthenia gravis patients and controls recognize epitopes that are not processed from whole acetylcholine receptor
    • Matsuo, H., Batocchi, A.-P., Hawke, S., Nicolle, M., Jacobson, L., Vincent, A., Newsom-Davis, J. and Willcox, N. (1995) Peptide-selected T cell lines from myasthenia gravis patients and controls recognize epitopes that are not processed from whole acetylcholine receptor. J.Immunol. 155, 3683.
    • (1995) J.Immunol. , vol.155 , pp. 3683
    • Matsuo, H.1    Batocchi, A.-P.2    Hawke, S.3    Nicolle, M.4    Jacobson, L.5    Vincent, A.6    Newsom-Davis, J.7    Willcox, N.8
  • 27
    • 0027218097 scopus 로고
    • Use of Epstein-Barr virus-based vectors for expression of thyroid auto-antigens in human B-lymphoblastoid cell lines
    • McIntosh, R.S., Mulcahy, A.F., Hales, J.M. and Diamond, A.G. (1993) Use of Epstein-Barr virus-based vectors for expression of thyroid auto-antigens in human B-lymphoblastoid cell lines. J. Autoimmun. 6, 353.
    • (1993) J. Autoimmun. , vol.6 , pp. 353
    • McIntosh, R.S.1    Mulcahy, A.F.2    Hales, J.M.3    Diamond, A.G.4
  • 28
    • 0026729487 scopus 로고
    • The molecular biology of thyroid peroxidase: Cloning, expression and role as autoantigen in autoimmune thyroid disease
    • McLachlan, S.M. and Rapoport, B. (1992) The molecular biology of thyroid peroxidase: cloning, expression and role as autoantigen in autoimmune thyroid disease. Endocrinol. Rev. 13, 192.
    • (1992) Endocrinol. Rev. , vol.13 , pp. 192
    • McLachlan, S.M.1    Rapoport, B.2
  • 29
    • 0029160330 scopus 로고
    • Genetic and epitopic analysis of thyroid peroxidase (TPO) autoantibodies: Markers of the human thyroid autoimmune response
    • McLachlan, S.M. and Rapoport, B. (1995) Genetic and epitopic analysis of thyroid peroxidase (TPO) autoantibodies: markers of the human thyroid autoimmune response. Clin. Exp. Immunol. 101, 200.
    • (1995) Clin. Exp. Immunol. , vol.101 , pp. 200
    • McLachlan, S.M.1    Rapoport, B.2
  • 30
    • 0029120165 scopus 로고
    • Consequences of IgE/CD23-mediated antigen presentation in allergy
    • Mudde, G.C., Bheekha, R. and Bruijnzeel-Koomen, C.A.F.M. (1995) Consequences of IgE/CD23-mediated antigen presentation in allergy. Immunol. Today 16, 380.
    • (1995) Immunol. Today , vol.16 , pp. 380
    • Mudde, G.C.1    Bheekha, R.2    Bruijnzeel-Koomen, C.A.F.M.3
  • 31
    • 0028240762 scopus 로고
    • Transfection of thyroid autoantigens into EBV-transformed B cell lines
    • Mullins, R.J., Chernajovsky, Y., Dayan, C., Londei, M. and Feldmann, M. (1994) Transfection of thyroid autoantigens into EBV-transformed B cell lines. J. Immunol. 152, 5572.
    • (1994) J. Immunol. , vol.152 , pp. 5572
    • Mullins, R.J.1    Chernajovsky, Y.2    Dayan, C.3    Londei, M.4    Feldmann, M.5
  • 32
    • 0024852495 scopus 로고
    • Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor
    • Nagayama, Y., Kaufman, K.D., Seto, P. and Rapoport, B. (1989) Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem. Biophys. Res. Commun. 165, 1184.
    • (1989) Biochem. Biophys. Res. Commun. , vol.165 , pp. 1184
    • Nagayama, Y.1    Kaufman, K.D.2    Seto, P.3    Rapoport, B.4
  • 33
    • 0028355129 scopus 로고
    • Recombinant thyroid peroxidase autoantibodies can be used for epitopic 'fingerprinting' of thyroid peroxidase autoantibodies in the sera of individual patients
    • Nishikawa, T., Costante, G., Prummel, M.F., McLachlan, S.M. and Rapoport, B. (1994) Recombinant thyroid peroxidase autoantibodies can be used for epitopic 'fingerprinting' of thyroid peroxidase autoantibodies in the sera of individual patients. J. Clin. Endocrinol. Metab. 78, 944.
    • (1994) J. Clin. Endocrinol. Metab. , vol.78 , pp. 944
    • Nishikawa, T.1    Costante, G.2    Prummel, M.F.3    McLachlan, S.M.4    Rapoport, B.5
  • 34
    • 0025372112 scopus 로고
    • IgE-dependent antigen focusing by human B lymphocytes is mediated by low-affinity receptor for IgE
    • Pirron, U., Schlunck, T., Prinz, J.C. and Rieber, E.P. (1990) IgE-dependent antigen focusing by human B lymphocytes is mediated by low-affinity receptor for IgE. Eur. J. Immunol. 20, 1547.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 1547
    • Pirron, U.1    Schlunck, T.2    Prinz, J.C.3    Rieber, E.P.4
  • 35
    • 0026733466 scopus 로고
    • Recognition by recombinant autoimmune thyroid disease-derived Fab fragments of a dominant conformational epitope on human thyroid peroxidase
    • Portolano, S., Chazenbalk, G.D., Seto, P., Hutchison, J.S., Rapoport, B. and McLachlan, S.M. (1992) Recognition by recombinant autoimmune thyroid disease-derived Fab fragments of a dominant conformational epitope on human thyroid peroxidase. J. Clin. Invest. 90, 720.
    • (1992) J. Clin. Invest. , vol.90 , pp. 720
    • Portolano, S.1    Chazenbalk, G.D.2    Seto, P.3    Hutchison, J.S.4    Rapoport, B.5    McLachlan, S.M.6
  • 36
    • 0028980901 scopus 로고
    • Combinatorial immunoglobulin gene libraries: New insights into human organ-specific autoantibodies
    • Rapoport, B., Portolano, S. and McLachlan, S.M. (1995) Combinatorial immunoglobulin gene libraries: new insights into human organ-specific autoantibodies. Immunol. Today 16, 43.
    • (1995) Immunol. Today , vol.16 , pp. 43
    • Rapoport, B.1    Portolano, S.2    McLachlan, S.M.3
  • 37
    • 0024430122 scopus 로고
    • Relationship between immunological structure and biochemical properties of human thyroid peroxidase
    • Ruf, J., Toubert, M., Czarnocka, B., Durand-Gorde, J., Ferrand, M. and Carayon, P. (1989) Relationship between immunological structure and biochemical properties of human thyroid peroxidase. Endocrinology 125, 1211.
    • (1989) Endocrinology , vol.125 , pp. 1211
    • Ruf, J.1    Toubert, M.2    Czarnocka, B.3    Durand-Gorde, J.4    Ferrand, M.5    Carayon, P.6
  • 38
    • 0019817187 scopus 로고
    • Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, 1,3,4,6-tetrachloro-3 alpha,6 alpha-diphenyl glycoluril (Iodogen)
    • Salacinski, P.R.P., McLean, C., Sykes, J.E.C., Clement-Jones, V.V. and Lowry, P.J. (1981) Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, 1,3,4,6-tetrachloro-3 alpha,6 alpha-diphenyl glycoluril (Iodogen). Anal. Biochem. 117, 136.
    • (1981) Anal. Biochem. , vol.117 , pp. 136
    • Salacinski, P.R.P.1    McLean, C.2    Sykes, J.E.C.3    Clement-Jones, V.V.4    Lowry, P.J.5
  • 40
    • 84969001783 scopus 로고
    • The attractions of proteins for small molecules and ions
    • Scatchard, G. (1949) The attractions of proteins for small molecules and ions. Ann. NY Acad. Sci. 51, 660.
    • (1949) Ann. NY Acad. Sci. , vol.51 , pp. 660
    • Scatchard, G.1
  • 41
    • 0029035307 scopus 로고
    • Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants
    • Simitsek, P.D., Cmpbell, D.G., Lanzavecchia, A., Fairweather, N. and Watts, C. (1995) Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants. J. Exp. Med. 181, 1957.
    • (1995) J. Exp. Med. , vol.181 , pp. 1957
    • Simitsek, P.D.1    Cmpbell, D.G.2    Lanzavecchia, A.3    Fairweather, N.4    Watts, C.5
  • 42
    • 0026049253 scopus 로고
    • T cell responses to synthetic thyroid peroxidase peptides in autoimmune thyroid disease
    • Tandon, N., Freeman, M. and Weetman, A.P. (1991) T cell responses to synthetic thyroid peroxidase peptides in autoimmune thyroid disease. Clin. Exp. Immunol. 86, 56.
    • (1991) Clin. Exp. Immunol. , vol.86 , pp. 56
    • Tandon, N.1    Freeman, M.2    Weetman, A.P.3
  • 43
    • 0013573650 scopus 로고
    • Specificities of antibodies to acetylcholine receptors in sera from myasthenia gravis patients measured by monoclonal antibodies
    • Tzartos, S.J., Seybold, M.E. and Lindstrom, J.M. (1982) Specificities of antibodies to acetylcholine receptors in sera from myasthenia gravis patients measured by monoclonal antibodies. Proc. Natl. Acad. Sci. USA 79, 188.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 188
    • Tzartos, S.J.1    Seybold, M.E.2    Lindstrom, J.M.3
  • 45
    • 0027267589 scopus 로고
    • Suppressive effect of antibody on processing of T cell epitopes
    • Watts, C. and Lanzavecchia, A. (1993) Suppressive effect of antibody on processing of T cell epitopes. J. Exp. Med. 178, 1459.
    • (1993) J. Exp. Med. , vol.178 , pp. 1459
    • Watts, C.1    Lanzavecchia, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.