Increased IL-6 and TGF-β1 concentrations in bronchoalveolar lavage fluid associated with thoracic radiotherapy

International Journal of Radiation Oncology Biology Physics

Volumn 58, Issue 3, 2004, Pages 758-767

  Barthelemy Brichant, Nicole ^a   Bosquée, Lionel ^b   Cataldo, Didier ^a   Corhay, Jean Luc ^a   Gustin, Michel ^b   Seidel, Laurence ^c   Thiry, Albert ^a   Ghaye, Benoît ^a   Nizet, Michel ^b   Albert, Adelin ^c   Deneufbourg, Jean Marie ^a   Bartsch, Pierre ^a   Nusgens, Betty ^c  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b Centre Hospitalier Regional de La Citadelle   (Belgium)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

BAL; IL 6; Lung; Radiotherapy; TGF 1

Indexed keywords

BIOLOGICAL ORGANS; PATIENT TREATMENT; RADIATION EFFECTS; RADIOTHERAPY; TISSUE; TOXICITY; TUMORS;

HUMAN LUNG TISSUES; LUNG CANCER;

ONCOLOGY;

INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; FOLLOW UP; HUMAN; LEUKOCYTE DIFFERENTIAL COUNT; LUNG CANCER; LUNG FUNCTION TEST; LUNG LAVAGE; MALE; PRIORITY JOURNAL; RADIATION PNEUMONIA; THORAX RADIOGRAPHY; TREATMENT OUTCOME;

EID: 10744220847     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(03)01614-6     Document Type: Article

References (51)

1. Landis S.H., Murray T., Bolden S., et al. Cancer statistics 1999. CA Cancer J Clin. 49:1999;8-31.
2. Martel M.K., Ten Haken R.K., Hazuka M.B., et al. Dose-volume histogram and 3-D treatment planning evaluation of patients with pneumonitis. Int J Radiat Oncol Biol Phys. 28:1994;575-581.
3. Roach M. III, Gandara D.R., Yuo H.S., et al. Radiation pneumonitis following combined modality therapy for lung cancer Analysis of prognostic factors . J Clin Oncol. 13:1995;2606-2612.
4. Dosoretz D.E., Galmarini D., Rubenstein J.H., et al. Local control in medically inoperable lung cancer An analysis of its importance in outcome and factors determining the probability of tumor eradication . Int J Radiat Oncol Biol Phys. 27:1993;507-516.
5. Rubin P., Johnston C.J., Williams J.P., et al. A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. Int J Radiat Oncol Biol Phys. 33:1995;99-109.
6. Anscher M.S., Marks L.B., Shafman T.D., et al. Using plasma transforming growth factor beta-1 during radiotherapy to select patients for dose escalation. J Clin Oncol. 19:2001;3758-3765.
7. Chen Y., Rubin P., Williams J., et al. Circulating IL-6 as a predictor of radiation pneumonitis. Int J Radiat Oncol Biol Phys. 49:2001;641-648.
8. Chen Y., Williams J., Ding I., et al. Radiation pneumonitis and early circulatory cytokine markers. Semin Radiat Oncol. 12:2002;26-33.
9. van Snick J. Interleukin-6 An overview . Annu Rev Immunol. 8:1990;253-278.
10. Hirano T. Interleukin-6 and its relation to inflammation and disease. Clin Immunol Immunopathol. 62:1992;S60-65.
11. Kelley J. State of the art Cytokines of the lung . Am Rev Respir Dis. 141:1990;765-788.
12. Elias J.A., Lentz V., Cummings P.J. Transforming growth factor-β regulation of IL-6 production by unstimulated and IL-1 stimulated human fibroblasts. J Immunol. 146:1991;3437-3443.
13. Cromwell O., Hamid Q., Corrigan C.J., et al. Expression and generation of interleukin-8, IL-6 and granulocyte-macrophage colony-stimulating factor by bronchial epithelial cells and enhancement by IL-1 β and tumour necrosis factor-α Immunology. 77:1992;330-337.
14. Crestani B., Cornillet P., Dehoux M., et al. Alveolar type II epithelial cells produce interleukin-6 in vitro and in vivo Regulation by alveolar macrophage secretory products . J Clin Invest. 94:1994;731-740.
15. Crestani B., Seta N., De Bandt M., et al. Interleukin 6 secretion by monocytes and alveolar macrophages in systemic sclerosis with lung involvement. Am J Respir Crit Care Med. 149:1994;1260-1265.
16. Wong C.K., Ho C.Y., Ko F.W., et al. Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-γ, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin Exp Immunol. 125:2001;177-183.
17. Hsieh C.C., Tang R.B., Tsai C.H., et al. Serum interleukin-6 and tumor necrosis factor-α concentrations in children with mycoplasma pneumonia. J Microbiol Immunol Infect. 34:2001;109-112.
18. Wedzicha J.A., Seemungal T.A.R., MacCallum P.K., et al. Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels. Thromb Haemost. 84:2000;210-215.
19. Headley A.S., Tolley E., Meduri G.U. Infections and the inflammatory response in acute respiratory distress syndrome. Chest. 111:1997;1306-1321.
20. Dobyns E.L., Eells P.L., Griebel J.L., et al. Elevated plasma endothelin-1 and cytokine levels in children with severe acute respiratory distress syndrome. J Pediatr. 135:1999;246-249.
21. Yanagawa H., Sone S., Takahashi Y., et al. Serum levels of interleukin 6 in patients with lung cancer. Br J Cancer. 71:1995;1095-1098.
22. Tyburski J.G., Dente C., Wilson R.F., et al. Differences in arterial and mixed venous IL-6 levels The lungs as a source of cytokine storm in sepsis . Surgery. 130:2001;748-752.
23. Schutte H., Lohmeyer J., Rosseau S., et al. Bronchoalveolar and systemic cytokine profiles in patients with ARDS, severe pneumonia and cardiogenic pulmonary oedema. Eur Respir J. 9:1996;1858-1867.
24. Maus U., Rosseau S., Knies U., et al. Expression of pro-inflammatory cytokines by flow-sorted alveolar macrophages in severe pneumonia. Eur Respir J. 11:1998;534-541.
25. Park C.S., Chung S.W., Ki S.Y., et al. Increased levels of interleukin-6 are associated with lymphocytosis in bronchoalveolar lavage fluids of idiopathic nonspecific interstitial pneumonia. Am J Respir Crit Care Med. 162:2000;1162-1168.
26. Park W.Y., Goodman R.B., Steinberg K.P., et al. Cytokine balance in the lungs of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 164:2001;1896-1903.
27. Magnan A., Mege J.L., Escallier J.C., et al. Balance between alveolar macrophage IL-6 and TGF-β in lung-transplant recipients. Am J Respir Crit Care Med. 153:1996;1431-1436.
28. Dowlati A., Levitan N., Remick S.C. Evaluation of interleukin-6 in bronchoalveolar lavage fluid and serum of patients with lung cancer. J Lab Clin Med. 134:1999;405-409.
29. Chyczewska E., Mroz R.M., Kowal E. TNF-alpha, IL-1 and IL-6 concentration in bronchoalveolar lavage fluid (BALF) of non-small cell lung cancer (NSCLC). Rocz Akad Med Bialymst. 42:(Suppl. 1):1997;123-135.
30. Song W., Zhao J., Li Z. Interleukin-6 in bronchoalveolar lavage fluid from patients with COPD. Chin Med J. 114:2001;1140-1142.
31. Scholma J., Slebos D.J., Boezen H.M., et al. Eosinophilic granulocytes and interleukin-6 level in bronchoalveolar lavage fluid are associated with the development of obliterative bronchiolitis after lung transplantation. Am J Respir Crit Care Med. 162:2000;2221-2225.
32. Hosoi Y., Miyachi H., Matsumoto Y., et al. Induction of Interleukin-1β and interleukin-6 mRNA by low doses of ionizing radiation in macrophages. Int J Cancer (Radiat Oncol Invest). 96:2001;270-276.
33. 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc Natl Acad Sci USA. 88:1991;6642-6646.
34. El-Gamel A., Sim E., Hasleton P., et al. Transforming growth factor beta (TGF-β) and obliterative bronchiolitis following pulmonary transplantation. J Heart Lung Transplant. 18:1999;828-837.
35. Jagirdar J., Begin R., Dufresne A., et al. Transforming growth factor-β (TGF-β) in silicosis. Am J Respir Crit Care Med. 154:1996;1076-1081.
36. Khalil N., O'Connor R.N., Flanders K.C., et al. TGF-β1, but not TGF-β2 or TGF-β3, is differentially present in epithelial cells of advanced pulmonary fibrosis An immuno-histochemical study . Am J Respir Cell Mol Biol. 14:1996;131-138.
37. Khalil N., O'Connor R.N., Unruh H.W., et al. Increased production and immunohistochemical localization of transforming growth factor-β in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 5:1991;155-162.
38. 1 in pulmonary injury after radiation therapy. Lung Cancer. 19:1998;109-120.
39. 30 and transforming growth factor β Int J Radiat Oncol Biol Phys. 50:2001;899-908.
40. Anscher M.S., Kong F.M., Andrews K., et al. Plasma transforming growth factor β1 as a predictor of radiation pneumonitis. Int J Radiat Oncol Biol Phys. 41:1998;1029-1035.
41. Anscher M.S., Kong F.M., Murase T., et al. Short communication Normal tissue injury after cancer therapy is a local response exacerbated by an endocrine effect of TGF-β Br J Radiol. 68:1995;331-333.
42. 1 plasma level in patients with lung cancer Potential mechanisms . Eur J Clin Invest. 32:2002;193-198.
43. Rube C.E., Uthe D., Schmid K.W., et al. Dose-dependent induction of transforming growth factor β (TGF-β) in the lung tissue of fibrosis-prone mice after thoracic irradiation. Int J Radiat Oncol Biol Phys. 47:2000;1033-1042.
44. Finkelstein J.N., Johnston C.J., Baggs R., et al. Early alterations in extracellular matrix and transforming growth factor β gene expression in mouse lung indicative of late radiation fibrosis. Int J Radiat Oncol Biol Phys. 28:1994;621-631.
45. Yi E.S., Bedoya A., Lee H., et al. Radiation-induced lung injury in vivo Expression of transforming growth factor-beta precedes fibrosis . Inflammation. 20:1996;339-352.
46. Hakenjos L., Bamberg M., Rodemann H.P. TGF-beta1-mediated alterations of rat lung fibroblast differentiation resulting in the radiation-induced fibrotic phenotype. Int J Radiat Biol. 76:2000;503-509.
47. 1 wild-type fibroblasts. Int J Radiat Biol. 78:2002;331-339.
48. Johnston C.J., Piedboeuf B., Baggs R., et al. Differences in correlation of mRNA gene expression in mice sensitive and resistant to radiation-induced pulmonary fibrosis. Radiat Res. 142:1995;197-203.
49. Franko A.J., Sharplin J., Ghahary A., et al. Immunohistochemical localization of transforming growth β and tumor necrosis factor α in the lungs of fibrosis-prone and "non-fibrosing" mice during the latent period and early phase after irradiation. Radiat Res. 147:1997;245-256.
50. Kong F.M., Washington M.K., Jirtle R.L., et al. Plasma transforming growth factor-β1 reflects disease status in patients with lung cancer after radiotherapy A possible tumor marker . Lung Cancer. 16:1996;47-59.
51. 1 level before radiotherapy correlates with long term outcome of patients with lung carcinoma. Cancer. 86:1999;1712-1719.