Instrumental investigations in primary headache. An updated review and new perspectives

Functional Neurology

Volumn 18, Issue 3, 2003, Pages 127-144

  Friberg, Lars ^a   Sandrini, Giorgio ^b   Jänig, Wilfrid ^c   Jensen, Rigmor ^d   Russell, David ^e   Sanchez Del Rio, Maria ^f   Sand, Trond ^g   Schoenen, Jean ^h   Van Buchem, Mark ⁱ   Van Dijk, J Gert ⁱ  

^a BISPEBJERG HOSPITAL   (Denmark)

^b C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

^c UNIVERSITY OF KIEL   (Germany)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e OSLO UNIVERSITY HOSPITAL   (Norway)

^f HOSPITAL RUBER INTERNACIONAL   (Spain)

^g NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^h CHR   (Belgium)

ⁱ LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Headache; Neuroimaging; Neurophysiology

Indexed keywords

BLINKING; BLOOD OXYGENATION; BRAIN BLOOD FLOW; CLINICAL PRACTICE; CLUSTER HEADACHE; CORNEA REFLEX; DOPPLER ECHOGRAPHY; ELECTROENCEPHALOGRAPHY; EPILEPSY; EVOKED AUDITORY RESPONSE; EVOKED VISUAL RESPONSE; HEADACHE; HUMAN; MEDICAL INSTRUMENTATION; MEDICAL RESEARCH; MIGRAINE; MIGRAINE WITH AURA; MIGRAINE WITHOUT AURA; NEUROPHYSIOLOGY; NOCICEPTIVE STIMULATION; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRACTICE GUIDELINE; REFLEX; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SYMPTOMATOLOGY;

BLINKING; DIAGNOSIS, DIFFERENTIAL; DIAGNOSTIC TECHNIQUES, NEUROLOGICAL; ELECTROENCEPHALOGRAPHY; ELECTROPHYSIOLOGY; EUROPE; EVOKED POTENTIALS; GUIDELINES; HEADACHE; HEADACHE DISORDERS; HUMANS; REFLEX;

EID: 10744222929     PISSN: 03935264     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (192)

1. Sandrini G, Friberg L, Jänig W et al. Neurophysiological tests and imaging procedures in primary headache: Guidelines and recommendations. Eur J Neurol 2003 (in press)
2. Sandrini G, Friberg L, Schoenen J, Nappi G eds. Exploring the pathophysiology of headache. Cephalalgia 2003;23 Suppl 1
3. Bile B, Koersner PE. Electroencephalographic investigations. In: Bille B ed Migraine in School Children. Acta Paediatrica 1962; 51:103-113
4. Whitehouse D, Pappas JA, Escala PH, Livingstone S. Electroencephalographic changes in children with migraine. N Engl J Med 1967; 276:23-27
5. Giel R, de Vlieger M, van Vliet AGM. Headache and the EEG. Electroencephalogr Clin Neurophysiol 1966;21:492-495
6. Hockaday JM, Whitty CW. Factors determining the electroencephalogram in migraine: A study of 560 patients, according to clinical type of migraine. Brain 1969;92:769-788
7. Engel GL, Ferris EB, Romano J. Focal electroencephalographic changes during the scotomas of migraine. Am J Med Sci 1945;209:650-657
8. Dow DJ, Whitty CWM. Electro-encephalographic changes in migraine. Lancet 1947;2:52-54
9. Gastaut H, Navarranne P, Simon y Canton L. EEG characteristics of migrainous cerebral attacks of a deficitory type (hemiplegic migraine). Electroencephalogr Clin Neurophysiol 1967;23:381
10. Bickerstaff ER. Basilar artery migraine. Lancet 1961;1:15-17
11. Parrino L, Pietrini V, Spaggiari MC, Terzano MG. Acute confusional migraine attacks resolved by sleep: Lack of significant abnormalities in post-ictal polysomnograms. Cephalalgia 1986;6:95-100
12. Rowan AJ. The electroencephalographic characteristics of migraine. Arch Neurobiol 1974; 37:95-113
13. Valdizan JR, Andreu C, Almarcegui C, Olivito A. Quantitative EEG in children with headache. Headache 1994;34:53-55
14. de Tommaso M, Sciruicchio V, Guido M, Sasanelli G, Puca F. Steady-state visual-evoked potentials in headache: Diagnostic value in migraine and tension-type headache patients. Cephalalgia 1999;19:23-26
15. Silvestri R, Narbone MC, De Domenico P, Di Maria F, Raffaele M. Generalized EEG abnormalities in cluster headache. Ital J Neurol Sci 1996;17:179 (letter)
16. Lipton RB, Ottmann R, Ehrenberg BL, Allen Hauser W. Comorbidity of migraine: The connection between migraine and epilepsy. Neurology 1994; 44(Suppl 7):S28-S38
17. Giroud M, Couillault G, Arnould S, Dauvergne M, Dumas R, Nivelon JL. Epilepsy with rolandic paroxysms and migraine, a non-fortuitous association. Results of a controlled study. Pediatrie 1989; 44:659-664
18. Welch KMA, Lewis D. Migraine and epilepsy. Neurol Clin 1997;15:107-114
19. Santucci M, Giovanardi Rossi P, Ambrosetto G, Sacquegna T, D'Alessandro R. Migraine and benign epilepsy with rolandic spikes in childhood: A case control study. Dev Med Child Neurol 1985;27:60-62
20. Andermann F, Zifkin B. The benign occipital epilepsies of childhood: An overview of the idiopathic syndromes and of the relationship to migraine. Epilepsia 1998;39:S9-S23
21. Blume WT, Young GB. Ictal pain: Unilateral, cephalic, and abdominal. In: Andermann F, Lugaresi E eds Migraine and Epilepsy. Boston; Butterworths 1987:235-248
22. Isler H, Wieser HG, Egli M. Hemicrania epileptica: Synchronous ipsilateral ictal headache with migraine features. In: Andermann F, Lugaresi E eds Migraine and Epilepsy. Boston; Butterworths 1987:249-264
23. Narbone MC, D'Amico D, Di Perri R. Classic migraine and intercalated seizures in a young woman: Efficacy of flunarizine. Headache 1988; 28:209-211
24. Gastaut H, Zifkin BG. Benign epilepsy of childhood with occipital spike and wave complexes. In: Andermann F, Lugaresi E eds Migraine and Epilepsy. Boston; Butterworths 1987:47-82
25. Guerrini R, Dravet C, Genton P et al. Idiopathic photosensitive occipital lobe epilepsy. Epilepsia 1995;36:883-891
26. Camfield PR, Metrakos K, Andermann F. Basilar migraine, seizures, and severe epileptiform EEG abnormalities. Neurology 1978;28:584-588
27. Kramer U, Nevo Y, Neufeld MY, Harel S. The value of EEG in children with chronic headaches. Brain Dev 1994;16:304-308
28. Gronseth GS, Greenberg MK. The utility of the electroencephalogram in the evaluation of patients presenting with headache. Neurology 1995;45:1263-1267
29. Slatter KH. Some clinical and EEG findings in patients with migraine. Brain 1968;91:85-98
30. Van Dijk JG, Haan J, Ferrari MD. Photic stimulation and the diagnosis of migraine. Headache Quarterly 1992;3:387-397
31. Genco D, De Tommaso M, Prudenzano AM, Savarese M, Puca FM. EEG features in juvenile migraine: Topographic analysis of spontaneous and visual evoked brain electrical activity: A comparison with adult migraine. Cephalalgia 1994;14:41-46
32. Puca FM, De Tommaso M, Tota P, Sciruicchio V. Photic driving in migraine: Correlations with clinical features. Cephalalgia 1996;16:246-250
33. Jonkman EJ, Lelieveld MHJ. EEG computer analysis in patients with migraine. Electroencephalogr Clin Neurophysiol 1981;52:652-655
34. Nyrke T, Kangasniemi P, Lang H. Alpha rhythm in classical migraine (migraine with aura): Abnormalities in the headache-free interval. Cephalalgia 1990;10:177-182
35. Schoenen J, Jamart B, Delwalde PJ. Cartographie electroencephalographique dans les migraines en periodes critiques et intercritiques. Rev EEG Neurophysiol Clin 1987;17:289-299
36. Fachetti D, Marsile C, Faggi L, Donati E, Kokodoko A, Poloni M. Cerebral mapping in subjects suffering from migraine with aura. Cephalalgia 1990;10:279-284
37. Lia C, Carenini L, Degioz C, Bottachi E. Computerized EEG analysis in migraine patients. Ital J Neurol Sci 1995;16:249-254
38. Neufeld MY, Treves TA, Korczyn AD. EEG and topographic frequency analysis in common and classic migraine. Headache 1991;31:232-236
39. Farkas V, Kohlhéb O, Benninger C, Matthis P. Comparison of the EEG background activity of epileptic children and children with migraine. Epilepsy Res Suppl 1992;6:199-205
40. Seri S, Cerquiglini A, Guidetti V. Computerized EEG topography in childhood migraine between and during attacks. Cephalalgia 1993;13:53-56
41. De Tommaso M, Sciruicchio V, Guido M, Sasanelli G, Specchio LM, Puca FM. EEG spectral analysis in migraine without aura attacks. Cephalalgia 1998;18:324-328
42. Rainero I, Amanzio M, Vighetti S, Bergamasco B, Pinessi L, Benedetti F. Quantitative EEG responses to ischaemic arm stress in migraine. Cephalalgia 2001;21:224-229
43. Vonderheid-Guth B, Todorova A, Wedekind W, Dimpfel W. Evidence for neuronal dysfunction in migraine: Concurrence between specific qEEG findings and clinical drug response - A retrospective analysis. Eur J Med Res 2000;5:473-483
44. Markand ON. Alpha rhythms. J Clin Neurophysiol 1990;7:163-189
45. De Tommaso M, Sciruicchio V, Belloti R et al. Discrimination between migraine patients and normal subjects based on steady state visual evoked potentials: Discriminant analysis and neural network classifiers. Funct Neurol 1997;12:333-338
46. Lahat E, Nadir E, Barr J, Eshel G, Aladjem M, Bistritze T. Visual evoked potentials: A diagnostic test for migraine headache in children. Dev Med Child Neurol 1997;39:85-87
47. Tagliati M, Sabbadini M, Bernardi G, Silvestrini M. Multi-channel visual evoked potentials in migraine. Electroencephalogr Clin Neurophysiol 1995;96:1-5
48. Van Dijk JG, Doresteijn M, Haan J, Ferrari MD. No confirmation of visual evoked potential diagnostic test for migraine. Lancet 1991;337:517-518
49. Van Dijk JG, Dorresteijn M, Haan J, Ferrari MD. Visual evoked potentials and background EEG activity in migraine. Headache 1991;31:392-395
50. Townsend H, Shaikh M, Heeley B, Blau JN. Visual-evoked potentials in migraine (Comment). Lancet 1991;337:976-977
51. Bank J, Bense E, Kirly CS. The blink reflex in migraine. Cephalalgia 1992;12:289-292
52. Sand T, Zwart JA. The blink reflex in chronic tension-type headache, migraine, and cervicogenic headache. Cephalalgia 1994;14:447-450
53. Lozza A, Schoenen J, Delwaide PJ. Inhibition of the blink reflex R2 component after supraorbital and index finger stimulations is reduced in cluster headache: An indication for both segmental and suprasegmental dysfunction? Pain 1997;1:81-88
54. Sandrini G, Alfonsi E, Ruiz L et al. Impairment of corneal pain perception in cluster headache. Pain 1991;3:299-304
55. Antonaci F, Sandrini G, Danilov A, Sand T. Neurophysiological studies in chronic paroxysmal hemicrania and hemicrania continua. Headache 1994;34:479-483
56. Schoenen J. Clinical neurophysiology of headache. Neurol Clin 1997;15:85-105
57. Zwart JA, Sand T. Exteroceptive suppression of the temporalis muscle activity: A blind study of different types of headache. Headache 1995;35:338-343
58. Bendtsen L, Jensen R, Brennum J, Arendt-Nielsen L, Olesen J. Exteroceptive suppression of temporal muscle activity is normal in chronic tension-type headache and not related to actual headache state. Cephalalgia 1996;16:251-256
59. Wang W, De Pasqua V, Gerard P, Schoenen J. Specificity and sensitivity of temporalis ES2 measurements in the diagnosis of chronic primary headache. Headache 1995;35:85-88
60. Lipchik GL, Holroyd KA, France CR et al. Central and peripheral mechanisms in chronic tension-type headache. Pain 1996;64:467-475
61. Willer JC. Comparative study of perceived pain and nociceptive flexion reflex in man. Pain 1977;3:69-80
62. Sandrini G, Arrigo A, Bono G, Nappi G. The nociceptive flexion reflex as a tool for exploring pain control systems in headache and other pain syndromes. Cephalalgia 1993;13:21-27
63. Langemark M, Bach FW, Jensen TS, Olesen J. Decreased nociceptive flexion reflex threshold in chronic tension-type headache. Arch Neurol 1993;10:1061-1064.
64. Kruszewski P, Salvesen R, White LR, Sjaastad O. Headache and the autonomic nervous system. In: Vinken PJ, Bruyn GW eds Handbook of Clinical Neurology, Vol. 75 (Revised Series 31) The Autonomic Nervous System, Part II: Dysfunctions (Appenzeller O editor) Amsterdam; Elsevier Science B.V. 2000:281-307
65. Thomsen L, Iversen HK, Boesen F, Olesen J. Transcranial Doppler and cardiovascular responses during cardiovascular autonomic tests in migraineurs during and outside of attacks. Brain 1995;118:1319-1327
66. Thomsen LL, Olesen J. Autonomic nervous system and the regulation of arterial tone in migraine. Clin Autonom Res 1995;5:243-250
67. Boiardi A, Munari L, Milanesi I, Pagetta C, Lamperti E, Bussone G. Impaired cardiovascular reflexes in cluster headache and migraine: Evidence for an autonomic dysfunction. Headache 1988;28:417-422
68. Pierangeli G, Parchi P, Barletta G, Chiogna M, Lugaresi E, Cortelli P. Power spectral analysis of heart rate and diastolic blood pressure variability in migraine with and without aura. Cephalalgia 1997;17:756-760
69. Micieli G, Magri M, Sandrini G, Tassorelli C, Nappi G. Pupil responsiveness in cluster headache: A dynamic TV pupillometric evaluation. Cephalalgia 1988;8:193-201
70. Fanciullacci M. Iris adrenergic impairment in idiopathic headache. Headache 1979;19:8-13
71. Battistella PA, Ruffilli R, Zacchello F. Pupillary adrenergic sensitivity and idiopathic headache in pediatric patients. Headache 1989;29:163-166
72. Fanciullacci M, Pietrini U, Gatto G, Boccuni M, Sicuteri F. Latent dysautonomic pupillary lateralization in cluster headache. A pupillometric study. Cephalalgia 1982;2:135-144
73. Salvesen R, De Souza Carvalho D, Sand T, Sjaastad O. Cluster headache: Forehead sweating pattern during heating and pilocarpine tests. Cephalalgia 1987;8:245-253
74. Kruszewski P, Zhao JM, Shen JM, Sjaastad O. SUNCT syndrome: Forehead sweating pattern. Cephalalgia 1993;13:108-113
75. Langemark M, Olesen J. Pericranial tenderness in tension headache. Cephalalgia 1987;7:249-255
76. Sandrini G, Antonaci F, Pucci E, Bono G, Nappi G. Comparative study with EMG, pressure algometry and manual palpation in tension-type headache and migraine. Cephalalgia 1994;14:451-457
77. Bendtsen L, Jensen R, Olesen J. Decreased pain detection and tolerance thresholds in chronic tension-type headache. Arch Neurol 1996;53:373-376
78. Jensen R, Rasmussen BK, Pedersen B, Lous I, Olesen J. Cephalic muscle tenderness and pressure pain threshold in a general population. Pain 1992;48:197-203
79. Jensen R, Rasmussen BK, Pedersen B, Olesen J. Muscle tenderness and pressure pain thresholds in headache. A population study. Pain 1993;52:193-199
80. Jensen R, Fuglsang-Frederiksen A, Olesen J. Quantitative surface EMG of pericranial muscles in headache. A population study. Electroencephalogr Clin Neurophysiol 1994;93:335-344
81. Jensen R, Rasmussen BK. Muscular disorders in tension-type headache. Cephalalgia 1996;16:97-103
82. Langemark M, Olesen J, Poulsen DL, Bech P. Clinical characteristics of patients with tension-type headache. Headache 1988;28:590-596
83. Hatch JP, Moore PJ, Cyr-Provost M, Boutros NN, Seleshi E, Borcherding S. The use of electromyography and muscle palpation in the diagnosis of tension-type headache with and without pericranial muscle involvement. Pain 1992;49:175-178
84. Jensen R, Fuglsang-Frederiksen A, Olesen J. Quantitative surface EMG of pericranial muscles. Reproducibility and variability. Electroencephalogr Clin Neurophysiol 1993;89:1-9
85. Schoenen J, Gerard P, De Pasqua V, Juprelle M. EMG activity in pericranial muscles during postural variation and mental activity in healthy volunteers and patients with chronic tension type headache. Headache 1991;31:321-324
86. Schoenen J, Gerard P, De Pasqua V, Sianard-Gainko J. Multiple clinical and paraclinical analyses of chronic tension-type headache associated or unassociated with disorder of pericranial muscles. Cephalalgia 1991b;11:135-139
87. Bovim G. Cervicogenic headache, migraine and tension-type headache. Pressure-pain threshold measurements. Pain 1992;51:169-173
88. Sand T, Zwart JA, Helde G, Bovim G. The reproducibility of cephalic pain pressure thresholds. Cephalalgia 1997;17:748-755
89. Schoenen J, Bottin D, Hardy F, Gerard P. Cephalic and extracephalic pressure pain thresholds in chronic tension-type headache. Pain 1991;47:145-149
90. Pikoff H. Is the muscular model of headache still viable? A review of conflicting data. Headache 1984;24:186-198
91. Bansevicius D, Westgaard RH, Sjaastad O. Tension-type headache: Pain, fatigue, tension, and EMG responses to mental activation. Headache 1999;39:417-425
92. Frishberg BJ. The utility of neuroimaging in the evaluation of headache in patients with normal neurological examinations. Neurology 1994;44:1191-1197
93. Anonymous. Practice parameter: The utility of neuroimaging in the evaluation of headache in patients with normal neurological examinations (summary statement). Neurology 1994;44:1353-1354
94. Maytal J, Bienkowski RS, Patel M, Eviatar L. The value of brain imaging in children with headaches. Pediatrics 1995;96:413-416
95. Wober-Bingol C, Wober C, Paryer D, et al. Magnetic resonance imaging for recurrent headache in childhood and adolescence. Headache 1996;36:83-90
96. Akpek S, Arac M, Atillia S, Onal B, Yucel C, Isik S. Cost-effectiveness of computed tomography in the evaluation of patients with headache. Headache 1995;35:228-230
97. Dumas MD, Pexman JH, Kreeft JH. Computed tomography evaluation of patients with chronic headache. CMAJ 1994;51:1447-1452
98. Olesen J, Friberg L, Olsen TS et al. Timing and topography of cerebral blood flow, aura, and headache during migraine attacks. Ann Neurol 1990;28:791-798
99. Friberg L. Cerebral blood flow changes in migraine: Methods, observations and hypotheses. J Neurol 1991;238(Suppl 1):S12-17
100. De Deyn PP, Nagels G, Pickut BA et al. SPECT in neurology and psychiatry. In: De Deyn PP, Dierckx RA, Alavi A, Pickut BA eds SPECT in Headache with Special Reference to Migraine. 54 1st ed. London; John Libbey & Co. Ltd 1997:455-466
101. Olesen J, Lauritzen M, Tfelt-Hansen P, Henriksen L, Larsen B. Spreading cerebral oligemia in classical and normal cerebral blood flow in common migraine. Headache 1982;22:242-248
102. Diener HC. Positron emission tomography studies in headache. Headache 1997;37:622-625
103. Andersen AR, Friberg L, Olsen TS, Olesen J. Delayed hyperemia following hypoperfusion in classic migraine. Single photon emission computed tomographic demonstration. Arch Neurol 1988;45:154-159
104. Olesen J, Larsen B, Lauritzen M. Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol 1981;9:344-352
105. Woods RP, Iacoboni M, Mazziotta JC. Brief report: Bilateral spreading cerebral hypoperfusion during spontaneous migraine headache. N Engl J Med 1994;331:1689-1692
106. Friberg L, Olsen TS. Cerebrovascular instability in a subset of stroke and TIA patients. Arch Neurol 1991;48:1026-1031
107. Friberg L, Olsen TS, Roland PE, Lassen NA. Focal ischaemia caused by instability of cerebrovascular tone during attacks of hemiplegic migraine. A regional cerebral blood flow study. Brain 1987;110:17-34
108. Friberg L, Olesen J, Iversen HK et al. Interictal 'patchy' regional cerebral blood flow patterns in migraine patients. A single photon emission computerized tomography study. Eur J Neurol 1994;1:35-45
109. Krabbe AA, Henriksen L, Olesen J. Tomographic determination of cerebral blood flow during attacks of cluster headache. Cephalalgia 1984;4:17-23
110. Dahl A, Russell D, Nyberg-Hansen R, Rootwelt K. Cluster headache: Transcranial Doppler ultrasound and rCBF studies. Cephalalgia 1990;10:87-94
111. Áfra J, Ertsey C, Jelencsik H, Dabasi G, Panczel G. SPECT and TCD studies in cluster headache patients. Funct Neurol 1995;10:259-264
112. Hsieh JC, Hannerz J, Ingvar M. Right-lateralised central processing for pain of nitroglycerin-induced cluster headache. Pain 1996;67:59-68
113. Di Piero V, Fiacco F, Tombari D, Pantano P. Tonic pain: A SPET study in normal subjects and cluster headache patients. Pain 1997;70:185-191
114. May A, Bahra A, Buchel C, Frackowiak RS, Goadsby PJ. Hypothalamic activation in cluster headache attacks. Lancet 1998;352:275-278
115. Battistella PA, Ruffilli R, Dalla PF et al. 99mTc HM-PAO SPECT in pediatric migraine. Headache 1990;30:646-649
116. Spina A, Damato V, Losito R, Marzocco P, Narducci P, Zizzo L. Brain SPECT and migraine in childhood. Acta Neurologica 1992;14:10-14
117. Soriani S, Feggi L, Battistella PA, Arnaldi C, De Carlo L, Stipa S. Interictal and ictal phase study with Tc 99m HM-PAO brain SPECT in juvenile migraine with aura. Headache 1997;37:31-36
118. Zanette EM, Agnoli A, Roberti C, Chiarotti F, Cerbo R, Fieschi C. Transcranial Doppler in spontaneous attacks of migraine. Stroke 1992;23:680-685
119. Zwetsloot CP, Caekebeke JF, Ferrari MD. Lack of asymmetry of middle cerebral artery blood velocity in unilateral migraine. Stroke 1993;24:1335-1338
120. Nattero G, Mengozzi G, Inconis T, Paradisi L. Nitric oxide, endothelin-1, and transcranial Doppler in migraine. Findings in interictal conditions and during migraine attacks. Headache 1996;36:307-311
121. Abernathy M, Donnelly G, Kay G et al. Transcranial Doppler sonography in headache-free migraineurs. Headache 1994;34:198-203
122. Totaro R, De Matties G, Marini C, Baldassarre M, Carolei A. Sumatriptan and cerebral blood flow velocity changes during migraine attacks. Headache 1997;37:635-639
123. Totaro R, De Matties G, Marini C, Prencipe M. Cerebral blood flow in migraine with aura: A transcranial Doppler sonography study. Headache 1992;32:446-451
124. Friberg L, Olesen J, Iversen HK, Sperling B. Migraine pain associated with middle cerebral artery dilatation: Reversal by sumatripan. Lancet 1991;338:13-17
125. Hannerz J, Hellström G, Klum T, Wahlgren NG. Cluster headache and "dynamite headache": Blood flow velocities in the middle artery. Cephalalgia 1990;10:31-38
126. Áfra J, Proietti Cecchini A, Sándor PS, Schoenen J. Comparison of visual and auditory evoked cortical potentials in migraine patients between attacks. Clin Neurophysiol 2000;111:1124-1129
127. Sand T, Vingen JV. Visual long-latency auditory and brainstem auditory evoked potentials in migraine: Relation to pattern size, stimulus, intensity, sound and light discomfort thresholds and pre-attack state. Cephalalgia 2000;20:804-820
128. Ambrosini A, De Pasqua V, Áfra J, Sándor PS, Schoenen J. Reduced gating of middle-latency auditory evoked potentials (P50) in migraine patients: Another indication of abnormal sensory processing? Neurosci Lett 2001;306:132-134
129. Ozkul Y, Uckardes A. Median nerve somatosensory evoked potentials in migraine. Eur J Neurol 2002;9:227-232
130. de Tommaso M, Murasecco D, Libro G, et al. Modulation of trigeminal reflex excitability in migraine: Effects of attention and habituation on the blink reflex. Int J Psychophysiol 2002;44:239-249
131. Sándor PS, Ambrosini A, Agosti RM, Schoenen J. Genetics of migraine: Possible links to neurophysiological abnormalities. Headache 2002;42:365-377
132. Göder R, Fritzer G, Kapsokalyvas A et al. Polysomnographic findings in nights preceding a migraine attack. Cephalalgia 2001;21:31-37
133. Kropp P, Gerber WD. Contigent negative variation during migraine attack and interval: Evidence for normalization of slow cortical potentials during the attack. Cephalalgia 1995;15:123-128
134. Schoenen J. Deficient habituation of evoked cortical potentials in migraine: A link between brain biology, behavior and trigeminovascular activation? Biomed Pharmacother 1996;50:71-78
135. Siniatchkin M, Kirsch E, Kropp P, Gerber WD, Stephani U. Contigent negative variation in migraine families. Cephalalgia 2000; 20:881-892
136. Grosser K, Oelkers R, Hummel T et al. Olfactory and trigeminal event-related potentials in migraine. Cephalalgia 2000;20:621-631
137. Avranidis TG, Podikoglu DG, Anastasopoulos IE, Koutroumanidis MA, Papadimitriou AL. Blink reflex in migraine and tension-type headache. Headache 1998;38:691-696
138. Aktekin B, Yaltkaya K, Ozkaynak S, Oguz Y. Recovery cycle of the blink reflex and exteroceptive suppression of temporalis muscle activity in migraine and tension-type headache. Headache 2001;41:142-149
139. Kaube H, Katsarava Z, Przywara S, Drepper J, Ellrich J, Diener HC. Acute migraine headache. Possible sensitization of neurons in the spinal trigeminal nucleus. Neurology 2002; 58:1234-1238
140. Burstein R, Yarnitsky D, Goor-Aryeh I, Ransil BJ, Bajwa ZH. An association between migraine and cutaneous allodynia. Ann Neurol 2000; 47:614-624
141. de Tommaso M, Guido M, Libro G, Sciruicchio V, Puca FM. Zolmitriptan reverses blink reflex changes induced during the migraine attack in humans. Neurosci Lett 2000;289:57-60
142. Raudino F. The blink reflex in cluster headache. Headache 1990;30:584-585
143. Sandrini G, Proietti Cecchini A, Milanov I, Tassorelli C, Buzzi MG, Nappi G. Electrophysiological evidence for trigeminal neuron sensitization in patients with migraine. Neurosci Lett 2002;317:135-138
144. Proietti Cecchini A, Sandrini G, Fokin IV, Moglia A, Nappi G. Trigeminal facial reflex in primary headaches. Cephalalgia 2003;23 (Suppl 1): 33-41
145. Cutrer FM, Sorensen AG, Weisskoff RM et al. Perfusion-weighted imaging defects during spontaneous migrainous aura. Ann Neurol 1998;43:25-31
146. Sanchez del Rio M, Bakker D, Wu O et al. Perfusion weighted imaging during migraine: Spontaneous visual aura and headache, Cephalalgia 1999;19:701-707
147. Masuzaki M, Utsunomiya H, Yasumoto S, Mitsudome A. A case of hemiplegic migraine in childhood: Transient unilateral hyperfusion revealed by perfusion MR imaging and MR angiography. AJNR Am J Neuroradiol 2001;22:1795-1797
148. Lindahl AJ, Allder S, Jefferson D, Allder S, Moody A, Martel A. Prolonged hemiplegic migraine associated with unilateral hyperfusion on perfusion weighted magnetic resonance imaging. J Neurol Neurosurg Psychiatry 2002;73:202-203
149. Gutschalk A, Kollmar R, Mohr A et al. Multimodal functional imaging of prolonged neurological deficits in a patient suffering from familial hemiplegic migraine. Neurosci Lett 2002; 332:115-118
150. Chabriat H, Vahedi K, Clark CA et al. Decreased hemispheric water mobility in hemiplegic migraine related to mutation of CACNA1A gene. Neurology 2000;54:510-512
151. Gekeler F, Holtmannspotter M, Straube A, Klopstock T. Diffusion-weighted magnetic resonance imaging during the aura of pseudomigraine with temporary neurologic symptoms and lymphocytic pleocytosis, Headache 2002;42:294-296
152. Caminero AB, Pareja JA, Arpa J, Vivancos F, Palomo F, Coya J. Migrainous syndrome with CSF pleocytosis. SPECT findings. Headache 1997;37:511-515
153. Hadjikhani N, Sanchez del Rio M, Wu O et al. Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci USA 2001;98:4687-4692.
154. Cao Y, Welch KM, Aurora S, Vikingstad EM. Functional MRI-BOLD of visually triggered headache in patients with migraine. Arch Neurol 1999;56:548-554
155. Welch KM, Cao Y, Aurora S, Wiggins G, Vikingstad EM. MRI of the occipital cortex, red nucleus, and substantia nigra during visual aura of migraine. Neurology 1998;51:1465-1469
156. May A, Bahra A, Buchel C, Turner R, Goadsby PJ. Functional magnetic resonance imaging in spontaneous attacks of SUNCT: Short-lasting neuralgiform headache with conjunctival injection and tearing. Ann Neurol 1999;46:791-794
157. Boska MD, Welch KM, Barker PB, Nelson JA, Schultz L. Contrasts in cortical magnesium, phospholipid and energy metabolism between migraine syndromes. Neurology 2002;58:1227-1233
158. Brooks WM, Welch KM, Jung RE, Friedman SD, Stidley CA, Rozell CL. 1H-MRS evidence of a mitochondrial disorder in migraine. Cephalalgia 1999;19:310 (abstract)
159. Montagna P, Lodi R, Cortelli P et al. Phosphorus magnetic resonance spectroscopy in cluster headache. Neurology 1997;48:113-118
160. Welch KM, Nagesh V, Aurora SK, Gelman N. Periaqueductal gray matter dysfunction in migraine: Cause or the burden of illness? Headache 2001; 41:629-637
161. Bowyer SM, Aurora KS, Moran JE, Tepley N, Welch KM. Magnetoencephalographic fields from patients with spontaneous and induced migraine aura. Ann Neurol 2001;50:582-587
162. Bowyer SM, Tepley N, Papuashvili N et al. Analysis of MEG signals of spreading cortical depression with propagation constrained to a rectangular cortical strip. II. Gyrencephalic swine model. Brain Res 1999; 843:79-86
163. Aurora SK, Welch KM. Brain excitability in migraine: Evidence from transcranial magnetic stimulation studies. Curr Opin Neurol 1998;11:205-209
164. Aurora SK, Ahmad BK, Welch KM, Bhardhwaj P, Ramadan NM. Transcranial magnetic stimulation confirms hyperexcitability of occipital cortex in migraine. Neurology 1998;50:1111-1114
165. Mulleners WM, Chronicle EP, Palmer JE, Koehler PJ, Vredeveld JW. Visual cortex excitability in migraine with and without aura. Headache 2001; 41:565-572
166. Mulleners WM, Chronicle EP, Palmer JE, Koehler PJ, Vredeveld JW. Suppression of perception in migraine: Evidence for reduced inhibition in the visual cortex. Neurology 2001; 56:178-183
167. Mulleners WM, Chronicle EP, Vredeveld JW, Koehler PJ. Visual cortex excitability in migraine before and after valproate prophylaxis: A pilot study using TMS. Eur J Neurol 2002; 9:35-40
168. Áfra J, Proietti Cecchini A, De Pasqua V, Albert A, Schoenen J. Visual evoked potentials during long periods of pattern-reversal stimulation in migraine. Brain 1998;121:233-241
169. Werhahn KJ, Wiseman K, Herzog J, Forderreuther S, Dichgans M, Straube A. Motor cortex excitability in patients with migraine with aura and hemiplegic migraine. Cephalalgia 2000;20:45-50
170. Ozturk V, Cakmur R, Donmez B, Yener GG, Kursad F, Idiman F. Comparison of cortical excitability in chronic migraine (transformed migraine) and migraine without aura. A transcranial magnetic stimulation study. J Neurol 2002;249:1268-1271
171. Andersson JL, Muhr C, Lilja A, Valind S, Lundberg PO, Langstrom B. Regional cerebral blood flow and oxygen metabolism during migraine with and without aura. Cephalalgia 1997;17:570-579
172. Bahra A, Matharu MS, Buchel C, Frackowiak RS, Goadsby PJ. Brainstem activation specific to migraine headache. Lancet 2001;357:1016-1017
173. Bednarczyk EM, Remler B, Weikart C, Nelson AD, Reed RC. Global cerebral blood flow, blood volume, and oxygen metabolism in patients with migraine headache. Neurology 1998;50:1736-1740
174. May A, Büchel C, Bahra A, Goadsby PJ, Frackowiak RS. Intracranial vessels in trigeminal transmitted pain: A PET study. Neuroimage 1999;9:453-460
175. Hsieh JC, Stahle-Backdahl M, Hagermark O, Stone-Elander S, Rosenquist G, Ingvar M. Traumatic nociceptive pain activates the hypothalamus and the periaqueductal gray: A positron emission tomography study. Pain 1996;64:303-314
176. Backer M, Sander D, Hammes MG et al. Altered cerebrovascular response pattern in interictal migraine during visual stimulation. Cephalalgia 2001;21:611-616
177. Sliwka U, Harscher S, Diehl RR, Van Schayck R, Niesen WD, Weiller C. Spontaneous oscillations in cerebral blood flow velocity give evidence of different autonomic dysfunctions in various types of headache. Headache 2001;41:157-163
178. Dora B, Balkan S. Exaggerated interictal cerebrovascular reactivity but normal blood flow velocities in migraine without aura. Cephalalgia 2002;22:288-290
179. Fiermonte G, Annulli A, Pierelli F. Transcranial Doppler evaluation of cerebral hemodynamics in migraineurs during prophylactic treatment with flunarizine. Cephalalgia 1999;19:492-496
180. Anzola GP, Magoni M, Guindani M, Rozzini L, Dalla VG. Potential source of cerebral embolism in migraine with aura: A transcranial Doppler study. Neurology 1999;52:1622-1625
181. Ng TM, Kohli A, Fagan SC, Mohamed AE, Geiszt G. The effect of intravenous verapamil on cerebral hemodynamics in a migraine patient with hemiplegia. Ann Pharmacother 2000;34:39-43
182. Barkley GL, Tepley N, Simkins R, Moran J, Welch KMA. Neuromagnetic fields in migraine: Preliminary findings. Cephalalgia 1990;10:171-176
183. Tepley N, Bowyer S, Clifton Y, Saligram U. A technique for sequential measurements of DC neuromagnetic fields. Electroencephalogr Clin Neurophysiol 1996;99:16-18
184. Jänig W. Relationship between pain and autonomic phenomena in headache and other pain syndromes. Cephalalgia 2003; 23 (suppl 1) in press
185. Baron R, Fields H, Jänig W, Kitt C, Levine JD. Reflex sympathetic dystrophy/complex regional pain syndromes (CRPS): State-of-the-science. Anaesthesia and Analgaesia 2002;95:1812-1818
186. Harden RN, Baron R, Jänig W eds Complex Regional Pain Syndrome. Progress in Brain Research and Management, Vol 22. Seattle; IASP Press 2001
187. Jänig W, Baron R. The role of the sympathetic nervous system in neuropathic pain: Clinical observations and animal models. In: Hansson PT, Fields HL, Hill RG, Marchetini P eds Neuropathic Pain: Pathophysiology and Treatment. Progress in Pain Research and Management, Seattle; IASP Press 2001:125-149
188. Jänig W, Baron R. Complex regional pain syndrome is a disease of the central nervous system. Clin Auton Res 2002;12:150-164
189. Jänig W, Levine JD, Michaelis M. Interaction of sympathetic and primary afferent neurons following nerve injury and tissue trauma. In: Kumazawa T, Kruger L, Mizumura K eds The Polymodal Receptor - A Gateway to Pathological Pain. Progress in Brain Res 1996;112:161-184
190. Jänig W. Pain and the sympathetic nervous system: Pathophysiological mechanisms. In: Mathias CJ, Bannister R eds Autonomic Failure, 4th Edition. Oxford; Oxford University Press 1999:99-108
191. Friberg L. In vivo neuroreceptor imaging by SPECT in migraine. Cephalalgia 1995;15:310-315
192. Weiller C, May A, Limmroth V et al. Brain stem activation in spontaneous human migraine attacks. Nat Med 1995;1:658-660