Comparative in vivo behavior studies of cyclen-based copper-64 complexes: Regioselective synthesis, X-ray structure, radiochemistry, log P, and biodistribution

Journal of Medicinal Chemistry

Volumn 47, Issue 26, 2004, Pages 6625-6637

  Yoo, Jeongsoo ^a   Reichert, David E ^a   Welch, Michael J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 TERT BUTYLBENZYL) 1,4,7,10 TETRAAZACYCLODODECANE; 1 (CARBOXYMETHYL) 4,7,10 TRIS(4 TERT BUTYLBENZYL) 1,4,7,10 TETRAAZACYCLODODECANE; 1,4 BIS(4 TERT BUTYLBENZYL) 1,4,7,10 TETRAAZACYCLODODECANE; 1,4 BIS(CARBOXYMETHYL) 7,10 BIS(4 TERT BUTYLBENZYL) 1,4,7,10 TETRAAZACYCLODODECANE; 1,4,7 TRIS(4 TERT BUTYLBENZYL) 1,4,7,10 TETRAAZACYCLODODECANE; 1,4,7 TRIS(CARBOXYMETHYL) 10 (4 TERT BUTYLBENZYL) 1,4,7,10 TETRAAZACYCLODODECANE; 1,4,7,10 TETRA(4 TERT BUTYLBENZYL) 1,4,7,10 TETRAAZACYCLODODECANE; 1,4,7,10 TETRAAZACYCLODODECANE; 1,7 BIS(4 TERT BUTYLBENZYL) 1,4,7,10 TETRAAZACYCLODODECANE; 1,7 BIS(CARBOXYMETHYL) 4,10 BIS(4 TERT BUTYLBENZYL) 1,4,7,10 TETRAAZACYCLODODECANE; 4 TERT BUTYLBENZYL; ACETIC ACID; BENZYL DERIVATIVE; CHLORIDE ION; COPPER 64; METAL COMPLEX; NITROGEN; UNCLASSIFIED DRUG;

ABSORPTION SPECTROSCOPY; ALKYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COPPER METABOLISM; CRYSTAL STRUCTURE; DEPROTECTION REACTION; DRUG CLEARANCE; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HYDROPHOBICITY; IN VIVO STUDY; ISOMER; LIGAND BINDING; LIPOPHILICITY; LIVER CLEARANCE; NONHUMAN; PARTITION COEFFICIENT; PLASMA CLEARANCE; RADIOCHEMISTRY; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TISSUE DISTRIBUTION; X RAY DIFFRACTION;

ANIMALS; COPPER RADIOISOTOPES; CRYSTALLOGRAPHY, X-RAY; FEMALE; HETEROCYCLIC COMPOUNDS; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 10844262360     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0496990     Document Type: Article

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