Genetics of migraine: Possible links to neurophysiological abnormalities

Headache

Volumn 42, Issue 5, 2002, Pages 365-377

  Sándor, Peter S ^a   Ambrosini, Anna ^a   Agosti, Reto M ^a   Schoenen, Jean ^b  

^a DIVISION OF REPRODUCTIVE BIOLOGY   (United States)

^b Centre Hospitalier Regional de La Citadelle   (Belgium)

Author keywords

CACNA1A; Familial hemiplegic migraine; Genetics; Migraine; Neurophysiology

Indexed keywords

ANIMAL MODEL; AUTOSOMAL DOMINANT DISORDER; BRAIN INFARCTION; CEREBROVASCULAR DISEASE; CHROMOSOME 1; CHROMOSOME 19; CHROMOSOME 4; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FAMILIAL DISEASE; GENE MUTATION; GENETIC DISORDER; GENETIC LINKAGE; GENETIC POLYMORPHISM; HEMIPLEGIA; HUMAN; LEUKOENCEPHALOPATHY; MEMBRANE CHANNEL; MIGRAINE; NEUROPATHOLOGY; NEUROPHYSIOLOGY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ALLELES; ANIMALS; CALCIUM CHANNELS; GENOTYPE; HUMANS; MICE; MIGRAINE DISORDERS; MUTATION; NERVOUS SYSTEM DISEASES; PHENOTYPE; POLYMORPHISM, GENETIC;

EID: 0036259336     PISSN: 00178748     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1526-4610.2002.02110.x     Document Type: Review

References (125)

1. Prevalence and sex-ratio of the subtypes of migraine
2. Testing models for genetic determination in migraine
3. The genetics of migraine without aura and migraine with aura
4. Familial risk of migraine: A population-based study
5. Genetics of migraine
6. Migraine as a complex disease: Heterogeneity, comorbidity and genotype-phenotype interactions
7. Increased familial risk and evidence of genetic factor in migraine
8. 2+ channel subunits
9. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain
10. The interrelations of migraine, vertigo, and migrainous vertigo
11. Is familial hemiplegic migraine a hereditary form of basilar migraine?
12. 2+ channel gene CACNL1A4
13. Episodic ataxia type 2 (EA2) and spinocerebellar ataxia type 6 (SCA6) due to CAG repeat expansion in the CACNA1A gene on chromosome 19p
14. Human epilepsy associated with dysfunction of the brain P/Q-type calcium channel
15. 1a calcium channel gene CACNA1A and idiopathic generalized epilepsy
16. Detection of a novel missense mutation and second recurrent mutation in the CACNA1A gene in individuals with EA-2 and FHM
17. A novel nonsense mutation in CACNA1A causes episodic ataxia and hemiplegia
18. A new CACNA1A gene mutation in acetazolamide-responsive familial hemiplegic migraine and ataxia
19. The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel
20. CACNA1A gene de novo mutation causing hemiplegic migraine, coma, and cerebellar atrophy
21. Delayed cerebral edema and fatal coma after minor head trauma: Role of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine
22. Familial typical migraine: Linkage to chromosome 19p13 and evidence for genetic heterogeneity
23. Familial hemiplegic migraine locus on 19p13 is involved in the common forms of migraine with and without aura
24. Involvement of the CACNA1A gene containing region on 19p13 in migraine with and without aura
25. Structure and function of voltage-gated ion channels
26. 2+ channels in mammalian central neurons
27. Localization and functional properties of a rat brain alpha 1A calcium channel reflect similarities to neuronal Q- and P-type channels
28. 2+ channel currents in rat cerebellar granule neurons
29. 1A subunit throughout the mature rat brain and its relationship to neurotransmitter pathways
30. 2+ channel blocker neurotoxins on transmitter release and presynaptic currents at the mouse neuromuscular junction
31. 2+ channel subtypes on rat spinal motor neurons, interneurons, and nerve terminals
32. Molecular genetics of migraine headaches: A review
33. Missense CACNA1A mutation causing episodic ataxia type 2
34. Loss-of-function EA2 mutations are associated with impaired neuromuscular transmission
35. Complete loss of P/Q calcium channel activity caused by a CACNA1A missense mutation carried by patients with episodic ataxia type 2
36. Patients with CACNA1A mutations and associated myasthenic weakness have presynaptic failure of neuromuscular transmission
37. Functional consequences of mutations in the human alpha1A calcium channel subunit linked to familial hemiplegic migraine
38. 2+ channel kinetics
39. 2+ channel kinetics
40. 2+ channel blocker, inhibits neurogenic vasodilation and extravasation following electrical stimulation of trigeminal ganglion
41. Familial migraine: Exclusion of the susceptibility gene from the reported locus of familial hemiplegic migraine on 19p
42. Subclinical cerebellar impairment in the common types of migraine: A three-dimensional analysis of reaching movements
43. Neurotology of migraine
44. Evidence of a genetic factor in migraine with aura: A population-based Danish twin study
45. Impairment of neuromuscular transmission in a subgroup of migraine patients
46. Neuromuscular transmission in migraine: A single-fiber EMG study in clinical subgroups
47. 2+-channels in common forms of migraine?
48. P-type voltage-dependent calcium channel mediates presynaptic calcium influx and transmitter release in mammalian synapses
49. 2+ channels trigger stimulus-evoked [3H]acetylcholine release from mammalian motor endplates
50. 2+ channel mutation
51. 2+ channel involvement in common forms of migraine
52. Correlation between single fibre EMG findings and CACNA1A gene polymorphisms in migraine
53. Hereditary paroxysmal ataxia: Response to acetazolamide
54. Acetazolamide responsiveness in familial hemiplegic migraine
55. Acetazolamide treatment for migraine aura status
56. Acetazolamide improves SFEMG abnormalities in migraine patients
57. 1044 women with migraine: The effect of environmental stimuli
58. Visual, long-latency auditory and brainstem auditory evoked potentials in migraine: Relation to pattern size, stimulus intensity, sound and light discomfort thresholds and preattack state
59. Cortical electrophysiology in migraine and possible pathogenetic implications
60. Contingent negative variation in headache
61. Is increased amplitude of contingent negative variation in migraine due to cortical hyperactivity or to reduced habituation?
62. Potentiation instead of habituation characterizes visual evoked potentials in migraine patients between attacks
63. Visual evoked potentials during long periods of pattern-reversal stimulation in migraine
64. Personality and response to repeated visual stimulation in migraine and tension-type headaches
65. Intensity dependence of auditory evoked potentials is pronounced in migraine: An indication of cortical potentiation and low serotonergic neurotransmission?
66. Intensity dependence of auditory evoked cortical potentials in migraine families
67. Functional magnetic resonance imaging during sustained visual stimulation: Less habituation-like changes of the BOLD signal in migraine with aura
68. Familial influences on cortical evoked potentials in migraine
69. Slow cortical potentials in migraine: A comparison of adults and children
70. Contingent negative variation in subjects at risk for migraine without aura
71. Effects of repetitive transcranial magnetic stimulation on visual evoked potentials in migraine
72. Phosphorus and proton magnetic resonance spectroscopy in episodic ataxia type 2
73. On the search of a metabolic equivalent of electrophysiologic dyshabituation: Cortical lactate changes during prolonged visual stimulation in migraine with aura, studied by functional magnetic resonance spectroscopy imaging (f-MRI-SI)
74. Absence epilepsy in tottering mutant mice is associated with calcium channel defects
75. Migraines in mice?
76. Mutations in the CACNL1A4 calcium channel gene are associated with seizures, cerebellar degeneration, and ataxia in tottering and leaner mutant mice
77. 2+ channels is associated with the ataxic mouse mutation rolling Nagoya (tg(rol))
78. Rocker is a new variant of the voltage-dependent calcium channel gene CACNA1A
79. 1A-subunit
80. The tottering mouse: A critical review of its usefulness in the study of the neuronal mechanisms underlying epilepsy
81. Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1A subunit of P/Q type calcium channels
82. Brain stem activation in spontaneous human migraine attacks
83. Brainstem activation specific to migraine headache
84. Mapping of a second locus for familial hemiplegic migraine to 1q21-q23 and evidence of further heterogeneity
85. A new locus for hemiplegic migraine maps to chromosome 1q31
86. Recurrent episodes of coma: An unusual phenotype of familial hemiplegic migraine with linkage to chromosome 1
87. Localization of migraine susceptibility genes to chromosomes 1q, 19p and Xq
88. A genomewide scan identifies a genetic locus for migraine with aura
89. Familial typical migraine: Significant linkage and localization of a gene to Xq24-28
90. Genetic analysis of chromosome X in migraine families
91. Clinical susceptibility to migraine with aura is modified by dopamine D2 receptor (DRD2) NcoI alleles
92. Association between dopamine receptor genes and migraine without aura in a Sardinian sample
93. Angiotensin-converting enzyme gene deletion polymorphism determines an increase in frequency of migraine attacks in patients suffering from migraine without aura
94. Altered allelic distributions of the serotonin transporter gene in migraine without aura and migraine with aura
95. Evidence for allelic association of the dopamine beta-hydroxylase gene (DBH) with susceptibility to typical migraine
96. Association between migraine and endothelin type A receptor (ETA - 231 A/G) gene polymorphism
97. Single nucleotide polymorphism (SNP) alleles in the insulin receptor (INSR) gene are associated with migraine
98. Tumor necrosis factor B gene polymorphism contributes to susceptibility to migraine without aura
99. Chromosome 6p-encoded HLA-DR2 determination discriminates migraine without aura from migraine with aura
100. The homozygous C677T mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for migraine
101. No evidence for involvement of the human inducible nitric oxide synthase (iNOS) gene in susceptibility to typical migraine
102. Clinical spectrum of CADASIL: A study of 7 families. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
103. New phenotype of the cerebral autosomal dominant arteriopathy mapped to chromosome 19: Migraine as the prominent clinical feature
104. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: A clinicopathological and genetic study of a Swiss family
105. Familial hemiplegic migraine and autosomal dominant arteriopathy with leukoencephalopathy (CADA-SIL)
106. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
107. Migraine with aura and white matter abnormalities: Notch3 mutation
108. Hereditary vascular retinopathy, cerebroretinal vasculopathy, and hereditary endotheliopathy with retinopathy, nephropathy, and stroke map to a single locus on chromosome 3p21.1-p21.3
109. Preliminary observations on brain energy metabolism in migraine studied by in vivo phosphorus 31 NMR spectroscopy
110. Muscle energy metabolism in female DMD/BMD carriers: A 31P-MR spectroscopy study
111. 31P-magnetic resonance spectroscopy in migraine without aura
112. Muscle mitochondrial DNA deletion and 31P-NMR spectroscopy alterations in a migraine patient
113. Mutation in platelet mitochondrial gene in patients with migraine
114. The T-C(8356) mitochondrial DNA mutation in a Japanese family
115. The common MELAS mutation A3243G in mitochondrial DNA among young patients with an occipital brain infarct
116. Cyclic vomiting syndrome and mitochondrial DNA mutations
117. Mitochondrial DNA haplogroup U as a risk factor for occipital stroke in migraine
118. Mitochondrial DNA in stroke and migraine with aura
119. Mitochondrial DNA in migraine with aura
120. Genetic heterogeneity of migraine with and without aura in Danes cannot be explained by mutation in mtDNA nucleotide pair 11084
121. Search for mitochondrial DNA mutations in migraine subgroups
122. mtDNA A3243G MELAS mutation is not associated with multigenerational female migraine
123. Low brain magnesium in migraine
124. Blood magnesium levels in migraine
125. Intracellular Mg++ concentration and electromyo-graphical ischemic test in juvenile headache