The study of mitoxantrone as a potential immunosuppressor in transgenic pig renal xenotransplantation in baboons: Comparison with cyclophosphamide

Xenotransplantation

Volumn 11, Issue 2, 2004, Pages 112-122

  Ashton Chess, Joanna ^a   Meurette, Guillaume ^a   Karam, Georges ^a   Petzold, Thomas ^b   Minault, David ^a   Naulet, Jeanne ^a   Tesson, Laurent ^a   Plat, Martine ^c   Anegon, Ignacio ^a   Soulillou, Jean Paul ^a   Blancho, Gilles ^a,d  

^a HÔTEL DIEU   (France)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UMR85 PHYSIOLOGIE DE LA REPRODUCTION ET DES COMPORTEMENTS   (France)

^d INSERM   (France)

Author keywords

Baboon; Mitoxantrone; Pig; Transgenic; Xenotransplantation

Indexed keywords

ANTIBODY; CD59 ANTIGEN; COMPLEMENT MEMBRANE ATTACK COMPLEX; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DECAY ACCELERATING FACTOR; GALACTOSYLGALACTOSE; GALACTOSYLGALACTOSE ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOSUPPRESSIVE AGENT; MITOXANTRONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; BABOON; BLOOD TOXICITY; CARDIOTOXICITY; COMPLEMENT ACTIVATION; CONTROLLED STUDY; DELAYED XENOGRAFT REJECTION; EXPERIMENTAL TRANSPLANTATION; GRAFT REJECTION; GRAFT SURVIVAL; HISTOPATHOLOGY; HUMORAL IMMUNITY; HYPERACUTE GRAFT REJECTION; IMMUNIZATION; IMMUNOGLOBULIN DEPOSITION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY FUNCTION; KIDNEY TRANSPLANTATION; LYMPHOCYTE DEPLETION; LYMPHOCYTIC INFILTRATION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; SWINE; T LYMPHOCYTE; TRANSGENIC ANIMAL; XENOTRANSPLANTATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIGENS, CD; ANTIGENS, CD55; ANTIGENS, CD59; CYCLOPHOSPHAMIDE; GRAFT REJECTION; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MITOXANTRONE; PAPIO; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 10744231680     PISSN: 0908665X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2004.00040.x     Document Type: Article

References (22)

1. Cozzl E, WHITE DJ. The generation of transgenic pigs as potential organ donors for humans. Nat Med 1995; 1: 964.
2. COWAN PJ, AMINIAN A, BARLOW H et al. Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons. Transplantation 2000; 69: 2504.
3. BUHLER L, YAMADA K, KITAMURA H et al. Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation. Transplantation 2001; 72: 1743.
4. ASHTON-CHESS J, ROUSSEL J, BERNARD P et al. The effect of immunoglobulin immunoadsorptions on delayed xenograft rejection of human CD55 transgenic pig kidneys in baboons. Xenotransplantation 2003; 10: 552.
5. ASHTON-CHESS J, ROUSSEL J, MANEZ R et al. Cellular participation in delayed xenograft rejection of hCD55 transgenic pig hearts by baboons. Xenotransplantation; In press.
6. VANGEROW B, HECKER JM, LORENZ R et al. Cl-inhibitor for treatment of acute vascular xenograft rejection in cynomolgus recipients of h-DAF transgenic porcine kidneys. Xenotransplantation 2001; 8: 266.
7. COZZl E, BHATTI F, SCHMOECKEL M et al. Long-term survival of nonhuman primates receiving life-supporting transgenic porcine kidney xenografts. Transplantation 2000; 70: 15.
8. LIN SS, HANAWAY MJ, GONZALEZ-STAWINSKI GV et al. The role of anti-Galalpha1-3Gal antibodies in acute vascular rejection and accommodation of xenografts. Transplantation 2000; 70: 1667.
9. ZAIDI A, SCHMOECKEL M, BHATTi F et al. Life-supporting pig-to-primate renal xenotransplantation using genetically modified donors. Transplantation 1998; 65: 1584.
10. VIAL CM, OSTLIE DJ, BHATTI FN et al. Life supporting function for over one month of a transgenic porcine heart in a baboon. J Heart Lung Transplant 2000; 19: 224.
11. CHEN RH, NAFICY S, LOGAN JS et al. Hearts from transgenic pigs constructed with CD59/DAF genomic clones demonstrate improved survival in primates. Xenotransplantation 1999; 6: 194.
12. PHELPS CJ, KOIKE C, VAUGHT TD et al. Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 2003; 299: 411.
13. BROUARD S, VANHOVE B, GAGNE K et al. T cell repertoire alterations of vascularized xenografts. J Immunol 1999; 162: 3367.
14. PETZOLD P, BARREAU N, ASHTON-CHESS J et al. The effect of Mitoxantrone on anti-pig immunization in baboons. Xenotransplantation 2003; 10: 422.
15. FIDLER JM, DEJOY SQ, GIBBONS JJ Jr. Selective immunomodulation by the antineoplastic agent mitoxantrone. I. Suppression of B lymphocyte function. J Immunol 1986; 137: 727.
16. FIDLER JM, DEJOY SQ, SMITH FR 3rd, GIBBONS JJ, Jr. Selective immunomodulation by the antineoplastic agent mitoxantrone. II. Nonspecific adherent suppressor cells derived from mitoxantrone-treated mice. J Immunol 1986; 136: 2747.
17. SLOBODA AE, ORONSKY AL, KERWAR SS. Studies of the effect of mitoxantrone on adjuvant induced arthritis in rats. Clin Immunol Immunopathol 1986; 40: 236.
18. BARREAU N, GODFRIN Y, BOUHOURS JF et al. Interaction of anti-HLA antibodies with pig xenoantigens. Transplantation 2000; 69: 148.
19. LOSS M, VANGEROW B, SCHMIDTKO J et al. Acute vascular rejection is associated with systemic complement activation in a pig-to-primate kidney xenograft model. Xenotransplantation 2000; 7: 186.
20. WATERWORTH PD, DUNNING J, TOLAN M et al. Life-supporting pig-to-baboon heart xenotransplantation. J Heart Lung Transplant 1998; 17: 1201.
21. DORLING A. Are anti-endothelial cell antibodies a pre-requisite for the acute vascular rejection of xenografts? Xenotransplantation 2003; 10: 16.
22. ZHONG R, Luo Y, YANG H et al. Improvement in human decay accelerating factor transgenic porcine kidney xenograft rejection with intravenous administration of gas914, a polymeric form of alphaGAL. Transplantation 2003; 75: 10.