-
1
-
-
0042454593
-
Comparative study of the potency and selectivity of anti-herpes compounds
-
Skoda J, Langen P, editors. Oxford: Pergamon Press
-
De Clercq E, Descamps J, Barr PJ, Jones AS, Serafinowski P, Walker RT, Huang GF, Torrence PF, Schmidt CL, Mertes MP, Kulikowski T, Shugar D. Comparative study of the potency and selectivity of anti-herpes compounds. In: Skoda J, Langen P, editors. Antimetabolites in biochemistry, biology, and medicine. Oxford: Pergamon Press; 1979. pp 275-285.
-
(1979)
Antimetabolites in Biochemistry, Biology, and Medicine
, pp. 275-285
-
-
De Clercq, E.1
Descamps, J.2
Barr, P.J.3
Jones, A.S.4
Serafinowski, P.5
Walker, R.T.6
Huang, G.F.7
Torrence, P.F.8
Schmidt, C.L.9
Mertes, M.P.10
Kulikowski, T.11
Shugar, D.12
-
2
-
-
84959799059
-
The synthesis and properties of some antiviral nucleosides
-
Walker RT, Barr PJ, De Clercq E, Descamps J, Jones AS, Serafinowski P. The synthesis and properties of some antiviral nucleosides. Nucleic Acids Res 1978;Special publication no. 4:s103-s106.
-
(1978)
Nucleic Acids Res
, Issue.4 SPECIAL PUBLICATION NO
-
-
Walker, R.T.1
Barr, P.J.2
De Clercq, E.3
Descamps, J.4
Jones, A.S.5
Serafinowski, P.6
-
3
-
-
0000393677
-
(E)-5-(2-Bromovinyl)-2′-deoxyuridine: A potent and selective anti-herpes agent
-
De Clercq E, Descamps J, De Somer P, Barr PJ, Jones AS, Walker RT. (E)-5-(2-Bromovinyl)-2′-deoxyuridine: A potent and selective anti-herpes agent. Proc Natl Acad Sci USA 1979;76:2947-2951.
-
(1979)
Proc Natl Acad Sci USA
, vol.76
, pp. 2947-2951
-
-
De Clercq, E.1
Descamps, J.2
De Somer, P.3
Barr, P.J.4
Jones, A.S.5
Walker, R.T.6
-
4
-
-
0010927080
-
A selective bromination of thymidine
-
Bärwolff D, Langen P. A selective bromination of thymidine. Nucleic Acids Res 1975;Special publication no. 1:s29-s31.
-
(1975)
Nucleic Acids Res
, Issue.1 SPECIAL PUBLICATION NO
-
-
Bärwolff, D.1
Langen, P.2
-
5
-
-
0020313902
-
Efficiency and selectivity of (E)-5-(2-bromovinyl)-2′-deoxyuridine and some other 5-substituted 2′-deoxypyrimidine nucleosides as antiherpes agents
-
Reefschläger J, Bärwolff D, Engelmann P, Langen P, Rosenthal HA. Efficiency and selectivity of (E)-5-(2-bromovinyl)-2′-deoxyuridine and some other 5-substituted 2′-deoxypyrimidine nucleosides as antiherpes agents. Antiviral Res 1982;2:41-52.
-
(1982)
Antiviral Res
, vol.2
, pp. 41-52
-
-
Reefschläger, J.1
Bärwolff, D.2
Engelmann, P.3
Langen, P.4
Rosenthal, H.A.5
-
6
-
-
0017639148
-
Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine
-
Elion GB, Furman PA, Fyfe JA, de Miranda P, Beauchamp L, Schaeffer HJ. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. Proc Natl Acad Sci USA 1977;74:5716-5720.
-
(1977)
Proc Natl Acad Sci USA
, vol.74
, pp. 5716-5720
-
-
Elion, G.B.1
Furman, P.A.2
Fyfe, J.A.3
De Miranda, P.4
Beauchamp, L.5
Schaeffer, H.J.6
-
7
-
-
0017811137
-
9-(2-Hydroxyethoxymethyl)-guanine activity against viruses of the herpes group
-
Schaeffer HJ, Beauchamp L, de Miranda P, Elion GB, Bauer DJ, Collins P. 9-(2-Hydroxyethoxymethyl)-guanine activity against viruses of the herpes group. Nature 1978;272:583-585.
-
(1978)
Nature
, vol.272
, pp. 583-585
-
-
Schaeffer, H.J.1
Beauchamp, L.2
De Miranda, P.3
Elion, G.B.4
Bauer, D.J.5
Collins, P.6
-
8
-
-
0018855986
-
2′-Fluoro-5-iodo-aracytosine, a potent and selective anti-herpesvirus agent
-
Lopez C, Watanabe KA, Fox JJ. 2′-Fluoro-5-iodo-aracytosine, a potent and selective anti-herpesvirus agent. Antimicrob Agents Chemother 1980;17:803-806.
-
(1980)
Antimicrob Agents Chemother
, vol.17
, pp. 803-806
-
-
Lopez, C.1
Watanabe, K.A.2
Fox, J.J.3
-
9
-
-
0018331237
-
Nucleosides. 110. Synthesis and antiherpes virus activity of some 2′-fluoro-2′-deoxyarabinofuranosyl-pyrimidine nucleosides
-
Watanabe KA, Reichman U, Hirota K, Lopez C, Fox JJ. Nucleosides. 110. Synthesis and antiherpes virus activity of some 2′-fluoro-2′- deoxyarabinofuranosyl-pyrimidine nucleosides. J Med Chem 1979;22: 21-24.
-
(1979)
J Med Chem
, vol.22
, pp. 21-24
-
-
Watanabe, K.A.1
Reichman, U.2
Hirota, K.3
Lopez, C.4
Fox, J.J.5
-
11
-
-
0019184111
-
Antiviral and antitumor activities of 5-substituted 2′- deoxyuridines
-
De Clercq E. Antiviral and antitumor activities of 5-substituted 2′-deoxyuridines. Meth Find Exp Clin Pharmacol 1980;2:253-267.
-
(1980)
Meth Find Exp Clin Pharmacol
, vol.2
, pp. 253-267
-
-
De Clercq, E.1
-
12
-
-
8844253416
-
Antiviral activity of pyrimidine nucleoside analogs: A structure-function analysis
-
Alderweireldt FC, Esmans EL, editors. Antwerp, 4-6 February 1981. Antwerp: The University of Antwerp
-
De Clercq E. Antiviral activity of pyrimidine nucleoside analogs: A structure-function analysis. In: Alderweireldt FC, Esmans EL, editors. Proceedings of the 4th International Round Table on Nucleosides, Nucleotides, and their Biological Applications, Antwerp, 4-6 February 1981. Antwerp: The University of Antwerp; 1982. pp 25-45.
-
(1982)
Proceedings of the 4th International Round Table on Nucleosides, Nucleotides, and Their Biological Applications
, pp. 25-45
-
-
De Clercq, E.1
-
13
-
-
0042088093
-
Selective antiherpes agents
-
De Clercq E. Selective antiherpes agents. Trends Pharmacol Sci 1982;3:492-495.
-
(1982)
Trends Pharmacol Sci
, vol.3
, pp. 492-495
-
-
De Clercq, E.1
-
14
-
-
0020112108
-
Antiviral activity of 5-substituted pyrimidine nucleoside analogues
-
De Clercq E. Antiviral activity of 5-substituted pyrimidine nucleoside analogues. Pure Appl Chem 1983;55:623-636.
-
(1983)
Pure Appl Chem
, vol.55
, pp. 623-636
-
-
De Clercq, E.1
-
15
-
-
85012541233
-
The chemotherapy of herpesvirus infections with reference to bromovinyldeoxyuridine and other antiviral compounds
-
Sir Stuart-Harris CH, Oxford J, editors. London: Academic Press
-
De Clercq E. The chemotherapy of herpesvirus infections with reference to bromovinyldeoxyuridine and other antiviral compounds. In: Sir Stuart-Harris CH, Oxford J, editors. Problems of antiviral therapy. London: Academic Press; 1983. pp 295-315.
-
(1983)
Problems of Antiviral Therapy
, pp. 295-315
-
-
De Clercq, E.1
-
16
-
-
8844230508
-
Bromovinyldeoxyuridine (BVDU): Current status in antiviral therapy
-
Kurstak E, editor. New York: Marcel Dekker, Inc.
-
De Clercq E. Bromovinyldeoxyuridine (BVDU): Current status in antiviral therapy. In: Kurstak E, editor. Control of virus diseases. New York: Marcel Dekker, Inc.; 1984. pp 443-458.
-
(1984)
Control of Virus Diseases
, pp. 443-458
-
-
De Clercq, E.1
-
17
-
-
8844237141
-
Therapeutic potentials of bromovinyldeoxyuridine (BVDU) in the treatment of herpesvirus infections. I. Fundamental aspects
-
Rapp F, editor. New York: Alan R. Liss, Inc.
-
De Clercq E. Therapeutic potentials of bromovinyldeoxyuridine (BVDU) in the treatment of herpesvirus infections. I. Fundamental aspects. In: Rapp F, editor. Herpesvirus. New York: Alan R. Liss, Inc.; 1984. pp 573-585.
-
(1984)
Herpesvirus
, pp. 573-585
-
-
De Clercq, E.1
-
18
-
-
8844262102
-
Therapeutic potentials of bromovinyldeoxyuridine (BVDU) in the treatment of herpesvirus infections. I. Clinical aspects
-
Rapp F, editor. New York: Alan R. Liss, Inc.
-
De Clercq E. Therapeutic potentials of bromovinyldeoxyuridine (BVDU) in the treatment of herpesvirus infections. I. Clinical aspects. In: Rapp F, editor. Herpesvirus. New York: Alan R. Liss, Inc.; 1984. pp 587-599.
-
(1984)
Herpesvirus
, pp. 587-599
-
-
De Clercq, E.1
-
19
-
-
0003234903
-
Synthetic pyrimidine nucleoside analogues
-
Harnden MR, editor. London: MacMillan Press
-
De Clercq E. Synthetic pyrimidine nucleoside analogues. In: Harnden MR, editor. Approaches to antiviral agents. London: MacMillan Press; 1985. pp 57-99.
-
(1985)
Approaches to Antiviral Agents
, pp. 57-99
-
-
De Clercq, E.1
-
20
-
-
0022498839
-
Towards a selective chemotherapy of virus infections. Development of bromovinyldeoxyuridine as a highly potent and selective antiherpetic drug
-
De Clercq E. Towards a selective chemotherapy of virus infections. Development of bromovinyldeoxyuridine as a highly potent and selective antiherpetic drug. Verh K Acad Geneesk Belg 1986;48:261-290.
-
(1986)
Verh K Acad Geneesk Belg
, vol.48
, pp. 261-290
-
-
De Clercq, E.1
-
21
-
-
0021673471
-
Synthesis and antiviral properties of 5-vinylpyrimidine nucleoside analogs
-
De Clercq E, Walker RT. Synthesis and antiviral properties of 5-vinylpyrimidine nucleoside analogs. Pharmacol Ther 1984;26:1-44.
-
(1984)
Pharmacol Ther
, vol.26
, pp. 1-44
-
-
De Clercq, E.1
Walker, R.T.2
-
22
-
-
0022849724
-
Chemotherapeutic agents for herpesvirus infections
-
Ellis GP, West GB, editors. Amsterdam: Elsevier Science Publishers, B.V.
-
De Clercq E, Walker RT. Chemotherapeutic agents for herpesvirus infections. In: Ellis GP, West GB, editors. Progress in medicinal chemistry, Vol. 23. Amsterdam: Elsevier Science Publishers, B.V.; 1986. pp 187-218.
-
(1986)
Progress in Medicinal Chemistry
, vol.23
, pp. 187-218
-
-
De Clercq, E.1
Walker, R.T.2
-
23
-
-
0019813270
-
Differential inhibition of herpes simplex viruses, type 1 (HSV-1) and type 2 (HSV-2), by (E)-5-(2-X-vinyl)-2′-deoxyuridines
-
De Clercq E, Verhelst G, Descamps J, Bergstrom DE. Differential inhibition of herpes simplex viruses, type 1 (HSV-1) and type 2 (HSV-2), by (E)-5-(2-X-vinyl)-2′-deoxyuridines. Acta Microbiol Acad Sci Hung 1981;28:307-312.
-
(1981)
Acta Microbiol Acad Sci Hung
, vol.28
, pp. 307-312
-
-
De Clercq, E.1
Verhelst, G.2
Descamps, J.3
Bergstrom, D.E.4
-
24
-
-
8844223584
-
Bromovinyluracil nucleoside analogues as antiherpes agents
-
Dahlbom R, Nilsson JLG, editors. Stockholm: Swedish Pharmaceutical Press
-
De Clercq E, Desgranges C, Herdewijn P, Sim IS, Walker RT. Bromovinyluracil nucleoside analogues as antiherpes agents. In: Dahlbom R, Nilsson JLG, editors. Proceedings of the VIIIth International Symposium on Medicinal Chemistry, Vol. 1. Stockholm: Swedish Pharmaceutical Press; 1985. pp 198-210.
-
(1985)
Proceedings of the VIIIth International Symposium on Medicinal Chemistry
, vol.1
, pp. 198-210
-
-
De Clercq, E.1
Desgranges, C.2
Herdewijn, P.3
Sim, I.S.4
Walker, R.T.5
-
25
-
-
0018819307
-
Comparative efficacy of antiherpes drugs against different strains of herpes simplex virus
-
De Clercq E, Descamps J, Verhelst G, Walker RT, Jones AS, Torrence PF, Shugar D. Comparative efficacy of antiherpes drugs against different strains of herpes simplex virus. J Infect Dis 1980;141:563-574.
-
(1980)
J Infect Dis
, vol.141
, pp. 563-574
-
-
De Clercq, E.1
Descamps, J.2
Verhelst, G.3
Walker, R.T.4
Jones, A.S.5
Torrence, P.F.6
Shugar, D.7
-
26
-
-
0020701070
-
Comparative efficacy of antiherpes drugs against various strains of varicella-zoster virus
-
Shigeta S, Yokota T, Iwabuchi T, Baba M, Konno K, Ogata M, De Clercq E. Comparative efficacy of antiherpes drugs against various strains of varicella-zoster virus. J Infect Dis 1983;147:576-584.
-
(1983)
J Infect Dis
, vol.147
, pp. 576-584
-
-
Shigeta, S.1
Yokota, T.2
Iwabuchi, T.3
Baba, M.4
Konno, K.5
Ogata, M.6
De Clercq, E.7
-
27
-
-
0018955821
-
Oral (E)-5-(2-bromovinyl)-2′-deoxyuridine in severe herpes zoster
-
De Clercq E, Degreef H, Wildiers J, de Jonge G, Drochmans A, Descamps J, De Somer P. Oral (E)-5-(2-bromovinyl)-2′-deoxyuridine in severe herpes zoster. Br Med J 1980;281:1178.
-
(1980)
Br Med J
, vol.281
, pp. 1178
-
-
De Clercq, E.1
Degreef, H.2
Wildiers, J.3
De Jonge, G.4
Drochmans, A.5
Descamps, J.6
De Somer, P.7
-
28
-
-
0019490136
-
Efficacy of (E)-5-(2-bromovinyl)-2′-deoxyuridine in the topical treatment of herpes simplex keratitis
-
Maudgal PC, Missotten L, De Clercq E, Descamps J, De Meuter E. Efficacy of (E)-5-(2-bromovinyl)-2′-deoxyuridine in the topical treatment of herpes simplex keratitis. Albrecht von Graefes Arch Klin Ophthalmol 1981;216:261-268.
-
(1981)
Albrecht Von Graefes Arch Klin Ophthalmol
, vol.216
, pp. 261-268
-
-
Maudgal, P.C.1
Missotten, L.2
De Clercq, E.3
Descamps, J.4
De Meuter, E.5
-
29
-
-
0021361194
-
Oral (E)-5-(2-bromovinyl)-2′-deoxyuridine treatment of severe herpes zoster in cancer patients
-
Wildiers J, De Clercq E. Oral (E)-5-(2-bromovinyl)-2′-deoxyuridine treatment of severe herpes zoster in cancer patients. Eur J Cancer Clin Oncol 1984;20:471-476.
-
(1984)
Eur J Cancer Clin Oncol
, vol.20
, pp. 471-476
-
-
Wildiers, J.1
De Clercq, E.2
-
30
-
-
0021940407
-
Oral BVDU treatment of varicella and zoster in children with cancer
-
Benoit Y, Laureys G, Delbeke M-J, De Clercq E. Oral BVDU treatment of varicella and zoster in children with cancer. Eur J Pediatr 1985;143:198-202.
-
(1985)
Eur J Pediatr
, vol.143
, pp. 198-202
-
-
Benoit, Y.1
Laureys, G.2
Delbeke, M.-J.3
De Clercq, E.4
-
31
-
-
0025832440
-
Bromovinyldeoxyuridine treatment of herpetic keratitis clinically resistant to other antiviral agents
-
Maudgal PC, De Clercq E. Bromovinyldeoxyuridine treatment of herpetic keratitis clinically resistant to other antiviral agents. Curr Eye Res 1991;10(Suppl):193-199.
-
(1991)
Curr Eye Res
, vol.10
, Issue.SUPPL.
, pp. 193-199
-
-
Maudgal, P.C.1
De Clercq, E.2
-
32
-
-
0021368843
-
Erste Erfahrungen mit dem Antiherpetikum (E)-5-(2-bromvinyl)-2′- desoxyuridin (BrVUdR) bei der Behandlung des Herpes corneae
-
Töpke H, Reefschläger J, Bärwolff D, Halibrand C. Erste Erfahrungen mit dem Antiherpetikum (E)-5-(2-bromvinyl)-2′-desoxyuridin (BrVUdR) bei der Behandlung des Herpes corneae. Folia Ophthal 1984;9: 39-48.
-
(1984)
Folia Ophthal
, vol.9
, pp. 39-48
-
-
Töpke, H.1
Reefschläger, J.2
Bärwolff, D.3
Halibrand, C.4
-
33
-
-
0024240083
-
BVDU-Therapie von Zostererkrankungen bei Patienten mit malignem Grundleiden
-
Wutzler P, Wutke K, Bärwolff D, Reefschläger J. BVDU-Therapie von Zostererkrankungen bei Patienten mit malignem Grundleiden. Z Gesamte Inn Med 1988;43:677-680.
-
(1988)
Z Gesamte Inn Med
, vol.43
, pp. 677-680
-
-
Wutzler, P.1
Wutke, K.2
Bärwolff, D.3
Reefschläger, J.4
-
34
-
-
0037375309
-
Herpes zoster guideline of the German Dermatology Society (DDG)
-
Gross G, Schöfer H, Wassilew S, Friese K, Timm A, Guthoff R, Pau HW, Malin JP, Wutzler P, Doerr HW. Herpes zoster guideline of the German Dermatology Society (DDG). J Clin Virol 2003;26:277-289.
-
(2003)
J Clin Virol
, vol.26
, pp. 277-289
-
-
Gross, G.1
Schöfer, H.2
Wassilew, S.3
Friese, K.4
Timm, A.5
Guthoff, R.6
Pau, H.W.7
Malin, J.P.8
Wutzler, P.9
Doerr, H.W.10
-
35
-
-
0021604868
-
The antiviral spectrum of (E)-5-(2-bromovinyl)-2′-deoxyuridine
-
De Clercq E. The antiviral spectrum of (E)-5-(2-bromovinyl)-2′- deoxyuridine. J Antimicrob Chemother 1984;14(Suppl A):85-95.
-
(1984)
J Antimicrob Chemother
, vol.14
, Issue.SUPPL. A
, pp. 85-95
-
-
De Clercq, E.1
-
36
-
-
0031962014
-
In vitro and in vivo inhibition of murine gamma herpesvirus 68 replication by selected antiviral agents
-
Neyts J, De Clercq E. In vitro and in vivo inhibition of murine gamma herpesvirus 68 replication by selected antiviral agents. Antimicrob Agents Chemother 1998;42:170-172.
-
(1998)
Antimicrob Agents Chemother
, vol.42
, pp. 170-172
-
-
Neyts, J.1
De Clercq, E.2
-
38
-
-
0032086448
-
(E)-5-(2′-Bromovinyl)-2′-deoxyuridine inhibition of macropodid herpesvirus 1 in vitro
-
Smith GA, Whalley JM. (E)-5-(2′-Bromovinyl)-2′-deoxyuridine inhibition of macropodid herpesvirus 1 in vitro. J Zoo Wildlife Med 1998;29:157-159.
-
(1998)
J Zoo Wildlife Med
, vol.29
, pp. 157-159
-
-
Smith, G.A.1
Whalley, J.M.2
-
39
-
-
0029687608
-
In vitro sensitivity of macropodid herpesvirus 2 to selected anti-herpetic compounds
-
Smith G. In vitro sensitivity of macropodid herpesvirus 2 to selected anti-herpetic compounds. J Wildlife Dis 1996;32:117-120.
-
(1996)
J Wildlife Dis
, vol.32
, pp. 117-120
-
-
Smith, G.1
-
40
-
-
0028884262
-
Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6
-
Reymen D, Naesens L, Balzarini J, Holý A, Dvoraková H, De Clercq E. Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6. Antiviral Res 1995;28:343-357.
-
(1995)
Antiviral Res
, vol.28
, pp. 343-357
-
-
Reymen, D.1
Naesens, L.2
Balzarini, J.3
Holý, A.4
Dvoraková, H.5
De Clercq, E.6
-
41
-
-
0032802986
-
Selective activity of various antiviral compounds against HHV-7 infection
-
Zhang Y, Schols D, De Clercq E. Selective activity of various antiviral compounds against HHV-7 infection. Antiviral Res 1999;43:23-35.
-
(1999)
Antiviral Res
, vol.43
, pp. 23-35
-
-
Zhang, Y.1
Schols, D.2
De Clercq, E.3
-
42
-
-
0030782743
-
Antiviral drug susceptibility of human herpesvirus 8
-
Neyts J, De Clercq E. Antiviral drug susceptibility of human herpesvirus 8. Antimicrob Agents Chemother 1997;41:2754-2756.
-
(1997)
Antimicrob Agents Chemother
, vol.41
, pp. 2754-2756
-
-
Neyts, J.1
De Clercq, E.2
-
43
-
-
0026530149
-
Comparative activity of various compounds against clinical strains of herpes simplex virus
-
Andrei G, Snoeck R, Goubau P, Desmyter J, De Clercq E. Comparative activity of various compounds against clinical strains of herpes simplex virus. Eur J Clin Microbiol Infect Dis 1992;11:143-151.
-
(1992)
Eur J Clin Microbiol Infect Dis
, vol.11
, pp. 143-151
-
-
Andrei, G.1
Snoeck, R.2
Goubau, P.3
Desmyter, J.4
De Clercq, E.5
-
44
-
-
0029019758
-
Comparative activity of selected antiviral compounds against clinical isolates of varicella-zoster virus
-
Andrei G, Snoeck R, Reymen D, Liesnard C, Goubau P, Desmyter J, De Clercq E. Comparative activity of selected antiviral compounds against clinical isolates of varicella-zoster virus. Eur J Clin Microbiol Infect Dis 1995;14:318-328.
-
(1995)
Eur J Clin Microbiol Infect Dis
, vol.14
, pp. 318-328
-
-
Andrei, G.1
Snoeck, R.2
Reymen, D.3
Liesnard, C.4
Goubau, P.5
Desmyter, J.6
De Clercq, E.7
-
45
-
-
0019827449
-
Specific phosphorylation of E-5-(2-iodovinyl)-2′-deoxyuridine by herpes simplex virus-infected cells
-
Descamps J, De Clercq E. Specific phosphorylation of E-5-(2-iodovinyl)- 2′-deoxyuridine by herpes simplex virus-infected cells. J Biol Chem 1981;256:5973-5976.
-
(1981)
J Biol Chem
, vol.256
, pp. 5973-5976
-
-
Descamps, J.1
De Clercq, E.2
-
46
-
-
0019417639
-
On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2′-deoxyuridine
-
Allaudeen HS, Kozarich JW, Bertino JR, De Clercq E. On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)- 2′-deoxyuridine. Proc Natl Acad Sci USA 1981;78: 2698-2702.
-
(1981)
Proc Natl Acad Sci USA
, vol.78
, pp. 2698-2702
-
-
Allaudeen, H.S.1
Kozarich, J.W.2
Bertino, J.R.3
De Clercq, E.4
-
47
-
-
0025260843
-
Role of the incorporation of (E)-5-(2-iodovinyl)-2′-deoxyuridine and its carbocyclic analogue into DNA of herpes simplex virus type 1-infected cells in the antiviral effects of these compounds
-
Balzarini J, Bernaerts R, Verbruggen A, De Clercq E. Role of the incorporation of (E)-5-(2-iodovinyl)-2′-deoxyuridine and its carbocyclic analogue into DNA of herpes simplex virus type 1-infected cells in the antiviral effects of these compounds. Mol Pharmacol 1990;37:402-407.
-
(1990)
Mol Pharmacol
, vol.37
, pp. 402-407
-
-
Balzarini, J.1
Bernaerts, R.2
Verbruggen, A.3
De Clercq, E.4
-
48
-
-
0020700708
-
The relationship between incorporation of E-5-(2-bromovinyl)-2′- deoxyuridine into herpes simplex virus type 1 DNA with virus infectivity and DNA integrity
-
Mancini WR, De Clercq E, Prusoff WH. The relationship between incorporation of E-5-(2-bromovinyl)-2′-deoxyuridine into herpes simplex virus type 1 DNA with virus infectivity and DNA integrity. J Biol Chem 1983;258:792-795.
-
(1983)
J Biol Chem
, vol.258
, pp. 792-795
-
-
Mancini, W.R.1
De Clercq, E.2
Prusoff, W.H.3
-
49
-
-
0020066676
-
Differential phosphorylation of (E)-5-(2-bromovinyl)-2′- deoxyuridine monophosphate by thymidylate kinases from herpes simplex viruses types 1 and 2 and varicella zoster virus
-
Fyfe JA. Differential phosphorylation of (E)-5-(2-bromovinyl)-2′- deoxyuridine monophosphate by thymidylate kinases from herpes simplex viruses types 1 and 2 and varicella zoster virus. Mol Pharmacol 1982;21:432-437.
-
(1982)
Mol Pharmacol
, vol.21
, pp. 432-437
-
-
Fyfe, J.A.1
-
50
-
-
0021749129
-
Metabolic fate of (E)-5-(2-bromovinyl)-2′-deoxyuridine in herpes simplex virus- and mock-infected cells
-
Ayisi NK, De Clercq E, Wall RA, Hughes H, Sacks SL. Metabolic fate of (E)-5-(2-bromovinyl)-2′-deoxyuridine in herpes simplex virus- and mock-infected cells. Antimicrob Agents Chemother 1984;26: 762-765.
-
(1984)
Antimicrob Agents Chemother
, vol.26
, pp. 762-765
-
-
Ayisi, N.K.1
De Clercq, E.2
Wall, R.A.3
Hughes, H.4
Sacks, S.L.5
-
51
-
-
0021049170
-
Thymidylate synthetase-catalyzed conversions of E-5-(2-bromovinyl)- 2′-deoxyuridylate
-
Barr PJ, Oppenheimer NJ, Santi DV. Thymidylate synthetase-catalyzed conversions of E-5-(2-bromovinyl)-2′-deoxyuridylate. J Biol Chem 1983;258:13627-13631.
-
(1983)
J Biol Chem
, vol.258
, pp. 13627-13631
-
-
Barr, P.J.1
Oppenheimer, N.J.2
Santi, D.V.3
-
52
-
-
0028275765
-
Inhibition of thymidylate synthetase activity induced in varicella-zoster virus infected cells by (E)-5-(2-bromovinyl)-2′-deoxyuridine
-
Yokota T, Konno K, Shigeta S. Inhibition of thymidylate synthetase activity induced in varicella-zoster virus infected cells by (E)-5-(2-bromovinyl)-2′-deoxyuridine. Antiviral Chem Chemother 1994;5:191-194.
-
(1994)
Antiviral Chem Chemother
, vol.5
, pp. 191-194
-
-
Yokota, T.1
Konno, K.2
Shigeta, S.3
-
53
-
-
0028334052
-
Analysis of the thymidine kinase of a herpes simplex virus type 1 isolate that exhibits resistance to (E)-5-(2-bromovinyl)-2′-deoxyuridine
-
Jennings Wilber BA, Docherty JJ. Analysis of the thymidine kinase of a herpes simplex virus type 1 isolate that exhibits resistance to (E)-5-(2-bromovinyl)-2′-deoxyuridine. J Gen Virol 1994;75:1743-1747.
-
(1994)
J Gen Virol
, vol.75
, pp. 1743-1747
-
-
Jennings Wilber, B.A.1
Docherty, J.J.2
-
54
-
-
0035139165
-
Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase
-
Degrève B, Esnouf R, De Clercq E, Balzarini J. Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase. Mol Pharmacol 2001;59:285-293.
-
(2001)
Mol Pharmacol
, vol.59
, pp. 285-293
-
-
Degrève, B.1
Esnouf, R.2
De Clercq, E.3
Balzarini, J.4
-
55
-
-
0019766626
-
Inhibition of simian varicella virus infection of African green monkeys by (E)-5-(2-bromovinyl)-21-deoxyuridine (BVDU)
-
Soike KF, Gibson S, Gerone PJ. Inhibition of simian varicella virus infection of African green monkeys by (E)-5-(2-bromovinyl)-21-deoxyuridine (BVDU). Antiviral Res 1981;1:325-337.
-
(1981)
Antiviral Res
, vol.1
, pp. 325-337
-
-
Soike, K.F.1
Gibson, S.2
Gerone, P.J.3
-
56
-
-
0029027496
-
Oral brivudin vs. intravenous acyclovir in the treatment of herpes zoster in immunocompromised patients: A randomized double-blind trial
-
Wutzler P, De Clercq E, Wutke K, Färber I. Oral brivudin vs. intravenous acyclovir in the treatment of herpes zoster in immunocompromised patients: A randomized double-blind trial. J Med Virol 1995;46: 252-257.
-
(1995)
J Med Virol
, vol.46
, pp. 252-257
-
-
Wutzler, P.1
De Clercq, E.2
Wutke, K.3
Färber, I.4
-
57
-
-
0031981859
-
Sorivudine versus acyclovir for treatment of dermatomal herpes zoster in human immunodeficiency virus-infected patients: Results from a randomized, controlled clinical trial
-
Gnann JW, Jr., Crumpacker CS, Lalezari JP, Smith JA, Tyring SK, Baum KF, Borucki MJ, Joseph WP, Mertz GJ, Steigbigel RT, Cloud GA, Soong S-J, Sherrill LC, DeHertogh DA, Whitley RJ, the Collaborative Antiviral Study Group (CASG)/AIDS Clinical Trials Group (ACTG) Herpes Zoster Study Group. Sorivudine versus acyclovir for treatment of dermatomal herpes zoster in human immunodeficiency virus-infected patients: Results from a randomized, controlled clinical trial. Antimicrob Agents Chemother 1998;42:1139-1145.
-
(1998)
Antimicrob Agents Chemother
, vol.42
, pp. 1139-1145
-
-
Gnann Jr., J.W.1
Crumpacker, C.S.2
Lalezari, J.P.3
Smith, J.A.4
Tyring, S.K.5
Baum, K.F.6
Borucki, M.J.7
Joseph, W.P.8
Mertz, G.J.9
Steigbigel, R.T.10
Cloud, G.A.11
Soong, S.-J.12
Sherrill, L.C.13
DeHertogh, D.A.14
Whitley, R.J.15
-
58
-
-
8844281763
-
A randomized, double-blind survey on the effect of brivudin in the prevention of postherpetic pain in comparison with acyclovir
-
La Jolla, CA, USA, 3-5 March
-
Wassilew SW, Stubinski BM, Staedtler G, Koch I, Schumacher K, Neubauer A. A randomized, double-blind survey on the effect of brivudin in the prevention of postherpetic pain in comparison with acyclovir. Abstracts of the 4th International Conference on Varicella, Herpes Zoster, and Post-Herpetic Neuralgia, La Jolla, CA, USA, 3-5 March 2001, no. 45.
-
(2001)
Abstracts of the 4th International Conference on Varicella, Herpes Zoster, and Post-Herpetic Neuralgia
, Issue.45
-
-
Wassilew, S.W.1
Stubinski, B.M.2
Staedtler, G.3
Koch, I.4
Schumacher, K.5
Neubauer, A.6
-
59
-
-
0344880816
-
Brivudin compared to famciclovir in the prevention of postherpetic neuralgia: A randomized, double-blind multicenter trial
-
La Jolla, CA, USA, 3-5 March
-
Wassilew SW, Schumacher K, Staedtler G, Koch I, Capriati A, Stubinski BM. Brivudin compared to famciclovir in the prevention of postherpetic neuralgia: A randomized, double-blind multicenter trial. Abstracts of the 4th International Conference on Varicella, Herpes Zoster, and Post-Herpetic Neuralgia, La Jolla, CA, USA, 3-5 March 2001, no. 46.
-
(2001)
Abstracts of the 4th International Conference on Varicella, Herpes Zoster, and Post-Herpetic Neuralgia
, Issue.46
-
-
Wassilew, S.W.1
Schumacher, K.2
Staedtler, G.3
Koch, I.4
Capriati, A.5
Stubinski, B.M.6
-
60
-
-
4243333463
-
Brivudin compared to acyclovir and famciclovir: Effect on zoster-associated pain
-
Abstracts of the 14th International Conference on Antiviral Research, Seattle, WA, USA, 8-13 April 2001
-
Wassilew SW, Stubinski BM, Koch I, Schumacher K, Städtler G. Brivudin compared to acyclovir and famciclovir: Effect on zoster-associated pain. Abstracts of the 14th International Conference on Antiviral Research, Seattle, WA, USA, 8-13 April 2001. Antiviral Res 2001;50:A90, no. 180.
-
(2001)
Antiviral Res
, vol.50
, Issue.180
-
-
Wassilew, S.W.1
Stubinski, B.M.2
Koch, I.3
Schumacher, K.4
Städtler, G.5
-
61
-
-
10344264645
-
Brivudin compared to acyclovir and famciclovir in acute herpes zoster
-
Abstracts of the CONVIR 2002, European Conference on Viral Diseases, Munich, Germany, 10-12 May 2002
-
Wassilew SW, Wutzler P, Stubinski BM, Koch I, Staedtler G, Capriati A. Brivudin compared to acyclovir and famciclovir in acute herpes zoster. Abstracts of the CONVIR 2002, European Conference on Viral Diseases, Munich, Germany, 10-12 May 2002. Infection 2002;30(Suppl 1):12, no. 056.
-
(2002)
Infection
, vol.30
, Issue.1-56 SUPPL.
, pp. 12
-
-
Wassilew, S.W.1
Wutzler, P.2
Stubinski, B.M.3
Koch, I.4
Staedtler, G.5
Capriati, A.6
-
62
-
-
84862472598
-
Brivudin compared to acyclovir for the treatment of herpes zoster: Effects on acute disease and postherpetic pain
-
Paris, France, 5-8 May
-
Wassilew SW, Wutzler P, Stubinski BM, Koch I, Städtler G, Capriati A. Brivudin compared to acyclovir for the treatment of herpes zoster: Effects on acute disease and postherpetic pain. Abstracts of the 4th European Congress of Chemotherapy and Infection, Paris, France, 5-8 May 2002.
-
(2002)
Abstracts of the 4th European Congress of Chemotherapy and Infection
-
-
Wassilew, S.W.1
Wutzler, P.2
Stubinski, B.M.3
Koch, I.4
Städtler, G.5
Capriati, A.6
-
63
-
-
8844279339
-
Oral brivudin for herpes zoster: Results of a famciclovir-controlled study in immunocompetent patients ≥ 50 years
-
28 February-2 March
-
Wassilew SW, Stubinski BM, Koch I, Staedtler G, Schumacher K, Capriati A. Oral brivudin for herpes zoster: Results of a famciclovir-controlled study in immunocompetent patients ≥ 50 years. Abstracts of the 10th Annual Meeting of the International Herpes Management Forum (HIMF), 28 February-2 March 2003, no. VZV-03.
-
(2003)
Abstracts of the 10th Annual Meeting of the International Herpes Management Forum (HIMF)
, Issue.VZV-03
-
-
Wassilew, S.W.1
Stubinski, B.M.2
Koch, I.3
Staedtler, G.4
Schumacher, K.5
Capriati, A.6
-
64
-
-
0038460859
-
Oral brivudin in comparison with acyclovir for improved therapy of herpes zoster in immunocompetent patients: Results of a randomized, double-blind, multicentered study
-
Wassilew SW, Wutzler P. On behalf of the Brivudin Herpes Zoster Study Group. Oral brivudin in comparison with acyclovir for improved therapy of herpes zoster in immunocompetent patients: Results of a randomized, double-blind, multicentered study. Antiviral Res 2003;59:49-56.
-
(2003)
Antiviral Res
, vol.59
, pp. 49-56
-
-
Wassilew, S.W.1
Wutzler, P.2
-
65
-
-
0038798619
-
Oral brivudin in comparison with acyclovir for herpes zoster: A survey study on postherpetic neuralgia
-
Wassilew SW, Wutzler P. On behalf of the Brivudin Herpes Zoster Study Group. Oral brivudin in comparison with acyclovir for herpes zoster: A survey study on postherpetic neuralgia. Antiviral Res 2003;59:57-60.
-
(2003)
Antiviral Res
, vol.59
, pp. 57-60
-
-
Wassilew, S.W.1
Wutzler, P.2
-
66
-
-
0344880816
-
Brivudin compared to acyclovir in the treatment of acute herpes zoster: A randomized, double-blind, multicenter trial
-
La Jolla, CA, USA, 3-5 March
-
Wutzler P, Stubinski BM, Koch I, Staedtler G, Schumacher K. Brivudin compared to acyclovir in the treatment of acute herpes zoster: A randomized, double-blind, multicenter trial. Abstracts of the 4th International Conference on Varicella, Herpes Zoster, and Post-Herpetic Neuralgia, La Jolla, CA, USA, 3-5 March 2001, no. 47.
-
(2001)
Abstracts of the 4th International Conference on Varicella, Herpes Zoster, and Post-Herpetic Neuralgia
, Issue.47
-
-
Wutzler, P.1
Stubinski, B.M.2
Koch, I.3
Staedtler, G.4
Schumacher, K.5
-
67
-
-
0038081362
-
Efficacy and safety of brivudin in the treatment of herpes zoster
-
Abstracts of the 14th International Conference on Antiviral Research, Seattle, WA, USA, 8-13 April 2001
-
Wutzler P, Wassilew SW, Stubinski BM, Koch I, Schumacher K, Staedtler G. Efficacy and safety of brivudin in the treatment of herpes zoster. Abstracts of the 14th International Conference on Antiviral Research, Seattle, WA, USA, 8-13 April 2001. Antiviral Res 2001, 50:A69, no. 108.
-
(2001)
Antiviral Res
, vol.50
, Issue.108
-
-
Wutzler, P.1
Wassilew, S.W.2
Stubinski, B.M.3
Koch, I.4
Schumacher, K.5
Staedtler, G.6
-
68
-
-
8844232002
-
Efficacy and safety of brivudin in the treatment of herpes zoster. Results of two randomised, controlled clinical trials
-
Perth, Australia, 1 -5 December
-
Wutzler P, Wassilew SW, Stubinski BM, Koch I, Schumacher K, Städtler G, Capriati A. Efficacy and safety of brivudin in the treatment of herpes zoster. Results of two randomised, controlled clinical trials. Abstracts of the 8th Western Pacific Congress of Chemotherapy and Infectious Diseases, Perth, Australia, 1 -5 December 2002.
-
(2002)
Abstracts of the 8th Western Pacific Congress of Chemotherapy and Infectious Diseases
-
-
Wutzler, P.1
Wassilew, S.W.2
Stubinski, B.M.3
Koch, I.4
Schumacher, K.5
Städtler, G.6
Capriati, A.7
-
69
-
-
0021130877
-
Topical treatment of cutaneous herpes simplex virus infection in hairless mice with (E)-5-(2-bromovinyl)-2′-deoxyuridine and related compounds
-
De Clercq E. Topical treatment of cutaneous herpes simplex virus infection in hairless mice with (E)-5-(2-bromovinyl)-2′-deoxyuridine and related compounds. Antimicrob Agents Chemother 1984;26:155-159.
-
(1984)
Antimicrob Agents Chemother
, vol.26
, pp. 155-159
-
-
De Clercq, E.1
-
70
-
-
0028049685
-
Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2′-deoxyuridine
-
Keizer HJ, DeBruijn EA, Tjaden UR, De Clercq E. Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2′-deoxyuridine. J Cancer Res Clin Oncol 1994;120:545-549.
-
(1994)
J Cancer Res Clin Oncol
, vol.120
, pp. 545-549
-
-
Keizer, H.J.1
DeBruijn, E.A.2
Tjaden, U.R.3
De Clercq, E.4
-
71
-
-
0023883431
-
Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5-fluorouracil against adenocarcinoma 755 in mice
-
Iigo M, Araki E, Nakajima Y, Hoshi A, De Clercq E. Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5-fluorouracil against adenocarcinoma 755 in mice. Biochem Pharmacol 1988; 37:1609-1613.
-
(1988)
Biochem Pharmacol
, vol.37
, pp. 1609-1613
-
-
Iigo, M.1
Araki, E.2
Nakajima, Y.3
Hoshi, A.4
De Clercq, E.5
-
72
-
-
0025687977
-
Effect of (E)-5-(2-bromovinyl)-2′-deoxyuridine on life-span and 5-fluorouracil metabolism in mice with hepatic metastases
-
Iigo M, Nishikata K-i, Nakajima Y, Hoshi A, De Clercq E. Effect of (E)-5-(2-bromovinyl)-2′-deoxyuridine on life-span and 5-fluorouracil metabolism in mice with hepatic metastases. Eur J Cancer 1990;26:1089-1092.
-
(1990)
Eur J Cancer
, vol.26
, pp. 1089-1092
-
-
Iigo, M.1
K-i, N.2
Nakajima, Y.3
Hoshi, A.4
De Clercq, E.5
-
73
-
-
0031024879
-
Lethal drug interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs
-
Okuda H, Nishiyama T, Ogura Y, Nagayama S, Ikeda K, Yamaguchi S, Nakamura Y, Kawaguchi K, Watabe T. Lethal drug interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs. Drug Metab Dispos 1997;25:270-273.
-
(1997)
Drug Metab Dispos
, vol.25
, pp. 270-273
-
-
Okuda, H.1
Nishiyama, T.2
Ogura, Y.3
Nagayama, S.4
Ikeda, K.5
Yamaguchi, S.6
Nakamura, Y.7
Kawaguchi, K.8
Watabe, T.9
-
74
-
-
0032470250
-
A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs
-
Okuda H, Ogura K, Kato A, Takubo H, Watabe T. A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs. J Pharmacol Exp Ther 1998;287:791-799.
-
(1998)
J Pharmacol Exp Ther
, vol.287
, pp. 791-799
-
-
Okuda, H.1
Ogura, K.2
Kato, A.3
Takubo, H.4
Watabe, T.5
-
75
-
-
0022550597
-
Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice
-
Desgranges C, Razaka G, De Clercq E, Herdewijn P, Balzarini J, Drouillet F, Bricaud H. Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice. Cancer Res 1986;46:1094-1101.
-
(1986)
Cancer Res
, vol.46
, pp. 1094-1101
-
-
Desgranges, C.1
Razaka, G.2
De Clercq, E.3
Herdewijn, P.4
Balzarini, J.5
Drouillet, F.6
Bricaud, H.7
-
76
-
-
0032498318
-
Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine
-
Ogura K, Nishiyama T, Takubo H, Kato A, Okuda H, Arakawa K, Fukushima M, Nagayama S, Kawaguchi Y Watabe T. Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine. Cancer Lett 1998;122:107-113.
-
(1998)
Cancer Lett
, vol.122
, pp. 107-113
-
-
Ogura, K.1
Nishiyama, T.2
Takubo, H.3
Kato, A.4
Okuda, H.5
Arakawa, K.6
Fukushima, M.7
Nagayama, S.8
Kawaguchi, Y.9
Watabe, T.10
-
77
-
-
0028921902
-
Deglycosylation of antiherpesviral 5-substituted arabinosyluracil derivatives by rat liver extract and enterobacteria cells
-
Machida H, Watanabe Y, Kano F, Sakata S, Kumagai M, Yamaguchi T. Deglycosylation of antiherpesviral 5-substituted arabinosyluracil derivatives by rat liver extract and enterobacteria cells. Biochem Pharmacol 1995;49:763-766.
-
(1995)
Biochem Pharmacol
, vol.49
, pp. 763-766
-
-
Machida, H.1
Watanabe, Y.2
Kano, F.3
Sakata, S.4
Kumagai, M.5
Yamaguchi, T.6
-
78
-
-
0030985696
-
Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-5-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil
-
Nakayama H, Kinouchi T, Kataoka K, Akimoto S, Matsuda Y, Ohnishi Y. Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-5-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil. Pharmacogenetics 1997;7:35-43.
-
(1997)
Pharmacogenetics
, vol.7
, pp. 35-43
-
-
Nakayama, H.1
Kinouchi, T.2
Kataoka, K.3
Akimoto, S.4
Matsuda, Y.5
Ohnishi, Y.6
-
79
-
-
0030951083
-
The effect of sorivudine on dihydropyrimidine dehydrogenase activity in patients with acute herpes zoster
-
Yan J, Tyring SK, McCrary MM, Lee PC, Haworth S, Raymond R, Olsen SJ, Diasio RB. The effect of sorivudine on dihydropyrimidine dehydrogenase activity in patients with acute herpes zoster. Clin Pharmacol Ther 1997;61:563-573.
-
(1997)
Clin Pharmacol Ther
, vol.61
, pp. 563-573
-
-
Yan, J.1
Tyring, S.K.2
McCrary, M.M.3
Lee, P.C.4
Haworth, S.5
Raymond, R.6
Olsen, S.J.7
Diasio, R.B.8
-
80
-
-
0031858786
-
Sorivudine and 5-fluorouracil: A clinically significant drug-drug interaction due to inhibition of dihydropyrimidine dehydrogenase
-
Diasio RB. Sorivudine and 5-fluorouracil: A clinically significant drug-drug interaction due to inhibition of dihydropyrimidine dehydrogenase. Br J Clin Pharmacol 1998;46:1-4.
-
(1998)
Br J Clin Pharmacol
, vol.46
, pp. 1-4
-
-
Diasio, R.B.1
-
81
-
-
0034074418
-
Prediction of in vivo drug-drug interactions based on mechanism-based inhibition from in vitro data: Inhibition of 5-fluorouracil metabolism by (E)-5-(2-bromovinyl)uracil
-
Kanamitsu S-I, Ito K, Okuda H, Ogura K, Watabe T, Muro K, Sugiyama Y. Prediction of in vivo drug-drug interactions based on mechanism-based inhibition from in vitro data: Inhibition of 5-fluorouracil metabolism by (E)-5-(2-bromovinyl)uracil. Drug Metab Dispos 2000;28:467-474.
-
(2000)
Drug Metab Dispos
, vol.28
, pp. 467-474
-
-
Kanamitsu, S.-I.1
Ito, K.2
Okuda, H.3
Ogura, K.4
Watabe, T.5
Muro, K.6
Sugiyama, Y.7
-
82
-
-
0034015812
-
Mechanism-based inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil in the presence of NADPH
-
Nishiyama T, Ogura K, Okuda H, Suda K, Kato A, Watabe T. Mechanism-based inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl) uracil in the presence of NADPH. Mol Pharmacol 2000;57:899-905.
-
(2000)
Mol Pharmacol
, vol.57
, pp. 899-905
-
-
Nishiyama, T.1
Ogura, K.2
Okuda, H.3
Suda, K.4
Kato, A.5
Watabe, T.6
-
83
-
-
0021843802
-
Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2′-deoxvuridine and related compounds
-
Balzarini J, De Clercq E, Ayusawa D, Seno T. Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2′-deoxvuridine and related compounds. FEBS Lett 1985;185:95-100.
-
(1985)
FEBS Lett
, vol.185
, pp. 95-100
-
-
Balzarini, J.1
De Clercq, E.2
Ayusawa, D.3
Seno, T.4
-
84
-
-
0022377534
-
Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2′- deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene
-
Balzarini J, De Clercq E, Verbruggen A, Ayusawa D, Seno T. Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2′-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene. Mol Pharmacol 1985;28:581-587.
-
(1985)
Mol Pharmacol
, vol.28
, pp. 581-587
-
-
Balzarini, J.1
De Clercq, E.2
Verbruggen, A.3
Ayusawa, D.4
Seno, T.5
-
85
-
-
0023514971
-
Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2′-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene
-
Balzarini J, De Clercq E, Verbruggen A, Ayusawa D, Shimizu K, Seno T. Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2′-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene. Mol Pharmacol 1987;32:410-416.
-
(1987)
Mol Pharmacol
, vol.32
, pp. 410-416
-
-
Balzarini, J.1
De Clercq, E.2
Verbruggen, A.3
Ayusawa, D.4
Shimizu, K.5
Seno, T.6
-
86
-
-
0027480081
-
Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)- 2′-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)-guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2
-
Balzarini J, Bohman C, De Clercq E. Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2′-deoxyuridine, 9-(1,3-dihydroxy-2- propoxymethyl)-guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2. J Biol Chem 1993;268:6332-6337.
-
(1993)
J Biol Chem
, vol.268
, pp. 6332-6337
-
-
Balzarini, J.1
Bohman, C.2
De Clercq, E.3
-
87
-
-
0028238797
-
Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells
-
Balzarini J, Bohman C, Walker RT, De Clercq E. Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells. Mol Pharmacol 1994;45:1253-1258.
-
(1994)
Mol Pharmacol
, vol.45
, pp. 1253-1258
-
-
Balzarini, J.1
Bohman, C.2
Walker, R.T.3
De Clercq, E.4
-
88
-
-
0029084206
-
Novel (E)-5-(2-iodovinyl)-2′-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors
-
Balzarini J, Morin KW, Knaus EE, Wiebe LI, De Clercq E. Novel (E)-5-(2-iodovinyl)-2′-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors. Gene Ther 1995;2:317-322.
-
(1995)
Gene Ther
, vol.2
, pp. 317-322
-
-
Balzarini, J.1
Morin, K.W.2
Knaus, E.E.3
Wiebe, L.I.4
De Clercq, E.5
-
89
-
-
18544405495
-
Bystander effect of purine nucleoside analogues in HSV-1tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues
-
Degrève B, De Clercq E, Balzarini J. Bystander effect of purine nucleoside analogues in HSV-1tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues. Gene Ther 1999;6:162-170.
-
(1999)
Gene Ther
, vol.6
, pp. 162-170
-
-
Degrève, B.1
De Clercq, E.2
Balzarini, J.3
-
90
-
-
0028805459
-
Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents
-
Kim JH, Kim SH, Kolozsvary A, Brown SL, Kim OB, Freytag SO. Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents. Int J Radiat Oncol Biol Phys 1995;33:861-868.
-
(1995)
Int J Radiat Oncol Biol Phys
, vol.33
, pp. 861-868
-
-
Kim, J.H.1
Kim, S.H.2
Kolozsvary, A.3
Brown, S.L.4
Kim, O.B.5
Freytag, S.O.6
-
91
-
-
0030758623
-
Potential of varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells
-
Grignet-Debrus C, Calberg-Bacq CM. Potential of varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells. Gene Ther 1997;4:560-569.
-
(1997)
Gene Ther
, vol.4
, pp. 560-569
-
-
Grignet-Debrus, C.1
Calberg-Bacq, C.M.2
-
92
-
-
0345814045
-
Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer
-
Degrève B, Andrei G, Izquierdo M, Piette J, Morin K, Knaus EE, Wiebe LI, Basrah I, Walker RT, De Clercq E, Balzarini J. Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer. Gene Ther 1997;4:1107-1114.
-
(1997)
Gene Ther
, vol.4
, pp. 1107-1114
-
-
Degrève, B.1
Andrei, G.2
Izquierdo, M.3
Piette, J.4
Morin, K.5
Knaus, E.E.6
Wiebe, L.I.7
Basrah, I.8
Walker, R.T.9
De Clercq, E.10
Balzarini, J.11
-
93
-
-
0037310208
-
Apoptosis induced by (E)-5-(2-bromovinyl)-2′-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8
-
Tomicic MT, Friedrichs C, Christmann M, Wutzler P, Thust R, Kaina B. Apoptosis induced by (E)-5-(2-bromovinyl)-2′-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8. Mol Pharmacol 2003;63:439-449.
-
(2003)
Mol Pharmacol
, vol.63
, pp. 439-449
-
-
Tomicic, M.T.1
Friedrichs, C.2
Christmann, M.3
Wutzler, P.4
Thust, R.5
Kaina, B.6
-
94
-
-
0029301041
-
Evaluation of a viral thymidine kinase gene for suicide selection in transfected mosquito cells
-
Mazzacano CA, Fallon AM. Evaluation of a viral thymidine kinase gene for suicide selection in transfected mosquito cells. Insect Mol Biol 1995;4:125-134.
-
(1995)
Insect Mol Biol
, vol.4
, pp. 125-134
-
-
Mazzacano, C.A.1
Fallon, A.M.2
-
95
-
-
0342424230
-
The multifunctional deoxynucleoside kinase of insect cells is a target for the development of new insecticides
-
Balzarini J, Degrève B, Hatse S, De Clercq E, Breuer M, Johansson M, Huybrechts R, Karlsson A. The multifunctional deoxynucleoside kinase of insect cells is a target for the development of new insecticides. Mol Pharmacol 2000;57:811-819.
-
(2000)
Mol Pharmacol
, vol.57
, pp. 811-819
-
-
Balzarini, J.1
Degrève, B.2
Hatse, S.3
De Clercq, E.4
Breuer, M.5
Johansson, M.6
Huybrechts, R.7
Karlsson, A.8
-
96
-
-
0033852240
-
Novel mouse models for the investigation of experimental drugs with activity against human varicella-zoster virus
-
Weber O. Novel mouse models for the investigation of experimental drugs with activity against human varicella-zoster virus. Antiviral Chem Chemother 2000;11:283-290.
-
(2000)
Antiviral Chem Chemother
, vol.11
, pp. 283-290
-
-
Weber, O.1
-
97
-
-
0019831269
-
Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2′- deoxyuridine
-
Jones AS, Rahim SG, Walker RT, De Clercq E. Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2′-deoxyuridine. J Med Chem 1981;24:759-760.
-
(1981)
J Med Chem
, vol.24
, pp. 759-760
-
-
Jones, A.S.1
Rahim, S.G.2
Walker, R.T.3
De Clercq, E.4
-
98
-
-
0023836413
-
Synthesis and antiviral properties of (E)-5-(2-bromovinyl)-2′- deoxycytidine-related compounds
-
Jones AS, Sayers JR, Walker RT, De Clercq E. Synthesis and antiviral properties of (E)-5-(2-bromovinyl)-2′-deoxycytidine-related compounds. J Med Chem 1988;31:268-271.
-
(1988)
J Med Chem
, vol.31
, pp. 268-271
-
-
Jones, A.S.1
Sayers, J.R.2
Walker, R.T.3
De Clercq, E.4
-
99
-
-
0025219482
-
Carbocyclic 5-iodo-2′-deoxyuridine (C-IDU) and carbocyclic (E)-5-(2-bromovinyl)-2′-deoxyuridine (C-BVDU) as unique examples of chiral molecules where the two enantiomeric forms are biologically active: Interaction of the (+) and (-)-enantiomers of C-IDU and C-BVDU with the thymidine kinase of herpes simplex virus type 1
-
Balzarini J, De Clercq E, Baumgartner H, Bodenteich M, Griengl H. Carbocyclic 5-iodo-2′-deoxyuridine (C-IDU) and carbocyclic (E)-5-(2-bromovinyl)-2′-deoxyuridine (C-BVDU) as unique examples of chiral molecules where the two enantiomeric forms are biologically active: Interaction of the (+) and (-)-enantiomers of C-IDU and C-BVDU with the thymidine kinase of herpes simplex virus type 1. Mol Pharmacol 1990;37:395-401.
-
(1990)
Mol Pharmacol
, vol.37
, pp. 395-401
-
-
Balzarini, J.1
De Clercq, E.2
Baumgartner, H.3
Bodenteich, M.4
Griengl, H.5
-
100
-
-
0029036828
-
5-Iodo-2′-deoxy-L-uridine and (E)-5-(2-bromovinyl)-2′-deoxy- L-uridine: Selective phosphorylation by herpes simplex virus type 1 thymidine kinase, antiherpetic activity, and cytotoxicity studies
-
Spadari S, Ciarrocchi G, Focher F, Verri A, Maga G, Arcamone F, Iafrate E, Manzini S, Garbesi A, Tondelli L. 5-Iodo-2′-deoxy-L-uridine and (E)-5-(2-bromovinyl)-2′-deoxy-L-uridine: Selective phosphorylation by herpes simplex virus type 1 thymidine kinase, antiherpetic activity, and cytotoxicity studies. Mol Pharmacol 1995;47:1231-1238.
-
(1995)
Mol Pharmacol
, vol.47
, pp. 1231-1238
-
-
Spadari, S.1
Ciarrocchi, G.2
Focher, F.3
Verri, A.4
Maga, G.5
Arcamone, F.6
Iafrate, E.7
Manzini, S.8
Garbesi, A.9
Tondelli, L.10
-
101
-
-
0034729670
-
Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses
-
Choi Ys, Li L, Grill S, Gullen E, Lee CS, Gumina G, Tsujii E, Cheng Y-C, Chu CK. Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses. J Med Chem 2000;43:2538-2546.
-
(2000)
J Med Chem
, vol.43
, pp. 2538-2546
-
-
Choi, Ys.1
Li, L.2
Grill, S.3
Gullen, E.4
Lee, C.S.5
Gumina, G.6
Tsujii, E.7
Cheng, Y.-C.8
Chu, C.K.9
-
102
-
-
0031912176
-
Efficient syntheses of (E)-5-(2-bromovinyl)-2′-deoxy-4′- thiouridine. A nucleoside analogue with potent biological activity
-
Basnak I, Otter GP, Buncombe RJ, Westwood NB, Pietrarelli M, Hardy GW, Mills G, Rahim SG, Walker RT. Efficient syntheses of (E)-5-(2-bromovinyl)- 2′-deoxy-4′-thiouridine. A nucleoside analogue with potent biological activity. Nucleosides Nucleotides 1998;17:29-38.
-
(1998)
Nucleosides Nucleotides
, vol.17
, pp. 29-38
-
-
Basnak, I.1
Otter, G.P.2
Buncombe, R.J.3
Westwood, N.B.4
Pietrarelli, M.5
Hardy, G.W.6
Mills, G.7
Rahim, S.G.8
Walker, R.T.9
-
103
-
-
0031886860
-
Synthesis and antiviral activities of 5-substituted 1-(2-deoxy-2-C- methylene-4-thio-β-D-erythro-pentofuranosyl)uracils
-
Satoh H, Yoshimura Y, Watanabe M, Ashida N, Ijichi K, Sakata S, Machida H, Matsuda A. Synthesis and antiviral activities of 5-substituted 1-(2-deoxy-2-C-methylene-4-thio-β-D-erythro-pentofuranosyl)uracils. Nucleosides Nucleotides 1998;17:65-79.
-
(1998)
Nucleosides Nucleotides
, vol.17
, pp. 65-79
-
-
Satoh, H.1
Yoshimura, Y.2
Watanabe, M.3
Ashida, N.4
Ijichi, K.5
Sakata, S.6
Machida, H.7
Matsuda, A.8
-
104
-
-
0033594170
-
Synthesis of novel 4′-C-methyl-pyrimidirie nucleosides and their biological activities
-
Kitano K, Machida H, Miura S, Ohrui H. Synthesis of novel 4′-C-methyl-pyrimidirie nucleosides and their biological activities. Bioorg Med Chem Lett 1999;9:827-830.
-
(1999)
Bioorg Med Chem Lett
, vol.9
, pp. 827-830
-
-
Kitano, K.1
Machida, H.2
Miura, S.3
Ohrui, H.4
-
105
-
-
0025110786
-
Synthesis and antiviral activity of 3′-deoxy-3′-C- hydroxymethyl nucleosides
-
Bamford MJ, Coe PL, Walker RT. Synthesis and antiviral activity of 3′-deoxy-3′-C-hydroxymethyl nucleosides. J Med Chem 1990;33:2494-2501.
-
(1990)
J Med Chem
, vol.33
, pp. 2494-2501
-
-
Bamford, M.J.1
Coe, P.L.2
Walker, R.T.3
-
106
-
-
0033583469
-
Synthesis of 2′,3′-dideoxy-3′-C-(hydroxymethyl)- 4′-thiopentofuranosyl nucleosides as potential antiviral agent
-
Ichikawa E, Yamamura S, Kato K. Synthesis of 2′,3′-dideoxy- 3′-C-(hydroxymethyl)-4′-thiopentofuranosyl nucleosides as potential antiviral agent. Bioorg Med Chem Lett 1999;9:1113-1114.
-
(1999)
Bioorg Med Chem Lett
, vol.9
, pp. 1113-1114
-
-
Ichikawa, E.1
Yamamura, S.2
Kato, K.3
-
107
-
-
0027299021
-
Synthesis and antiviral activity of novel isonucleoside analogs
-
Tino JA, Clark JM, Field AK, Jacobs GA, Lis KA, Michalik TL, McGeever-Rubin B, Slusarchyk WA, Spergel SH, Sundeen JE, Tuomari AV, Weaver ER, Young MG, Zahler R. Synthesis and antiviral activity of novel isonucleoside analogs. J Med Chem 1993;36:1221-1229.
-
(1993)
J Med Chem
, vol.36
, pp. 1221-1229
-
-
Tino, J.A.1
Clark, J.M.2
Field, A.K.3
Jacobs, G.A.4
Lis, K.A.5
Michalik, T.L.6
McGeever-Rubin, B.7
Slusarchyk, W.A.8
Spergel, S.H.9
Sundeen, J.E.10
Tuomari, A.V.11
Weaver, E.R.12
Young, M.G.13
Zahler, R.14
-
108
-
-
0028345779
-
Pharmacokinetics and antiviral activity of a novel isonucleoside, BMS-181165, against simian varicella virus infection in African green monkeys
-
Soike KF, Huang J-L, Russell JW, Whiterock VJ, Sundeen JE, Stratton LW, Clark JM. Pharmacokinetics and antiviral activity of a novel isonucleoside, BMS-181165, against simian varicella virus infection in African green monkeys. Antiviral Res 1994;23:219-224.
-
(1994)
Antiviral Res
, vol.23
, pp. 219-224
-
-
Soike, K.F.1
Huang, J.-L.2
Russell, J.W.3
Whiterock, V.J.4
Sundeen, J.E.5
Stratton, L.W.6
Clark, J.M.7
-
109
-
-
0034719434
-
Synthesis and antiviral activity of novel anti-VZV 5-substituted uracil nucleosides with a cyclopropane sugar moiety
-
Onishi T, Mukai C, Nakagawa R, Sekiyama T, Aoki M, Suzuki K, Nakazawa H, Ono N, Ohmura Y, Iwayama S, Okunishi M, Tsuji T. Synthesis and antiviral activity of novel anti-VZV 5-substituted uracil nucleosides with a cyclopropane sugar moiety. J Med Chem 2000;43:278-282.
-
(2000)
J Med Chem
, vol.43
, pp. 278-282
-
-
Onishi, T.1
Mukai, C.2
Nakagawa, R.3
Sekiyama, T.4
Aoki, M.5
Suzuki, K.6
Nakazawa, H.7
Ono, N.8
Ohmura, Y.9
Iwayama, S.10
Okunishi, M.11
Tsuji, T.12
-
110
-
-
0037027990
-
A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity
-
Guenther S, Balzarini J, De Clercq E, Nair V. A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity. J Med Chem 2002;45:5426-5429.
-
(2002)
J Med Chem
, vol.45
, pp. 5426-5429
-
-
Guenther, S.1
Balzarini, J.2
De Clercq, E.3
Nair, V.4
-
111
-
-
0242299579
-
Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine
-
Russ P, Schelling P, Scapozza L, Folkers G, De Clercq E, Marquez VE. Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine. J Med Chem 2003;46:5045-5054.
-
(2003)
J Med Chem
, vol.46
, pp. 5045-5054
-
-
Russ, P.1
Schelling, P.2
Scapozza, L.3
Folkers, G.4
De Clercq, E.5
Marquez, V.E.6
-
112
-
-
0022633248
-
Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine
-
De Clercq E, Desgranges C, Herdewijn P, Sim IS, Jones AS, McLean MJ, Walker RT. Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine. J Med Chem 1986;29: 213-217.
-
(1986)
J Med Chem
, vol.29
, pp. 213-217
-
-
De Clercq, E.1
Desgranges, C.2
Herdewijn, P.3
Sim, I.S.4
Jones, A.S.5
McLean, M.J.6
Walker, R.T.7
-
113
-
-
0024312350
-
(E)-5-(2-bromovinyl)uridine requires phosphorylation by the herpes simplex virus (type 1)-induced thymidine kinase to express its antiviral activity
-
Bernaerts R, Desgranges C, De Clercq E. (E)-5-(2-bromovinyl)uridine requires phosphorylation by the herpes simplex virus (type 1)-induced thymidine kinase to express its antiviral activity. Biochem Pharmacol 1989;38:1955-1961.
-
(1989)
Biochem Pharmacol
, vol.38
, pp. 1955-1961
-
-
Bernaerts, R.1
Desgranges, C.2
De Clercq, E.3
-
114
-
-
0025350764
-
Synthesis and biological properties of novel phosphotriesters: A new approach to the introduction of biologically active nucleotides into cells
-
Farrow SN, Jones AS, Kumar A, Walker RT, Balzarini J, De Clercq E. Synthesis and biological properties of novel phosphotriesters: A new approach to the introduction of biologically active nucleotides into cells. J Med Chem 1990;33:1400-1406.
-
(1990)
J Med Chem
, vol.33
, pp. 1400-1406
-
-
Farrow, S.N.1
Jones, A.S.2
Kumar, A.3
Walker, R.T.4
Balzarini, J.5
De Clercq, E.6
-
115
-
-
0025091612
-
Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives
-
Kumar A, Coe PL, Jones AS, Walker RT, Balzarini J, De Clercq E. Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives. J Med Chem 1990;33:2368-2375.
-
(1990)
J Med Chem
, vol.33
, pp. 2368-2375
-
-
Kumar, A.1
Coe, P.L.2
Jones, A.S.3
Walker, R.T.4
Balzarini, J.5
De Clercq, E.6
-
116
-
-
8844219944
-
3′-O-benzyl-(E)-5-(2-bromovinyl)-2′-deoxyuridine is active as an anti-herpes agent in vivo but not in vitro
-
De Clercq E, Walker RT, Whale RF. 3′-O-benzyl-(E)-5-(2-bromovinyl)- 2′-deoxyuridine is active as an anti-herpes agent in vivo but not in vitro. Med Chem Res 1992;2:111-118.
-
(1992)
Med Chem Res
, vol.2
, pp. 111-118
-
-
De Clercq, E.1
Walker, R.T.2
Whale, R.F.3
|