Red and white wine differently affect collagen-induced platelet aggregation

Pathophysiology of Haemostasis and Thrombosis

Volumn 32, Issue 5-6, 2002, Pages 356-358

  Pignatelli, Pasquale ^a   Lenti, Luisa ^a   Pulcinelli, Fabio M ^a   Catasca, Roberto ^c   Saccani, Gloria ^c   Germanò, Giuseppe ^a   Marcoccia, Antonella ^a   Silvestri, Maria Assunta ^c   Ghiselli, Andrea ^b   Violi, Francesco ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

^c UNIVERSITY OF PARMA   (Italy)

Author keywords

Flavonoids; Platelets; Wine

Indexed keywords

ALCOHOL; COLLAGEN; POLYPHENOL DERIVATIVE; RECEPTOR BLOCKING AGENT; DIAGNOSTIC AGENT;

ADULT; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; LABORATORY; LABORATORY TEST; MALE; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; WINE; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; DRINKING BEHAVIOR; DRUG EFFECT; MEDITERRANEAN DIET; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL;

ADULT; ALCOHOL DRINKING; COLLAGEN; DIET, MEDITERRANEAN; FEMALE; HUMANS; MALE; MIDDLE AGED; PLATELET AGGREGATION; WINE;

EID: 10744233525     PISSN: 14248832     EISSN: None     Source Type: Journal    
DOI: 10.1159/000073599     Document Type: Conference Paper

References (15)

1. Di Castelnuovo A, Rotondo S, Iacoviello L, Donati MB, De Gaetano G: Meta-analysis of wine and beer consumption in relation to vascular risk. Circulation. 2002;105:2836-44.
2. De Lorgeril M, Salen P, Martin JL, Boucher F, Paillard F, De Leiris J: Wine drinking and risks of cardiovascular complications after recent acute myocardial infarction. Circulation. 2002;106:1465-9.
3. Goldberg IJ, Mosca L, Piano MR, et al. AHA Science Advisory: Wine and your heart: a science advisory for healthcare professionals from the Nutrition Committee, Council on Epidemiology and Prevention, and Council on Cardiovascular Nursing of the American Heart Association. Circulation 2001;103:472-5.
4. Demrow HS, Slane PR, and Folts JD. Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries. Circulation 1995; 91: 1182-88.
5. Freedman JE, Parker C 3rd, Li L, et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 2001;103 :2792-8.
6. Neiva TJ, Morais L, Polack M, et al. Effects of catechins on human blood platelet aggregation and lipid peroxidation. Phytother Res 1999;13(7):597-600.
7. Wang Z, Huang Y, Zou J, et al. Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro. Int J Mol Med 2002;9(1):77-9.
8. Janssen PLTMK, Mensink RP, Cox FJJ, et al. Effect of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and dietary supplement study. Am J Clin Nutr 1998; 67: 255-62.
9. Wu JM, Wang ZR, Hsieh TC, et al. Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine. Int J Mol Med. 2001; 8:3-17.
10. Pignatelli P, Pulcinelli FM, Celestini A, et al. The flavonoids quercetin and catechin synergistically inhibit platelet function by antagonizing the intracellular production of hydrogen peroxide. Am. J. Clin. Nutr 2000; 72:1150-5.
11. Pignatelli P, Pulcinelli FM, Lenti L, et al. Hydrogen peroxide is involved in collagen-induced platelet activation. Blood 1998; 91: 484-490.
12. Pignatelli P, Pulcinelli FM, Lenti L, et al. Vitamin E inhibits collagen induced platelet activation by blunting hydrogen peroxide. Arterioscler Thromb Vasc Biol 1999; 91: 2542-2547.
13. Armitage P, Berry G. Statistical methods in Medical Research. 2nd ed. Blackwell Scientific, 1990.
14. Pace-Asciak CR, Rounova O, Hahn S, et al. Wines and grape juices as modulator of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82.
15. Violi F, Pignatelli P, Pulcinelli FM. Synergysm among flavonoids in inhibiting platelet aggregation and H2O2 production. Circulation 2002; 105:53.