Cyclic nitrone free radical traps: Isolation, identification, and synthesis of 3,3-dimethyl-3,4-dihydroisoquinolin-4-ol N-oxide, a metabolite with reduced side effects

Journal of Medicinal Chemistry

Volumn 39, Issue 25, 1996, Pages 4997-5004

  Thomas, Craig E ^b,c   Bernardelli, Patrick ^a   Bowen, S Marc ^b   Chaney, Stephen F ^b   Friedrich, Dirk ^b   Janowick, David A ^b,d   Jones, Bryan K ^b   Keeley, Frederick J ^b   Kehne, John H ^b,e   Ketteler, Bert ^b   Ohlweiler, David F ^b   Paquette, Leo A ^a   Robke, David J ^b   Fevig, Thomas L ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b SANOFI   (France)

^c ELI LILLY AND COMPANY   (United States)

^d ABBOTT LABORATORIES   (United States)

^e NEUROGEN CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,3 DIMETHYL 3,4 DIHYDROISOQUINOLIN 4 OL N OXIDE; ANTIOXIDANT; FREE RADICAL; N TERT BUTYL ALPHA PHENYLNITRONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CEREBELLUM; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG PENETRATION; DRUG POTENCY; DRUG SYNTHESIS; GRANULE CELL; LIPID PEROXIDATION; LOCOMOTION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; SEDATION; STROKE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELLS, CULTURED; CEREBELLUM; FREE RADICAL SCAVENGERS; ISOQUINOLINES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MOTOR ACTIVITY; NITROGEN OXIDES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 10544240359     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960244n     Document Type: Article

References (29)

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