Life supporting function for over one month of a transgenic porcine heart in a baboon

Journal of Heart and Lung Transplantation

Volumn 19, Issue 2, 2000, Pages 224-229

  Vial, C M ^a,b,c   Ostlie, D J ^c,d   Bhatti, F N K ^b,c   Cozzi, E ^c,e   Goddard, M ^b   Pino Chavez, G ^c   Wallwork, J ^b   White, D J G ^c,e   Dunning, J J ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PAPWORTH HOSPITAL   (United Kingdom)

^c Imutran Ltd A Novartis Pharma AG C   (United Kingdom)

^d MAYO CLINIC   (United States)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DECAY ACCELERATING FACTOR; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; AUTOPSY; BABOON; CONTROLLED STUDY; GRAFT REJECTION; HEART GRAFT; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HISTOPATHOLOGY; HUMORAL IMMUNITY; IMMUNOSUPPRESSIVE TREATMENT; LONG TERM CARE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL TIME; SWINE; TRANSGENIC ANIMAL; XENOTRANSPLANTATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIBODY FORMATION; ANTIGENS, CD55; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNITY, CELLULAR; IMMUNOSUPPRESSIVE AGENTS; LIFE SUPPORT CARE; MYOCARDIUM; PAPIO; SWINE; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS;

EID: 0033981751     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1053-2498(99)00099-6     Document Type: Article

References (21)

1. United Network for Organ Sharing, Richmond, Virginia. World Wide Web Site (www.unos.org).
2. Report on Transplant Activity -1997. United Kingdom Transplant Support Service Authority.
3. Evans R.W., Orians C.E., Ascher N.L. The potential supply of organ donors an assessment of the efficacy of organ procurement efforts in the United States . JAMA. 267:1992;239-246.
4. Calne R.Y. Organ transplantation between widely disparate species. Transplant Proc. 11:1970;550-556.
5. Cozzi E., White D.J.G. The generation of transgenic pigs as potential organ donors for humans. Nature Medicine. 1:(9):1995;964-966.
6. Cozzi E, Yannoutsos N, Langford GA, Pino-Cavez G, Wallwork J, White DJG. Effect of transgenic expression of hDAF on the inhibition of hyperacute rejection of pig organs. in Xenotransplantation 2nd ed., edited by Cooper DKC, Kemp E, Platt JL, White DJG. Berlin: Springer-Verlag, 1997.
7. Schmoeckel M., Nollert G., Shahmohammadi M., et al. Prevention of hyperacute rejection by human decay accelerating factor in xenogeneic perfused working hearts. Transplantation. 62:1996;729-734.
8. Bhatti FNK, Cozzi E, Zaidi A, et al. Immunosuppression of pig to primate cardiac xenografts. submitted.
9. Schmoeckel M., Bhatti F.N.K., Zaidi A., et al. Orthotopic heart transplantation in a transgenic pig to primate model. Transplantation. 65:1998;1570-1577.
10. Cozzi E., Tucker A.W., Langford G.A., et al. Characterisation of pigs transgenic for human decay accelerating factor. Transplantation. 64:1997;1383-1392.
11. Rosengard A.M., Cary N.R.B., Langford G.A., Tucker A.W., Wallwork J., White D.J.G. Tissue expression of human complement inhibitor, decay accelerating factor, in transgenic pigs-a potential approach for preventing xenograft rejection. Transplantation. 59:1995;1325-1333.
12. Lower R.R., Shumway N.E. Studies on the orthotopic homotransplantation of the canine heart. Surg Forum. 11:1960;18.
13. Stark J.H., Smit J.A., Gridelli B. Sensitivity of baboon lymphocytes to cyclosporin A and FK506 relative resistance of alloactivated cells to CyA . Transplant Int. 7:1994;372-378.
14. Good A.H., Cooper D.K.C., Malcolm A.J., et al. Identification of carbohydrate structures that bind human antiporcine antibodies implications for discordant xenografting in humans . Transpl Proc. 24:1992;559-562.
15. Galili U. Significance of natural human anti-Gal antibody in xenotransplantation. Xeno. 2:1994;84-87.
16. Sandrin M.S., Vaughan H.A., Dabkowski P.L., et al. Anti-pig IgM antibodies in human serum react predominantly with Gal(alpha 1-3)Gal epitopes. Proc Natl Acad Sci USA. 90:(23):1993;11391-11395.
17. Reding R., Davies H., White D., et al. Effect of plasma exchange on guinea pig-to-rat heart xenografts. Transplant Proc. 21:1989;534.
18. Cooper D.K.C., Human P.A., Lexer G., et al. Effects of cyclosporin and antibody adsorption on pig cardiac xenograft survival in the baboon. J Heart Transplant. 7:1988;238-246.
19. Leventhal J.R., Dalmasso A.P., Cromwell J.W., et al. Prolongation of cardiac xenograft survival by depletion of complement. Transplantation. 55:1993;857-866.
20. O'Hair D.P., McManus R.P., Komorowski R. Inhibition of chronic vascular rejection in primate cardiac xenografts using mycophenolate mofetil. Ann Thorac Surg. 58:1995;1311-1315.
21. Xu H., Gundry S.R., Hancock W.W., et al. Prolonged discordant xenograft survival and delayed xenograft rejection in a pig-to-baboon orthotopic cardiac xenograft model. J Thorac Cardiovasc Surg. 115:1998;1342-1349.