Association between plasma homocysteine levels and coronary artery disease: A population-based study in northern Greece

Current Medical Research and Opinion

Volumn 20, Issue 2, 2004, Pages 175-180

  Boufidou, Amalia I ^a,b   Makedou, Areti D ^a   Adamidis, Dimitrios N ^a   Karvounis, Haralampos I ^a   Gourassas, John T ^a   Kesidis, Haralampos T ^a   Makedou, Kali G ^a   Papadopoulos, Christodoulos E ^a   Parharidis, Georgios E ^a   Louridas, Georgios E ^a  

^a AHEPA UNIVERSITY HOSPITAL   (Greece)

^b NONE   (Greece)

Author keywords

Coronary artery disease; Homocysteine; Risk factor

Indexed keywords

ACETYLSALICYLIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; CYANOCOBALAMIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FOLIC ACID; HOMOCYSTEINE; LIPOPROTEIN; STATINE DERIVATIVE;

ADULT; AGED; ANAMNESIS; ANGIOGRAPHY; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIET RESTRICTION; FEMALE; FOLIC ACID BLOOD LEVEL; GREECE; HEART INFARCTION; HUMAN; LIPOPROTEIN BLOOD LEVEL; MALE; MULTIVARIATE ANALYSIS; POPULATION RESEARCH; PROSPECTIVE STUDY; RISK FACTOR; VITAMIN BLOOD LEVEL;

ADULT; AGED; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CORONARY DISEASE; FEMALE; GREECE; HOMOCYSTEINE; HUMANS; LOGISTIC MODELS; MALE; MATCHED-PAIR ANALYSIS; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 10744229616     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/030079903125002856     Document Type: Article

References (28)

1. Mudd SH, Levy HL, Skovby G. Disorders of transulfuration. In: Scriver C, Beaudet AL, Sly WS, Valle D, eds. The Metabolic Basis of Inherited Disease, 6th edn, Vol. 1. New York: McGraw-Hill, 1989:693-734
2. Mudd SH, Skovby F, Levy HL, et al. The natural history of homocystinuria due to cystathionine beta-synthase deficiency. Am J Hum Genet 1985;37:1-31
3. Refsum H, Ueland PM, Nygard O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med 1998;49:31-62
4. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. JAMA 1995;274:1049-57
5. Cleophas TJ, Hornstra N, van Hoogstraten B, van der Meulen J. Homocysteine, a risk factor for coronary artery disease or not? A meta-analysis. Am J Cardiol 2000;86:1005-9
6. Murphy-Chutorian DR, Wexman MP, Grieco AJ, et al. Methionine intolerance: a possible risk factor for coronary artery disease. J Am Coll Cardiol 1985;6:725-30
7. Genest JJ Jr, Mc Namara JR, Salem DN, Wilson PW, Schaefer EJ, Malinow MR. Plasma homocysteine levels in men with premature coronary artery disease. J Am Coll Cardiol 1990;16:1114-19
8. Kang S-S, Wong PW, Cook HY, et al. Protein-bound homocysteine: a possible risk factor for coronary artery disease. J Clin Invest 1986;77:1482-6
9. Wilcken DEL, Reddy SG, Gupta VJ. Homocysteinemia ischemic heart disease, and the carrier state for homocystinuria. Metabolism 1983;32:363-70
10. Israelsson B, Brattstrom LE, Hultberg BL. Homocysteine and myocardial infarction Atherosclerosis 1988;71:227-33
11. Ubbink JB, Vermaak WJH, Bennett JM, Becker PI, van Staden DA, Bissbort S. The prevalence of homocysteinemia and hypercholesterolemia in angiographically defined coronary artery disease Klin Wochenschr 1991;69:527-34
12. 12 concentrations and risk for early-onset coronary artery disease Am J Clin Nutr 1994;59:940-8
13. von Eckardstein A, Malinow MR, Upson B, et al. Effects of age, lipoproteins, and hemostatic parameters on the role of homocyst(e)inemia as a cardiovascular risk factor in men. Arterioscler Thromb Vasc Biol 1994;14:460-4
14. Wu LL, Wu J, Hunt SC, et al. Plasma homocyst(e)ine as a risk factor for early familial coronary artery disease. Clin Chem. 1994;40:552-61
15. 6, pyridoxal phosphate, and folate. Am J Cardiol 1995;75:1107-11
16. Landgren F, Israelsson B, Lindgren A, Hultberg B, Anderson A, Brattstrom L. Plasma homocysteine in acute myocardial infarction: homocysteine-lowering effect of folic acid. J Intern Med 1995;237:381-8
17. Robinson K, Mayer EL, Miller DP, et al. Hyperhomocysteinemia and low pyridoxal phosphate: common and independent reversible risk factors for coronary artery disease. Circulation 1995;92:2825-30
18. 12, and folate. Am J Epidemiol 1996;143:845-59
19. Graham IM, Daly LE, Refsum HM, et al. Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project. JAMA 1997;277:1775-81
20. Schwartz SM, Siscovick DS, Malinow MR, et al. Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylene-tetrahydrofolate reductase gene. Circulation 1997;96:412-17
21. Verhoef P, Kok FJ, Kruyssen ACM, et al. Plasma total homocysteine, B vitamins and risk of coronary atherosclerosis. Arterioscler Thromb Vasc Biol 1997;17:989-95
22. Doshi SN, McDowell Ian FW, Moat SJ, et al. Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering. Circulation 2002;105:22-6
23. Evans RW, Shaten BJ, Hempel JD, et al. Homocysteine and risk of cardiovascular disease in the Multiple Risk Factor Intervention Trial. Arterioscler Thromb Vasc Biol 1997;17:1947-53
24. Christen WG, Ajani UA, Glynn RJ, Hennekens CH. Blood levels of homocysteine and increased risks of cardiovascular disease. Arch Intern Med 2000;160:422-34
25. Nygard O, Nordrehaug JE, Refsum H, et al. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997;337:230-6
26. Welch NG, Loscalzo J. Homocysteine and atherothrombosis (review article). N Engl J Med 1998;338:1042-50
27. Stubbs PJ, Al-Obaidi MK, Conroy RM, Collinson PO, et al. Effect of plasma homocysteine concentration on early and late events in patients with acute coronary syndromes. Circulation 2000;102:605-10
28. Schnyder G, Pin R, Roffi M, Flammer Y, Hess OM. Association of plasma homocysteine with the number of major coronary arteries severely narrowed. Am J Cardiol 2001;88:1027-30