Evidence for a Selective Role of the δ-Opioid Agonist [8R-(4bS*, 8aα,8aβ,12bβ )]7,10-Dimethyl-1-methoxy-11-(2-methylpropyl)oxycarbonyl 5,6,7,8,12,12b-hexahydro-(9H)-4,8-methanobenzofuro[3,2-e]pyrrolo[2,3-g] isoquinoline Hydrochloride (SB-235863) in Blocking Hyperalgesia Associated with Inflammatory and Neuropathic Pain Responses

Journal of Pharmacology and Experimental Therapeutics

Volumn 307, Issue 3, 2003, Pages 1079-1089

  Petrillo, Paola ^a   Angelici, Ornella ^a   Bingham, Sharon ^b   Ficalora, Giovanna ^a   Garnier, Martine ^a   Zaratin, Paola F ^a   Petrone, Giuseppe ^a   Pozzi, Ottorino ^a   Sbacchi, Massimo ^a   Stean, Tania O ^b   Upton, Neil ^b   Dondio, Guillio M ^a   Scheideler, Mark A ^a,c  

^a GSK   (Italy)

^b Neurol Ctr Excellence Drug Discov   (United Kingdom)

^c Box 16 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7,10 DIMETHYL 1 METHOXY 11 (2 METHYLPROPYL)OXYCARBONYL 5,6,7,8,12,12B HEXAHYDRO (9H) 4,8 METHANOBENZOFURO[3,2 E]PYRROLO[2,3 G]ISOQUINOLINE; CARRAGEENAN; DELTA OPIATE RECEPTOR AGONIST; KAPPA OPIATE RECEPTOR ANTAGONIST; MORPHINAN DERIVATIVE; MU OPIATE RECEPTOR ANTAGONIST; NALTRINDOLE; PYRROLE DERIVATIVE; SB 235863; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; EMBRYO CELL; HOT PLATE TEST; HUMAN; HUMAN CELL; HYPERALGESIA; INFLAMMATION; NEUROPATHIC PAIN; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TAIL FLICK TEST;

ANIMALS; BINDING, COMPETITIVE; CARRAGEENAN; CELLS, CULTURED; CONVULSANTS; CYCLIC AMP; ELECTROSHOCK; ENZYMES; GASTROINTESTINAL TRANSIT; GENES, REPORTER; HYPERALGESIA; INFLAMMATION; INJECTIONS, INTRAVENTRICULAR; LUCIFERASES; MALE; MORPHINE DERIVATIVES; MUSCULOSKELETAL EQUILIBRIUM; NARCOTICS; PENTYLENETETRAZOLE; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA; SCIATIC NEUROPATHY; SEIZURES; TRANSFECTION;

EID: 10744228114     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.055590     Document Type: Article

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