Increased yield of heterologous viral glycoprotein in the seeds of homozygous transgenic tobacco plants cultivated underground

Genome

Volumn 46, Issue 3, 2003, Pages 521-526

  Tackaberry, Eilleen S ^a,b   Prior, Fiona ^a   Bell, Margaret ^a   Tocchi, Monika ^a   Porter, Suzanne ^a   Mehic, Jelica ^a   Ganz, Peter R ^a,b   Sardana, Ravinder ^b   Altosaar, Illimar ^b   Dudani, Anil ^b  

^a HEALTH CANADA   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Glycoprotein B; Homozygous second generation; Human cytomegalovirus; Transgenic tobacco seeds; Underground mine; Vaccine

Indexed keywords

CROSSES, GENETIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLUTEN; PLANTS, GENETICALLY MODIFIED; SEEDS; TOBACCO; VIRAL ENVELOPE PROTEINS;

HUMAN HERPESVIRUS 5; NICOTIANA OBTUSIFOLIA; NICOTIANA TABACUM;

EID: 10744222488     PISSN: 08312796     EISSN: None     Source Type: Journal    
DOI: 10.1139/g03-008     Document Type: Article

References (30)

1. Alli, Z., Sardana, R.K., Pierre, B., Andonov, A., Robert, L.S., Schernthaner, J.P., Porter, S.L., Dudani, A.K., Ganz, P.R., Tackaberry, E.S., and Altosaar, I. 2002. Pharming vaccines for hepatitis and cytomegalovirus: towards the development of multivalent and subunit vaccines for oral delivery of antigens. Phytochem. Rev. 1: 55-66.
2. Cramer, C.L., Boothe, J.G., and Oishi, K.K. 1999. Transgenic plants for therapeutic proteins: linking upstream and downstream strategies. Curr. Top. Microbiol. Immunol. 240: 95-118.
3. Daniell, H., Streatfield, S.J., and Wycoff, K. 2001. Medical molecular farming: Production of antibodies, biopharmaceuticals and edible vaccines in plants. Trends Plant Sci. 6: 219-226.
4. Datla, R.S.S., Hammerlindl, J.K., Panchuk, B., Pelcher, L.E., and Keller, W. 1992. Modified plant transformation vectors with the wild-type gene encoding NPTII. Gene, 122: 383-384.
5. Finnegan, J., and McElroy, D. 1994. Transgene inactivation: plants fight back! Bio/Technol. 12: 883-888.
6. Ganz, P.R., Sardana, R.K., Dudani, A.K., Tackaberry, E.S., Sauder, C., and Altosaar, I. 1996. Expression of human blood proteins in transgenic plants. In Transgenic Plants: A Production System for Pharmaceutical and Industrial Proteins. Edited by M.R.L. Owen and J. Pen. John Wiley and Sons Ltd., New York. pp. 281-297.
7. Giddings, G. 2001. Transgenic plants as protein factories. Curr. Opin. Biotech. 12: 450-454.
8. Giddings, G., Allison, G., Brooks, D., and Carter, A. 2000. Transgenic plants as factories for biopharmaceuticals. Nat. Biotech. 18: 1151-1155.
9. Ho, M. (Editor). 1991. Cytomegalovirus: biology and infection. 2nd ed. Plenum Medical Book Co., New York.
10. Horsch, R.B., Fry, J.E., Hoffmann, N.L., Eichholtz, D., Rogers, S.G., and Fraley, R.T. 1985. A simple and general method for transferring genes into plants. Science (Washington, D.C.), 227: 1229-1231.
11. Iglesias, V.A., Moscone, E.A., Neuhuber, F., Michalowski, S., Phelan, T., Spiker, S., Matzke, M., and Matzke A.J. 1997. Molecular and cytogenic analyses of stably and unstably expressed transgenic loci in tobacco. Plant Cell. 9: 1251-1264.
12. Kong, Q., Richter, L., Yang, Y.F., Arntzen, C.J., Mason, H.S., and Thanavala, Y. 2001. Oral immunization with hepatitis B surface antigen expressed in transgenic plants. Proc. Natl. Acad. Sci. U.S.A. 98: 11 539-11 544.
13. Leisy, D.J., Hnilo, J., Zhao, Y., and Okita, T.W. 1990. Expression of a rice glutelin promoter in transgenic tobacco. Plant Mol. Biol. 14: 41-50.
14. Miki, B.L.A., McHugh, S.G., Labbé, H., Ouellet, T., Tolman, J.H., and Brandle, J.E. 1999. Transgenic tobacco: Gene expression and applications. In Transgenic medicinal plants - biotechnology in agriculture and forestry. Vol. 45. Edited by Y.P.S. Bajaj. Springer, Berlin-Heidelberg.
15. Morino, K., Olsen, O.A., and Shimamoto, K. 1999. Silencing of an aleurone-specific gene in transgenic rice is caused by a rear-ranged transgene. Plant J. 17: 275-285.
16. Okita, T.W., Hwang, Y.S., Hnilo, J., Kim, W.T., Aryan, A.P., Larson, R., and Krishnan, H.B. 1989. Structure and expression of the rice glutelin multigene family. J. Biol. Chem. 264: 12 573-12 581.
17. Robert, L.S., Donaldson, P.A., Ladaique, C., Altosaar, I., Arnison, P.G., and Fabijanski, S.F. 1989. Antisense RNA inhibition of β-glucuronidase gene expression in transgenic tobacco plants. Plant Mol. Biol. 13: 399-409.
18. Sardana, R.K., Alli, Z., Dudani, A.K., Tackaberry, E.S., Narayanan, M., Panahi, M., Ganz, P.R., and Altosaar, I. 2002. Biological activity of human granulocyte-macrophage colony stimulating factor is maintained in a fusion with seed glutelin peptide. Transgenic Res. 11: 521-531.
19. Sardana, R.K., Ganz, P.R., Dudani, A.K., Tackaberry, E.S., Cheng, X., and Altosaar, I. 1997. Synthesis of recombinant human cytokine GM-CSF in the seeds of transgenic tobacco plants. In Methods in biotechnology. Vol. 3. Recombinant Proteins from Plants: Production and Isolation of Clinically Useful Compounds. Edited by C. Cunningham and A. Porter. Humana Press, Totowa, N.J. pp.77-87.
20. Scott, R., Draper, J., Jefferson, R., Dury, G., and Jacob, L. 1988. Analysis of gene organization and expression in plants. In Plant genetic transformation and gene expression: a laboratory manual. Edited by J. Draper, R. Scott, and P. Armitage. Blackwell Scientific Publications, Oxford, U.K. pp. 263-339.
21. Tackaberry, E.S., Dudani, A.K., Prior, F., Tocchi, M., Sardana, R., Altosaar I., and Ganz, P.R. 1999. Development of biopharmaceuticals in plant expression systems: cloning, expression and immunological reactivity of human cytomegalovirus glycoprotein B (UL55) in seeds of transgenic tobacco. Vaccine, 17: 3020-3029.
22. Tackaberry, E.S., Hamel, J., Larose, Y., and Brodeur, B.R. 1993. Anti-idiotypic mimicry of a neutralizing epitope on the glycoprotein B (gB) complex of human cytomegalovirus. J. Virol. 67: 6815-6819.
23. Tackaberry, E.S., Wright, K.E., Dudani, A.K., Sardana, R., Altosaar, I., and Ganz, P.R. 2002. A seed-derived oral subunit vaccine for human cytomegalovirus. In Molecular Farming of Plants and Animals for Human and Veterinary Medicine. Edited by L. Erickson. Kluwer Press. pp. 25-51.
24. Walmsley, A.M., and Arntzen, C.J. 2000. Plants for delivery of edible vaccines. Curr. Opin. Biotechnol. 11: 126-129.
25. Washida, H., Wu, C.Y., Suzuki, A., Yamanouchi, U., Akihama, T., and Takaiwa, E. 1999. Identification of cis-regulatory elements required for endosperm expression of rice storage protein glutelin gene GluB-1. Plant Mol. Biol. 40: 1-12.
26. Wright, K.E., Prior, F., Sardana, R., Altosaar, I., Dudani, A.K., Ganz, P.R., and Tackaberry, E.S. 2001. Sorting of glycoprotein B from human cytomegalovirus to protein storage vesicles in seeds of transgenic tobacco. Transgenic Res. 10: 177-181.
27. Yang, D., Wu, L., Hwang, Y.S., Chen, L., and Huang, N. 2001. Expression of the REB transcriptional activator in rice grains improves the yield of recombinant proteins whose genes are controlled by a Reb-responsive promoter. Proc. Natl. Acad. Sci. U.S.A. 98: 11 438-11 443.
28. Zambryski, P. 1998. Basic processes underlying Agrobacterium mediated DNA transfer to plant cells. Annu. Rev. Genet. 22: 1-30.
29. Zhao, Y., Leisy, D., and Okita, T.W. 1994. Tissue-specific expression and temporal regulation of the rice glutelin Gt3 gene are conferred by at least two spatially separated cis-regulatory elements. Plant Mol. Biol. 25: 429-436.
30. Zheng, Z., Sumi, K., Tanaka, K., and Murai, N. 1995. The bean seed storage protein [beta]-phaseolin is synthesized, processed, and accumulated in the vacuolar type-II protein bodies of transgenic rice endosperm. Plant Physiol. 109: 777-786.