Mutation and association analysis of the Fyn kinase gene with alcoholism and schizophrenia

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 96, Issue 6, 2000, Pages 716-720

  Ishiguro, Hiroki ^a   Saito, Toshikazu ^b   Shibuya, Haruo ^c   Toru, Michio ^d   Arinami, Tadao ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b University Sapporo   (Japan)

^c National Minamihanamaki Hospital   (Japan)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Disequilibrium; Intron; Linkage; Polymorphism; Promoter

Indexed keywords

ALCOHOL; MICROSATELLITE DNA; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN TYROSINE KINASE;

ADULT; AGED; ALCOHOLISM; ARTICLE; CHROMOSOME 6Q; CONTROLLED STUDY; DNA FLANKING REGION; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENE MUTATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; INTRON; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; SCHIZOPHRENIA; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 0034606263     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/1096-8628(20001204)96:6<716::aid-ajmg3>3.0.co;2-n     Document Type: Article

References (18)

1. Effects of c-Src tyrosine kinase on ethanol sensitivity of recombinant NMDA receptors expressed in HEK 293 cells
2. Fyn tyrosine kinase reduces the ethanol inhibition of recombinant NR1/NR2A but not NR1/NR2B NMDA receptors expressed in HEK 293 cells
3. Nonreceptor tyrosine protein kinases
4. Tyrosine kinases and synaptic transmission
5. Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees
6. Current methods of mutation detection
7. The Src family of protein tyrosine kinases: Regulation and functions
8. Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice
9. Overexpression of src family gene for tyrosine-kinase p59fyn in CD4-CD8- T cells of mice with a lymphoproliferative disorder
10. Abnormal synaptic transmission in the olfactory bulb of Fyn-kinase-deficient mice
11. Fyn-kinase as a determinant of ethanol sensitivity: Relation to NMDA-receptor function
12. Fyn, a Src family tyrosine kinase
13. Relapse prevention by acamprosate. Results from a placebo-controlled study on alcohol dependence
14. Schizophrenia and glutamatergic transmission
15. Cellular functions regulated by Src family kinases
16. Comparison of acamprosate and placebo in long-term treatment of alcohol dependence
17. Molecular mechanisms of Fyn-tyrosine kinase for regulating mammalian behaviors and ethanol sensitivity
18. Regional localization of Fyn in adult brain; studies with mice in which fyn gene was replaced by lacZ