Non-organ specific autoantibodies in children with chronic hepatitis C

Journal of Hepatology

Volumn 25, Issue 5, 1996, Pages 614-620

  Bortolotti, Flavia ^a   Vajro, Pietro ^c   Balli, Fiorella ^c   Giacchino, Raffaella ^c   Crivellaro, Carlo ^c   Barbera, Cristiana ^c   Cataleta, Michela ^b   Muratori, Luigi ^b   Pontisso, Patrizia ^a   Nebbia, Gabriella ^c   Zancan, Lucia ^c   Bertolini, Adalberto ^a   Alberti, Alfredo ^a   Bianchi, Francesco ^b  

^a Clinica Medica 3   (Italy)

^b Internal Medicine   (Italy)

^c Dept of Pediatrics ^*

Author keywords

Children; Hepatitis C; Hepatitis C virus genotypes; Interferon therapy; Liver kidney microsomal autoantibodies; Non organ specific autoantibodies

Indexed keywords

ALANINE AMINOTRANSFERASE; AUTOANTIBODY; CORTICOSTEROID; INTERFERON; PREDNISOLONE;

ADOLESCENT; ARTICLE; AUTOIMMUNITY; CHILD; CHRONIC HEPATITIS; CLINICAL ARTICLE; FEMALE; GENOTYPE; HEPATITIS C; HUMAN; IMMUNOFLUORESCENCE; MALE; PRIORITY JOURNAL; VIRUS HEPATITIS; VIRUS INFECTION;

EID: 0030297023     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(96)80228-5     Document Type: Article

References (28)

1. 1. Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989; 244: 359-62.
2. 2. Esteban JI, Esteban R, Viladomiu L, Lopez-Talavera JC, Gonzalez A, Hernandez JM, Roget M, Vargas V, Genesca J, Buti M, Guardia J, Houghton M, Choo QL, Kuo G. Hepatitis C virus antibodies among risk groups in Spain. Lancet 1989; 2: 294-7.
3. 3. McFarlane IG, Smith HM, Johnson PJ, Bray GP, Vergani D, Williams R. Hepatitis C virus antibodies in chronic active hepatitis: pathogenetic factor or false-positive result? Lancet 1990; 335: 754-7.
4. 4. Lenzi M, Ballardini G, Fusconi M, Cassani P, Selleri L, Volta U, Zauli D, Bianchi FB. Type 2 autoimmune hepatitis and hepatitis C virus infection. Lancet 1990; 335: 258-9.
5. 5. Homberg JC, Abuaf N, Bernard O, Islam S, Alvarez F, Khalil SH, Poupon R, Darnis F, Lèvy VG, Grippon P, Opolon P, Bernuau J, Benhamou JP, Alagille D. Chronic active hepatitis associated with anti liver-kidney microsome antibody type 1 : a second type of "autoimmune hepatitis". Hepatology 1987; 7: 1333-9.
6. 6. Lenzi M, Johnson PJ, McFarlane IG, Ballardini G, Smith HM, McFarlane BM, Bridger C, Vergani D, Bianchi FB, Williams R. Antibodies to hepatitis C virus in autoimmune liver disease: evidence for geographical heterogeneity. Lancet 1991; 338: 277-80.
7. 7. Lunel F, Abuaf N, Frangeul L, Grippon P, Perrin M, Le Coz Y, Valla D, Borotto E, Yamamoto AM, Huraux JM, Opolon P, Homberg JC. Liver-kidney microsome antibody type 1 and hepatitis C virus infection. Hepatology 1992; 16: 630-6.
8. 8. Michel G, Ritter A, Gerken G, Meyer zum Büschenfelde KH, Decker R, Manns MP. Anti-Gor and hepatitis C virus in autoimmune liver disease. Lancet 1992; 339: 267-9.
9. 9. Abuaf N, Lunel F, Giral P, Borotto E, Laperche S, Poupon R, Opolon P, Huraux JM, Homberg JC. Non-organ specific autoantibodies associated with chronic C virus hepatitis. J Hepatol 1993; 18: 359-64.
10. 10. Czaia AJ, Carpenter HA, Santrach PJ, Moore SB, Taswell HF, Homburger HA. Evidence against hepatitis viruses as important causes of severe autoimmune hepatitis in the United States. J Hepatol 1993; 18: 342-52.
11. 11. Bianchi FB. Autoimmune hepatitis: the lesson of the discovery of hepatitis C virus. J Hepatol 1993; 18: 273-5.
12. 12. Ma Y, Peakmann M, Lenzi M, Gäken J, Thomas MG, Farzanem F, Ballardini G, Cassani F, Mieli-Vergani G, Bianchi FB, Vergani D. Case against subclassification of type II autoimmune chronic active hepatitis. Lancet 1993; 341: 60.
13. 13. Dussaix E, Maggiore G, De Giacomo C, Mondelli M, Martres P, Alvarez F. Autoimmune hepatitis in children and hepatitis C virus testing. Lancet 1990; 335: 1160-1.
14. 14. Alvarez F, Martres P, Maggiore G, Bernard O, Dussaix E. False positive result of hepatitis C enzyme-linked immuno-sorbent assay in children with autoimmune hepatitis. J Pediatr 1991; 119: 75-7.
15. 15. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Sheuer PJ. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 1994; 19: 1513-20.
16. 16. Muratori L, Cataleta M, Muratori P, Manotti P, Lenzi M, Cassani F, Bianchi FB. Detection of anti-liver cytosol antibody type 1 (anti-LC1) by immunodiffusion, counterimmunoelectrophoresis and immunoblotting: comparison of different techniques. J Immunol Meth 1995; 187: 259-64.
17. 17. Muratori L, Lenzi M, Ma Y, Cataleta M, Mieli-Vergani G, Vergani D, Bianchi FB. Heterogeneity of liver/kidney microsomal antibody type 1 in autoimmune hepatitis and hepatitis C virus related liver disease. Gut 1995; 37: 406-12.
18. 18. Tisminetzky SG, Gerotto M, Pontisso P, Chemello L, Ruvoletto MG, Baralle F, Alberti A. Genotypes of hepatitis C virus in Italian patients with chronic hepatitis C. International Hepatology Communications 1994; 2: 105-12.
19. 19. Pontisso P, Gerotto M. Chemello L, Casarin C, Tisminetzky S, Baralle F, Alberti A. Hepatitis C virus genotypes HCV-1a and HCV-1b: the clinical point of view. J Infect Dis 1995; 171: 760.
20. 20. Gregorio GV, Jones HW, Vegnente A, Bortolotti F, Mieli-Vergani G, Vergani D. Alpha Interferon treatment does not increase autoantibody prevalence in children with chronic hepatitis B virus infection. Hepatology 1994; 20 (Pt 2): 300A.
21. 21. Seelig R, Renz M, Bünger G, Schröter H, Seelig HP. Anti-LKM-1 antibodies determined by use of recombinant P450 2D6 in ELISA and Western blot and their association with anti-HCV and HCV RNA. Clin Exp Immunol 1993; 92: 373-80.
22. 22. Gerotto M, Pontisso P, Giostra F, Francesconi R, Muratori L, Ballardini G, Lenzi M, Tisminetzky S, Bianchi FB, Baralle FB, Alberti A. Analysis of the hepatitis C virus genome in patients with anti-LKM-1 autoantibodies. J. Hepatol 1994: 21: 273-6.
23. 23. Giostra F, Francesconi R, Manzin A, Lenzi M, Terlizzi P, Solforosi L, Clementi M, Bianchi FB. Correlation between HCV viremia and genotypes in LKM1 positive chronic hepatitis. Hepatology 1994; 20 (Pt 2): 351A.
24. 24. Mieli-Vergani G, Vergani D. Progress in pediatric autoimmune hepatitis. Semin Liver Dis 1994; 14: 282-8.
25. 25. Abuaf N, Johanet C, Homberg JC. Autoantibodies in autoimmune chronic active hepatitis. In: Krawitt L, Wiesner RH, eds. Autoimmune Liver Disease. New York: Raven Press, 1991; 93-109.
26. 26. Manns MP, Griffin KJ, Sullivan KF, Johnson EF. LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxigenase. J Clin Invest 1991; 88: 1370-8.
27. 27. Yamamoto AM, Cresteil D, Boniface O, Clerc FF, Alvarez F. Identification and analysis of cytochrome P450IID6 antigenic sites recognized by anti-liver kidney microsome type-1 antibodies (LKM1). Eur J Immunol 1993; 23: 1105-11.
28. 28. Muratori L, Lenzi M, Cataleta M, Giostra F, Cassani F, Ballardini G, Zauli D, Bianchi FB. Interferon therapy in liver/ kidney microsomal antibody type 1-positive patients with chronic hepatitis C. J Hepatol 1994; 21: 199-203.