Principles of pharmacodynamics and their applications in veterinary pharmacology

Journal of Veterinary Pharmacology and Therapeutics

Volumn 27, Issue 6, 2004, Pages 397-414

  Lees, P ^a   Cunningham, F M ^a   Elliott, J ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT;

ANIMAL CARE; ANTIMICROBIAL ACTIVITY; COMPETITIVE INHIBITION; CONFERENCE PAPER; DOSE TIME EFFECT RELATION; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG TARGETING; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; VETERINARY MEDICINE;

ANIMALS; MODELS, ANIMAL; MODELS, BIOLOGICAL; PHARMACOLOGY; VETERINARY DRUGS;

ANIMALIA;

EID: 10844235779     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2004.00620.x     Document Type: Conference Paper

References (32)

1. Aliabadi, F.S. & Lees, P. (2000) Antibiotic treatment for animals: effect on bacterial population and dosage regimen optimisation. International Journal of Antimicrobial Agents, 14, 307-313.
2. Aliabadi, F.S. & Lees, P. (2002) Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of marbofloxacin in calf serum, exudate and transudate. Journal of Veterinary Pharmacology and Therapeutics, 25, 161-174.
3. Allabadi, F.S. & Lees, P. (2003a) Pharmacokinetics (PK) pharmacodynamics (PD) and PK-PD integration of danofloxacin in sheep biological fluids. Antimicrobial Agents and Chemotherapy, 47, 626-635.
4. Aliabadi, F.S. & Lees, P. (2003b) Pharmacokinetic-pharmacodynamic integration of danofloxacin in the calf. Research in Veterinary Science, 74, 247-259.
5. Ariens, E.J. (1954) Affinity and intrinsic activity in the theory of competitive inhibition. Archives Internationale Pharmacodynamic Therapie, 99, 32-49.
6. 1B/1D receptors mediating vasoconstriction of equine digital arteries and veins. European Journal of Pharmacology, 355, 175-187. Reprinted with permission from Elsevier.
7. Benz, F.W. (1997a) Pharmacodynamics: drug-receptor interactions. Fig 2-18. In: Textbook of Ocular Pharmacology. Ed. Zimmerman, T.J. Lippincott-Raven Publishers. Philadelphia, PA, USA. Figure reproduced with permission.
8. Benz, F.W. (1997b) Pharmacodynamics: drug-receptor interactions. In Textbook of Ocular Pharmacology. Ed. Zimmerman, T.J. Lippincott-Raven Publishers, Philadelphia, PA, USA.
9. Black, J.W. & Stephensen, J.S. (1962) The pharmacology of a new β-adrenergic receptor blocking compound (nethalide). Lancet, ii, 311-314.
10. Black, J.W. & Leff, P. (1983) Operational model of pharmacological agonist. Proceedings of the Royal Society of London (Biology), 220, 141-162.
11. Clark, A.J. (1937). General pharmacology. In Heffner's Handbuch der Experimentellen Pharmacologie Erganzungsband, Band 4. pp. 38-51. Springer, Berlin.
12. Dale, H.H. (1906) On some physiological actions of ergot. Journal of Physiology, 34, 163-206.
13. Ebert, S.C. (1995). Pharmacokinetic-pharmacodynamic modeling of irreversible drug effects. In Handbook of Pharmacokinetic/Pharmacodynamic Correlation. Eds Derendorf, H. & Hockhaus, G. pp. 35-55. CRC Press, Boca Raton, FL, USA (Chapter 2).
14. Ehrlich, P. (1909) Über den jetzigen Stand der Chemotherapie. Berichte der Deutschen Chemischen Gesellschaft, 42, 17-47.
15. Elliott, J. & Brady, F.E. (1998) Characterization of vasodilatory adenosine receptors in equine digital veins. Journal of Veterinary Pharmacology and Therapeutics, 21, 74-81.
16. Giraudel, J.M., Toutain, P.L. & Lees, P. (2004) Development of in vitro assays for the evaluation of cyclooxygenase inhibitors and application for predicting the selectivity of NSAIDs in the cat. American Journal of Veterinary Research, in press.
17. Horn, J., Bailey, S., Berhane, Y., Marr, C.M. & Elliott, J. (2002) Density and binding characteristics of beta-adrenoceptors in the normal and failing equine myocardium. Equine Veterinary Journal, 34, 411-416.
18. Kenakin, T. (1997) Pharmacologic Analysis of Drug-Receptor Interaction, 3rd Edn. Lippincott-Raven, Philadelphia, PA, USA.
19. Lees, P. & Aliabadi, F.S. (2002) Rational dosing of antimicrobial drugs: animals versus humans. International Journal of Antimicrobial Agents, 19, 269-284.
20. Lees, P., Landoni, M.F., Giraudel, J.M. & Toutain, P.L. (2004) PK-PD integration and PK-PD modelling of non-steroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology. Journal of Veterinary Pharmacology and Therapeutics, 27, 491-502.
21. Lees, P. & Toutain, P.L. (2004) PK-PD modelling: an alternative to dose titration studies for antimicrobial drug dosage selection. Regulatory Affairs Journal, 15, 1-6.
22. McKellar, Q.A., Sanchez, S.F. & Jones, D.G. (2004) Pharmacokinetic/pharmacodynamic relationships of antimicrobial drugs used in veterinary medicine. Journal of Veterinary Pharmacology and Therapeutics, 27, 503-514.
23. Neubig, R.R., Spedding, M., Kenakin, T. & Christopoulos, A. (2003) International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology. Pharmacological Reviews, 55, 597-606.
24. Nolting, A. & Derendorf, H. (1995) Pharmacokinetic/pharmacodynamic modelling of antibiotics. In Handbook of Pharmacokinetic/Pharmacodynamic Correlation. Eds Derendorf, H. & Hochhaus, G. pp. 363-387. CRC Press, Boca Raton, FL, USA (Chapter 15).
25. Paton, W.D.M. (1961) A theory of drug action based on the rate of drug-receptor combination. Proceedings of the Royal Society of London (Biology), 154, 21-69.
26. Stephenson, R.P. (1956) A modification of receptor theory. British Journal of Pharmacology, 11, 379-393.
27. Toutain, P.L., Cester, C.C., Haak, T. & Metge, S. (2001) Pharmacokinetic profile and in vitro selective cyclooxygenase-2 inhibition by nimesulide in the dog. Journal of Veterinary Pharmacology and Therapeutics, 24, 35-42.
28. Toutain, P.L., Del Castillo, J.R.E. & Bousquet-Melou, A. (2002) The pharmacokinetic-pharmacodynamic approach to a rational dosage regimen for antibiotics. Research in Veterinary Science, 73, 105-114.
29. Toutain, P.L. (2003) Pharmacokinetics/pharmacodynamics integration in dosage regimen optimisation for veterinary medicine. Journal of Veterinary Pharmacology and Therapeutics, 26 (Suppl. 1), 1-8.
30. Toutain, P.L. & Lees, P. (2004) Integration and modelling of pharmacokinetic and pharmacodynamic data to optimise dosage regimens in veterinary medicine. Journal of Veterinary Pharmacology and Therapeutics, 27, 467-477.
31. Zhi, J., Nightingale, C.H. & Quintiliani, R. (1986) A pharmacodynamic model for the activity of antibiotics against microorganisms under nonsaturable conditions. Journal of Pharmaceutical Sciences, 75, 1063-1069.
32. Zhi, J., Nightingale, C.H. & Quintiliani, R. (1988) Microbial pharmacodynamics of piperacillin in neutropenic mice of systemic infection due to Pseudomonas aerguinosa. Journal of Pharmacokinetics and Biopharmaceutics, 16, 359-361.