Solid-phase synthesis and conformational properties of angiotensin converting enzyme catalytic-site peptides: The basis for a structural study on the enzyme-substrate interaction

Biopolymers - Peptide Science Section

Volumn 76, Issue 6, 2004, Pages 512-526

  Galanis, Athanassios S ^a   Spyroulias, Georgios A ^a   Pairas, George ^a   Manessi Zoupa, Evy ^a   Cordopatis, Paul ^a  

^a UNIVERSITY OF PATRAS   (Greece)

Author keywords

Angiotenisn I; Angiotensin converting enzyme; Chemical shift index; NMR spectroscopy; Structure determination

Indexed keywords

BIOSYNTHESIS; CARBOXYLATION; CONFORMATIONS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE; SUBSTRATES;

ANGIOTENSIN CONVERTING ENZYME (ACE); BIOLOGICAL STRUCTURES; ENZYME SEQUENCES; SOLID-PHASE SYNTHESIS;

POLYPEPTIDES;

9 FLUORENYLMETHYL CHLOROFORMATE; ANGIOTENSIN I; DIPEPTIDYL CARBOXYPEPTIDASE; PEPTIDE DERIVATIVE; ZINC;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CONFERENCE PAPER; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; ENZYME SYNTHESIS; MODEL; PROTEIN DOMAIN; PROTON NUCLEAR MAGNETIC RESONANCE; SOLID STATE; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANGIOTENSIN I; ANIMALS; CATALYTIC DOMAIN; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PEPTIDYL-DIPEPTIDASE A; PROTEIN CONFORMATION; SOLUTIONS; SUBSTRATE SPECIFICITY; ZINC;

EID: 10844220487     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/bip.20163     Document Type: Conference Paper

References (48)

1. Piquilloud, Y.; Reinharz, A.; Roth, M. Biochim Biophys Acta 1970, 206, 136-142.
2. Soffer, R. L. Annu Rev Biochem 1976, 45, 73-94.
3. Hooper, N. M. FEBS Lett 1994, 354, 1-6.
4. Yang, H. Y. Y.; Erdös, E. G.; Levin, V. A. Biochim Biophys Acta 1970, 214, 374-376.
5. Burell, L. M.; Johnston, C. I. In Drugs, Enzymes, and Receptors of the Renin-Angiotensin System: Celebrating a Century of Discovery; Husain, A., Graham, R. M., Eds.; Harwood Academic Publishers, The Netherlands, 2000; pp 191-200.
6. Skeggs, L. T.; Kahn, J. R.; Shumway, N. P. J Exp Med 1956, 103, 295-299.
7. Bönning, P.; Riordan, J. F. Biochemistry 1983, 22, 110-116.
8. Ehlers, M. R. W.; Fox, E. A.; Strydom, D. J.; Riordan, J. F. Proc Natl Acad Sci USA 1989, 86, 7741-7745.
9. Lattion, A. L.; Soubrier, F.; Allegrini, J.; Hubert, C.; Corvol, P.; Alhenc-Gelas, F. FEBS Lett 1989, 252, 99-104.
10. Ehlers, M. R.; Riordan, J. F. Biochemistry. 1991, 30, 7118-7126.
11. Rieder, M. J.; Taylor, S. L.; Clark, A. G.; Nickerson, D. A. Nat Genet 1999, 22, 59-62.
12. Barrett, A. J.; Rawlings, N. D.; Woessner, J. F. In Handbook of Proteolytic Enzymes; Academic Press, New York, 1998; pp 992-993.
13. Ferreira, S. H.; Bartelt, D. C.; Greene, L. J. Biochemistry 1970, 9, 2583-2593.
14. Ondetti, M. A.; Williams, N. J.; Sabo, E. F.; Pluscec, J.; Weaver, E. R.; Kocy, O. Biochemistry 1971, 10, 4033-4039.
15. Cheung, H. S.; Cushman, D. W. Biochim Biophys Acta 1973, 293, 451-463.
16. Steitz, T. A.; Ludwig, M. L.; Quiocho, F. A.; Lipscomb, W. N. J Biol Chem 1967, 242, 4662-4668.
17. Cushman, D. W.; Ondetti, M. A. Nat Med 1999, 5, 1110-1113.
18. Natesh, R.; Schwager, S. L.; Sturrock, E. D.; Acharya, K. R. Nature 2003, 421, 551-554.
19. Kim, H. M.; Shin, D. R.; Yoo, O. J.; Lee, H.; Lee, J. O. FEBS Lett 2003, 538, 65-70.
20. Towler, P.; Staker, B.; Prasad, S. G.; Menon, S.; Tang, J.; Parsons, T.; Ryan, D.; Fisher, M.; Williams, D.; Dales, N. A.; Patane, M. A.; Pantoliano, M. W. J Biol Chem 2004, 279, 17996-18007.
21. Galanis, A. S.; Spyroulias, G. A.; Pierattelli, R.; Tzakos, A.; Troganis, A.; Gerothanassis, I. P.; Pairas, G.; Manessi-Zoupa, E.; Cordopatis, P. Biopolymers 2003, 69, 244-252.
22. Spyroulias, G. A.; Galanis, A. S.; Pairas, G.; Manessi-Zoupa, E.; Cordopatis P. Curr Top Med Chem 2004, 4, 403-429.
23. Holland, D. R.; Hausrath, A. C.; Juers, D.; Matthews, B. W. Protein Sci 1995, 4, 1955-1965.
24. Colman, P. M; Jansonius, J. N.; Matthews, B. W. J Mol Biol 1972, 70, 701-724.
25. Matthews, B. W.; Weaver, L. H.; Kester W. R. J Biol Chem 1974, 249, 8030-8044.
26. Holmes, M. A.; Matthews, B. W. J Mol Biol 1982, 160, 623-639.
27. Garnier, J.; Osguthorpe, D. J.; Robson, B. J Mol Biol 1978, 120, 97-120.
28. Carpino, L. A.; Han, G. Y. J Am Chem Soc 1970, 92, 5748-5749.
29. Barlos, K.; Gatos, D.; Kallitsis, J.; Papaphotiou, G.; Sotiriou, P.; Wenquing, Y.; Shafer, W. Tetraedron Lett 1989, 30, 3943-3946.
30. King, D. S.; Fields, C. G.; Fields G. B. Int J Pept Protein Res 1990, 36, 255-266.
31. Piantini, U.; Sorensen, O. W.; Ernst, R. R. J Am Chem Soc 1982, 104, 6800-6801.
32. Bax, A.; Davis, D. G. J Magn Reson 1985, 65, 355-360.
33. Palmer, A. G., III; Cavanagh, J.; Wright, P. E.; Ranee M. J Magn Reson 1991, 93, 151-170.
34. Marion, D.; Wüthrich, K. Biochem Biophys Res Commun 1983, 113, 967-974.
35. Jeener, J.; Meier, B. H.; Bachmann, P.; Ernst R. R. J Chem Phys 1979, 71, 4546-4553.
36. Macura, S.; Wüthrich, K.; Ernst, R. R. J Magn Reson 1982, 47, 351-357.
37. Eccles, C.; Güntert, P.; Billeter, M.; Wüthrich, K. J Biomol NMR 1991, 1, 111-130.
38. Güntert, P.; Braun, W.; Wüthrich, K. J Mol Biol 1991, 217, 517-530.
39. Wüthrich, K. In NMR of Proteins and Nucleic Acids; Wiley: New York, 1986.
40. Wishart, D.; Sykes, B.; Richards, F. J Mol Biol 1991, 222, 311-333.
41. Wishart, D.; Sykes, B.; Richards, F. Biochemistry 1992, 31, 1647-1651.
42. Merutka, G.; Dyson, H. J.; Wright, P. E. J Biomol NMR 1995, 5, 14-24.
43. Güntert, P.; Mumenthaler, C.; Wüthrich, K. J Mol Biol 1997, 273, 283-298.
44. Wüthrich, K.; Billeter, M.; Brown, W. J Mol Biol 1983, 169, 949-961.
45. Koradi, R.; Billeter, M.; Wüthrich, K. J Mol Graph 1996, 14, 51-55.
46. Zuiderweg, E. R. P. Biochemistry 2002, 41, 1-7.
47. Spyroulias, G. A.; Nikolakopoulou, P.; Tzakos, A.; Gerothanassis, I. P.; Magafa, V.; Manessi-Zoupa, E.; Cordopatis, P. Eur J Biochem 2003, 270, 2163-2173.
48. Brown, C. K.; Madauss, K; Lian, W.; Beck, M. R.; Tolbert, W. D.; Rodgers, D. W. Proc Natl Acad Sci USA 2001, 98, 3127-3132.