Interpreting the mechanisms of continuous renal replacement therapy in sepsis: The peak concentration hypothesis

Artificial Organs

Volumn 27, Issue 9, 2003, Pages 792-801

  Ronco, Claudio ^a   Tetta, Ciro ^b   Mariano, Filippo ^a   Wratten, Mary Lou ^a   Bonello, Monica ^a   Bordoni, Valeria ^a   Cardona, Ximena ^a   Inguaggiato, Paola ^a   Pilotto, Lidia ^a   D'Intini, Vince ^a   Bellomo, Rinaldo ^c  

^a SAN BORTOLO HOSPITAL   (Italy)

^b S GIOVANNI BOSCO HOSPITAL   (Italy)

^c AUSTIN HEALTH   (Australia)

Author keywords

Acute renal failure; Continuous renal replacement therapy; Homeostasis; Multiple organ dysfunction syndrome; Peak concentration; Sepsis

Indexed keywords

PATIENT TREATMENT;

ACUTE RENAL FAILURE; CONTINUOUS RENAL REPLACEMENT THERAPY; HEMOFILTRATION; HOMOEOSTASIS; MULTIPLE ORGAN DYSFUNCTION SYNDROME; PEAK CONCENTRATIONS; RENAL FAILURE; RENAL REPLACEMENT THERAPIES; SEPSIS; SOLUBLE MEDIATORS;

INTENSIVE CARE UNITS;

INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ACUTE KIDNEY FAILURE; CAUSE OF DEATH; CLINICAL TRIAL; CONTINUOUS RENAL REPLACEMENT THERAPY; HEMOFILTRATION; HUMAN; INTENSIVE CARE UNIT; KIDNEY TRANSPLANTATION; MULTIPLE ORGAN FAILURE; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SEPSIS; SEPTIC SHOCK; SWINE;

SUS SCROFA;

EID: 10744222374     PISSN: 0160564X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1594.2003.07289.x     Document Type: Review

References (91)

1. Cosentino F, Chaff C, Piedmonte M. Risk factors influencing survival in ICU acute renal failure. Nephrol Dial Transplant 1994;9(suppl 4):179-82.
2. Liano G, Pascual J. Acute renal failure. Madrid Acute Renal Failure Study Group. Lancet 1996;347:479.
3. Bellomo R, Ronco C. Indications and criteria for initiating renal replacement therapy in the intensive care unit. Kidney Int 1998;53(suppl 66):S106-9.
4. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 1992;101:1644-55.
5. Camussi G, Montrucchio G, Diminioni L, Dionigi R. Septic shock: the unravelling of molecular mechanism. Nephrol Dial Transplant 1995;10:1808-13.
6. Glauser MP, Zanetti G, Baumgartner JD, Cohen J. Septic shock: pathogenesis. Lancet 1991;338:732-6.
7. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997;388:394-7.
8. Shimazu R, Akashi S, Ogata H, et al. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 1999;189:1777-82.
9. Medzhitov R, Preston-Hurlburt P, Kopp E, et al. My88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell 1998;2:253-8.
10. Von Bommel EFH, Bouvy ND, So KL, et al. Acute dialytic support for the critically ill: intermittent hemodialysis versus continuous arteriovenous hemodiafiltration. Am J Nephrol 1995;15:192-200.
11. Bellomo R, Mehta R. Acute renal replacement in the intensive care unit: now and tomorrow. New Horiz 1995;3:760-7.
12. Canaud B, Mion C. Extracorporeal treatment of acute renal failure: methods, indications, quantified and personalized therapeutic approach. Adv Nephrol 1995;24:271-81.
13. Silvester W, Bellomo R, Ronco C. Continuous versus intermittent renal replacement therapy in the critically ill. In: C. Ronco, R. Bellomo, eds. Critical Care Nephrology. Dordrecht: Kluwer Academic Publishers, 1998;1225-38.
14. Canaud B, Mion C. Extracorporeal treatment of acute renal failure: methods, indications, quantified and personalized therapeutic approach. Adv Nephrol 1995;24:271-81.
15. Bellomo R, Tipping P, Boyce N. Continuous veno-venous hemofiltration with dialysis cytokines from the circulation of septic patients. Crit Care Med 1993;21:522-6.
16. Schetz M, Ferdinande P, Van der Berghe G, et al. Removal of pro-inflammatory cytokines with renal replacement therapy: sense or nonsense? Intensive Care Med 1995;21:169-76.
17. van Bommel EF, Hesse CJ, Jutte NHPM, et al. Cytokine kinetics (TNF-alpha, IL-1 beta, IL-6) during continuous hemofiltration: a laboratory and clinical study. Contrib Nephrol 1995;116:62-75.
18. Bellomo R, Tipping P, Boyce N. Interleukin-6 and interleukin-8 extraction during continuous venovenous-hemodiafiltration in septic acute renal failure. Ren Fail 1995;17:457-66.
19. Millar AB, Armstrong L, van der Linden J, et al. Cytokine production and hemofiltration in children undergoing cardiopulmonary bypass. Ann Thor Surg 1993;56:1499-502.
20. Journois D, Pouard P, Greely WJ, et al. Hemofiltration during cardiopulmonary bypass in pediatric cardiac surgery. Anesthesiology 1994;81:1181-9.
21. Goldfarb S, Golper TA. Proinflammatory cytokines and hemofiltration membranes. J Am Soc Nephrol 1994;5:228-32.
22. Ronco C, Tetta C, Lupi A, et al. Removal for platelet-activating factor in experimental continuous arteriovenous hemofiltration. Crit Care Med 1995;23:99-107.
23. Cavaillon JM, Munoz C, Fitting C, Misset B, Carlet J. Circulating cytokines: the tip of the iceberg? Circ Shock 1992;38:145-52.
24. Reidy MA, Bowyer DE. Scanning electron microscopy: morphology of aortic endothelium following injury by endotoxin and during subsequent repair. Atherosclerosis 1997;26:319-28.
25. Tellez Gil LY, Rosello AM, Torres AC, Moreno RL, Ferròn-Orihuela JA. Modulation of soluble phases of endothelial/leukocyte adhesion molecule 1, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 with interleukin 1β after experimental endotoxic challenge. Crit Care Med 2001;29:776-81.
26. Dinarello CA, Cannon JC, Wolff SM, et al. Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1. J Exp Med 1986;163:1433-40.
27. van Deventer SJH, Buller HR, ten Cate JW, Aarden LA, Hack CE, Sturk A. Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic and complement pathways. Blood 1990;76:2520-6.
28. Rosenberg RD, Aird WC. Vascular-bed specific hemostasis and hypercoagulable states. N Engl J Med 1999;340:1555-64.
29. Esmon CT. The protein C pathway. Crit Care Med 2000;28:S44-8.
30. Taylor FB, Haddad PA, Hack E, et al. Two-stage response to endotoxin infusion into normal human subjects: correlation of blood phagocyte luminescence with clinical and laboratory markers of the inflammatory, hemostatic response. Crit Care Med 2001;29:326-34.
31. Faust SN, Levin M, Harrison OB, et al. Dysfunction of endothelial protein C activation in severe meningococcal sepsis. N Engl J Med 2001;345:408-16.
32. Pinsky MR. Sepsis: a pro- and anti-inflammatory disequilibrium syndrome. Contrib Nephrol 2001;132:354-66.
33. Cavaillon JM, Adib-Conquy M, Cloez-Tayarani I, Fitting C. Immunodepression in sepsis and SIRS assessed by ex vivo cytokine production is not a generalized phenomenon: a review. J Endotoxin Res 2001;7:85-93.
34. Suffredini AF, Fromm RE, Parker MM, et al. The cardiovascular response of normal humans to the administration of endotoxin. N Engl J Med 1989;321:280-7.
35. Matrich GD, Danner RL, Ceska M, et al. Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents. J Exp Med 1991;173:1021-4.
36. Michie HR, Manogue KR, Spriggs DR, et al. Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med 1988;318:1481-6.
37. Suffredini AF, Harpel PC, Parrillo JE. Promotion and subsequent inhibition of plasminogen activator after administration of intravenous endotoxin to normal subjects. N Engl J Med 1989;320:1165-72.
38. Kumasaka T, Quinlan W, Doyle N, et al. Role of the intercellular adhesion molecule (ICAM-1) in endotoxin-induced pneumonitis using ICAM-1 anti-sense oligonucleotides, anti-ICAM-1 monoclonai antibodies and ICAM-1 mutant mice. J Clin Invest 1996;97:2362-9.
39. Volk HD, Reinke P, Krausch D, et al. Monocyte deactivation: rationale for a new therapeutic strategy in sepsis. Intensive Care Med 1996;22(suppl 4):S474-81.
40. Cavaillon JM, Adib-Conquy M, Cloez-Tayarani I, Fitting C. Immunosuppression in sepsis and SIRS assessed by ex-vivo cytokine production is not a generalized phenomenon: a review. J Endotoxin Res 2001;7:85-93.
41. Munoz C, Carlet J, Fitting C, Misset B, Bleriot JP, Cavaillon JM. Dysregulation of in vitro cytokine production by monocytes during sepsis. J Clin Invest 1991;88:1747-54.
42. Randow F, Syrbe V, Meisel C, et al. Mechanism of endotoxin desensitization: involvement of interleukin-10 and transforming growth factor. J Exp Med 1995;181:1887-92.
43. Brandtzaeg P, Osnes L, Ostebo R, et al. Net inflammatory capacity of human septic shock plasma evaluated by a monocyte-based target cell assay: identification of interleukin-10 as a major functional deactivator of human monocytes. J Exp Med 1996;184:51-60.
44. Marie C, Muret J, Fitting C, et al. Interleukin-1 receptor antagonist production during infectious and noninfectious systemic inflammatory response syndrome. Crit Care Med 2000;28:2277-82.
45. Granowitz EV, Porat R, Mier JW, et al. Intravenous endotoxin suppresses the cytokine response of peripheral blood mononuclear cells in healthy humans. J Immunol 1993;151:1637-45.
46. Shapiro L, Panayotatos N, Meydani SN, Wu D, Dinarello CA. Ciliary neurotrophic factor combined with solubile receptor inhibits synthesis of proinflammatory cytokines and prostaglandin-E2 in vitro. Exp Cell Res 1994;215:51-6.
47. Bone RC, Grodzin CJ, Balk RA. Sepsis: a new hypothesis for pathogenesis of the disease process. Chest 1997;112:235-43.
48. Adib-Conquy M, Asehnoune K, Moine P, Cavaillon JM. Long-term-impaired expression of nuclear factor-kappa B and I kappa B alpha in peripheral blood mononuclear cells of trauma patients. J Leukoc Biol 2001;70:30-8.
49. Riche FC, Cholley BP, Laisne MJ, et al. Inflammatory cytokines, C reactive protein, and procalcitonin as early predictors of necrosis infections in acute necrotizing pancreatitis. Surgery 2003;133:257-62.
50. Parrillo JE, Burch C, Stelhamer JH, et al. A circulating myocardial depressant substance in humans with septic shock: septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance. J Clin Invest 1985;76:1539-53.
51. Marshall JC. Such stuff as dreams are made on: mediator-directed therapy sepsis. Nat Rev Drug Discov 2003;2:391-405.
52. Abraham E, Glauser MP, Butler T, et al. p55 tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 study group. JAMA 1997;277:1531-8.
53. Fisher CJ, Agosti JM, Opal SM. Treatment of septic shock with the tumor necrosis factor receptor: Fc fusion protein. New Engl J Med 1996;334:1697-702.
54. Echtenacher B, Falk W, Mannel D, Krammer PH. Requirement of endogenous tumour necrosis factor/cachectin for recovery from experimental peritonitis. J Immunol 1990;145:3762-6.
55. van der Meer JWM. The effects of recombinant interleukin-1 and recombinant tumor necrosis factor on non-specific resistance to infection. Biotherapy 1988;1:19-25.
56. Ronco C, Ricci Z, Bellomo R. Importance of increased ultrafiltration volume and impact on mortality: sepsis and cytokine story and the role of continuous veno-venous hemofiltration. Curr Opin Nephrol Hypertens 2001;10:755-61.
57. Hoffmann JN, Hartl WH, Deppisch R, et al. Hemofiltration in human sepsis: evidence for elimination of immunomodulatory substances. Kidney Int 1995;48:1563-70.
58. Gasche Y, Pascual M, Suter PM, Favre H, Chevrolet JC, Schifferli JA. Complement depletion during haemofiltration with polyacilonitrile membranes. Nephrol Dial Transplant 1996;11:117-9.
59. Kellum JA, Johnson JP, Kramer D, Palevsky P, Brady JJ, Pinsky MR. Diffusive vs. convective therapy: effects on mediators of inflammation in patients with severe systemic inflammatory response syndrome. Crit Care Med 1998;26:1995-2000.
60. Braun N, Giolai M, Rosenfeld S, et al. Clearance of interleukin-6 during continuous veno-venous hemofiltration in patients with septic shock. A prospective, controlled clinical study. J Am Soc Nephrol 1993;4:336.
61. Kellum JA, Bellomo R, Mehta R, Ronco C. Blood purification in non-renal critical illness. Blood Purif 2003;21:6-13.
62. Mariano F, Tetta C, Guida GE, Triolo G, Camussi G. Hemofiltration reduces the priming activity on neutrophil chemiluminescence in septic patients. Kidney Int 2001;60:1598-605.
63. Ronco C, Tetta C, Lupi A, et al. Removal of platelet-activating factor in experimental continuous arteriovenous hemofiltration. Crit Care Med 1995;23:99-107.
64. Mariano F, Bussolati B, Migliori M, Russo S, Triolo G, Camussi G. Platelet-activating factor synthesis by neutrophils, monocytes, and endothelial cells is modulated by nitric oxide production. Shock 2003;19:339-44.
65. Sander A, Armbruster W, Sander B, et al. Haemofiltration increases IL-6 clearance in early systemic inflammatory response syndrome but does not alter IL-6 and TNF alpha plasma concentrations. Intensive Care Med 1997;23:878-84.
66. De Vriese AS, Colardyn FA, Philippe JJ, Vanholder RC, De Sutter JH, Lameire NH. Cytokine removal during continuous hemofiltration in septic patients. J Am Soc Nephrol 1999;10:846-53.
67. Cole L, Bellomo R, Hart G, et al. A phase II randomized controlled trial of continuous hemofiltration in sepsis. Crit Care Med 2002;30:100-6.
68. Heering P, Morgera S, Schmitz FJ, et al. Cytokine removal and cardiovascular hemodynamics in septic patients with continuous venovenous hemofiltration. Intensive Care Med 1997;23:288-96.
69. Ronco C, Brendolan A, Lonnemann G, et al. A pilot study on coupled plasma filtration with adsorption in septic shock. Crit Care Med 2002;30:1250-5.
70. De Vriese AS, Vanholder RC, Pascual M, Lameire NH, Colardyn FA. Can inflammatory cytokines be removed efficiently by continous renal replacement therapies? Intensive Care Med 1999;25:903-10.
71. Grootendorst AF, van Bommel EFH, van der Hoven B, van Leengoed LAM, van Osta ALM. High volume hemofiltration improves hemodynamics of endotoxin-induced shock in the pig. J Crit Care 1992;7:67-75.
72. Grootendorst AF, van Bommel EFH, van der Hoven B, van Leengoed LAM, van Osta ALM. High volume hemofiltration improves right ventricular function of endotoxin-induced shock in the pig. Intensive Care Med 1992;18:235-240.
73. Grootendorst AF, van Bommel EF, van Leengoed LA, van Zanten AR, Huipen HJ, Groeneveld AB. Infusion of ultrafiltrate from endotoxemic pigs depresses myocardial performance in normal pigs. J Crit Care 1993;8:161-9.
74. Grootendorst AF, van Bommel EFH, van Leengoed LAM, Naburus M, Bouman CSC, Groeneveld ABJ. High volume hemofiltration improves hemodynamics and survival of pigs exposed to gut ischemia and reperfusion. Shock 1994;2:72-8.
75. Lee PA, Matson JR, Pryor RW, Hinshaw LB. Continuous arteriovenous hemofiltration therapy for Staphylococcus aureus-induced septicemia in immature swine. Crit Care Med 1993;21:914-24.
76. Rogiers P, Zhang H, Smail N, Pauwels D, Vincent JL. Continuous venovenous hemofiltration improves cardiac performance by mechanisms other than tumor necrosis factor-alpha attenuation during endotoxic shock. Crit Care Med 1999;27:1848-55.
77. Yekebas EF, Eisenberger CF, Ohnesorge H, et al. Attenuation of sepsis-related immunoparalysis by continuous veno-venous hemofiltration in experimental porcine pancreatitis. Crit Care Med 2001;29:1423-30.
78. Nagashima M, Shin'oka T, Nollert G, Shum-Tim D, Rader CM, Mayer JE Jr. High-volume continuous hemofiltration during cardiopulmonary bypass attenuates pulmonary dysfunction in neonatal lambs after deep hypothermic circulatory arrest. Circulation 1998;98(suppl 19):II378-84.
79. Bellomo R, Kellum JA, Gandhi CR, Pinsky MR. The effect of intensive plasma water exchange by hemofiltration on hemodynamics and soluble mediators in canine endotoxemia. Am J Respir Crit Care Med 2000;161:1429-36.
80. Ronco C, Bellomo R, Homel P, et al. Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet 2000;356:26-30.
81. Journois D, Israel Biet D, Pouard P, et al. High-volume, zero-balanced hemofiltration to reduce delayed inflammatory response to cardiopulmonary bypass in children. Anesthesiology 1996;85:965-76.
82. Oudemans-van Straaten HM, Bosman RJ, van der Spoe JI, Zandstra DF. Outcome of critically ill patients treated with intermittent high-volume haemofiltration: a prospective cohort analysis. Intensive Care Med 1999;25:814-21.
83. Cole L, Bellomo R, Journois D, Davenport P, Baldwin I, Tipping P. High-volume hemofiltration in human septic shock. Intensive Care Med 2001;27:978-86.
84. Honore PM, Jamez J, Wauthier M, et al. Prospective evaluation of short-term, high-volume isovolemic hemofiltration on the hemodynamic course and outcome in patients with intractable circulatory failure resulting from septic shock. Crit Care Med 2000;28:3581-7.
85. Lee PA, Weger G, Pryor RW, Matson JR. Effects of filter pore size on efficacy of continuous arteriovenous hemofiltration therapy for Staphylococcus aureus-induced septicemia in immature swine. Crit Care Med 1998;26:730-7.
86. Kline JA, Gordon BE, Williams C, Blumenthal S, Watts JA, Diaz-Buxo J. Large-pore hemodialysis in acute endotoxin shock. Crit Care Med 1999;27:588-96.
87. Morgera S, Buder W, Lehmann C, et al. High cut off membrane haemofiltration in septic patients with multiorgan failure. A preliminary report. Blood Purif 2000;18:61.
88. Reeves JH, Butt WW, Shann F, et al., and the plasmafiltration in sepsis study group. Continuous plasmafiltration in sepsis syndrome. Crit Care Med 1999;27:2096-104.
89. Tetta C, Cavaillon JM, Schulze M, et al. Removal of cytokines and activated complement components in an experimental model of continuous plasma filtration coupled with sorbent adsorption. Nephrol Dial Transplant 1998;13:1458-64.
90. Tetta C, Gianotti L, Cavaillon JM, et al. Coupled plasma filtration-adsorption in a rabbit model of endotoxic shock. Crit Care Med 2000;28:1526-33.
91. Lonnemann G, Bechstein M, Linnenweber S, Burg M, Koch KM. Tumor necrosis factor-alpha during continuous high-flux hemodialysis in sepsis with acute renal failure. Kidney Int 1999;56(suppl 72):S84-7.