Cytochrome P450 1A2 is a hepatic autoantigen in autoimmune polyglandular syndrome type 1

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 5, 1997, Pages 1353-1361

  Clemente, Maria Grazia ^a,b   Obermayer Straub, Petra ^a   Meloni, Antonella ^b   Strassburg, Christian P ^a   Arangino, Vincenzo ^b   Tukey, Robert H ^c   De Virgiliis, Stefano ^b   Manns, Michael P ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYTOCHROME P450; RECOMBINANT PROTEIN;

ADRENAL CORTEX; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE HEPATITIS; AUTOIMMUNITY; CHRONIC HEPATITIS; CLINICAL FEATURE; CONTROLLED STUDY; DIAGNOSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; KIDNEY PROXIMAL TUBULE; LIVER; MAJOR CLINICAL STUDY; MALE; MULTIPLE ENDOCRINE ADENOMATOSIS; NONHUMAN; PRIORITY JOURNAL; RAT; STAINING;

EID: 0030919380     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.5.1353     Document Type: Article

References (29)

1. Neufeld M, Maclaren N, Blizzard R. 1980 Autoimmune polyglandular syndromes. Pediatr Ann. 9:154-162.
2. Ahonen P, Myllärniemi S, Sipilä I, Perheentupa J. 1990 Clinical variation of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a series of 68 patients. N Engl J Med. 322:1829-1836.
3. Riley WJ. 1992 Autoimmune polyglandular syndromes. Horm Res. [Suppl 38]2:9-15.
4. Arulantham K, Dwyer JM, Genel M. 1979 Evidence for defective immunoregulation in the syndrome of familial candidiasis endocrinopathy. N Engl J Med. 300:164-168.
5. Krohn K, Uibo R, Aavik E, Peterson P, Savilahti K. 1992 Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17α-hydroxylase. Lancet. 339:770-773.
6. Winqvist O, Karlsson FA, Kämpe O. 1992 21-hydroxylase, a major autoantigen in idiopathic Addison's disease. Lancet. 339:1559-1562.
7. Winqvist O, Gustafsson J, Rorsman F, Karlsson F, Kampe O. 1994 Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type 1 and Addison's disease. J Clin Invest. 92:2377-2385.
8. Uibo R, Aavik E, Peterson P, Perheentupa J, Aranko S, Pelkonen R, Krohn K. 1994 Autoantibodies to cytochrome P450 enzymes P450 scc, P450 c17 and P450 c21 in autoimmune polyglandular diseases types I and II and in isolated Addison's disease. J Clin Endocrinol Metab. 78:323-328.
9. Uibo R, Perheentupa J, Ovod V, Krohn KJE. 1994 Characterization of adrenal autoantigens recognized by serta from patients with autoimmune polyglandular syndrome (APS) type 1. J Autoimmun. 7:399-411.
10. Song YH, Connor EL, Muir A, et al. 1994 Autoantibody epitope mapping in autoimmune Addison's disease. J Clin Endocrinol Metab. 78:1108-1112.
11. Peterson P, Krohn JE. 1994 Mapping of B cell epitopes on steroid 17a-hydroxylase, an autoantigen in autoimmune polyglandular syndrome type I. Clin Exp Immunol. 98:104-109.
12. Winqvist O, Gebre-Mehedin G, Gustafsson J, et al. 1995 Identification of the main gonadal autoantigens in patients with adrenal insufficiency and associated ovarian failure. J Clin Endocrinol Metabol. 80:1717-1723.
13. Nebert DW, Gonzalez FJ. 1987 P450 genes: structure, evolution, and regulation. Annu Rev Biochem. 56:945-993.
14. Ahonen P, Miettinen A, Perheentupa J. 1987 Adrenal and steroidal cell antibodies in patients with autoimmune polyglandular disease type I and risk of adrenocortical and ovarian failure. J Clin Endocrinol Metab. 64:494-500.
15. Michele TM, Fleckenstein J, Sgrignoli AR, Tuluvath PJ. 1994 Chronic active hepatitis in the type I polyglandular autoimmune syndrome. Postgrad Med J. 70:128-131.
16. Chung BC, Matteson KJ, Voutilainen R, Mohandas TK, Miller WL. 1986 Human cholesterol side-chain cleavage enzyme P450 scc; cDNA cloning, assignment of the gene to chromosome 15 and expression in the placenta. Proc Natl Acad Sci USA. 83:8962-8966.
17. Chung BC, Picardo-Leonard J, Haniu H, et al. 1987 Cytochrome P450 c17 (steroid 17 hydroxylase-17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues. Proc Natl Acad Sci USA. 84:407-411.
18. Laemmli UK. 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:680-685.
19. Towbin HT, Staehelin T, Gordon J. 1979 Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some application. Proc Natl Acad Sci USA 76:4350-4354.
20. Sambrook J, Fritsch EF, Maniatis T. 1989 Molecular cloning. A laboratory manual. 2nd ed. New York: Cold Spring Harbor Laboratory Press; 18.67-18.74.
21. Barnes HJ, Arlotto MP, Waterman MR. 1991 Expression and enzymatic activity of recombinant cytochrome P450 c17 hydroxylase in E. coli. Proc Natl Acad Sci USA. 88:5597-5601.
22. Manns MP, Griffin KJ, Sullivan KF, Johnson EF. 1991 LKM1 autoantibodies recognize a short linear sequence in P450 IID6, a cytochrome P450 monooxygenase. J Clin Invest. 88:1370-1378.
23. Philipp T, Durazzo M, Trautwein C, et al. 1994 Recognition of uridine-diphosphate-glucuronosyl-transferases by LKM3 antibodies in chronic hepatitis D. Lancet. 344:578-581.
24. Bourdi M, Larrey D, Nataf J, et al. 1991 Anti-liver endoplasmatic reticulum autoantibodies are directed against human cytochrome P450 1A2. J Clin Invest. 85:1967-1973.
25. Irvine WJ, Chan MMW, Scarth L. 1969 The further characterization of autoantibodies reactive with extra-adrenal steroid-producing cells in patients with adrenal disorders. Clin Exp Immunol. 4:489-503.
26. Elder M, Maclaren N, Riley W. 1981 Gonadal autoantibodies in patients with hypogonadism and/or Addison's disease. J Clin Endocrinol Metab. 52-1137-1142.
27. Betterle C, Rossi A, Pria SD, et al. 1993 Premature ovarian failure: autoimmunity and natural history. Clin Endocrinol (Oxf). 389:35-43.
28. Sacher M, Blumel P, Thaler H, Manns M. 1990 Chronic active hepatitis associated with vitiligo, nail dystrophy, alopecia and a new variant of LKM antibodies. J Hepatol. 10:364-369.
29. Manns MP, Griffin KJ, Quattrochi L, et al. 1990 Identification of cytochrome P450 IA2 as a human autoantigen. Arch Biochem Biophys. 280:229-232.