Alteration of p16 (CDKN2) gene is associated with interleukin-2-induced tumor cell growth in adult T-cell leukemia

Experimental Hematology

Volumn 27, Issue 6, 1999, Pages 1004-1009

  Fujiwara, Hiroshi ^a   Arima, Naomichi ^a   Hashimoto Tamaoki, Tomoko ^b   Matsushita, Kakushi ^a   Ohtsubo, Hideo ^a   Arimura, Kosei ^a   Hidaka, Shiroh ^a   Tei, Chuwa ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Adult T cell leukemia; CDKN2; Cell growth; Leukemogenesis; P16

Indexed keywords

CYTOKINE; INTERLEUKIN 2; PROTEIN P16;

ARTICLE; CELL CYCLE; CELL GROWTH; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL; LEUKEMOGENESIS; PRIORITY JOURNAL; T CELL LEUKEMIA; TUMOR SUPPRESSOR GENE;

BLOTTING, SOUTHERN; CELL DIVISION; CYCLIN-DEPENDENT KINASE INHIBITOR P16; EXONS; GENE DELETION; HUMANS; INTERLEUKIN-2; LEUKEMIA, T-CELL; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL;

EID: 0033052641     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(99)00035-1     Document Type: Article

References (36)

1. Hinuma Y., Nagata K., Hanaoka M., Nakai M., Matsumoto T., Kinoshita K., Shirakawa S., Miyoshi I. Adult T cell leukemia. antigen in an ATL cell line and detection of antibodies to the antigen in human sera Proc Natl Acad Sci U S A. 78:1981;6476.
2. Yoshida M., Miyoshi I., Hinuma Y. Isolation and characterization of retrovirus (ATLV) from cell lines of adult T cell leukemia and its implication in the disease. Proc Natl Acad Sci U S A. 79:1982;2031.
3. Seiki M., Hattori S., Hirayama Y., Yoshida M. Human adult T cell leukemia virus. complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA Proc Natl Acad Sci U S A. 80:1983;3618.
4. Seiki M., Eddy R., Shows T.B., Yoshida M. Nonspecific integration of the HTLV provirus genome into adult T-cell leukaemia cells. Nature. 309:1984;640.
5. Sherr C.J., Roberts J.M. Inhibitions of mammalian G1 cyclin-dependent kinases. Genes Dev. 9:1995;1149.
6. Serrano M., Hannon G.J., Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature. 366:1993;704.
7. Yokota J., Wada M., Shimosato Y., Terada M., Sugimura T. Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung. Proc Natl Acad Sci U S A. 84:1987;9252.
8. Kamb A., Gruis N.A., Weaver-Feldhaus K., Liu Q., Harshman K., Tavtigian S.V., Stockert E., Day RS 3rd, Johnson B.E., Skolnick M.H. A cell cycle regulator potentially involved in genesis of many tumor types. Science. 264:1994;436.
9. Nobori T., Miura K., Wu D.J., Lois A., Takabayashi K., Carson D.A. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature. 386:1994;753.
10. Sakashita A., Hattori T., Miller C.W., Suzushima H., Asou N., Takatsuki K., Koeffler H.P. Mutations of the p53 gene in adult T-cell leukemia. Blood. 79:1992;477.
11. Hatta Y., Hirama T., Miller C.W., Yamada Y., Tomonaga M., Koeffler H.P. Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia. Blood. 85:1995;2699.
12. Uchida T., Kinoshita T., Watanabe T., Nagai H., Murate T., Saito H., Hotta T. The CDKN2 gene alterations in various types of adult T-cell leukaemia. Br J Haematol. 94:1996;665.
13. Yamada Y., Hatta Y., Murata K., Sugawara K., Ikeda S., Mine M., Maeda T., Hirakata Y., Kamihira S., Tsukasaki K., Ogawa S., Hirai H.et al. Deletion of p15 and/or o16 genes as a poor-prognosis factor in adult T-cell leukemia. J Clin Oncol. 15:1997;1778.
14. Shimoyama M., for members of the Lymphoma Study Group Diagnostic criteria and classification of clinical subtypes of adult T-cell leukemia-lymphoma. Br J Haematol. 79:1991;428.
15. Matsushita K., Arima N., Fujiyoshi T., Daitoku Y., Hidaka S., Ohtsubo H., Fukumori J., Fujiwara H., Matsumoto T., Tanaka H. Interleukin-2-mediated growth of leukemic cells in lymph nodes of patients with adult T-cell leukemia/lymphoma. Leukemia Res. 20:1996;135.
16. Arima N., Daitoku Y., Yamamoto Y., Fujimoto K., Ohgaki S., Kojima K., Fukumori J., Matsushita K., Tanaka H., Onoue K. Heterogeneity in response to interleukin 2 and interleukin 2-producing ability of adult T cell leukemic cells. J Immunol. 138:1987;3069.
17. Arima N., Hidaka S., Fujiwara H., Matsushita K., Ohtsubo H., Arimura K., Kukita T., Fukumori J., Tanaka H. Relation of autonomous and interleukein-2-responsive growth of leukemic cells to survival in adult T-cell leukemia. Blood. 87:1996;2900.
18. Southern E.M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 98:1975;503.
19. Orita M., Suzuki Y., Sekiya T., Hayashi K. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics. 5:1989;874.
20. Koh J., Enders G.H., Dynlacht B.D., Harlow E.D. Tumor-derived p16 alleles encording proteins defective in cell-cycle inhibition. Nature. 375:1995;506.
21. ink4 gene inactivation in acute lymphocytic leukemia. Blood. 85:1995;3431.
22. INK4B gene deletions in primary leukemias. Blood. 86:1995;311.
23. Ogawa S., Hirano N., Sato N., Takahashi T., Tanaka K., Kurokawa M., Tanaka T., Mitani K., Yazaki Y., Hirai H. Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias. Blood. 84:1994;2431.
24. Fizzotti M., Cimino G., Pisegna S., Alimena G., Quartarone C., Mandelli F., Pelicci P.G., Lo Coco F. Detection of homozygous deletion of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features. Blood. 85:1995;2685.
25. INK4b/MTS2 in pediatric acute lymphoblastic leukemia. Blood. 85:1995;2321.
26. Hebert J., Cayuela J.M., Berkeley J., Sigaux F. Candidate tumor-suppressor genes MTS1 (p16 INK4A) and MTS2 (p15 INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias. Blood. 84:1994;4038.
27. Cayuela J.M., Madani A., Sanhes L., Stern M.-H., Sigaux F. Multiple tumor-suppressor gene I inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia. Blood. 87:1996;2180.
28. Arima N., Daitoku Y., Ohgakai S., Fukumori J., Tanaka H., Yamamoto Y., Fujimoto K., Onoue K. Autocrine growth of interleukin 2-producing leukemic cells in a patients with adult T cell leukemia. Blood. 68:1986;779.
29. Modiano J.F., Domenico J., Szepesi A., Lucas J.J., Gelfand E.W. Differential requirements for interleukin-2 distinguish the expression and activity of the cyclin-dependent kinases Cdk4 and Cdk2 in human T cells. J Biol Chem. 269:1994;32972.
30. Lukas J., Parry D., Aagaard L., Mann D.J., Bartkova J., Strauss M., Peters G., Barket J. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumor suppressor p16. Nature. 375:1995;503.
31. el-Deiry W.S., Tokino T., Velculescu V.E., Levy D.B., Parsons R., Trent J.M., Lin D., Mercer W.E., Kinzler K.W., Vogelstein B. WAFl, a potential mediator of p53 tumor suppression. Cell. 75:1993;817.
32. Harper J.W., Adami G.R., Wei N., Keyomarsi K., Elledge S.J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 75:1993;805.
33. Suzuki T., Kitao S., Matsushime H., Yoshida M. HTLV-I Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4. EMBO J. 15:1996;1607.
34. Nakano S., Ando Y., Saito K., Moriyama I., Ichijo M., Toyama T., Sugamura K., Imai J., Hinuma Y. Primary infection of Japanese infants with adult T-cell leukaemia-associated retrovirus (ATLV). evidence for viral transmission from mothers to children J Infect. 12:1996;205.
35. The T- and B-Cell Malignancy Study Group Statistical analyses of clinico-pathological, virological and epidemiological data on lymphoid malignancies with specific references to adult T-cell leukemia/lymphoma. a report of the second nationwide study of Japan Jpn J Clin Oncol. 15:1985;517.
36. Okamoto T., Ohno Y., Tsugane S., Watanabe S., Shimoyama M., Tajima K., Miwa M., Shimotohno K. Multi-step carcinogenesis model for adult T-cell leukemia. Jpn J Cancer Res. 80:1989;191.