Gene expression clustering using self-organizing maps: Analysis of the macrophage response to particulate biomaterials

Biomaterials

Volumn 26, Issue 16, 2005, Pages 2933-2945

  Garrigues, Grant E ^a   Cho, David R ^b   Rubash, Harry E ^a   Goldring, Steven R ^b   Herndon, James H ^a   Shanbhag, Arun S ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Aseptic loosening; Gene expression; Macrophage; Microarrays; Osteolysis; Self organizing maps; Ti alloy; Total joint replacement; UHMWPE; Wear debris

Indexed keywords

ASEPTIC LOOSENING; OSTEOLYSIS; PHAGOCYTOSIS; SELF-ORGANIZING MAPS;

BIOMATERIALS; POLYETHYLENES; PROSTHETICS; PROTEINS; RNA; TITANIUM ALLOYS;

GENES;

BIOMATERIAL; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; POLYETHYLENE; TITANIUM; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CLUSTER ANALYSIS; CONTROLLED STUDY; DATA ANALYSIS; DNA MICROARRAY; DOWN REGULATION; EXPOSURE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; UPREGULATION;

ALGORITHMS; ALLOYS; BIOCOMPATIBLE MATERIALS; CLUSTER ANALYSIS; DNA, COMPLEMENTARY; DOWN-REGULATION; GENE EXPRESSION REGULATION; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INFLAMMATION; LIGANDS; MACROPHAGES; MALE; MONOCYTES; MULTIGENE FAMILY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOLYSIS; PHAGOCYTOSIS; POLYETHYLENE; POLYETHYLENES; PROSTHESIS FAILURE; RNA, MESSENGER; SIGNAL TRANSDUCTION; STATISTICS; TIME FACTORS; TITANIUM; UP-REGULATION;

EID: 10644233985     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2004.06.034     Document Type: Article

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